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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 128123cNMPAdd
BLAST
DNA bindingi175 – 19420H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSYNEL:NTCA.

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Gene namesi
Name:ntcA
Ordered Locus Names:Synpcc7942_0127
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Global nitrogen regulatorPRO_0000100186Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-59550N.
STRINGi1140.Synpcc7942_0127.

Structurei

Secondary structure

1
222
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 154Combined sources
Beta strandi18 – 203Combined sources
Beta strandi23 – 275Combined sources
Beta strandi32 – 343Combined sources
Beta strandi42 – 498Combined sources
Beta strandi51 – 566Combined sources
Beta strandi58 – 603Combined sources
Beta strandi62 – 687Combined sources
Beta strandi72 – 743Combined sources
Helixi78 – 814Combined sources
Helixi82 – 843Combined sources
Beta strandi89 – 957Combined sources
Beta strandi97 – 1037Combined sources
Helixi104 – 1063Combined sources
Helixi107 – 1137Combined sources
Helixi116 – 14025Combined sources
Helixi144 – 15916Combined sources
Beta strandi160 – 1634Combined sources
Beta strandi166 – 1716Combined sources
Helixi175 – 1828Combined sources
Helixi186 – 19813Combined sources
Beta strandi201 – 2055Combined sources
Beta strandi208 – 2125Combined sources
Helixi214 – 2196Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XGXX-ray2.85A/B1-222[»]
2XHKX-ray2.30A/B1-222[»]
2XKOX-ray2.25A/B1-222[»]
2XKPX-ray3.05A/B/C/D/E/F1-222[»]
ProteinModelPortaliP29283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 21574HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000232503.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANENSLLT MFRELGSGKL PLQIEQFERG KTIFFPGDPA ERVYLLVKGA
60 70 80 90 100
VKLSRVYESG EEITVALLRE NSVFGVLSLL TGQRSDRFYH AVAFTPVQLF
110 120 130 140 150
SVPIEFMQKA LIERPELANV MLQGLSSRIL QTEMMIETLA HRDMGSRLVS
160 170 180 190 200
FLLILCRDFG IPSPDGITID LKLSHQAIAE AIGSTRVTVT RLLGDLRESK
210 220
LIAIHKKRIT VFNPVALSQQ FS
Length:222
Mass (Da):24,833
Last modified:December 1, 1992 - v1
Checksum:iC6A9DC575D15A69A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60197 Genomic DNA. Translation: CAA42755.1.
CP000100 Genomic DNA. Translation: ABB56159.1.
PIRiS25244.
RefSeqiWP_011243689.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56159; ABB56159; Synpcc7942_0127.
KEGGisyf:Synpcc7942_0127.
PATRICi23785295. VBISynElo51371_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60197 Genomic DNA. Translation: CAA42755.1.
CP000100 Genomic DNA. Translation: ABB56159.1.
PIRiS25244.
RefSeqiWP_011243689.1. NC_007604.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XGXX-ray2.85A/B1-222[»]
2XHKX-ray2.30A/B1-222[»]
2XKOX-ray2.25A/B1-222[»]
2XKPX-ray3.05A/B/C/D/E/F1-222[»]
ProteinModelPortaliP29283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59550N.
STRINGi1140.Synpcc7942_0127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB56159; ABB56159; Synpcc7942_0127.
KEGGisyf:Synpcc7942_0127.
PATRICi23785295. VBISynElo51371_0195.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000232503.
OrthoDBiEOG6QRWC5.

Enzyme and pathway databases

BioCyciSYNEL:NTCA.

Miscellaneous databases

EvolutionaryTraceiP29283.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "NtcA, a global nitrogen regulator from the cyanobacterium Synechococcus that belongs to the Crp family of bacterial regulators."
    Vega-Palas M.A., Flores E., Herrero A.
    Mol. Microbiol. 6:1853-1859(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiNTCA_SYNE7
AccessioniPrimary (citable) accession number: P29283
Secondary accession number(s): Q31S10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.