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P29336

- GTFS_STRDO

UniProt

P29336 - GTFS_STRDO

Protein

Glucosyltransferase-S

Gene

gtfS

Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

    Catalytic activityi

    Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

    Enzyme regulationi

    Glucan synthesis by GTF-S is independent of primer glucan unlike GTF-I.

    GO - Molecular functioni

    1. dextransucrase activity Source: UniProtKB-EC
    2. glucosyltransferase activity Source: InterPro

    GO - Biological processi

    1. glucan biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGH70. Glycoside Hydrolase Family 70.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucosyltransferase-S (EC:2.4.1.5)
    Short name:
    GTF-S
    Alternative name(s):
    Dextransucrase
    Sucrose 6-glucosyltransferase
    Gene namesi
    Name:gtfS
    OrganismiStreptococcus downei (Streptococcus sobrinus)
    Taxonomic identifieri1317 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Pathology & Biotechi

    Keywords - Diseasei

    Dental caries

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Or 37Sequence AnalysisAdd
    BLAST
    Chaini37 – 13651329Glucosyltransferase-SPRO_0000021388Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP29336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati146 – 16621Cell wall-binding 1Add
    BLAST
    Repeati168 – 18720Cell wall-binding 2Add
    BLAST
    Repeati1052 – 107120Cell wall-binding 3Add
    BLAST
    Repeati1073 – 109220Cell wall-binding 4Add
    BLAST
    Repeati1093 – 111220Cell wall-binding 5Add
    BLAST
    Repeati1113 – 113321Cell wall-binding 6Add
    BLAST
    Repeati1136 – 115924Cell wall-binding 7Add
    BLAST
    Repeati1160 – 117920Cell wall-binding 8Add
    BLAST
    Repeati1234 – 125320Cell wall-binding 9Add
    BLAST
    Repeati1278 – 129821Cell wall-binding 10Add
    BLAST
    Repeati1299 – 131820Cell wall-binding 11Add
    BLAST
    Repeati1343 – 136220Cell wall-binding 12Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni200 – 1000801Catalytic; approximateAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 70 family.Curated
    Contains 12 cell wall-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di3.20.20.80. 2 hits.
    InterProiIPR018337. Cell_wall/Cho-bd_repeat.
    IPR027636. Glucan-bd_rpt.
    IPR003318. Glyco_hydro70cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR022263. KxYKxGKxW.
    [Graphical view]
    PfamiPF01473. CW_binding_1. 2 hits.
    PF02324. Glyco_hydro_70. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 3 hits.
    TIGRFAMsiTIGR04035. glucan_65_rpt. 4 hits.
    TIGR03715. KxYKxGKxW. 1 hit.
    PROSITEiPS51170. CW. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29336-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKNLRYKLH KVKKQWVAIG VTTVTLSFLA GGQVVAADTN NNDGTSVQVN     50
    KMVPSDPKFD AQAQNGQLAQ AMFKAANQAD QTATSQVSPA TDGRVDNQVT 100
    PAANQPAANV ANQDVANPAT DAGALNRQSA ADTSTDGKAV PQTSDQPGHL 150
    ETVDGKTYYV DANGQRLKNY SMVIDGKTYY FDGQTGEAQT DLPKTGQANQ 200
    DNVPDSYQAN NQAYSNEASS FETVDNYLTA DSWYRPRKIL KNGQSWQASS 250
    EGDLRPILMT WWPDAATKAA YANFWAKEGL ISGSYRQNSA NLDAATQNIQ 300
    SAIEKKIASE GNTNWLRDKM SQFVKSQNQW SIASENETVY PNQDHMQGGA 350
    LLFSNSKDTE HANSDWRLLN RNPTFQTGKQ KYFTTNYAGY ELLLANDVDN 400
    SNPVVQAEQL NHLHYLMNWG DIVMGDKDAN FDGVRVDAVD NVNADLLQIQ 450
    RDYYKAKYGT DQNEKNAIDH LSILEAWSGN DNDYVKDQNN FSLSIDNDQR 500
    SGMLKAFGYA SAYRGNLSNL ATAGLKNRSA NPDSDPVPNY VFIRAHDSEV 550
    QTRIAKIIRE KLGKTNADGL TNLTLDDLNK AFDIYNQDMN ATDKVYYPNN 600
    LPMAYAWMLQ NKDTVTRVYY GDMYTDNGQY MATKTPFYNA IETLLKGRIK 650
    YVAGGQAVSY KQDWSSGILT SVRYGKGANS ASDAGNTETR NSGMALLINN 700
    RPNFRAYRNL TLNMGAAHKS QAYRPLLLST KDGIATYLND SDVDSRQYKY 750
    TDSQGNLSFS ASELQSVANA QVSGMIQVWV PVGAADNQDV RTSPSTQATK 800
    DGNIYHQSDA LDSQVIYEGF SNFQAFAQSP DQYTNAVIAK NGDLFKSWGI 850
    TQFEMAPQYV SSEDGTFLDS VILNGYAFSD RYDLAMSKNN KYGSKQDLAN 900
    AIKGLQSAGI KVLSDLVPNQ LYNLPGKEVV TATRVNQYGQ AKSGATINKT 950
    PYVANTRSYG DYQEQYGGKF LDDLQKLYPR LFSTKQISTG KPIDPSVKIT 1000
    NWSAKYFNGS NILGRGAKYV LSEGNKYLNL ADGKLFLPTV LNNTYGQPQV 1050
    SANGFISKNG GIHYLDKNGQ EVKNRFKEIS GSWYYFDSDG KMATGKTKIG 1100
    NDTYLFMPNG KQLKEGVWYD GKKAYYYDDN GRTWTNKGFV EFRVDGQDKW 1150
    RYFNGDGTIA IGLVSLDNRT LYFDAYGYQV KGQTVTINGK SYTFDADQGD 1200
    LVQTDNANPA PQGQAGWKLL GDNQWGYRKD GQLLTGEQTI DGQKVFFQDN 1250
    GVQVKGGTAT DASGVLRFYD RDQGHQVGKG WYSTSDDNWV YVNESGQVLT 1300
    GLQTIDGQTV YFDDKGIQAK GKAVWDENGN LRYFDADSGN MLRDRWKNVD 1350
    GNWYYFNRNG LATRW 1365
    Length:1,365
    Mass (Da):151,591
    Last modified:December 1, 1992 - v1
    Checksum:i167296B5A2E8C476
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30943 Genomic DNA. Translation: AAA26898.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30943 Genomic DNA. Translation: AAA26898.1 .

    3D structure databases

    ProteinModelPortali P29336.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH70. Glycoside Hydrolase Family 70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 2 hits.
    InterProi IPR018337. Cell_wall/Cho-bd_repeat.
    IPR027636. Glucan-bd_rpt.
    IPR003318. Glyco_hydro70cat.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR022263. KxYKxGKxW.
    [Graphical view ]
    Pfami PF01473. CW_binding_1. 2 hits.
    PF02324. Glyco_hydro_70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 3 hits.
    TIGRFAMsi TIGR04035. glucan_65_rpt. 4 hits.
    TIGR03715. KxYKxGKxW. 1 hit.
    PROSITEi PS51170. CW. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Streptococcus downei gtfS gene, which specifies a glucosyltransferase that synthesizes soluble glucans."
      Gilmore K.S., Russell R.R., Ferretti J.J.
      Infect. Immun. 58:2452-2458(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MFE28.

    Entry informationi

    Entry nameiGTFS_STRDO
    AccessioniPrimary (citable) accession number: P29336
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Synthesizes water-soluble glucans (alpha 1,6-glucose).

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3