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P29279

- CTGF_HUMAN

UniProt

P29279 - CTGF_HUMAN

Protein

Connective tissue growth factor

Gene

CTGF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.2 Publications

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. insulin-like growth factor binding Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. cartilage condensation Source: Ensembl
    3. cell differentiation Source: Ensembl
    4. cell-matrix adhesion Source: Ensembl
    5. cell migration Source: Ensembl
    6. cellular lipid metabolic process Source: Reactome
    7. chondrocyte proliferation Source: Ensembl
    8. cytosolic calcium ion transport Source: Ensembl
    9. DNA replication Source: UniProtKB-KW
    10. epidermis development Source: ProtInc
    11. extracellular matrix constituent secretion Source: Ensembl
    12. fibroblast growth factor receptor signaling pathway Source: Ensembl
    13. gene expression Source: Reactome
    14. integrin-mediated signaling pathway Source: Ensembl
    15. intracellular signal transduction Source: Ensembl
    16. lung development Source: Ensembl
    17. negative regulation of cell death Source: Ensembl
    18. negative regulation of gene expression Source: Ensembl
    19. organ senescence Source: Ensembl
    20. ossification Source: Ensembl
    21. positive regulation of cardiac muscle contraction Source: Ensembl
    22. positive regulation of cell activation Source: Ensembl
    23. positive regulation of cell death Source: Ensembl
    24. positive regulation of cell differentiation Source: BHF-UCL
    25. positive regulation of cell proliferation Source: Ensembl
    26. positive regulation of collagen biosynthetic process Source: Ensembl
    27. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    28. positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
    29. positive regulation of G0 to G1 transition Source: Ensembl
    30. positive regulation of gene expression Source: Ensembl
    31. positive regulation of JNK cascade Source: BHF-UCL
    32. positive regulation of protein phosphorylation Source: Ensembl
    33. positive regulation of stress fiber assembly Source: BHF-UCL
    34. reactive oxygen species metabolic process Source: Ensembl
    35. regulation of cell growth Source: InterPro
    36. regulation of chondrocyte differentiation Source: Ensembl
    37. response to amino acid Source: Ensembl
    38. response to anoxia Source: Ensembl
    39. response to estradiol Source: Ensembl
    40. response to fatty acid Source: Ensembl
    41. response to glucose Source: Ensembl
    42. response to mineralocorticoid Source: Ensembl
    43. response to peptide hormone Source: Ensembl
    44. response to wounding Source: ProtInc
    45. small molecule metabolic process Source: Reactome
    46. transcription initiation from RNA polymerase II promoter Source: Reactome

    Keywords - Biological processi

    Cell adhesion, DNA synthesis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Connective tissue growth factor
    Alternative name(s):
    CCN family member 2
    Hypertrophic chondrocyte-specific protein 24
    Insulin-like growth factor-binding protein 8
    Short name:
    IBP-8
    Short name:
    IGF-binding protein 8
    Short name:
    IGFBP-8
    Gene namesi
    Name:CTGF
    Synonyms:CCN2, HCS24, IGFBP8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:2500. CTGF.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cis-Golgi network Source: Ensembl
    3. cytosol Source: Ensembl
    4. extracellular region Source: Reactome
    5. extracellular space Source: Ensembl
    6. Golgi apparatus Source: HPA
    7. intracellular membrane-bounded organelle Source: HPA
    8. perinuclear region of cytoplasm Source: Ensembl
    9. plasma membrane Source: ProtInc
    10. proteinaceous extracellular matrix Source: ProtInc

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti220393. Diffuse cutaneous systemic sclerosis.
    220402. Limited cutaneous systemic sclerosis.
    PharmGKBiPA27003.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 349323Connective tissue growth factorPRO_0000014402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi256 ↔ 293By similarity
    Disulfide bondi273 ↔ 307By similarity
    Disulfide bondi284 ↔ 323By similarity
    Disulfide bondi287 ↔ 325By similarity
    Disulfide bondi292 ↔ 329By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP29279.
    PaxDbiP29279.
    PRIDEiP29279.

    PTM databases

    PhosphoSiteiP29279.

    Expressioni

    Tissue specificityi

    Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.1 Publication

    Gene expression databases

    ArrayExpressiP29279.
    BgeeiP29279.
    CleanExiHS_CTGF.
    GenevestigatoriP29279.

    Organism-specific databases

    HPAiCAB005123.
    HPA031074.
    HPA031075.

    Interactioni

    Subunit structurei

    Monomer.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FN1P027515EBI-2835375,EBI-1220319

    Protein-protein interaction databases

    BioGridi107872. 7 interactions.
    IntActiP29279. 15 interactions.
    MINTiMINT-1779737.
    STRINGi9606.ENSP00000356954.

    Structurei

    3D structure databases

    ProteinModelPortaliP29279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 9872IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini101 – 16767VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini198 – 24346TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini256 – 33075CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 349103Heparin-bindingAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72934.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiP29279.
    KOiK06827.
    OMAiKTYRAKF.
    OrthoDBiEOG7N8ZXB.
    PhylomeDBiP29279.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P29279-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV    50
    LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG 100
    APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF 150
    PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL 200
    VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI 250
    KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 300
    LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 349
    Length:349
    Mass (Da):38,091
    Last modified:October 17, 2006 - v2
    Checksum:i62CF878C7F57EC1F
    GO
    Isoform 2 (identifier: P29279-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         172-198: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:322
    Mass (Da):35,205
    Checksum:i372DBF768AA2B2D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751V → L no nucleotide entry (PubMed:1756408)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831H → D.8 Publications
    Corresponds to variant rs7451102 [ dbSNP | Ensembl ].
    VAR_027925

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei172 – 19827Missing in isoform 2. CuratedVSP_002460Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92934 mRNA. Translation: AAA91279.1.
    X78947 mRNA. Translation: CAA55544.1.
    AY395801 mRNA. Translation: AAQ95223.1.
    AY550024 mRNA. Translation: AAS55639.1.
    BT019794 mRNA. Translation: AAV38597.1.
    BT019795 mRNA. Translation: AAV38598.1.
    CR541759 mRNA. Translation: CAG46559.1.
    AL354866 Genomic DNA. Translation: CAC44023.1.
    X92511 Genomic DNA. Translation: CAA63267.1.
    CH471051 Genomic DNA. Translation: EAW48038.1.
    CH471051 Genomic DNA. Translation: EAW48039.1.
    AF316366 Genomic DNA. Translation: AAK60505.1.
    AF316367 Genomic DNA. Translation: AAK60506.1.
    AF316368 Genomic DNA. Translation: AAK60507.1.
    U14750 mRNA. Translation: AAA75378.1.
    CCDSiCCDS5151.1. [P29279-1]
    PIRiA40551.
    RefSeqiNP_001892.1. NM_001901.2.
    UniGeneiHs.410037.

    Genome annotation databases

    EnsembliENST00000367976; ENSP00000356954; ENSG00000118523. [P29279-1]
    GeneIDi1490.
    KEGGihsa:1490.

    Polymorphism databases

    DMDMi116241320.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M92934 mRNA. Translation: AAA91279.1 .
    X78947 mRNA. Translation: CAA55544.1 .
    AY395801 mRNA. Translation: AAQ95223.1 .
    AY550024 mRNA. Translation: AAS55639.1 .
    BT019794 mRNA. Translation: AAV38597.1 .
    BT019795 mRNA. Translation: AAV38598.1 .
    CR541759 mRNA. Translation: CAG46559.1 .
    AL354866 Genomic DNA. Translation: CAC44023.1 .
    X92511 Genomic DNA. Translation: CAA63267.1 .
    CH471051 Genomic DNA. Translation: EAW48038.1 .
    CH471051 Genomic DNA. Translation: EAW48039.1 .
    AF316366 Genomic DNA. Translation: AAK60505.1 .
    AF316367 Genomic DNA. Translation: AAK60506.1 .
    AF316368 Genomic DNA. Translation: AAK60507.1 .
    U14750 mRNA. Translation: AAA75378.1 .
    CCDSi CCDS5151.1. [P29279-1 ]
    PIRi A40551.
    RefSeqi NP_001892.1. NM_001901.2.
    UniGenei Hs.410037.

    3D structure databases

    ProteinModelPortali P29279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107872. 7 interactions.
    IntActi P29279. 15 interactions.
    MINTi MINT-1779737.
    STRINGi 9606.ENSP00000356954.

    PTM databases

    PhosphoSitei P29279.

    Polymorphism databases

    DMDMi 116241320.

    Proteomic databases

    MaxQBi P29279.
    PaxDbi P29279.
    PRIDEi P29279.

    Protocols and materials databases

    DNASUi 1490.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367976 ; ENSP00000356954 ; ENSG00000118523 . [P29279-1 ]
    GeneIDi 1490.
    KEGGi hsa:1490.

    Organism-specific databases

    CTDi 1490.
    GeneCardsi GC06M132269.
    HGNCi HGNC:2500. CTGF.
    HPAi CAB005123.
    HPA031074.
    HPA031075.
    MIMi 121009. gene.
    neXtProti NX_P29279.
    Orphaneti 220393. Diffuse cutaneous systemic sclerosis.
    220402. Limited cutaneous systemic sclerosis.
    PharmGKBi PA27003.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72934.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi P29279.
    KOi K06827.
    OMAi KTYRAKF.
    OrthoDBi EOG7N8ZXB.
    PhylomeDBi P29279.
    TreeFami TF326070.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_118713. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Miscellaneous databases

    ChiTaRSi CTGF. human.
    GeneWikii CTGF.
    GenomeRNAii 1490.
    NextBioi 6123.
    PROi P29279.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29279.
    Bgeei P29279.
    CleanExi HS_CTGF.
    Genevestigatori P29279.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."
      Bradham D.M., Igarashi A., Potter R.L., Grotendorst G.R.
      J. Cell Biol. 114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
      Tissue: Umbilical vein endothelial cell.
    2. "Connective tissue growth factor."
      Igarashi A., Bradham D.M., Okochi H., Grotendorst G.R.
      J. Dermatol. 19:642-643(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
      Tissue: Umbilical vein endothelial cell.
    3. "Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."
      Oemar B.S., Werner A., Garnier J.-M., Do D.D., Godoy N., Nauck M., Marz W., Rupp J., Pech M., Luescher T.F.
      Circulation 95:831-839(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
      Tissue: Aorta.
    4. "Expression, purification and bio-activity of human connective tissue growth factor."
      Li Q.-H., Wang L.-C., Liu L.-D., Dong S.-Z., Wang J.-J., Hu F., Wang J., He S.-Q., Dong C.-H., Zhao S.-D., Zhao H.-L.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
    5. "Complete mRNA sequence of human connective tissue growth factor."
      Dai W.-J., Jiang H.-C., Fu S.-B.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
      Tissue: Liver.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
    8. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "Differential expression of novH and CTGF in human glioma cell lines."
      Xin L.W., Martinerie C., Zumkeller W., Westphal M., Perbal B.
      Clin. Mol. Pathol. 49:91-97(1996)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
      Tissue: Placenta.
    11. "Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."
      Blom I.E., van Dijk A.J., de Weger R.A., Tilanus M.G.J., Goldschmeding R.
      J. Clin. Pathol. 54:192-196(2001)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
    12. "Connective tissue growth factor mRNA is expressed in human keratinocytes as an immediate early gene that responds to serum, EGF, or wounding."
      Cody C.W., Walker N.J., Greenlee W.F., Sutter T.R.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-349, VARIANT ASP-83.
    13. "Expression of a gene encoding a novel potential IGF binding protein in human tissues."
      Martinerie C., Perbal B.
      C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1), TISSUE SPECIFICITY.
    14. "Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."
      Nakanishi T., Nishida T., Shimo T., Kobayashi K., Kubo T., Tamatani T., Tezuka K., Takigawa M.
      Endocrinology 141:264-273(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Tissue: Chondrocyte.
    15. "The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."
      Ball D.K., Rachfal A.W., Kemper S.A., Brigstock D.R.
      J. Endocrinol. 176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: HEPARIN-BINDING, FUNCTION IN CELL ADHESION.

    Entry informationi

    Entry nameiCTGF_HUMAN
    AccessioniPrimary (citable) accession number: P29279
    Secondary accession number(s): E1P578
    , Q6LCY0, Q96A79, Q96QX2, Q9UDL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3