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P29336

- GTFS_STRDO

UniProt

P29336 - GTFS_STRDO

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Protein

Glucosyltransferase-S

Gene

gtfS

Organism
Streptococcus downei (Streptococcus sobrinus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.

Catalytic activityi

Sucrose + ((1->6)-alpha-D-glucosyl)(n) = D-fructose + ((1->6)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Glucan synthesis by GTF-S is independent of primer glucan unlike GTF-I.

GO - Molecular functioni

  1. dextransucrase activity Source: UniProtKB-EC
  2. glucosyltransferase activity Source: InterPro

GO - Biological processi

  1. glucan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGH70. Glycoside Hydrolase Family 70.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosyltransferase-S (EC:2.4.1.5)
Short name:
GTF-S
Alternative name(s):
Dextransucrase
Sucrose 6-glucosyltransferase
Gene namesi
Name:gtfS
OrganismiStreptococcus downei (Streptococcus sobrinus)
Taxonomic identifieri1317 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Pathology & Biotechi

Keywords - Diseasei

Dental caries

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Or 37Sequence AnalysisAdd
BLAST
Chaini37 – 13651329Glucosyltransferase-SPRO_0000021388Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati146 – 16621Cell wall-binding 1Add
BLAST
Repeati168 – 18720Cell wall-binding 2Add
BLAST
Repeati1052 – 107120Cell wall-binding 3Add
BLAST
Repeati1073 – 109220Cell wall-binding 4Add
BLAST
Repeati1093 – 111220Cell wall-binding 5Add
BLAST
Repeati1113 – 113321Cell wall-binding 6Add
BLAST
Repeati1136 – 115924Cell wall-binding 7Add
BLAST
Repeati1160 – 117920Cell wall-binding 8Add
BLAST
Repeati1234 – 125320Cell wall-binding 9Add
BLAST
Repeati1278 – 129821Cell wall-binding 10Add
BLAST
Repeati1299 – 131820Cell wall-binding 11Add
BLAST
Repeati1343 – 136220Cell wall-binding 12Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 1000801Catalytic; approximateAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 70 family.Curated
Contains 12 cell wall-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view]
PfamiPF01473. CW_binding_1. 2 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 3 hits.
TIGRFAMsiTIGR04035. glucan_65_rpt. 4 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEiPS51170. CW. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29336 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKNLRYKLH KVKKQWVAIG VTTVTLSFLA GGQVVAADTN NNDGTSVQVN
60 70 80 90 100
KMVPSDPKFD AQAQNGQLAQ AMFKAANQAD QTATSQVSPA TDGRVDNQVT
110 120 130 140 150
PAANQPAANV ANQDVANPAT DAGALNRQSA ADTSTDGKAV PQTSDQPGHL
160 170 180 190 200
ETVDGKTYYV DANGQRLKNY SMVIDGKTYY FDGQTGEAQT DLPKTGQANQ
210 220 230 240 250
DNVPDSYQAN NQAYSNEASS FETVDNYLTA DSWYRPRKIL KNGQSWQASS
260 270 280 290 300
EGDLRPILMT WWPDAATKAA YANFWAKEGL ISGSYRQNSA NLDAATQNIQ
310 320 330 340 350
SAIEKKIASE GNTNWLRDKM SQFVKSQNQW SIASENETVY PNQDHMQGGA
360 370 380 390 400
LLFSNSKDTE HANSDWRLLN RNPTFQTGKQ KYFTTNYAGY ELLLANDVDN
410 420 430 440 450
SNPVVQAEQL NHLHYLMNWG DIVMGDKDAN FDGVRVDAVD NVNADLLQIQ
460 470 480 490 500
RDYYKAKYGT DQNEKNAIDH LSILEAWSGN DNDYVKDQNN FSLSIDNDQR
510 520 530 540 550
SGMLKAFGYA SAYRGNLSNL ATAGLKNRSA NPDSDPVPNY VFIRAHDSEV
560 570 580 590 600
QTRIAKIIRE KLGKTNADGL TNLTLDDLNK AFDIYNQDMN ATDKVYYPNN
610 620 630 640 650
LPMAYAWMLQ NKDTVTRVYY GDMYTDNGQY MATKTPFYNA IETLLKGRIK
660 670 680 690 700
YVAGGQAVSY KQDWSSGILT SVRYGKGANS ASDAGNTETR NSGMALLINN
710 720 730 740 750
RPNFRAYRNL TLNMGAAHKS QAYRPLLLST KDGIATYLND SDVDSRQYKY
760 770 780 790 800
TDSQGNLSFS ASELQSVANA QVSGMIQVWV PVGAADNQDV RTSPSTQATK
810 820 830 840 850
DGNIYHQSDA LDSQVIYEGF SNFQAFAQSP DQYTNAVIAK NGDLFKSWGI
860 870 880 890 900
TQFEMAPQYV SSEDGTFLDS VILNGYAFSD RYDLAMSKNN KYGSKQDLAN
910 920 930 940 950
AIKGLQSAGI KVLSDLVPNQ LYNLPGKEVV TATRVNQYGQ AKSGATINKT
960 970 980 990 1000
PYVANTRSYG DYQEQYGGKF LDDLQKLYPR LFSTKQISTG KPIDPSVKIT
1010 1020 1030 1040 1050
NWSAKYFNGS NILGRGAKYV LSEGNKYLNL ADGKLFLPTV LNNTYGQPQV
1060 1070 1080 1090 1100
SANGFISKNG GIHYLDKNGQ EVKNRFKEIS GSWYYFDSDG KMATGKTKIG
1110 1120 1130 1140 1150
NDTYLFMPNG KQLKEGVWYD GKKAYYYDDN GRTWTNKGFV EFRVDGQDKW
1160 1170 1180 1190 1200
RYFNGDGTIA IGLVSLDNRT LYFDAYGYQV KGQTVTINGK SYTFDADQGD
1210 1220 1230 1240 1250
LVQTDNANPA PQGQAGWKLL GDNQWGYRKD GQLLTGEQTI DGQKVFFQDN
1260 1270 1280 1290 1300
GVQVKGGTAT DASGVLRFYD RDQGHQVGKG WYSTSDDNWV YVNESGQVLT
1310 1320 1330 1340 1350
GLQTIDGQTV YFDDKGIQAK GKAVWDENGN LRYFDADSGN MLRDRWKNVD
1360
GNWYYFNRNG LATRW
Length:1,365
Mass (Da):151,591
Last modified:December 1, 1992 - v1
Checksum:i167296B5A2E8C476
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30943 Genomic DNA. Translation: AAA26898.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30943 Genomic DNA. Translation: AAA26898.1 .

3D structure databases

ProteinModelPortali P29336.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH70. Glycoside Hydrolase Family 70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR027636. Glucan-bd_rpt.
IPR003318. Glyco_hydro70cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR022263. KxYKxGKxW.
[Graphical view ]
Pfami PF01473. CW_binding_1. 2 hits.
PF02324. Glyco_hydro_70. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 3 hits.
TIGRFAMsi TIGR04035. glucan_65_rpt. 4 hits.
TIGR03715. KxYKxGKxW. 1 hit.
PROSITEi PS51170. CW. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Streptococcus downei gtfS gene, which specifies a glucosyltransferase that synthesizes soluble glucans."
    Gilmore K.S., Russell R.R., Ferretti J.J.
    Infect. Immun. 58:2452-2458(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MFE28.

Entry informationi

Entry nameiGTFS_STRDO
AccessioniPrimary (citable) accession number: P29336
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Synthesizes water-soluble glucans (alpha 1,6-glucose).

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3