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P29283 (NTCA_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Global nitrogen regulator
Gene names
Name:ntcA
Ordered Locus Names:Synpcc7942_0127
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionActivator
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Global nitrogen regulator
PRO_0000100186

Regions

Domain142 – 21574HTH crp-type
Nucleotide binding6 – 128123cNMP
DNA binding175 – 19420H-T-H motif By similarity

Secondary structure

............................................. 222
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P29283 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: C6A9DC575D15A69A

FASTA22224,833
        10         20         30         40         50         60 
MLANENSLLT MFRELGSGKL PLQIEQFERG KTIFFPGDPA ERVYLLVKGA VKLSRVYESG 

        70         80         90        100        110        120 
EEITVALLRE NSVFGVLSLL TGQRSDRFYH AVAFTPVQLF SVPIEFMQKA LIERPELANV 

       130        140        150        160        170        180 
MLQGLSSRIL QTEMMIETLA HRDMGSRLVS FLLILCRDFG IPSPDGITID LKLSHQAIAE 

       190        200        210        220 
AIGSTRVTVT RLLGDLRESK LIAIHKKRIT VFNPVALSQQ FS 

« Hide

References

« Hide 'large scale' references
[1]"NtcA, a global nitrogen regulator from the cyanobacterium Synechococcus that belongs to the Crp family of bacterial regulators."
Vega-Palas M.A., Flores E., Herrero A.
Mol. Microbiol. 6:1853-1859(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60197 Genomic DNA. Translation: CAA42755.1.
CP000100 Genomic DNA. Translation: ABB56159.1.
PIRS25244.
RefSeqYP_399146.1. NC_007604.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XGXX-ray2.85A/B1-222[»]
2XHKX-ray2.30A/B1-222[»]
2XKOX-ray2.25A/B1-222[»]
2XKPX-ray3.05A/B/C/D/E/F1-222[»]
ProteinModelPortalP29283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59550N.
STRING1140.Synpcc7942_0127.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB56159; ABB56159; Synpcc7942_0127.
GeneID3773467.
KEGGsyf:Synpcc7942_0127.
PATRIC23785295. VBISynElo51371_0195.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000232503.
OrthoDBEOG6QRWC5.

Enzyme and pathway databases

BioCycSYNEL:NTCA.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
TIGRFAMsTIGR03697. NtcA_cyano. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP29283.

Entry information

Entry nameNTCA_SYNE7
AccessionPrimary (citable) accession number: P29283
Secondary accession number(s): Q31S10
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references