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P29275

- AA2BR_HUMAN

UniProt

P29275 - AA2BR_HUMAN

Protein

Adenosine receptor A2b

Gene

ADORA2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. G-protein coupled adenosine receptor activity Source: InterPro

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: ProtInc
    2. activation of MAPK activity Source: ProtInc
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    4. cellular defense response Source: ProtInc
    5. cellular response to extracellular stimulus Source: Ensembl
    6. excretion Source: ProtInc
    7. G-protein coupled receptor signaling pathway Source: ProtInc
    8. JNK cascade Source: ProtInc
    9. positive regulation of cGMP biosynthetic process Source: Ensembl
    10. positive regulation of chemokine production Source: Ensembl
    11. positive regulation of chronic inflammatory response to non-antigenic stimulus Source: Ensembl
    12. positive regulation of guanylate cyclase activity Source: Ensembl
    13. positive regulation of interleukin-6 production Source: Ensembl
    14. positive regulation of mast cell degranulation Source: Ensembl
    15. positive regulation vascular endothelial growth factor production Source: Ensembl
    16. relaxation of vascular smooth muscle Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18288. Adenosine P1 receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosine receptor A2b
    Gene namesi
    Name:ADORA2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:264. ADORA2B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24585.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Adenosine receptor A2bPRO_0000069003Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Lipidationi311 – 3111S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP29275.
    PRIDEiP29275.

    PTM databases

    PhosphoSiteiP29275.

    Expressioni

    Gene expression databases

    ArrayExpressiP29275.
    BgeeiP29275.
    CleanExiHS_ADORA2B.
    GenevestigatoriP29275.

    Interactioni

    Protein-protein interaction databases

    BioGridi106648. 4 interactions.
    IntActiP29275. 2 interactions.
    STRINGi9606.ENSP00000304501.

    Structurei

    3D structure databases

    ProteinModelPortaliP29275.
    SMRiP29275. Positions 8-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 88ExtracellularBy similarity
    Topological domaini34 – 4310CytoplasmicBy similarity
    Topological domaini68 – 7811ExtracellularBy similarityAdd
    BLAST
    Topological domaini102 – 12120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini145 – 17834ExtracellularBy similarityAdd
    BLAST
    Topological domaini204 – 23532CytoplasmicBy similarityAdd
    BLAST
    Topological domaini260 – 2678ExtracellularBy similarity
    Topological domaini292 – 33241CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 3325Helical; Name=1By similarityAdd
    BLAST
    Transmembranei44 – 6724Helical; Name=2By similarityAdd
    BLAST
    Transmembranei79 – 10123Helical; Name=3By similarityAdd
    BLAST
    Transmembranei122 – 14423Helical; Name=4By similarityAdd
    BLAST
    Transmembranei179 – 20325Helical; Name=5By similarityAdd
    BLAST
    Transmembranei236 – 25924Helical; Name=6By similarityAdd
    BLAST
    Transmembranei268 – 29124Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 18210Agonist bindingBy similarity
    Regioni247 – 2548Agonist bindingBy similarity
    Regioni266 – 27611Agonist bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287824.
    HOGENOMiHOG000015770.
    HOVERGENiHBG106962.
    InParanoidiP29275.
    KOiK04267.
    OMAiGWNSKDS.
    OrthoDBiEOG79SDXQ.
    PhylomeDBiP29275.
    TreeFamiTF325296.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001435. Adeno_A2B_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00554. ADENOSINA2BR.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29275-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA    50
    AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA 100
    VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA 150
    TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV 200
    IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV 250
    HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT 300
    FHKIISRYLL CQADVKSGNG QAGVQPALGV GL 332
    Length:332
    Mass (Da):36,333
    Last modified:December 1, 1992 - v1
    Checksum:i38AD088E2439C7FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97759 mRNA. Translation: AAA51598.1.
    X68487 mRNA. Translation: CAA48505.1.
    AY136748 mRNA. Translation: AAN01274.1.
    BC025722 mRNA. Translation: AAH25722.1.
    CCDSiCCDS11173.1.
    PIRiJC1229.
    RefSeqiNP_000667.1. NM_000676.2.
    UniGeneiHs.167046.

    Genome annotation databases

    EnsembliENST00000304222; ENSP00000304501; ENSG00000170425.
    GeneIDi136.
    KEGGihsa:136.
    UCSCiuc002gpd.1. human.

    Polymorphism databases

    DMDMi112938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97759 mRNA. Translation: AAA51598.1 .
    X68487 mRNA. Translation: CAA48505.1 .
    AY136748 mRNA. Translation: AAN01274.1 .
    BC025722 mRNA. Translation: AAH25722.1 .
    CCDSi CCDS11173.1.
    PIRi JC1229.
    RefSeqi NP_000667.1. NM_000676.2.
    UniGenei Hs.167046.

    3D structure databases

    ProteinModelPortali P29275.
    SMRi P29275. Positions 8-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106648. 4 interactions.
    IntActi P29275. 2 interactions.
    STRINGi 9606.ENSP00000304501.

    Chemistry

    BindingDBi P29275.
    ChEMBLi CHEMBL2096679.
    DrugBanki DB04932. Defibrotide.
    DB00824. Enprofylline.
    DB00061. Pegademase bovine.
    DB00277. Theophylline.
    GuidetoPHARMACOLOGYi 20.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P29275.

    Polymorphism databases

    DMDMi 112938.

    Proteomic databases

    PaxDbi P29275.
    PRIDEi P29275.

    Protocols and materials databases

    DNASUi 136.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304222 ; ENSP00000304501 ; ENSG00000170425 .
    GeneIDi 136.
    KEGGi hsa:136.
    UCSCi uc002gpd.1. human.

    Organism-specific databases

    CTDi 136.
    GeneCardsi GC17P015788.
    HGNCi HGNC:264. ADORA2B.
    MIMi 600446. gene.
    neXtProti NX_P29275.
    PharmGKBi PA24585.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287824.
    HOGENOMi HOG000015770.
    HOVERGENi HBG106962.
    InParanoidi P29275.
    KOi K04267.
    OMAi GWNSKDS.
    OrthoDBi EOG79SDXQ.
    PhylomeDBi P29275.
    TreeFami TF325296.

    Enzyme and pathway databases

    Reactomei REACT_18288. Adenosine P1 receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    ChiTaRSi ADORA2B. human.
    GeneWikii Adenosine_A2B_receptor.
    GenomeRNAii 136.
    NextBioi 547.
    PROi P29275.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29275.
    Bgeei P29275.
    CleanExi HS_ADORA2B.
    Genevestigatori P29275.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001435. Adeno_A2B_rcpt.
    IPR001634. Adenosn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00554. ADENOSINA2BR.
    PR00424. ADENOSINER.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of an adenosine A2b receptor from human brain."
      Pierce K.D., Furlong T.J., Selbie L.A., Shine J.
      Biochem. Biophys. Res. Commun. 187:86-93(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene."
      Jacobson M.A., Johnson R.G., Luneau C.J., Salvatore C.A.
      Genomics 27:374-376(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiAA2BR_HUMAN
    AccessioniPrimary (citable) accession number: P29275
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3