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P29279

- CTGF_HUMAN

UniProt

P29279 - CTGF_HUMAN

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Protein
Connective tissue growth factor
Gene
CTGF, CCN2, HCS24, IGFBP8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.2 Publications

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. insulin-like growth factor binding Source: ProtInc
  3. protein binding Source: IntAct

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. angiogenesis Source: Ensembl
  3. cartilage condensation Source: Ensembl
  4. cell differentiation Source: Ensembl
  5. cell migration Source: Ensembl
  6. cell-matrix adhesion Source: Ensembl
  7. cellular lipid metabolic process Source: Reactome
  8. chondrocyte proliferation Source: Ensembl
  9. cytosolic calcium ion transport Source: Ensembl
  10. epidermis development Source: ProtInc
  11. extracellular matrix constituent secretion Source: Ensembl
  12. fibroblast growth factor receptor signaling pathway Source: Ensembl
  13. gene expression Source: Reactome
  14. integrin-mediated signaling pathway Source: Ensembl
  15. intracellular signal transduction Source: Ensembl
  16. lung development Source: Ensembl
  17. negative regulation of cell death Source: Ensembl
  18. negative regulation of gene expression Source: Ensembl
  19. organ senescence Source: Ensembl
  20. ossification Source: Ensembl
  21. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  22. positive regulation of G0 to G1 transition Source: Ensembl
  23. positive regulation of JNK cascade Source: BHF-UCL
  24. positive regulation of cardiac muscle contraction Source: Ensembl
  25. positive regulation of cell activation Source: Ensembl
  26. positive regulation of cell death Source: Ensembl
  27. positive regulation of cell differentiation Source: BHF-UCL
  28. positive regulation of cell proliferation Source: Ensembl
  29. positive regulation of collagen biosynthetic process Source: Ensembl
  30. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  31. positive regulation of gene expression Source: Ensembl
  32. positive regulation of protein phosphorylation Source: Ensembl
  33. positive regulation of stress fiber assembly Source: BHF-UCL
  34. reactive oxygen species metabolic process Source: Ensembl
  35. regulation of cell growth Source: InterPro
  36. regulation of chondrocyte differentiation Source: Ensembl
  37. response to amino acid Source: Ensembl
  38. response to anoxia Source: Ensembl
  39. response to estradiol Source: Ensembl
  40. response to fatty acid Source: Ensembl
  41. response to glucose Source: Ensembl
  42. response to mineralocorticoid Source: Ensembl
  43. response to peptide hormone Source: Ensembl
  44. response to wounding Source: ProtInc
  45. small molecule metabolic process Source: Reactome
  46. transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, DNA synthesis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_116145. PPARA activates gene expression.
REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
Short name:
IBP-8
Short name:
IGF-binding protein 8
Short name:
IGFBP-8
Gene namesi
Name:CTGF
Synonyms:CCN2, HCS24, IGFBP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2500. CTGF.

Subcellular locationi

Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. cell cortex Source: Ensembl
  3. cis-Golgi network Source: Ensembl
  4. cytosol Source: Ensembl
  5. extracellular region Source: Reactome
  6. extracellular space Source: Ensembl
  7. intracellular membrane-bounded organelle Source: HPA
  8. perinuclear region of cytoplasm Source: Ensembl
  9. plasma membrane Source: ProtInc
  10. proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA27003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 349323Connective tissue growth factor
PRO_0000014402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi256 ↔ 293 By similarity
Disulfide bondi273 ↔ 307 By similarity
Disulfide bondi284 ↔ 323 By similarity
Disulfide bondi287 ↔ 325 By similarity
Disulfide bondi292 ↔ 329 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29279.
PaxDbiP29279.
PRIDEiP29279.

PTM databases

PhosphoSiteiP29279.

Expressioni

Tissue specificityi

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.1 Publication

Gene expression databases

ArrayExpressiP29279.
BgeeiP29279.
CleanExiHS_CTGF.
GenevestigatoriP29279.

Organism-specific databases

HPAiCAB005123.
HPA031074.
HPA031075.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
FN1P027515EBI-2835375,EBI-1220319

Protein-protein interaction databases

BioGridi107872. 7 interactions.
IntActiP29279. 15 interactions.
MINTiMINT-1779737.
STRINGi9606.ENSP00000356954.

Structurei

3D structure databases

ProteinModelPortaliP29279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 9872IGFBP N-terminal
Add
BLAST
Domaini101 – 16767VWFC
Add
BLAST
Domaini198 – 24346TSP type-1
Add
BLAST
Domaini256 – 33075CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 349103Heparin-binding
Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP29279.
KOiK06827.
OMAiKTYRAKF.
OrthoDBiEOG7N8ZXB.
PhylomeDBiP29279.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P29279-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV    50
LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG 100
APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF 150
PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL 200
VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI 250
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 300
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 349
Length:349
Mass (Da):38,091
Last modified:October 17, 2006 - v2
Checksum:i62CF878C7F57EC1F
GO
Isoform 2 (identifier: P29279-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: Missing.

Note: No experimental confirmation available.

Show »
Length:322
Mass (Da):35,205
Checksum:i372DBF768AA2B2D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831H → D.8 Publications
Corresponds to variant rs7451102 [ dbSNP | Ensembl ].
VAR_027925

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei172 – 19827Missing in isoform 2.
VSP_002460Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751V → L no nucleotide entry 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92934 mRNA. Translation: AAA91279.1.
X78947 mRNA. Translation: CAA55544.1.
AY395801 mRNA. Translation: AAQ95223.1.
AY550024 mRNA. Translation: AAS55639.1.
BT019794 mRNA. Translation: AAV38597.1.
BT019795 mRNA. Translation: AAV38598.1.
CR541759 mRNA. Translation: CAG46559.1.
AL354866 Genomic DNA. Translation: CAC44023.1.
X92511 Genomic DNA. Translation: CAA63267.1.
CH471051 Genomic DNA. Translation: EAW48038.1.
CH471051 Genomic DNA. Translation: EAW48039.1.
AF316366 Genomic DNA. Translation: AAK60505.1.
AF316367 Genomic DNA. Translation: AAK60506.1.
AF316368 Genomic DNA. Translation: AAK60507.1.
U14750 mRNA. Translation: AAA75378.1.
CCDSiCCDS5151.1. [P29279-1]
PIRiA40551.
RefSeqiNP_001892.1. NM_001901.2.
UniGeneiHs.410037.

Genome annotation databases

EnsembliENST00000367976; ENSP00000356954; ENSG00000118523. [P29279-1]
GeneIDi1490.
KEGGihsa:1490.

Polymorphism databases

DMDMi116241320.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M92934 mRNA. Translation: AAA91279.1 .
X78947 mRNA. Translation: CAA55544.1 .
AY395801 mRNA. Translation: AAQ95223.1 .
AY550024 mRNA. Translation: AAS55639.1 .
BT019794 mRNA. Translation: AAV38597.1 .
BT019795 mRNA. Translation: AAV38598.1 .
CR541759 mRNA. Translation: CAG46559.1 .
AL354866 Genomic DNA. Translation: CAC44023.1 .
X92511 Genomic DNA. Translation: CAA63267.1 .
CH471051 Genomic DNA. Translation: EAW48038.1 .
CH471051 Genomic DNA. Translation: EAW48039.1 .
AF316366 Genomic DNA. Translation: AAK60505.1 .
AF316367 Genomic DNA. Translation: AAK60506.1 .
AF316368 Genomic DNA. Translation: AAK60507.1 .
U14750 mRNA. Translation: AAA75378.1 .
CCDSi CCDS5151.1. [P29279-1 ]
PIRi A40551.
RefSeqi NP_001892.1. NM_001901.2.
UniGenei Hs.410037.

3D structure databases

ProteinModelPortali P29279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107872. 7 interactions.
IntActi P29279. 15 interactions.
MINTi MINT-1779737.
STRINGi 9606.ENSP00000356954.

PTM databases

PhosphoSitei P29279.

Polymorphism databases

DMDMi 116241320.

Proteomic databases

MaxQBi P29279.
PaxDbi P29279.
PRIDEi P29279.

Protocols and materials databases

DNASUi 1490.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367976 ; ENSP00000356954 ; ENSG00000118523 . [P29279-1 ]
GeneIDi 1490.
KEGGi hsa:1490.

Organism-specific databases

CTDi 1490.
GeneCardsi GC06M132269.
HGNCi HGNC:2500. CTGF.
HPAi CAB005123.
HPA031074.
HPA031075.
MIMi 121009. gene.
neXtProti NX_P29279.
Orphaneti 220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBi PA27003.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72934.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi P29279.
KOi K06827.
OMAi KTYRAKF.
OrthoDBi EOG7N8ZXB.
PhylomeDBi P29279.
TreeFami TF326070.

Enzyme and pathway databases

Reactomei REACT_116145. PPARA activates gene expression.
REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

Miscellaneous databases

ChiTaRSi CTGF. human.
GeneWikii CTGF.
GenomeRNAii 1490.
NextBioi 6123.
PROi P29279.
SOURCEi Search...

Gene expression databases

ArrayExpressi P29279.
Bgeei P29279.
CleanExi HS_CTGF.
Genevestigatori P29279.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."
    Bradham D.M., Igarashi A., Potter R.L., Grotendorst G.R.
    J. Cell Biol. 114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
    Tissue: Umbilical vein endothelial cell.
  2. "Connective tissue growth factor."
    Igarashi A., Bradham D.M., Okochi H., Grotendorst G.R.
    J. Dermatol. 19:642-643(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
    Tissue: Umbilical vein endothelial cell.
  3. "Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."
    Oemar B.S., Werner A., Garnier J.-M., Do D.D., Godoy N., Nauck M., Marz W., Rupp J., Pech M., Luescher T.F.
    Circulation 95:831-839(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
    Tissue: Aorta.
  4. "Expression, purification and bio-activity of human connective tissue growth factor."
    Li Q.-H., Wang L.-C., Liu L.-D., Dong S.-Z., Wang J.-J., Hu F., Wang J., He S.-Q., Dong C.-H., Zhao S.-D., Zhao H.-L.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
  5. "Complete mRNA sequence of human connective tissue growth factor."
    Dai W.-J., Jiang H.-C., Fu S.-B.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
    Tissue: Liver.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
  8. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "Differential expression of novH and CTGF in human glioma cell lines."
    Xin L.W., Martinerie C., Zumkeller W., Westphal M., Perbal B.
    Clin. Mol. Pathol. 49:91-97(1996)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
    Tissue: Placenta.
  11. "Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."
    Blom I.E., van Dijk A.J., de Weger R.A., Tilanus M.G.J., Goldschmeding R.
    J. Clin. Pathol. 54:192-196(2001)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
  12. "Connective tissue growth factor mRNA is expressed in human keratinocytes as an immediate early gene that responds to serum, EGF, or wounding."
    Cody C.W., Walker N.J., Greenlee W.F., Sutter T.R.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-349, VARIANT ASP-83.
  13. "Expression of a gene encoding a novel potential IGF binding protein in human tissues."
    Martinerie C., Perbal B.
    C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1), TISSUE SPECIFICITY.
  14. "Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."
    Nakanishi T., Nishida T., Shimo T., Kobayashi K., Kubo T., Tamatani T., Tezuka K., Takigawa M.
    Endocrinology 141:264-273(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Tissue: Chondrocyte.
  15. "The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."
    Ball D.K., Rachfal A.W., Kemper S.A., Brigstock D.R.
    J. Endocrinol. 176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: HEPARIN-BINDING, FUNCTION IN CELL ADHESION.

Entry informationi

Entry nameiCTGF_HUMAN
AccessioniPrimary (citable) accession number: P29279
Secondary accession number(s): E1P578
, Q6LCY0, Q96A79, Q96QX2, Q9UDL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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