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P29279 (CTGF_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 145. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Connective tissue growth factor
Alternative name(s):
CCN family member 2
Hypertrophic chondrocyte-specific protein 24
Insulin-like growth factor-binding protein 8
Short name=IBP-8
Short name=IGF-binding protein 8
Short name=IGFBP-8
Gene names
Name:CTGF
Synonyms:CCN2, HCS24, IGFBP8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Ref.14 Ref.15

Subunit structure

Monomer.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity. Secreted By similarity.

Tissue specificity

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. Ref.13

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Biological processCell adhesion
DNA synthesis
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   LigandHeparin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

angiogenesis

Inferred from electronic annotation. Source: Ensembl

cartilage condensation

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from electronic annotation. Source: Ensembl

cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

cellular lipid metabolic process

Traceable author statement. Source: Reactome

chondrocyte proliferation

Inferred from electronic annotation. Source: Ensembl

cytosolic calcium ion transport

Inferred from electronic annotation. Source: Ensembl

epidermis development

Traceable author statement PubMed 10809757. Source: ProtInc

extracellular matrix constituent secretion

Inferred from electronic annotation. Source: Ensembl

fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

gene expression

Traceable author statement. Source: Reactome

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

intracellular signal transduction

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell death

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

organ senescence

Inferred from electronic annotation. Source: Ensembl

ossification

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 20008146. Source: BHF-UCL

positive regulation of G0 to G1 transition

Inferred from electronic annotation. Source: Ensembl

positive regulation of JNK cascade

Inferred from direct assay PubMed 20008146. Source: BHF-UCL

positive regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell differentiation

Inferred from direct assay PubMed 20008146. Source: BHF-UCL

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of stress fiber assembly

Inferred from direct assay PubMed 20008146. Source: BHF-UCL

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of cell growth

Inferred from electronic annotation. Source: InterPro

regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from electronic annotation. Source: Ensembl

response to anoxia

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to fatty acid

Inferred from electronic annotation. Source: Ensembl

response to glucose

Inferred from electronic annotation. Source: Ensembl

response to mineralocorticoid

Inferred from electronic annotation. Source: Ensembl

response to peptide hormone

Inferred from electronic annotation. Source: Ensembl

response to wounding

Traceable author statement PubMed 10809757. Source: ProtInc

small molecule metabolic process

Traceable author statement. Source: Reactome

transcription initiation from RNA polymerase II promoter

Traceable author statement. Source: Reactome

   Cellular_componentGolgi apparatus

Inferred from direct assay. Source: HPA

cell cortex

Inferred from electronic annotation. Source: Ensembl

cis-Golgi network

Inferred from electronic annotation. Source: Ensembl

cytosol

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from electronic annotation. Source: Ensembl

intracellular membrane-bounded organelle

Inferred from direct assay. Source: HPA

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement PubMed 10809757. Source: ProtInc

proteinaceous extracellular matrix

Traceable author statement PubMed 10809757. Source: ProtInc

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

insulin-like growth factor binding

Traceable author statement PubMed 9371786. Source: ProtInc

protein binding

Inferred from physical interaction PubMed 16457822. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FN1P027515EBI-2835375,EBI-1220319

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P29279-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P29279-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 349323Connective tissue growth factor
PRO_0000014402

Regions

Domain27 – 9872IGFBP N-terminal
Domain101 – 16767VWFC
Domain198 – 24346TSP type-1
Domain256 – 33075CTCK
Region247 – 349103Heparin-binding

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Disulfide bond256 ↔ 293 By similarity
Disulfide bond273 ↔ 307 By similarity
Disulfide bond284 ↔ 323 By similarity
Disulfide bond287 ↔ 325 By similarity
Disulfide bond292 ↔ 329 By similarity

Natural variations

Alternative sequence172 – 19827Missing in isoform 2.
VSP_002460
Natural variant831H → D. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.12
Corresponds to variant rs7451102 [ dbSNP | Ensembl ].
VAR_027925

Experimental info

Sequence conflict1751V → L no nucleotide entry Ref.13

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 62CF878C7F57EC1F

FASTA34938,091
        10         20         30         40         50         60 
MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC 

        70         80         90        100        110        120 
AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC 

       130        140        150        160        170        180 
KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA 

       190        200        210        220        230        240 
AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR 

       250        260        270        280        290        300 
PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT 

       310        320        330        340 
LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 372DBF768AA2B2D0
Show »

FASTA32235,205

References

« Hide 'large scale' references
[1]"Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."
Bradham D.M., Igarashi A., Potter R.L., Grotendorst G.R.
J. Cell Biol. 114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
Tissue: Umbilical vein endothelial cell.
[2]"Connective tissue growth factor."
Igarashi A., Bradham D.M., Okochi H., Grotendorst G.R.
J. Dermatol. 19:642-643(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
Tissue: Umbilical vein endothelial cell.
[3]"Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."
Oemar B.S., Werner A., Garnier J.-M., Do D.D., Godoy N., Nauck M., Marz W., Rupp J., Pech M., Luescher T.F.
Circulation 95:831-839(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-83.
Tissue: Aorta.
[4]"Expression, purification and bio-activity of human connective tissue growth factor."
Li Q.-H., Wang L.-C., Liu L.-D., Dong S.-Z., Wang J.-J., Hu F., Wang J., He S.-Q., Dong C.-H., Zhao S.-D., Zhao H.-L.
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
[5]"Complete mRNA sequence of human connective tissue growth factor."
Dai W.-J., Jiang H.-C., Fu S.-B.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-83.
Tissue: Liver.
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
[7]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-83.
[8]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"Differential expression of novH and CTGF in human glioma cell lines."
Xin L.W., Martinerie C., Zumkeller W., Westphal M., Perbal B.
Clin. Mol. Pathol. 49:91-97(1996)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
Tissue: Placenta.
[11]"Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."
Blom I.E., van Dijk A.J., de Weger R.A., Tilanus M.G.J., Goldschmeding R.
J. Clin. Pathol. 54:192-196(2001)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
[12]"Connective tissue growth factor mRNA is expressed in human keratinocytes as an immediate early gene that responds to serum, EGF, or wounding."
Cody C.W., Walker N.J., Greenlee W.F., Sutter T.R.
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-349, VARIANT ASP-83.
[13]"Expression of a gene encoding a novel potential IGF binding protein in human tissues."
Martinerie C., Perbal B.
C. R. Acad. Sci. III, Sci. Vie 313:345-351(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1), TISSUE SPECIFICITY.
[14]"Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."
Nakanishi T., Nishida T., Shimo T., Kobayashi K., Kubo T., Tamatani T., Tezuka K., Takigawa M.
Endocrinology 141:264-273(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Tissue: Chondrocyte.
[15]"The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."
Ball D.K., Rachfal A.W., Kemper S.A., Brigstock D.R.
J. Endocrinol. 176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: HEPARIN-BINDING, FUNCTION IN CELL ADHESION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92934 mRNA. Translation: AAA91279.1.
X78947 mRNA. Translation: CAA55544.1.
AY395801 mRNA. Translation: AAQ95223.1.
AY550024 mRNA. Translation: AAS55639.1.
BT019794 mRNA. Translation: AAV38597.1.
BT019795 mRNA. Translation: AAV38598.1.
CR541759 mRNA. Translation: CAG46559.1.
AL354866 Genomic DNA. Translation: CAC44023.1.
X92511 Genomic DNA. Translation: CAA63267.1.
CH471051 Genomic DNA. Translation: EAW48038.1.
CH471051 Genomic DNA. Translation: EAW48039.1.
AF316366 Genomic DNA. Translation: AAK60505.1.
AF316367 Genomic DNA. Translation: AAK60506.1.
AF316368 Genomic DNA. Translation: AAK60507.1.
U14750 mRNA. Translation: AAA75378.1.
CCDSCCDS5151.1. [P29279-1]
PIRA40551.
RefSeqNP_001892.1. NM_001901.2.
UniGeneHs.410037.

3D structure databases

ProteinModelPortalP29279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107872. 7 interactions.
IntActP29279. 15 interactions.
MINTMINT-1779737.
STRING9606.ENSP00000356954.

PTM databases

PhosphoSiteP29279.

Polymorphism databases

DMDM116241320.

Proteomic databases

MaxQBP29279.
PaxDbP29279.
PRIDEP29279.

Protocols and materials databases

DNASU1490.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367976; ENSP00000356954; ENSG00000118523. [P29279-1]
GeneID1490.
KEGGhsa:1490.

Organism-specific databases

CTD1490.
GeneCardsGC06M132269.
HGNCHGNC:2500. CTGF.
HPACAB005123.
HPA031074.
HPA031075.
MIM121009. gene.
neXtProtNX_P29279.
Orphanet220393. Diffuse cutaneous systemic sclerosis.
220402. Limited cutaneous systemic sclerosis.
PharmGKBPA27003.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG72934.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidP29279.
KOK06827.
OMAKTYRAKF.
OrthoDBEOG7N8ZXB.
PhylomeDBP29279.
TreeFamTF326070.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressP29279.
BgeeP29279.
CleanExHS_CTGF.
GenevestigatorP29279.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCTGF. human.
GeneWikiCTGF.
GenomeRNAi1490.
NextBio6123.
PROP29279.
SOURCESearch...

Entry information

Entry nameCTGF_HUMAN
AccessionPrimary (citable) accession number: P29279
Secondary accession number(s): E1P578 expand/collapse secondary AC list , Q6LCY0, Q96A79, Q96QX2, Q9UDL6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM