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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 128cNMPAdd BLAST123
DNA bindingi175 – 194H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSYNEL:NTCA.

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Gene namesi
Name:ntcA
Ordered Locus Names:Synpcc7942_0127
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000002717 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001861 – 222Global nitrogen regulatorAdd BLAST222

Proteomic databases

PRIDEiP29283.

Interactioni

Protein-protein interaction databases

DIPiDIP-59550N.
STRINGi1140.Synpcc7942_0127.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 15Combined sources4
Beta strandi18 – 20Combined sources3
Beta strandi23 – 27Combined sources5
Beta strandi32 – 34Combined sources3
Beta strandi42 – 49Combined sources8
Beta strandi51 – 56Combined sources6
Beta strandi58 – 60Combined sources3
Beta strandi62 – 68Combined sources7
Beta strandi72 – 74Combined sources3
Helixi78 – 81Combined sources4
Helixi82 – 84Combined sources3
Beta strandi89 – 95Combined sources7
Beta strandi97 – 103Combined sources7
Helixi104 – 106Combined sources3
Helixi107 – 113Combined sources7
Helixi116 – 140Combined sources25
Helixi144 – 159Combined sources16
Beta strandi160 – 163Combined sources4
Beta strandi166 – 171Combined sources6
Helixi175 – 182Combined sources8
Helixi186 – 198Combined sources13
Beta strandi201 – 205Combined sources5
Beta strandi208 – 212Combined sources5
Helixi214 – 219Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XGXX-ray2.85A/B1-222[»]
2XHKX-ray2.30A/B1-222[»]
2XKOX-ray2.25A/B1-222[»]
2XKPX-ray3.05A/B/C/D/E/F1-222[»]
ProteinModelPortaliP29283.
SMRiP29283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 215HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107RU9. Bacteria.
ENOG410XVK4. LUCA.
HOGENOMiHOG000232503.
OrthoDBiPOG091H03PG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANENSLLT MFRELGSGKL PLQIEQFERG KTIFFPGDPA ERVYLLVKGA
60 70 80 90 100
VKLSRVYESG EEITVALLRE NSVFGVLSLL TGQRSDRFYH AVAFTPVQLF
110 120 130 140 150
SVPIEFMQKA LIERPELANV MLQGLSSRIL QTEMMIETLA HRDMGSRLVS
160 170 180 190 200
FLLILCRDFG IPSPDGITID LKLSHQAIAE AIGSTRVTVT RLLGDLRESK
210 220
LIAIHKKRIT VFNPVALSQQ FS
Length:222
Mass (Da):24,833
Last modified:December 1, 1992 - v1
Checksum:iC6A9DC575D15A69A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60197 Genomic DNA. Translation: CAA42755.1.
CP000100 Genomic DNA. Translation: ABB56159.1.
PIRiS25244.

Genome annotation databases

EnsemblBacteriaiABB56159; ABB56159; Synpcc7942_0127.
KEGGisyf:Synpcc7942_0127.
PATRICi23785295. VBISynElo51371_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60197 Genomic DNA. Translation: CAA42755.1.
CP000100 Genomic DNA. Translation: ABB56159.1.
PIRiS25244.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XGXX-ray2.85A/B1-222[»]
2XHKX-ray2.30A/B1-222[»]
2XKOX-ray2.25A/B1-222[»]
2XKPX-ray3.05A/B/C/D/E/F1-222[»]
ProteinModelPortaliP29283.
SMRiP29283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59550N.
STRINGi1140.Synpcc7942_0127.

Proteomic databases

PRIDEiP29283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB56159; ABB56159; Synpcc7942_0127.
KEGGisyf:Synpcc7942_0127.
PATRICi23785295. VBISynElo51371_0195.

Phylogenomic databases

eggNOGiENOG4107RU9. Bacteria.
ENOG410XVK4. LUCA.
HOGENOMiHOG000232503.
OrthoDBiPOG091H03PG.

Enzyme and pathway databases

BioCyciSYNEL:NTCA.

Miscellaneous databases

EvolutionaryTraceiP29283.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTCA_SYNE7
AccessioniPrimary (citable) accession number: P29283
Secondary accession number(s): Q31S10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.