P29279 (CTGF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Connective tissue growth factor

Alternative name(s):
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
Short name=IBP-8
Short name=IGF-binding protein 8
Short name=IGFBP-8

Gene names

Name:	CTGF
Synonyms:	CCN2, HCS24, IGFBP8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Ref.14 Ref.15
Subunit structure	Monomer.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity. Secreted By similarity.
Tissue specificity	Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. Ref.13
Sequence similarities	Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Biological process	Cell adhesion DNA synthesis
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Ligand	Heparin-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW angiogenesis Inferred from electronic annotation. Source: Compara cartilage condensation Inferred from electronic annotation. Source: Compara cell differentiation Inferred from electronic annotation. Source: Compara cell migration Inferred from electronic annotation. Source: Compara cell-matrix adhesion Inferred from electronic annotation. Source: Compara cellular lipid metabolic process Traceable author statement. Source: Reactome chondrocyte proliferation Inferred from electronic annotation. Source: Compara cytosolic calcium ion transport Inferred from electronic annotation. Source: Compara epidermis development Traceable author statement PubMed 10809757. Source: ProtInc extracellular matrix constituent secretion Inferred from electronic annotation. Source: Compara fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: Compara intracellular signal transduction Inferred from electronic annotation. Source: Compara lung development Inferred from electronic annotation. Source: Compara negative regulation of gene expression Inferred from electronic annotation. Source: Compara organ senescence Inferred from electronic annotation. Source: Compara ossification Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from direct assay PubMed 20008146. Source: BHF-UCL positive regulation of G0 to G1 transition Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from direct assay PubMed 20008146. Source: BHF-UCL positive regulation of cardiac muscle contraction Inferred from electronic annotation. Source: Compara positive regulation of cell activation Inferred from electronic annotation. Source: Compara positive regulation of cell death Inferred from electronic annotation. Source: Compara positive regulation of cell differentiation Inferred from direct assay PubMed 20008146. Source: BHF-UCL positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of collagen biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of gene expression Inferred from electronic annotation. Source: Compara positive regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of stress fiber assembly Inferred from direct assay PubMed 20008146. Source: BHF-UCL reactive oxygen species metabolic process Inferred from electronic annotation. Source: Compara regulation of cell growth Inferred from electronic annotation. Source: InterPro regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from electronic annotation. Source: Compara response to anoxia Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to fatty acid Inferred from electronic annotation. Source: Compara response to glucose stimulus Inferred from electronic annotation. Source: Compara response to mineralocorticoid stimulus Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to wounding Traceable author statement PubMed 10809757. Source: ProtInc small molecule metabolic process Traceable author statement. Source: Reactome transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome
Cellular_component	Golgi apparatus Inferred from direct assay. Source: HPA cell cortex Inferred from electronic annotation. Source: Compara cis-Golgi network Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement PubMed 10809757. Source: ProtInc proteinaceous extracellular matrix Traceable author statement PubMed 10809757. Source: ProtInc
Molecular_function	heparin binding Inferred from electronic annotation. Source: UniProtKB-KW insulin-like growth factor binding Traceable author statement PubMed 9371786. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P29279-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P29279-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 349	323	Connective tissue growth factor		PRO_0000014402
Regions
	Domain	27 – 98	72	IGFBP N-terminal
	Domain	101 – 167	67	VWFC
	Domain	198 – 243	46	TSP type-1
	Domain	256 – 330	75	CTCK
	Region	247 – 349	103	Heparin-binding
Amino acid modifications
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Disulfide bond	256 ↔ 293		By similarity
	Disulfide bond	273 ↔ 307		By similarity
	Disulfide bond	284 ↔ 323		By similarity
	Disulfide bond	287 ↔ 325		By similarity
	Disulfide bond	292 ↔ 329		By similarity
Natural variations
	Alternative sequence	172 – 198	27	Missing in isoform 2.		VSP_002460
	Natural variant	83	1	H → D. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.12 Corresponds to variant rs7451102 [ dbSNP | Ensembl ].		VAR_027925
Experimental info
	Sequence conflict	175	1	V → L no nucleotide entry Ref.13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 62CF878C7F57EC1F	FASTA	349	38,091
	10 20 30 40 50 60 MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 70 80 90 100 110 120 AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 130 140 150 160 170 180 KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 190 200 210 220 230 240 AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 250 260 270 280 290 300 PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 310 320 330 340 LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
	Isoform 2 (Short) [UniParc]. Checksum: 372DBF768AA2B2D0	FASTA	322	35,205
	10 20 30 40 50 60 MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 70 80 90 100 110 120 AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 130 140 150 160 170 180 KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DCLVQTTEWS 190 200 210 220 230 240 ACSKTCGMGI STRVTNDNAS CRLEKQSRLC MVRPCEADLE ENIKKGKKCI RTPKISKPIK 250 260 270 280 290 300 FELSGCTSMK TYRAKFCGVC TDGRCCTPHR TTTLPVEFKC PDGEVMKKNM MFIKTCACHY 310 320 NCPGDNDIFE SLYYRKMYGD MA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10." Bradham D.M., Igarashi A., Potter R.L., Grotendorst G.R. J. Cell Biol. 114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83. Tissue: Umbilical vein endothelial cell.
[2]	"Connective tissue growth factor." Igarashi A., Bradham D.M., Okochi H., Grotendorst G.R. J. Dermatol. 19:642-643(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83. Tissue: Umbilical vein endothelial cell.
[3]	"Human connective tissue growth factor is expressed in advanced atherosclerotic lesions." Oemar B.S., Werner A., Garnier J.-M., Do D.D., Godoy N., Nauck M., Marz W., Rupp J., Pech M., Luescher T.F. Circulation 95:831-839(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83. Tissue: Aorta.
[4]	"Expression, purification and bio-activity of human connective tissue growth factor." Li Q.-H., Wang L.-C., Liu L.-D., Dong S.-Z., Wang J.-J., Hu F., Wang J., He S.-Q., Dong C.-H., Zhao S.-D., Zhao H.-L. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
[5]	"Complete mRNA sequence of human connective tissue growth factor." Dai W.-J., Jiang H.-C., Fu S.-B. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83. Tissue: Liver.
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
[8]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"Differential expression of novH and CTGF in human glioma cell lines." Xin L.W., Martinerie C., Zumkeller W., Westphal M., Perbal B. Clin. Mol. Pathol. 49:91-97(1996) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20. Tissue: Placenta.
[11]	"Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms." Blom I.E., van Dijk A.J., de Weger R.A., Tilanus M.G.J., Goldschmeding R. J. Clin. Pathol. 54:192-196(2001) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
[12]	"Connective tissue growth factor mRNA is expressed in human keratinocytes as an immediate early gene that responds to serum, EGF, or wounding." Cody C.W., Walker N.J., Greenlee W.F., Sutter T.R. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-349, VARIANT ASP-83.
[13]	"Expression of a gene encoding a novel potential IGF binding protein in human tissues." Martinerie C., Perbal B. C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1), TISSUE SPECIFICITY.
[14]	"Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture." Nakanishi T., Nishida T., Shimo T., Kobayashi K., Kubo T., Tamatani T., Tezuka K., Takigawa M. Endocrinology 141:264-273(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Tissue: Chondrocyte.
[15]	"The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion." Ball D.K., Rachfal A.W., Kemper S.A., Brigstock D.R. J. Endocrinol. 176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract] Cited for: HEPARIN-BINDING, FUNCTION IN CELL ADHESION.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	M92934 mRNA. Translation: AAA91279.1. X78947 mRNA. Translation: CAA55544.1. AY395801 mRNA. Translation: AAQ95223.1. AY550024 mRNA. Translation: AAS55639.1. BT019794 mRNA. Translation: AAV38597.1. BT019795 mRNA. Translation: AAV38598.1. CR541759 mRNA. Translation: CAG46559.1. AL354866 Genomic DNA. Translation: CAC44023.1. X92511 Genomic DNA. Translation: CAA63267.1. CH471051 Genomic DNA. Translation: EAW48038.1. CH471051 Genomic DNA. Translation: EAW48039.1. AF316366 Genomic DNA. Translation: AAK60505.1. AF316367 Genomic DNA. Translation: AAK60506.1. AF316368 Genomic DNA. Translation: AAK60507.1. U14750 mRNA. Translation: AAA75378.1.
IPI	IPI00020977. IPI00220647.
PIR	A40551.
RefSeq	NP_001892.1. NM_001901.2.
UniGene	Hs.410037.
3D structure databases
ProteinModelPortal	P29279.
ModBase	Search...
Protein-protein interaction databases
IntAct	P29279. 9 interactions.
MINT	MINT-1779737.
STRING	9606.ENSP00000356954.
PTM databases
PhosphoSite	P29279.
Polymorphism databases
DMDM	116241320.
Proteomic databases
PaxDb	P29279.
PRIDE	P29279.
Protocols and materials databases
DNASU	1490.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367976; ENSP00000356954; ENSG00000118523.
GeneID	1490.
KEGG	hsa:1490.
Organism-specific databases
CTD	1490.
GeneCards	GC06M132311.
HGNC	HGNC:2500. CTGF.
HPA	CAB005123. HPA031074. HPA031075.
MIM	121009. gene.
neXtProt	NX_P29279.
Orphanet	220393. Diffuse cutaneous systemic sclerosis. 220402. Limited cutaneous systemic sclerosis.
PharmGKB	PA27003.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG72934.
HOGENOM	HOG000231462.
HOVERGEN	HBG000635.
InParanoid	P29279.
KO	K06827.
OMA	KTYRAKF.
OrthoDB	EOG44XJGZ.
PhylomeDB	P29279.
Enzyme and pathway databases
Pathway_Interaction_DB	amb2_neutrophils_pathway. amb2 Integrin signaling. tgfbrpathway. TGF-beta receptor signaling.
Reactome	REACT_111217. Metabolism. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P29279.
Bgee	P29279.
CleanEx	HS_CTGF.
Genevestigator	P29279.
GermOnline	ENSG00000118523. Homo sapiens.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR000867. IGFBP-like. IPR012395. IGFBP_CNN. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
PIRSF	PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMART	SM00041. CT. 1 hit. SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CTGF. human.
GenomeRNAi	1490.
NextBio	6123.
SOURCE	Search...

Entry information

Entry name

CTGF_HUMAN

Accession

Primary (citable) accession number: P29279
Secondary accession number(s): E1P578 , Q6LCY0, Q96A79, Q96QX2, Q9UDL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 134 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.