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P29275 (AA2BR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosine receptor A2b
Gene names
Name:ADORA2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement Ref.2. Source: ProtInc

JNK cascade

Traceable author statement PubMed 10101031. Source: ProtInc

activation of MAPK activity

Traceable author statement PubMed 10101031. Source: ProtInc

activation of adenylate cyclase activity

Traceable author statement PubMed 8022409. Source: ProtInc

adenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

cellular defense response

Traceable author statement PubMed 10101031. Source: ProtInc

cellular response to extracellular stimulus

Inferred from electronic annotation. Source: Ensembl

excretion

Traceable author statement PubMed 7836474. Source: ProtInc

positive regulation of cGMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine production

Inferred from electronic annotation. Source: Ensembl

positive regulation of chronic inflammatory response to non-antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

positive regulation of guanylate cyclase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of mast cell degranulation

Inferred from electronic annotation. Source: Ensembl

positive regulation vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

relaxation of vascular smooth muscle

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.2. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled adenosine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Adenosine receptor A2b
PRO_0000069003

Regions

Topological domain1 – 88Extracellular By similarity
Transmembrane9 – 3325Helical; Name=1; By similarity
Topological domain34 – 4310Cytoplasmic By similarity
Transmembrane44 – 6724Helical; Name=2; By similarity
Topological domain68 – 7811Extracellular By similarity
Transmembrane79 – 10123Helical; Name=3; By similarity
Topological domain102 – 12120Cytoplasmic By similarity
Transmembrane122 – 14423Helical; Name=4; By similarity
Topological domain145 – 17834Extracellular By similarity
Transmembrane179 – 20325Helical; Name=5; By similarity
Topological domain204 – 23532Cytoplasmic By similarity
Transmembrane236 – 25924Helical; Name=6; By similarity
Topological domain260 – 2678Extracellular By similarity
Transmembrane268 – 29124Helical; Name=7; By similarity
Topological domain292 – 33241Cytoplasmic By similarity
Region173 – 18210Agonist binding By similarity
Region247 – 2548Agonist binding By similarity
Region266 – 27611Agonist binding By similarity

Amino acid modifications

Lipidation3111S-palmitoyl cysteine Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Disulfide bond78 ↔ 171 By similarity

Sequences

Sequence LengthMass (Da)Tools
P29275 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 38AD088E2439C7FA

FASTA33236,333
        10         20         30         40         50         60 
MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA AADVAVGLFA 

        70         80         90        100        110        120 
IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAICVP LRYKSLVTGT 

       130        140        150        160        170        180 
RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TNNCTEPWDG TTNESCCLVK CLFENVVPMS 

       190        200        210        220        230        240 
YMVYFNFFGC VLPPLLIMLV IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV 

       250        260        270        280        290        300 
GIFALCWLPV HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT 

       310        320        330 
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and expression of an adenosine A2b receptor from human brain."
Pierce K.D., Furlong T.J., Selbie L.A., Shine J.
Biochem. Biophys. Res. Commun. 187:86-93(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene."
Jacobson M.A., Johnson R.G., Luneau C.J., Salvatore C.A.
Genomics 27:374-376(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97759 mRNA. Translation: AAA51598.1.
X68487 mRNA. Translation: CAA48505.1.
AY136748 mRNA. Translation: AAN01274.1.
BC025722 mRNA. Translation: AAH25722.1.
PIRJC1229.
RefSeqNP_000667.1. NM_000676.2.
UniGeneHs.167046.

3D structure databases

ProteinModelPortalP29275.
SMRP29275. Positions 8-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106648. 4 interactions.
IntActP29275. 2 interactions.
STRING9606.ENSP00000304501.

Chemistry

BindingDBP29275.
ChEMBLCHEMBL2096679.
DrugBankDB04932. Defibrotide.
DB00824. Enprofylline.
DB00061. Pegademase bovine.
DB00277. Theophylline.
GuidetoPHARMACOLOGY20.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP29275.

Polymorphism databases

DMDM112938.

Proteomic databases

PaxDbP29275.
PRIDEP29275.

Protocols and materials databases

DNASU136.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304222; ENSP00000304501; ENSG00000170425.
GeneID136.
KEGGhsa:136.
UCSCuc002gpd.1. human.

Organism-specific databases

CTD136.
GeneCardsGC17P015788.
HGNCHGNC:264. ADORA2B.
MIM600446. gene.
neXtProtNX_P29275.
PharmGKBPA24585.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287824.
HOGENOMHOG000015770.
HOVERGENHBG106962.
InParanoidP29275.
KOK04267.
OMAGWNSKDS.
OrthoDBEOG79SDXQ.
PhylomeDBP29275.
TreeFamTF325296.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP29275.
BgeeP29275.
CleanExHS_ADORA2B.
GenevestigatorP29275.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSADORA2B. human.
GeneWikiAdenosine_A2B_receptor.
GenomeRNAi136.
NextBio547.
PROP29275.
SOURCESearch...

Entry information

Entry nameAA2BR_HUMAN
AccessionPrimary (citable) accession number: P29275
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries