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P29336

- GTFS_STRDO

UniProt

P29336 - GTFS_STRDO

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Protein
Glucosyltransferase-S
Gene
gtfS
Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Glucan synthesis by GTF-S is independent of primer glucan unlike GTF-I.

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-S (EC:2.4.1.5)
Short name:
GTF-S
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfS
OrganismiStreptococcus downei (Streptococcus sobrinus)
Taxonomic identifieri1317 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Or 37 Reviewed prediction
Add
BLAST
Chaini37 – 13651329Glucosyltransferase-S
PRO_0000021388Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29336.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 16621Cell wall-binding 1
Add
BLAST
Repeati168 – 18720Cell wall-binding 2
Add
BLAST
Repeati1052 – 107120Cell wall-binding 3
Add
BLAST
Repeati1073 – 109220Cell wall-binding 4
Add
BLAST
Repeati1093 – 111220Cell wall-binding 5
Add
BLAST
Repeati1113 – 113321Cell wall-binding 6
Add
BLAST
Repeati1136 – 115924Cell wall-binding 7
Add
BLAST
Repeati1160 – 117920Cell wall-binding 8
Add
BLAST
Repeati1234 – 125320Cell wall-binding 9
Add
BLAST
Repeati1278 – 129821Cell wall-binding 10
Add
BLAST
Repeati1299 – 131820Cell wall-binding 11
Add
BLAST
Repeati1343 – 136220Cell wall-binding 12
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 1000801Catalytic; approximate
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 2 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 3 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 4 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29336-1 [UniParc]FASTAAdd to Basket

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MEKNLRYKLH KVKKQWVAIG VTTVTLSFLA GGQVVAADTN NNDGTSVQVN     50
KMVPSDPKFD AQAQNGQLAQ AMFKAANQAD QTATSQVSPA TDGRVDNQVT 100
PAANQPAANV ANQDVANPAT DAGALNRQSA ADTSTDGKAV PQTSDQPGHL 150
ETVDGKTYYV DANGQRLKNY SMVIDGKTYY FDGQTGEAQT DLPKTGQANQ 200
DNVPDSYQAN NQAYSNEASS FETVDNYLTA DSWYRPRKIL KNGQSWQASS 250
EGDLRPILMT WWPDAATKAA YANFWAKEGL ISGSYRQNSA NLDAATQNIQ 300
SAIEKKIASE GNTNWLRDKM SQFVKSQNQW SIASENETVY PNQDHMQGGA 350
LLFSNSKDTE HANSDWRLLN RNPTFQTGKQ KYFTTNYAGY ELLLANDVDN 400
SNPVVQAEQL NHLHYLMNWG DIVMGDKDAN FDGVRVDAVD NVNADLLQIQ 450
RDYYKAKYGT DQNEKNAIDH LSILEAWSGN DNDYVKDQNN FSLSIDNDQR 500
SGMLKAFGYA SAYRGNLSNL ATAGLKNRSA NPDSDPVPNY VFIRAHDSEV 550
QTRIAKIIRE KLGKTNADGL TNLTLDDLNK AFDIYNQDMN ATDKVYYPNN 600
LPMAYAWMLQ NKDTVTRVYY GDMYTDNGQY MATKTPFYNA IETLLKGRIK 650
YVAGGQAVSY KQDWSSGILT SVRYGKGANS ASDAGNTETR NSGMALLINN 700
RPNFRAYRNL TLNMGAAHKS QAYRPLLLST KDGIATYLND SDVDSRQYKY 750
TDSQGNLSFS ASELQSVANA QVSGMIQVWV PVGAADNQDV RTSPSTQATK 800
DGNIYHQSDA LDSQVIYEGF SNFQAFAQSP DQYTNAVIAK NGDLFKSWGI 850
TQFEMAPQYV SSEDGTFLDS VILNGYAFSD RYDLAMSKNN KYGSKQDLAN 900
AIKGLQSAGI KVLSDLVPNQ LYNLPGKEVV TATRVNQYGQ AKSGATINKT 950
PYVANTRSYG DYQEQYGGKF LDDLQKLYPR LFSTKQISTG KPIDPSVKIT 1000
NWSAKYFNGS NILGRGAKYV LSEGNKYLNL ADGKLFLPTV LNNTYGQPQV 1050
SANGFISKNG GIHYLDKNGQ EVKNRFKEIS GSWYYFDSDG KMATGKTKIG 1100
NDTYLFMPNG KQLKEGVWYD GKKAYYYDDN GRTWTNKGFV EFRVDGQDKW 1150
RYFNGDGTIA IGLVSLDNRT LYFDAYGYQV KGQTVTINGK SYTFDADQGD 1200
LVQTDNANPA PQGQAGWKLL GDNQWGYRKD GQLLTGEQTI DGQKVFFQDN 1250
GVQVKGGTAT DASGVLRFYD RDQGHQVGKG WYSTSDDNWV YVNESGQVLT 1300
GLQTIDGQTV YFDDKGIQAK GKAVWDENGN LRYFDADSGN MLRDRWKNVD 1350
GNWYYFNRNG LATRW 1365
Length:1,365
Mass (Da):151,591
Last modified:December 1, 1992 - v1
Checksum:i167296B5A2E8C476
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30943 Genomic DNA. Translation: AAA26898.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30943 Genomic DNA. Translation: AAA26898.1 .

3D structure databases

ProteinModelPortali P29336.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 2 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 3 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 4 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Streptococcus downei gtfS gene, which specifies a glucosyltransferase that synthesizes soluble glucans."
    Gilmore K.S., Russell R.R., Ferretti J.J.
    Infect. Immun. 58:2452-2458(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MFE28.

Entry informationi

Entry nameiGTFS_STRDO
AccessioniPrimary (citable) accession number: P29336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 16, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Synthesizes water-soluble glucans (alpha 1,6-glucose).

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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