Reviewed, UniProtKB/Swiss-Prot P29333 (G6PI2_CLALE)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase, cytosolic 2A
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
    PGI3
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:

PGIC2-A

Organism

Clarkia lewisii (Farewell-to-spring) (Clarkia bottae)

Taxonomic identifier

3936 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Myrtales › Onagraceae › Clarkia

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 569	569	Glucose-6-phosphate isomerase, cytosolic 2A		PRO_0000180561
Sites
	Active site	360	1	Proton donor By similarity
	Active site	391	1	By similarity
	Active site	516	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P29333-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: A76BA3D41557259B	FASTA	569	62,854
	10 20 30 40 50 60 MATPALISET EAWKDLKAHL EGIKRTHLRE LMGDTERCQS MMVEFDNIFL DYSRQQASPD 70 80 90 100 110 120 TINKLYKLAE AAHLKQKIDR MYNGDHINST ENRSVLHVAL RAPRNSAICS DGKNVVPDVW 130 140 150 160 170 180 NVLDKIKDFS ERVRNGSWVG ATGKELKDVI AVGIGGSFLG PLFVHTALQT DPEASKNARG 190 200 210 220 230 240 RELRFLANVD PIDAARNISG LNPETTLVVV VSKTFTTAET MLNARTLREW ISSALGVAAV 250 260 270 280 290 300 AKHMVAVSTN LPLVEKFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFAVVEKFLQ 310 320 330 340 350 360 GAHNIDQHFS SAPFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL APHIQQVSME 370 380 390 400 410 420 SNGKGVSIDG LPLPFESGEI DFGEPGTNGQ HSFYQLIHQG RVIPCDFIGV VKSQQPVYLK 430 440 450 460 470 480 GEVVNNHDEL MSNFFAQPDA LAYGKTPEEL KKENVSEHLI PHKTFTGNRP CLSILLPTLD 490 500 510 520 530 540 AYRIGQLLAI YEHRVAVQGF VWGINSFDQW GVELGKSLAT QVRKQLHASR VKGEPVEEGF 550 560 NFSTKTLLTR YLQATTDVPA DPSTLLPNI

References

[1]	"Molecular analysis of the plant gene encoding cytosolic phosphoglucose isomerase." Thomas B.R., Laudencia-Chingcuanco D.L., Gottlieb L.D. Plant Mol. Biol. 19:745-757(1992) [PubMed: 1643281] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phylogenetic relationships among the sections of Clarkia (Onagraceae) inferred from the nucleotide sequences of PgiC." Gottlieb L.D., Ford V.S. Syst. Bot. 21:1-18(1996) [Agricola: IND20535960] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Population LDG 795.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64332 Genomic DNA. Translation: CAA45616.1. X89385 Genomic DNA. Translation: CAA61565.1.
PIR	S23542.
3D structure databases
SMR	P29333. Positions 2-553.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.3.1.9. 308678.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI2_CLALE

Accession

Primary (citable) accession number: P29333

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)