Protein BMH1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P29311 (BMH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 128. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein BMH1

Gene names

Name:	BMH1
Ordered Locus Names:	YER177W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in growth regulation.
Subunit structure	Interacts with FIN1. Ref.6
Miscellaneous	Present with 158000 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the 14-3-3 family.

Ontologies

Keywords
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage checkpoint Inferred from mutant phenotype PubMed 14704161. Source: SGD Ras protein signal transduction Inferred from genetic interaction PubMed 9215628. Source: SGD ascospore formation Inferred from genetic interaction PubMed 9215628. Source: SGD fungal-type cell wall chitin biosynthetic process Inferred from genetic interaction PubMed 17559233. Source: SGD glycogen metabolic process Inferred from genetic interaction PubMed 9215628. Source: SGD negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Inferred from physical interaction PubMed 17030612. Source: SGD pseudohyphal growth Inferred from genetic interaction PubMed 9215628. Source: SGD signal transduction involved in filamentous growth Inferred from genetic interaction PubMed 9215628. Source: SGD
Cellular_component	cytoplasm Inferred from direct assay PubMed 22842922. Source: SGD nucleus Inferred from direct assay PubMed 12167636 PubMed 22842922. Source: SGD plasma membrane Inferred from direct assay PubMed 16622836. Source: SGD
Molecular_function	DNA replication origin binding Inferred from direct assay PubMed 12167636. Source: SGD phosphoserine binding Inferred from mutant phenotype PubMed 9822578. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 267

266

Protein BMH1

PRO_0000058715

Amino acid modifications

Modified residue

N-acetylserine Ref.5

Modified residue

Phosphoserine Ref.8

Modified residue

Phosphoserine Ref.8

Modified residue

Phosphoserine Ref.8

Modified residue

Phosphoserine Ref.8

Experimental info

Sequence conflict

197

A → R in CAA50656. Ref.1

Sequence conflict

197

A → R in CAA46959. Ref.2

Sequence conflict

263 – 267

GEAPK → VKHQSKYSDKSKEKLLKKRK KKERGCNNL in CAA50656. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P29311 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 0A234167E313688B
Show »

FASTA

267

30,091

        10         20         30         40         50         60 
MSTSREDSVY LAKLAEQAER YEEMVENMKT VASSGQELSV EERNLLSVAY KNVIGARRAS 

        70         80         90        100        110        120 
WRIVSSIEQK EESKEKSEHQ VELICSYRSK IETELTKISD DILSVLDSHL IPSATTGESK 

       130        140        150        160        170        180 
VFYYKMKGDY HRYLAEFSSG DAREKATNAS LEAYKTASEI ATTELPPTHP IRLGLALNFS 

       190        200        210        220        230        240 
VFYYEIQNSP DKACHLAKQA FDDAIAELDT LSEESYKDST LIMQLLRDNL TLWTSDMSES 

       250        260 
GQAEDQQQQQ QHQQQQPPAA AEGEAPK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the yeast BMH1 gene encoding a putative protein homologous to mammalian protein kinase II activators and protein kinase C inhibitors." van Heusden G.P., Wenzel T.J., Lagendijk E.L., de Steensma H.Y., van den Berg J.A. FEBS Lett. 302:145-150(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 26109 / X2180.
[2]	Mulligan J.T., Dietrich F.S., Hennessey K.M., Sehl P., Komp C., Wei Y., Taylor P., Nakahara K., Roberts D., Davis R.W. Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome V." Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. Davis R.W. Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins." Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I., Kobayashi R., Schwender B., Volpe T., Anderson D.S., Mesquita-Fuentes R., Payne W.E. Electrophoresis 18:1347-1360(1997) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION AT SER-2.
[6]	"Self-association of the spindle pole body-related intermediate filament protein Fin1p and its phosphorylation-dependent interaction with 14-3-3 proteins in yeast." van Hemert M.J., Deelder A.M., Molenaar C., Steensma H.Y., van Heusden G.P.H. J. Biol. Chem. 278:15049-15055(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FIN1.
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65; SER-66; SER-86 AND SER-89, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71664 Genomic DNA. Translation: CAA50656.1. X66206 Genomic DNA. Translation: CAA46959.1. U18922 Genomic DNA. Translation: AAB64704.1. BK006939 Genomic DNA. Translation: DAA07840.1.
PIR	S30863.
RefSeq	NP_011104.3. NM_001179067.3.
3D structure databases
ProteinModelPortal	P29311.
SMR	P29311. Positions 5-234.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4313N.
IntAct	P29311. 55 interactions.
MINT	MINT-382223.
STRING	4932.YER177W.
2D gel databases
COMPLUYEAST-2DPAGE	P29311.
SWISS-2DPAGE	P29311.
Proteomic databases
PeptideAtlas	P29311.
PRIDE	P29311.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YER177W; YER177W; YER177W.
GeneID	856924.
KEGG	sce:YER177W. sce:YER180C-A.
Organism-specific databases
SGD	S000000979. BMH1.
Phylogenomic databases
GeneTree	ENSGT00690000101991.
HOGENOM	HOG000240379.
KO	K06630.
OMA	EIREAPK.
OrthoDB	EOG4VX5F8.
Gene expression databases
Genevestigator	P29311.
GermOnline	YER177W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.20.190.20. 1 hit.
InterPro	IPR000308. 14-3-3. IPR023409. 14-3-3_CS. IPR023410. 14-3-3_domain. [Graphical view]
PANTHER	PTHR18860. PTHR18860. 1 hit.
Pfam	PF00244. 14-3-3. 1 hit. [Graphical view]
PIRSF	PIRSF000868. 14-3-3. 1 hit.
PRINTS	PR00305. 1433ZETA.
SMART	SM00101. 14_3_3. 1 hit. [Graphical view]
SUPFAM	SSF48445. 14-3-3. 1 hit.
PROSITE	PS00796. 1433_1. 1 hit. PS00797. 1433_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	983392.

Entry information

Entry name

BMH1_YEAST

Accession

Primary (citable) accession number: P29311
Secondary accession number(s): D3DM86, Q06854

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 128 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents