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Protein

Adenosine receptor A2b

Gene

ADORA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18288. Adenosine P1 receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:ADORA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:264. ADORA2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88ExtracellularBy similarity
Transmembranei9 – 3325Helical; Name=1By similarityAdd
BLAST
Topological domaini34 – 4310CytoplasmicBy similarity
Transmembranei44 – 6724Helical; Name=2By similarityAdd
BLAST
Topological domaini68 – 7811ExtracellularBy similarityAdd
BLAST
Transmembranei79 – 10123Helical; Name=3By similarityAdd
BLAST
Topological domaini102 – 12120CytoplasmicBy similarityAdd
BLAST
Transmembranei122 – 14423Helical; Name=4By similarityAdd
BLAST
Topological domaini145 – 17834ExtracellularBy similarityAdd
BLAST
Transmembranei179 – 20325Helical; Name=5By similarityAdd
BLAST
Topological domaini204 – 23532CytoplasmicBy similarityAdd
BLAST
Transmembranei236 – 25924Helical; Name=6By similarityAdd
BLAST
Topological domaini260 – 2678ExtracellularBy similarity
Transmembranei268 – 29124Helical; Name=7By similarityAdd
BLAST
Topological domaini292 – 33241CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24585.

Chemistry

DrugBankiDB00640. Adenosine.
DB04932. Defibrotide.
DB00824. Enprofylline.
DB00277. Theophylline.

Polymorphism and mutation databases

BioMutaiADORA2B.
DMDMi112938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Adenosine receptor A2bPRO_0000069003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Lipidationi311 – 3111S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP29275.
PRIDEiP29275.

PTM databases

PhosphoSiteiP29275.

Expressioni

Gene expression databases

BgeeiP29275.
CleanExiHS_ADORA2B.
GenevisibleiP29275. HS.

Interactioni

Protein-protein interaction databases

BioGridi106648. 5 interactions.
IntActiP29275. 2 interactions.
STRINGi9606.ENSP00000304501.

Structurei

3D structure databases

ProteinModelPortaliP29275.
SMRiP29275. Positions 8-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni173 – 18210Agonist bindingBy similarity
Regioni247 – 2548Agonist bindingBy similarity
Regioni266 – 27611Agonist bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP29275.
KOiK04267.
OMAiCTDFYGC.
OrthoDBiEOG79SDXQ.
PhylomeDBiP29275.
TreeFamiTF325296.

Family and domain databases

InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA
60 70 80 90 100
AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA
160 170 180 190 200
TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV
210 220 230 240 250
IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT
310 320 330
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL
Length:332
Mass (Da):36,333
Last modified:December 1, 1992 - v1
Checksum:i38AD088E2439C7FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97759 mRNA. Translation: AAA51598.1.
X68487 mRNA. Translation: CAA48505.1.
AY136748 mRNA. Translation: AAN01274.1.
BC025722 mRNA. Translation: AAH25722.1.
CCDSiCCDS11173.1.
PIRiJC1229.
RefSeqiNP_000667.1. NM_000676.2.
UniGeneiHs.167046.

Genome annotation databases

EnsembliENST00000304222; ENSP00000304501; ENSG00000170425.
GeneIDi136.
KEGGihsa:136.
UCSCiuc002gpd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97759 mRNA. Translation: AAA51598.1.
X68487 mRNA. Translation: CAA48505.1.
AY136748 mRNA. Translation: AAN01274.1.
BC025722 mRNA. Translation: AAH25722.1.
CCDSiCCDS11173.1.
PIRiJC1229.
RefSeqiNP_000667.1. NM_000676.2.
UniGeneiHs.167046.

3D structure databases

ProteinModelPortaliP29275.
SMRiP29275. Positions 8-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106648. 5 interactions.
IntActiP29275. 2 interactions.
STRINGi9606.ENSP00000304501.

Chemistry

BindingDBiP29275.
ChEMBLiCHEMBL2096679.
DrugBankiDB00640. Adenosine.
DB04932. Defibrotide.
DB00824. Enprofylline.
DB00277. Theophylline.
GuidetoPHARMACOLOGYi20.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP29275.

Polymorphism and mutation databases

BioMutaiADORA2B.
DMDMi112938.

Proteomic databases

PaxDbiP29275.
PRIDEiP29275.

Protocols and materials databases

DNASUi136.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304222; ENSP00000304501; ENSG00000170425.
GeneIDi136.
KEGGihsa:136.
UCSCiuc002gpd.1. human.

Organism-specific databases

CTDi136.
GeneCardsiGC17P015788.
HGNCiHGNC:264. ADORA2B.
MIMi600446. gene.
neXtProtiNX_P29275.
PharmGKBiPA24585.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287824.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP29275.
KOiK04267.
OMAiCTDFYGC.
OrthoDBiEOG79SDXQ.
PhylomeDBiP29275.
TreeFamiTF325296.

Enzyme and pathway databases

ReactomeiREACT_18288. Adenosine P1 receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSiADORA2B. human.
GeneWikiiAdenosine_A2B_receptor.
GenomeRNAii136.
NextBioi547.
PROiP29275.
SOURCEiSearch...

Gene expression databases

BgeeiP29275.
CleanExiHS_ADORA2B.
GenevisibleiP29275. HS.

Family and domain databases

InterProiIPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of an adenosine A2b receptor from human brain."
    Pierce K.D., Furlong T.J., Selbie L.A., Shine J.
    Biochem. Biophys. Res. Commun. 187:86-93(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene."
    Jacobson M.A., Johnson R.G., Luneau C.J., Salvatore C.A.
    Genomics 27:374-376(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAA2BR_HUMAN
AccessioniPrimary (citable) accession number: P29275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 24, 2015
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.