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Protein

Ephrin type-B receptor 2

Gene

EPHB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei653ATPPROSITE-ProRule annotation1
Active sitei746Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi627 – 635ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05749-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-2682334. EPH-Ephrin signaling.
R-HSA-373760. L1CAM interactions.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-3928664. Ephrin signaling.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.
SignaLinkiP29323.
SIGNORiP29323.

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-B receptor 2 (EC:2.7.10.1)
Alternative name(s):
Developmentally-regulated Eph-related tyrosine kinase
ELK-related tyrosine kinase
EPH tyrosine kinase 3
EPH-like kinase 5
Short name:
EK5
Short name:
hEK5
Renal carcinoma antigen NY-REN-47
Tyrosine-protein kinase TYRO5
Tyrosine-protein kinase receptor EPH-3
Gene namesi
Name:EPHB2
Synonyms:DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3393. EPHB2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 543ExtracellularSequence analysisAdd BLAST525
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 1055CytoplasmicSequence analysisAdd BLAST491

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Involvement in diseasei

Prostate cancer (PC)2 Publications
The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:176807

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi2048.
MalaCardsiEPHB2.
MIMi176807. phenotype.
603688. phenotype.
OpenTargetsiENSG00000133216.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA27825.

Chemistry databases

ChEMBLiCHEMBL3290.
GuidetoPHARMACOLOGYi1831.

Polymorphism and mutation databases

BioMutaiEPHB2.
DMDMi76803654.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001682719 – 1055Ephrin type-B receptor 2Add BLAST1037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 1841 Publication
Disulfide bondi97 ↔ 1071 Publication
Glycosylationi265N-linked (GlcNAc...)Sequence analysis1
Glycosylationi336N-linked (GlcNAc...)Sequence analysis1
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1
Modified residuei602PhosphotyrosineBy similarity1
Isoform 2 (identifier: P29323-2)
Modified residuei983PhosphoserineCombined sources1
Isoform 3 (identifier: P29323-3)
Modified residuei984PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP29323.
MaxQBiP29323.
PaxDbiP29323.
PeptideAtlasiP29323.
PRIDEiP29323.

PTM databases

iPTMnetiP29323.
PhosphoSitePlusiP29323.
SwissPalmiP29323.

Expressioni

Tissue specificityi

Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.

Gene expression databases

BgeeiENSG00000133216.
CleanExiHS_EPHB2.
ExpressionAtlasiP29323. baseline and differential.
GenevisibleiP29323. HS.

Organism-specific databases

HPAiCAB013647.

Interactioni

Subunit structurei

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP153P497902EBI-1059294,EBI-286779

Protein-protein interaction databases

BioGridi108362. 18 interactors.
DIPiDIP-1162N.
IntActiP29323. 4 interactors.
MINTiMINT-5005955.
STRINGi9606.ENSP00000363763.

Chemistry databases

BindingDBiP29323.

Structurei

Secondary structure

11055
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 25Combined sources5
Helixi26 – 28Combined sources3
Beta strandi36 – 39Combined sources4
Beta strandi44 – 49Combined sources6
Beta strandi55 – 61Combined sources7
Beta strandi66 – 68Combined sources3
Beta strandi71 – 74Combined sources4
Beta strandi84 – 94Combined sources11
Helixi97 – 99Combined sources3
Beta strandi111 – 120Combined sources10
Beta strandi130 – 132Combined sources3
Beta strandi135 – 141Combined sources7
Beta strandi148 – 152Combined sources5
Beta strandi155 – 166Combined sources12
Beta strandi171 – 183Combined sources13
Beta strandi185 – 194Combined sources10
Helixi618 – 620Combined sources3
Beta strandi621 – 626Combined sources6
Beta strandi635 – 640Combined sources6
Beta strandi648 – 655Combined sources8
Helixi661 – 674Combined sources14
Beta strandi685 – 689Combined sources5
Beta strandi691 – 700Combined sources10
Helixi707 – 712Combined sources6
Turni713 – 716Combined sources4
Helixi720 – 739Combined sources20
Helixi749 – 751Combined sources3
Beta strandi752 – 754Combined sources3
Beta strandi760 – 762Combined sources3
Helixi790 – 792Combined sources3
Helixi795 – 800Combined sources6
Helixi805 – 820Combined sources16
Turni826 – 829Combined sources4
Helixi832 – 840Combined sources9
Helixi853 – 862Combined sources10
Helixi873 – 885Combined sources13
Helixi887 – 890Combined sources4
Helixi918 – 924Combined sources7
Helixi928 – 930Combined sources3
Helixi931 – 936Combined sources6
Helixi942 – 945Combined sources4
Helixi950 – 955Combined sources6
Helixi961 – 982Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B4FX-ray1.95A/B/C/D/E/F/G/H908-985[»]
1F0MX-ray2.20A908-985[»]
2QBXX-ray2.30A/B20-196[»]
3ZFMX-ray2.27A604-898[»]
ProteinModelPortaliP29323.
SMRiP29323.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 202Eph LBDPROSITE-ProRule annotationAdd BLAST183
Domaini324 – 434Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST111
Domaini435 – 530Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini621 – 884Protein kinasePROSITE-ProRule annotationAdd BLAST264
Domaini913 – 977SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi984 – 986PDZ-binding (in isoform 2)Sequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi184 – 324Cys-richAdd BLAST141

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiP29323.
KOiK05111.
OMAiVNNLDKM.
OrthoDBiEOG091G00W0.
PhylomeDBiP29323.
TreeFamiTF315608.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29323-1) [UniParc]FASTAAdd to basket
Also known as: EPHB2v, Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD
60 70 80 90 100
ENMNTIRTYQ VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI
110 120 130 140 150
PSVPGSCKET FNLYYYEADF DSATKTFPNW MENPWVKVDT IAADESFSQV
160 170 180 190 200
DLGGRVMKIN TEVRSFGPVS RSGFYLAFQD YGGCMSLIAV RVFYRKCPRI
210 220 230 240 250
IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY CNGDGEWLVP
260 270 280 290 300
IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA
310 320 330 340 350
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS
360 370 380 390 400
GGREDLVYNI ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA
410 420 430 440 450
HTQYTFEIQA VNGVTDQSPF SPQFASVNIT TNQAAPSAVS IMHQVSRTVD
460 470 480 490 500
SITLSWSQPD QPNGVILDYE LQYYEKELSE YNATAIKSPT NTVTVQGLKA
510 520 530 540 550
GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIQEK LPLIIGSSAA
560 570 580 590 600
GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF
610 620 630 640 650
TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV
660 670 680 690 700
AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE
710 720 730 740 750
FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM NYVHRDLAAR
760 770 780 790 800
NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY
810 820 830 840 850
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD
860 870 880 890 900
CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI
910 920 930 940 950
NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM
960 970 980 990 1000
EDILRVGVTL AGHQKKILNS IQVMRAQMNQ IQSVEGQPLA RRPRATGRTK
1010 1020 1030 1040 1050
RCQPRDVTKK TCNSNDGKKK GMGKKKTDPG RGREIQGIFF KEDSHKESND

CSCGG
Length:1,055
Mass (Da):117,493
Last modified:September 27, 2005 - v5
Checksum:i4F8BFEDC45986483
GO
Isoform 2 (identifier: P29323-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     986-986: G → V
     987-1055: Missing.

Show »
Length:986
Mass (Da):109,874
Checksum:i4B9B532A48B754A6
GO
Isoform 3 (identifier: P29323-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     568-568: R → RR
     986-986: G → V
     987-1055: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:987
Mass (Da):110,030
Checksum:iEF6DA7A63D894E47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 20MALRR…LAAVE → MWVPVLALPVCTYA in BAA06506 (PubMed:8033077).CuratedAdd BLAST20
Sequence conflicti154G → D in BAA06506 (PubMed:8033077).Curated1
Sequence conflicti476K → KQ in BAA06506 (PubMed:8033077).Curated1
Sequence conflicti495 – 496Missing in AAA74244 (PubMed:7898931).Curated2
Sequence conflicti532E → D in BAA06506 (PubMed:8033077).Curated1
Sequence conflicti589M → I in AAA74244 (PubMed:7898931).Curated1
Sequence conflicti671A → R in BAA03537 (PubMed:7688222).Curated1
Sequence conflicti788I → F in AAA74244 (PubMed:7898931).Curated1
Sequence conflicti853S → A in BAA06506 (PubMed:8033077).Curated1
Sequence conflicti853S → A in BAA07073 (PubMed:7601466).Curated1
Sequence conflicti853S → A in BAA03537 (PubMed:7688222).Curated1
Sequence conflicti923E → K in BAA06506 (PubMed:8033077).Curated1
Sequence conflicti923E → K in BAA07073 (PubMed:7601466).Curated1
Sequence conflicti923E → K in BAA03537 (PubMed:7688222).Curated1
Sequence conflicti958V → L in AAA99310 (PubMed:8589679).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032853199R → H in prostate cancer. 1 PublicationCorresponds to variant rs201754821dbSNPEnsembl.1
Natural variantiVAR_032854279A → S in prostate cancer. 3 PublicationsCorresponds to variant rs35882952dbSNPEnsembl.1
Natural variantiVAR_042172289C → G.1 Publication1
Natural variantiVAR_042173361I → V.1 PublicationCorresponds to variant rs56180036dbSNPEnsembl.1
Natural variantiVAR_032855650V → A in prostate cancer. 1 PublicationCorresponds to variant rs142173175dbSNPEnsembl.1
Natural variantiVAR_042174678D → N.1 PublicationCorresponds to variant rs28936395dbSNPEnsembl.1
Natural variantiVAR_032856679H → N in prostate cancer. 1 Publication1
Natural variantiVAR_042175844R → W.1 PublicationCorresponds to variant rs55826626dbSNPEnsembl.1
Natural variantiVAR_032857883M → V in prostate cancer. 1 PublicationCorresponds to variant rs372653137dbSNPEnsembl.1
Natural variantiVAR_032858909I → M in prostate cancer. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015713568R → RR in isoform 3. 1 Publication1
Alternative sequenceiVSP_003016986G → V in isoform 2 and isoform 3. 5 Publications1
Alternative sequenceiVSP_003017987 – 1055Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31661 mRNA. Translation: BAA06506.1.
L41939 mRNA. Translation: AAA99310.1.
AF025304 mRNA. Translation: AAB94602.1.
AL035704, AL158086, AL512444 Genomic DNA. Translation: CAI22645.1.
AL035704, AL158086, AL512444 Genomic DNA. Translation: CAI22646.1.
AL035704, AL158086, AL512444 Genomic DNA. Translation: CAI22647.2.
AL158086, AL035704, AL512444 Genomic DNA. Translation: CAI22897.1.
AL158086, AL512444, AL035704 Genomic DNA. Translation: CAI22898.1.
AL158086, AL035704, AL512444 Genomic DNA. Translation: CAI22899.2.
AL512444, AL035704, AL158086 Genomic DNA. Translation: CAI16428.1.
AL512444, AL035704, AL158086 Genomic DNA. Translation: CAI16429.1.
AL512444, AL035704, AL158086 Genomic DNA. Translation: CAI16430.2.
L36643 mRNA. Translation: AAA74244.1.
D37827 mRNA. Translation: BAA07073.1.
D14717 mRNA. Translation: BAA03537.1.
X59292 Genomic DNA. Translation: CAA41981.1.
CCDSiCCDS229.2. [P29323-2]
CCDS230.1. [P29323-3]
CCDS81279.1. [P29323-1]
PIRiA57174.
I78842.
RefSeqiNP_001296122.1. NM_001309193.1. [P29323-1]
NP_004433.2. NM_004442.7. [P29323-3]
NP_059145.2. NM_017449.4. [P29323-2]
UniGeneiHs.380705.
Hs.523329.

Genome annotation databases

EnsembliENST00000374630; ENSP00000363761; ENSG00000133216. [P29323-2]
ENST00000374632; ENSP00000363763; ENSG00000133216. [P29323-3]
ENST00000400191; ENSP00000383053; ENSG00000133216. [P29323-1]
GeneIDi2048.
KEGGihsa:2048.
UCSCiuc001bge.4. human. [P29323-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31661 mRNA. Translation: BAA06506.1.
L41939 mRNA. Translation: AAA99310.1.
AF025304 mRNA. Translation: AAB94602.1.
AL035704, AL158086, AL512444 Genomic DNA. Translation: CAI22645.1.
AL035704, AL158086, AL512444 Genomic DNA. Translation: CAI22646.1.
AL035704, AL158086, AL512444 Genomic DNA. Translation: CAI22647.2.
AL158086, AL035704, AL512444 Genomic DNA. Translation: CAI22897.1.
AL158086, AL512444, AL035704 Genomic DNA. Translation: CAI22898.1.
AL158086, AL035704, AL512444 Genomic DNA. Translation: CAI22899.2.
AL512444, AL035704, AL158086 Genomic DNA. Translation: CAI16428.1.
AL512444, AL035704, AL158086 Genomic DNA. Translation: CAI16429.1.
AL512444, AL035704, AL158086 Genomic DNA. Translation: CAI16430.2.
L36643 mRNA. Translation: AAA74244.1.
D37827 mRNA. Translation: BAA07073.1.
D14717 mRNA. Translation: BAA03537.1.
X59292 Genomic DNA. Translation: CAA41981.1.
CCDSiCCDS229.2. [P29323-2]
CCDS230.1. [P29323-3]
CCDS81279.1. [P29323-1]
PIRiA57174.
I78842.
RefSeqiNP_001296122.1. NM_001309193.1. [P29323-1]
NP_004433.2. NM_004442.7. [P29323-3]
NP_059145.2. NM_017449.4. [P29323-2]
UniGeneiHs.380705.
Hs.523329.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B4FX-ray1.95A/B/C/D/E/F/G/H908-985[»]
1F0MX-ray2.20A908-985[»]
2QBXX-ray2.30A/B20-196[»]
3ZFMX-ray2.27A604-898[»]
ProteinModelPortaliP29323.
SMRiP29323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108362. 18 interactors.
DIPiDIP-1162N.
IntActiP29323. 4 interactors.
MINTiMINT-5005955.
STRINGi9606.ENSP00000363763.

Chemistry databases

BindingDBiP29323.
ChEMBLiCHEMBL3290.
GuidetoPHARMACOLOGYi1831.

PTM databases

iPTMnetiP29323.
PhosphoSitePlusiP29323.
SwissPalmiP29323.

Polymorphism and mutation databases

BioMutaiEPHB2.
DMDMi76803654.

Proteomic databases

EPDiP29323.
MaxQBiP29323.
PaxDbiP29323.
PeptideAtlasiP29323.
PRIDEiP29323.

Protocols and materials databases

DNASUi2048.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374630; ENSP00000363761; ENSG00000133216. [P29323-2]
ENST00000374632; ENSP00000363763; ENSG00000133216. [P29323-3]
ENST00000400191; ENSP00000383053; ENSG00000133216. [P29323-1]
GeneIDi2048.
KEGGihsa:2048.
UCSCiuc001bge.4. human. [P29323-1]

Organism-specific databases

CTDi2048.
DisGeNETi2048.
GeneCardsiEPHB2.
H-InvDBHIX0028518.
HGNCiHGNC:3393. EPHB2.
HPAiCAB013647.
MalaCardsiEPHB2.
MIMi176807. phenotype.
600997. gene.
603688. phenotype.
neXtProtiNX_P29323.
OpenTargetsiENSG00000133216.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA27825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0196. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118975.
HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiP29323.
KOiK05111.
OMAiVNNLDKM.
OrthoDBiEOG091G00W0.
PhylomeDBiP29323.
TreeFamiTF315608.

Enzyme and pathway databases

BioCyciZFISH:HS05749-MONOMER.
BRENDAi2.7.10.1. 2681.
ReactomeiR-HSA-2682334. EPH-Ephrin signaling.
R-HSA-373760. L1CAM interactions.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-3928664. Ephrin signaling.
R-HSA-3928665. EPH-ephrin mediated repulsion of cells.
SignaLinkiP29323.
SIGNORiP29323.

Miscellaneous databases

ChiTaRSiEPHB2. human.
EvolutionaryTraceiP29323.
GeneWikiiEPH_receptor_B2.
GenomeRNAii2048.
PROiP29323.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133216.
CleanExiHS_EPHB2.
ExpressionAtlasiP29323. baseline and differential.
GenevisibleiP29323. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF07699. Ephrin_rec_like. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPHB2_HUMAN
AccessioniPrimary (citable) accession number: P29323
Secondary accession number(s): O43477
, Q5T0U6, Q5T0U7, Q5T0U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 27, 2005
Last modified: November 30, 2016
This is version 206 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.