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P29311

- BMH1_YEAST

UniProt

P29311 - BMH1_YEAST

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Protein

Protein BMH1

Gene
BMH1, YER177W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in growth regulation.

GO - Molecular functioni

  1. DNA replication origin binding Source: SGD
  2. phosphoserine binding Source: SGD
  3. protein binding Source: IntAct
  4. RNA polymerase II activating transcription factor binding Source: SGD

GO - Biological processi

  1. aggresome assembly Source: SGD
  2. ascospore formation Source: SGD
  3. DNA damage checkpoint Source: SGD
  4. fungal-type cell wall chitin biosynthetic process Source: SGD
  5. glycogen metabolic process Source: SGD
  6. negative regulation of apoptotic process Source: SGD
  7. negative regulation of transcription from RNA polymerase II promoter Source: SGD
  8. negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Source: SGD
  9. pseudohyphal growth Source: SGD
  10. Ras protein signal transduction Source: SGD
  11. signal transduction involved in filamentous growth Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30336-MONOMER.
ReactomeiREACT_205607. Regulation of HSF1-mediated heat shock response.
REACT_209789. HSF1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BMH1
Gene namesi
Name:BMH1
Ordered Locus Names:YER177W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

SGDiS000000979. BMH1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 267266Protein BMH1PRO_0000058715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei89 – 891Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP29311.
PeptideAtlasiP29311.
PRIDEiP29311.

2D gel databases

COMPLUYEAST-2DPAGEP29311.
SWISS-2DPAGEP29311.

Expressioni

Gene expression databases

GenevestigatoriP29311.

Interactioni

Subunit structurei

Interacts with FIN1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1S1Q96B363EBI-3661,EBI-720593From a different organism.
NTH1P323566EBI-3661,EBI-19509

Protein-protein interaction databases

BioGridi36930. 314 interactions.
DIPiDIP-4313N.
IntActiP29311. 65 interactions.
MINTiMINT-382223.
STRINGi4932.YER177W.

Structurei

3D structure databases

ProteinModelPortaliP29311.
SMRiP29311. Positions 5-234.

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.

Phylogenomic databases

GeneTreeiENSGT00730000110613.
HOGENOMiHOG000240379.
KOiK06630.
OMAiAYQKATD.
OrthoDBiEOG7TXKTD.

Family and domain databases

Gene3Di1.20.190.20. 1 hit.
InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29311-1 [UniParc]FASTAAdd to Basket

« Hide

MSTSREDSVY LAKLAEQAER YEEMVENMKT VASSGQELSV EERNLLSVAY    50
KNVIGARRAS WRIVSSIEQK EESKEKSEHQ VELICSYRSK IETELTKISD 100
DILSVLDSHL IPSATTGESK VFYYKMKGDY HRYLAEFSSG DAREKATNAS 150
LEAYKTASEI ATTELPPTHP IRLGLALNFS VFYYEIQNSP DKACHLAKQA 200
FDDAIAELDT LSEESYKDST LIMQLLRDNL TLWTSDMSES GQAEDQQQQQ 250
QHQQQQPPAA AEGEAPK 267
Length:267
Mass (Da):30,091
Last modified:January 23, 2007 - v4
Checksum:i0A234167E313688B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971A → R in CAA50656. 1 Publication
Sequence conflicti197 – 1971A → R in CAA46959. 1 Publication
Sequence conflicti263 – 2675GEAPK → VKHQSKYSDKSKEKLLKKRK KKERGCNNL in CAA50656. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71664 Genomic DNA. Translation: CAA50656.1.
X66206 Genomic DNA. Translation: CAA46959.1.
U18922 Genomic DNA. Translation: AAB64704.1.
BK006939 Genomic DNA. Translation: DAA07840.1.
PIRiS30863.
RefSeqiNP_011104.3. NM_001179067.3.

Genome annotation databases

EnsemblFungiiYER177W; YER177W; YER177W.
GeneIDi856924.
KEGGisce:YER177W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71664 Genomic DNA. Translation: CAA50656.1 .
X66206 Genomic DNA. Translation: CAA46959.1 .
U18922 Genomic DNA. Translation: AAB64704.1 .
BK006939 Genomic DNA. Translation: DAA07840.1 .
PIRi S30863.
RefSeqi NP_011104.3. NM_001179067.3.

3D structure databases

ProteinModelPortali P29311.
SMRi P29311. Positions 5-234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36930. 314 interactions.
DIPi DIP-4313N.
IntActi P29311. 65 interactions.
MINTi MINT-382223.
STRINGi 4932.YER177W.

2D gel databases

COMPLUYEAST-2DPAGE P29311.
SWISS-2DPAGE P29311.

Proteomic databases

MaxQBi P29311.
PeptideAtlasi P29311.
PRIDEi P29311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER177W ; YER177W ; YER177W .
GeneIDi 856924.
KEGGi sce:YER177W.

Organism-specific databases

SGDi S000000979. BMH1.

Phylogenomic databases

GeneTreei ENSGT00730000110613.
HOGENOMi HOG000240379.
KOi K06630.
OMAi AYQKATD.
OrthoDBi EOG7TXKTD.

Enzyme and pathway databases

BioCyci YEAST:G3O-30336-MONOMER.
Reactomei REACT_205607. Regulation of HSF1-mediated heat shock response.
REACT_209789. HSF1 activation.

Miscellaneous databases

NextBioi 983392.

Gene expression databases

Genevestigatori P29311.

Family and domain databases

Gene3Di 1.20.190.20. 1 hit.
InterProi IPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view ]
PANTHERi PTHR18860. PTHR18860. 1 hit.
Pfami PF00244. 14-3-3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000868. 14-3-3. 1 hit.
PRINTSi PR00305. 1433ZETA.
SMARTi SM00101. 14_3_3. 1 hit.
[Graphical view ]
SUPFAMi SSF48445. SSF48445. 1 hit.
PROSITEi PS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the yeast BMH1 gene encoding a putative protein homologous to mammalian protein kinase II activators and protein kinase C inhibitors."
    van Heusden G.P., Wenzel T.J., Lagendijk E.L., de Steensma H.Y., van den Berg J.A.
    FEBS Lett. 302:145-150(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 26109 / X2180.
  2. Mulligan J.T., Dietrich F.S., Hennessey K.M., Sehl P., Komp C., Wei Y., Taylor P., Nakahara K., Roberts D., Davis R.W.
    Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Proteome studies of Saccharomyces cerevisiae: identification and characterization of abundant proteins."
    Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I., Kobayashi R., Schwender B., Volpe T., Anderson D.S., Mesquita-Fuentes R., Payne W.E.
    Electrophoresis 18:1347-1360(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION AT SER-2.
  6. "Self-association of the spindle pole body-related intermediate filament protein Fin1p and its phosphorylation-dependent interaction with 14-3-3 proteins in yeast."
    van Hemert M.J., Deelder A.M., Molenaar C., Steensma H.Y., van Heusden G.P.H.
    J. Biol. Chem. 278:15049-15055(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FIN1.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBMH1_YEAST
AccessioniPrimary (citable) accession number: P29311
Secondary accession number(s): D3DM86, Q06854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 158000 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3

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