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P29283

- NTCA_SYNE7

UniProt

P29283 - NTCA_SYNE7

Protein

Global nitrogen regulator

Gene

ntcA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 128123cNMPAdd
    BLAST
    DNA bindingi175 – 19420H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciSYNEL:NTCA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Global nitrogen regulator
    Gene namesi
    Name:ntcA
    Ordered Locus Names:Synpcc7942_0127
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Global nitrogen regulatorPRO_0000100186Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59550N.
    STRINGi1140.Synpcc7942_0127.

    Structurei

    Secondary structure

    1
    222
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 154
    Beta strandi18 – 203
    Beta strandi23 – 275
    Beta strandi32 – 343
    Beta strandi42 – 498
    Beta strandi51 – 566
    Beta strandi58 – 603
    Beta strandi62 – 687
    Beta strandi72 – 743
    Helixi78 – 814
    Helixi82 – 843
    Beta strandi89 – 957
    Beta strandi97 – 1037
    Helixi104 – 1063
    Helixi107 – 1137
    Helixi116 – 14025
    Helixi144 – 15916
    Beta strandi160 – 1634
    Beta strandi166 – 1716
    Helixi175 – 1828
    Helixi186 – 19813
    Beta strandi201 – 2055
    Beta strandi208 – 2125
    Helixi214 – 2196

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XGXX-ray2.85A/B1-222[»]
    2XHKX-ray2.30A/B1-222[»]
    2XKOX-ray2.25A/B1-222[»]
    2XKPX-ray3.05A/B/C/D/E/F1-222[»]
    ProteinModelPortaliP29283.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP29283.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini142 – 21574HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000232503.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR022299. Tscrpt_reg_NtcA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLANENSLLT MFRELGSGKL PLQIEQFERG KTIFFPGDPA ERVYLLVKGA    50
    VKLSRVYESG EEITVALLRE NSVFGVLSLL TGQRSDRFYH AVAFTPVQLF 100
    SVPIEFMQKA LIERPELANV MLQGLSSRIL QTEMMIETLA HRDMGSRLVS 150
    FLLILCRDFG IPSPDGITID LKLSHQAIAE AIGSTRVTVT RLLGDLRESK 200
    LIAIHKKRIT VFNPVALSQQ FS 222
    Length:222
    Mass (Da):24,833
    Last modified:December 1, 1992 - v1
    Checksum:iC6A9DC575D15A69A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60197 Genomic DNA. Translation: CAA42755.1.
    CP000100 Genomic DNA. Translation: ABB56159.1.
    PIRiS25244.
    RefSeqiYP_399146.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB56159; ABB56159; Synpcc7942_0127.
    GeneIDi3773467.
    KEGGisyf:Synpcc7942_0127.
    PATRICi23785295. VBISynElo51371_0195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60197 Genomic DNA. Translation: CAA42755.1 .
    CP000100 Genomic DNA. Translation: ABB56159.1 .
    PIRi S25244.
    RefSeqi YP_399146.1. NC_007604.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XGX X-ray 2.85 A/B 1-222 [» ]
    2XHK X-ray 2.30 A/B 1-222 [» ]
    2XKO X-ray 2.25 A/B 1-222 [» ]
    2XKP X-ray 3.05 A/B/C/D/E/F 1-222 [» ]
    ProteinModelPortali P29283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59550N.
    STRINGi 1140.Synpcc7942_0127.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB56159 ; ABB56159 ; Synpcc7942_0127 .
    GeneIDi 3773467.
    KEGGi syf:Synpcc7942_0127.
    PATRICi 23785295. VBISynElo51371_0195.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000232503.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci SYNEL:NTCA.

    Miscellaneous databases

    EvolutionaryTracei P29283.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR022299. Tscrpt_reg_NtcA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    TIGRFAMsi TIGR03697. NtcA_cyano. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NtcA, a global nitrogen regulator from the cyanobacterium Synechococcus that belongs to the Crp family of bacterial regulators."
      Vega-Palas M.A., Flores E., Herrero A.
      Mol. Microbiol. 6:1853-1859(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiNTCA_SYNE7
    AccessioniPrimary (citable) accession number: P29283
    Secondary accession number(s): Q31S10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3