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P29275

- AA2BR_HUMAN

UniProt

P29275 - AA2BR_HUMAN

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Protein

Adenosine receptor A2b

Gene
ADORA2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. G-protein coupled adenosine receptor activity Source: InterPro

GO - Biological processi

  1. activation of adenylate cyclase activity Source: ProtInc
  2. activation of MAPK activity Source: ProtInc
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  4. cellular defense response Source: ProtInc
  5. cellular response to extracellular stimulus Source: Ensembl
  6. excretion Source: ProtInc
  7. G-protein coupled receptor signaling pathway Source: ProtInc
  8. JNK cascade Source: ProtInc
  9. positive regulation of cGMP biosynthetic process Source: Ensembl
  10. positive regulation of chemokine production Source: Ensembl
  11. positive regulation of chronic inflammatory response to non-antigenic stimulus Source: Ensembl
  12. positive regulation of guanylate cyclase activity Source: Ensembl
  13. positive regulation of interleukin-6 production Source: Ensembl
  14. positive regulation of mast cell degranulation Source: Ensembl
  15. positive regulation vascular endothelial growth factor production Source: Ensembl
  16. relaxation of vascular smooth muscle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18288. Adenosine P1 receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:ADORA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:264. ADORA2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88Extracellular By similarity
Transmembranei9 – 3325Helical; Name=1; By similarityAdd
BLAST
Topological domaini34 – 4310Cytoplasmic By similarity
Transmembranei44 – 6724Helical; Name=2; By similarityAdd
BLAST
Topological domaini68 – 7811Extracellular By similarityAdd
BLAST
Transmembranei79 – 10123Helical; Name=3; By similarityAdd
BLAST
Topological domaini102 – 12120Cytoplasmic By similarityAdd
BLAST
Transmembranei122 – 14423Helical; Name=4; By similarityAdd
BLAST
Topological domaini145 – 17834Extracellular By similarityAdd
BLAST
Transmembranei179 – 20325Helical; Name=5; By similarityAdd
BLAST
Topological domaini204 – 23532Cytoplasmic By similarityAdd
BLAST
Transmembranei236 – 25924Helical; Name=6; By similarityAdd
BLAST
Topological domaini260 – 2678Extracellular By similarity
Transmembranei268 – 29124Helical; Name=7; By similarityAdd
BLAST
Topological domaini292 – 33241Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Adenosine receptor A2bPRO_0000069003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 171 By similarity
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Lipidationi311 – 3111S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP29275.
PRIDEiP29275.

PTM databases

PhosphoSiteiP29275.

Expressioni

Gene expression databases

ArrayExpressiP29275.
BgeeiP29275.
CleanExiHS_ADORA2B.
GenevestigatoriP29275.

Interactioni

Protein-protein interaction databases

BioGridi106648. 4 interactions.
IntActiP29275. 2 interactions.
STRINGi9606.ENSP00000304501.

Structurei

3D structure databases

ProteinModelPortaliP29275.
SMRiP29275. Positions 8-310.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni173 – 18210Agonist binding By similarity
Regioni247 – 2548Agonist binding By similarity
Regioni266 – 27611Agonist binding By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287824.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP29275.
KOiK04267.
OMAiGWNSKDS.
OrthoDBiEOG79SDXQ.
PhylomeDBiP29275.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29275-1 [UniParc]FASTAAdd to Basket

« Hide

MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA    50
AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA 100
VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA 150
TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV 200
IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV 250
HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT 300
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL 332
Length:332
Mass (Da):36,333
Last modified:December 1, 1992 - v1
Checksum:i38AD088E2439C7FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97759 mRNA. Translation: AAA51598.1.
X68487 mRNA. Translation: CAA48505.1.
AY136748 mRNA. Translation: AAN01274.1.
BC025722 mRNA. Translation: AAH25722.1.
CCDSiCCDS11173.1.
PIRiJC1229.
RefSeqiNP_000667.1. NM_000676.2.
UniGeneiHs.167046.

Genome annotation databases

EnsembliENST00000304222; ENSP00000304501; ENSG00000170425.
GeneIDi136.
KEGGihsa:136.
UCSCiuc002gpd.1. human.

Polymorphism databases

DMDMi112938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97759 mRNA. Translation: AAA51598.1 .
X68487 mRNA. Translation: CAA48505.1 .
AY136748 mRNA. Translation: AAN01274.1 .
BC025722 mRNA. Translation: AAH25722.1 .
CCDSi CCDS11173.1.
PIRi JC1229.
RefSeqi NP_000667.1. NM_000676.2.
UniGenei Hs.167046.

3D structure databases

ProteinModelPortali P29275.
SMRi P29275. Positions 8-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106648. 4 interactions.
IntActi P29275. 2 interactions.
STRINGi 9606.ENSP00000304501.

Chemistry

BindingDBi P29275.
ChEMBLi CHEMBL2096679.
DrugBanki DB04932. Defibrotide.
DB00824. Enprofylline.
DB00061. Pegademase bovine.
DB00277. Theophylline.
GuidetoPHARMACOLOGYi 20.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P29275.

Polymorphism databases

DMDMi 112938.

Proteomic databases

PaxDbi P29275.
PRIDEi P29275.

Protocols and materials databases

DNASUi 136.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304222 ; ENSP00000304501 ; ENSG00000170425 .
GeneIDi 136.
KEGGi hsa:136.
UCSCi uc002gpd.1. human.

Organism-specific databases

CTDi 136.
GeneCardsi GC17P015788.
HGNCi HGNC:264. ADORA2B.
MIMi 600446. gene.
neXtProti NX_P29275.
PharmGKBi PA24585.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287824.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
InParanoidi P29275.
KOi K04267.
OMAi GWNSKDS.
OrthoDBi EOG79SDXQ.
PhylomeDBi P29275.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_18288. Adenosine P1 receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSi ADORA2B. human.
GeneWikii Adenosine_A2B_receptor.
GenomeRNAii 136.
NextBioi 547.
PROi P29275.
SOURCEi Search...

Gene expression databases

ArrayExpressi P29275.
Bgeei P29275.
CleanExi HS_ADORA2B.
Genevestigatori P29275.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of an adenosine A2b receptor from human brain."
    Pierce K.D., Furlong T.J., Selbie L.A., Shine J.
    Biochem. Biophys. Res. Commun. 187:86-93(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene."
    Jacobson M.A., Johnson R.G., Luneau C.J., Salvatore C.A.
    Genomics 27:374-376(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAA2BR_HUMAN
AccessioniPrimary (citable) accession number: P29275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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