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Protein

Connective tissue growth factor

Gene

CTGF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.2 Publications

GO - Molecular functioni

  • heparin binding Source: GO_Central
  • insulin-like growth factor binding Source: ProtInc
  • integrin binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, DNA synthesis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118523-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SIGNORiP29279.

Names & Taxonomyi

Protein namesi
Recommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
Short name:
IBP-8
Short name:
IGF-binding protein 8
Short name:
IGFBP-8
Gene namesi
Name:CTGF
Synonyms:CCN2, HCS24, IGFBP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:2500. CTGF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1490.
MalaCardsiCTGF.
OpenTargetsiENSG00000118523.
Orphaneti220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA27003.

Polymorphism and mutation databases

BioMutaiCTGF.
DMDMi116241320.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001440227 – 349Connective tissue growth factorAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi256 ↔ 293By similarity
Disulfide bondi273 ↔ 307By similarity
Disulfide bondi284 ↔ 323By similarity
Disulfide bondi287 ↔ 325By similarity
Disulfide bondi292 ↔ 329By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP29279.
MaxQBiP29279.
PaxDbiP29279.
PeptideAtlasiP29279.
PRIDEiP29279.

PTM databases

iPTMnetiP29279.
PhosphoSitePlusiP29279.

Expressioni

Tissue specificityi

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.1 Publication

Gene expression databases

BgeeiENSG00000118523.
CleanExiHS_CTGF.
GenevisibleiP29279. HS.

Organism-specific databases

HPAiCAB005123.
HPA031074.
HPA031075.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
FN1P027515EBI-2835375,EBI-1220319

GO - Molecular functioni

  • insulin-like growth factor binding Source: ProtInc
  • integrin binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107872. 13 interactors.
IntActiP29279. 15 interactors.
MINTiMINT-1779737.
STRINGi9606.ENSP00000356954.

Structurei

3D structure databases

ProteinModelPortaliP29279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST72
Domaini101 – 167VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini198 – 243TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini256 – 330CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 349Heparin-bindingAdd BLAST103

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH0W. Eukaryota.
ENOG4111F77. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP29279.
KOiK06827.
OMAiKCIRTPR.
OrthoDBiEOG091G0SQP.
PhylomeDBiP29279.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29279-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV
60 70 80 90 100
LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG
110 120 130 140 150
APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF
160 170 180 190 200
PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL
210 220 230 240 250
VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI
260 270 280 290 300
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
310 320 330 340
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
Length:349
Mass (Da):38,091
Last modified:October 17, 2006 - v2
Checksum:i62CF878C7F57EC1F
GO
Isoform 2 (identifier: P29279-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: Missing.

Note: No experimental confirmation available.
Show »
Length:322
Mass (Da):35,205
Checksum:i372DBF768AA2B2D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175V → L no nucleotide entry (PubMed:1756408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02792583H → D.8 PublicationsCorresponds to variant rs7451102dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002460172 – 198Missing in isoform 2. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92934 mRNA. Translation: AAA91279.1.
X78947 mRNA. Translation: CAA55544.1.
AY395801 mRNA. Translation: AAQ95223.1.
AY550024 mRNA. Translation: AAS55639.1.
BT019794 mRNA. Translation: AAV38597.1.
BT019795 mRNA. Translation: AAV38598.1.
CR541759 mRNA. Translation: CAG46559.1.
AL354866 Genomic DNA. Translation: CAC44023.1.
X92511 Genomic DNA. Translation: CAA63267.1.
CH471051 Genomic DNA. Translation: EAW48038.1.
CH471051 Genomic DNA. Translation: EAW48039.1.
AF316366 Genomic DNA. Translation: AAK60505.1.
AF316367 Genomic DNA. Translation: AAK60506.1.
AF316368 Genomic DNA. Translation: AAK60507.1.
U14750 mRNA. Translation: AAA75378.1.
CCDSiCCDS5151.1. [P29279-1]
PIRiA40551.
RefSeqiNP_001892.1. NM_001901.2.
UniGeneiHs.410037.

Genome annotation databases

EnsembliENST00000367976; ENSP00000356954; ENSG00000118523. [P29279-1]
GeneIDi1490.
KEGGihsa:1490.
UCSCiuc003qcz.4. human. [P29279-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92934 mRNA. Translation: AAA91279.1.
X78947 mRNA. Translation: CAA55544.1.
AY395801 mRNA. Translation: AAQ95223.1.
AY550024 mRNA. Translation: AAS55639.1.
BT019794 mRNA. Translation: AAV38597.1.
BT019795 mRNA. Translation: AAV38598.1.
CR541759 mRNA. Translation: CAG46559.1.
AL354866 Genomic DNA. Translation: CAC44023.1.
X92511 Genomic DNA. Translation: CAA63267.1.
CH471051 Genomic DNA. Translation: EAW48038.1.
CH471051 Genomic DNA. Translation: EAW48039.1.
AF316366 Genomic DNA. Translation: AAK60505.1.
AF316367 Genomic DNA. Translation: AAK60506.1.
AF316368 Genomic DNA. Translation: AAK60507.1.
U14750 mRNA. Translation: AAA75378.1.
CCDSiCCDS5151.1. [P29279-1]
PIRiA40551.
RefSeqiNP_001892.1. NM_001901.2.
UniGeneiHs.410037.

3D structure databases

ProteinModelPortaliP29279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107872. 13 interactors.
IntActiP29279. 15 interactors.
MINTiMINT-1779737.
STRINGi9606.ENSP00000356954.

PTM databases

iPTMnetiP29279.
PhosphoSitePlusiP29279.

Polymorphism and mutation databases

BioMutaiCTGF.
DMDMi116241320.

Proteomic databases

EPDiP29279.
MaxQBiP29279.
PaxDbiP29279.
PeptideAtlasiP29279.
PRIDEiP29279.

Protocols and materials databases

DNASUi1490.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367976; ENSP00000356954; ENSG00000118523. [P29279-1]
GeneIDi1490.
KEGGihsa:1490.
UCSCiuc003qcz.4. human. [P29279-1]

Organism-specific databases

CTDi1490.
DisGeNETi1490.
GeneCardsiCTGF.
HGNCiHGNC:2500. CTGF.
HPAiCAB005123.
HPA031074.
HPA031075.
MalaCardsiCTGF.
MIMi121009. gene.
neXtProtiNX_P29279.
OpenTargetsiENSG00000118523.
Orphaneti220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBiPA27003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH0W. Eukaryota.
ENOG4111F77. LUCA.
GeneTreeiENSGT00760000119225.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP29279.
KOiK06827.
OMAiKCIRTPR.
OrthoDBiEOG091G0SQP.
PhylomeDBiP29279.
TreeFamiTF326070.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118523-MONOMER.
ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-2032785. YAP1- and WWTR1 (TAZ)-stimulated gene expression.
SIGNORiP29279.

Miscellaneous databases

ChiTaRSiCTGF. human.
GeneWikiiCTGF.
GenomeRNAii1490.
PROiP29279.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118523.
CleanExiHS_CTGF.
GenevisibleiP29279. HS.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTGF_HUMAN
AccessioniPrimary (citable) accession number: P29279
Secondary accession number(s): E1P578
, Q6LCY0, Q96A79, Q96QX2, Q9UDL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.