P29330 (ADX_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adrenodoxin

Alternative name(s):
Adrenal ferredoxin
Ferredoxin-1

Gene names

Name:

FDX1

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adrenodoxin transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450.
Cofactor	Binds 1 2Fe-2S cluster.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the adrenodoxin/putidaredoxin family. Contains 1 2Fe-2S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Mitochondrion
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	Adrenodoxin		PRO_0000201161
Regions
	Domain	7 – 111	105	2Fe-2S ferredoxin-type
Sites
	Metal binding	46	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	52	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	55	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	92	1	Iron-sulfur (2Fe-2S) By similarity
Experimental info
	Sequence conflict	123	1	N → D no nucleotide entry Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P29330 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 46135A661315E463	FASTA	128	14,014
	10 20 30 40 50 60 SSSEDKVTVN FINRDGETLT TKGKVGDSLL DVVVENNLDI DGFGACEGTL ACSTCHLIFE 70 80 90 100 110 120 QHIYEKLEAI TDEENDMLDL AYGLTDRSRL GCQICLTKAM DNMTVRVPDA VSDARESIDM GMNSSKIE

References

[1]	"Determination of the amino acid sequence of adreno-ferredoxin from sheep adrenocortical mitochondria." Shimizu C., Tomita S., Matsuo Y., Miyatake A., Ichikawa Y. Int. J. Biochem. 24:281-288(1992) [PubMed: 1733794] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-127. Tissue: Adrenal gland.
[2]	"Expression cloning of a sheep adreno-ferredoxin using the polymerase chain reaction." Matsuo Y., Tsujita M., Mizoguchi K., Ichikawa Y. FEBS Lett. 301:132-136(1992) [PubMed: 1568470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-128.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	S21131.
3D structure databases
ProteinModelPortal	P29330.
SMR	P29330. Positions 5-117.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000092.
Family and domain databases
InterPro	IPR001055. Adrenodoxin. IPR018298. Adrenodoxin_Fe-S_BS. IPR012675. Beta-grasp_ferredoxin-type. IPR001041. Ferredoxin. [Graphical view]
Gene3D	G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF00111. Fer2. 1 hit. [Graphical view]
PRINTS	PR00355. ADRENODOXIN.
SUPFAM	SSF54292. Ferredoxin. 1 hit.
PROSITE	PS51085. 2FE2S_FER_2. 1 hit. PS00814. ADX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADX_SHEEP

Accession

Primary (citable) accession number: P29330

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	July 15, 1998
Last modified:	January 11, 2011
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program