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P29283

- NTCA_SYNE7

UniProt

P29283 - NTCA_SYNE7

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Protein

Global nitrogen regulator

Gene
ntcA, Synpcc7942_0127
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 128123cNMPAdd
BLAST
DNA bindingi175 – 19420H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSYNEL:NTCA.

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Gene namesi
Name:ntcA
Ordered Locus Names:Synpcc7942_0127
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Global nitrogen regulatorPRO_0000100186Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-59550N.
STRINGi1140.Synpcc7942_0127.

Structurei

Secondary structure

1
222
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 154
Beta strandi18 – 203
Beta strandi23 – 275
Beta strandi32 – 343
Beta strandi42 – 498
Beta strandi51 – 566
Beta strandi58 – 603
Beta strandi62 – 687
Beta strandi72 – 743
Helixi78 – 814
Helixi82 – 843
Beta strandi89 – 957
Beta strandi97 – 1037
Helixi104 – 1063
Helixi107 – 1137
Helixi116 – 14025
Helixi144 – 15916
Beta strandi160 – 1634
Beta strandi166 – 1716
Helixi175 – 1828
Helixi186 – 19813
Beta strandi201 – 2055
Beta strandi208 – 2125
Helixi214 – 2196

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XGXX-ray2.85A/B1-222[»]
2XHKX-ray2.30A/B1-222[»]
2XKOX-ray2.25A/B1-222[»]
2XKPX-ray3.05A/B/C/D/E/F1-222[»]
ProteinModelPortaliP29283.

Miscellaneous databases

EvolutionaryTraceiP29283.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 21574HTH crp-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000232503.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29283-1 [UniParc]FASTAAdd to Basket

« Hide

MLANENSLLT MFRELGSGKL PLQIEQFERG KTIFFPGDPA ERVYLLVKGA    50
VKLSRVYESG EEITVALLRE NSVFGVLSLL TGQRSDRFYH AVAFTPVQLF 100
SVPIEFMQKA LIERPELANV MLQGLSSRIL QTEMMIETLA HRDMGSRLVS 150
FLLILCRDFG IPSPDGITID LKLSHQAIAE AIGSTRVTVT RLLGDLRESK 200
LIAIHKKRIT VFNPVALSQQ FS 222
Length:222
Mass (Da):24,833
Last modified:December 1, 1992 - v1
Checksum:iC6A9DC575D15A69A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60197 Genomic DNA. Translation: CAA42755.1.
CP000100 Genomic DNA. Translation: ABB56159.1.
PIRiS25244.
RefSeqiYP_399146.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56159; ABB56159; Synpcc7942_0127.
GeneIDi3773467.
KEGGisyf:Synpcc7942_0127.
PATRICi23785295. VBISynElo51371_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60197 Genomic DNA. Translation: CAA42755.1 .
CP000100 Genomic DNA. Translation: ABB56159.1 .
PIRi S25244.
RefSeqi YP_399146.1. NC_007604.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XGX X-ray 2.85 A/B 1-222 [» ]
2XHK X-ray 2.30 A/B 1-222 [» ]
2XKO X-ray 2.25 A/B 1-222 [» ]
2XKP X-ray 3.05 A/B/C/D/E/F 1-222 [» ]
ProteinModelPortali P29283.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59550N.
STRINGi 1140.Synpcc7942_0127.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56159 ; ABB56159 ; Synpcc7942_0127 .
GeneIDi 3773467.
KEGGi syf:Synpcc7942_0127.
PATRICi 23785295. VBISynElo51371_0195.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000232503.
OrthoDBi EOG6QRWC5.

Enzyme and pathway databases

BioCyci SYNEL:NTCA.

Miscellaneous databases

EvolutionaryTracei P29283.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
TIGRFAMsi TIGR03697. NtcA_cyano. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NtcA, a global nitrogen regulator from the cyanobacterium Synechococcus that belongs to the Crp family of bacterial regulators."
    Vega-Palas M.A., Flores E., Herrero A.
    Mol. Microbiol. 6:1853-1859(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiNTCA_SYNE7
AccessioniPrimary (citable) accession number: P29283
Secondary accession number(s): Q31S10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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