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Protein

Adenosine receptor A2b

Gene

ADORA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-417973. Adenosine P1 receptors.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:ADORA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000170425.3.
HGNCiHGNC:264. ADORA2B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularBy similarity8
Transmembranei9 – 33Helical; Name=1By similarityAdd BLAST25
Topological domaini34 – 43CytoplasmicBy similarity10
Transmembranei44 – 67Helical; Name=2By similarityAdd BLAST24
Topological domaini68 – 78ExtracellularBy similarityAdd BLAST11
Transmembranei79 – 101Helical; Name=3By similarityAdd BLAST23
Topological domaini102 – 121CytoplasmicBy similarityAdd BLAST20
Transmembranei122 – 144Helical; Name=4By similarityAdd BLAST23
Topological domaini145 – 178ExtracellularBy similarityAdd BLAST34
Transmembranei179 – 203Helical; Name=5By similarityAdd BLAST25
Topological domaini204 – 235CytoplasmicBy similarityAdd BLAST32
Transmembranei236 – 259Helical; Name=6By similarityAdd BLAST24
Topological domaini260 – 267ExtracellularBy similarity8
Transmembranei268 – 291Helical; Name=7By similarityAdd BLAST24
Topological domaini292 – 332CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi136.
OpenTargetsiENSG00000170425.
PharmGKBiPA24585.

Chemistry databases

ChEMBLiCHEMBL255.
DrugBankiDB00640. Adenosine.
DB04932. Defibrotide.
DB00824. Enprofylline.
DB00277. Theophylline.
GuidetoPHARMACOLOGYi20.

Polymorphism and mutation databases

BioMutaiADORA2B.
DMDMi112938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690031 – 332Adenosine receptor A2bAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi311S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP29275.
PeptideAtlasiP29275.
PRIDEiP29275.

PTM databases

iPTMnetiP29275.
PhosphoSitePlusiP29275.

Expressioni

Gene expression databases

BgeeiENSG00000170425.
CleanExiHS_ADORA2B.
GenevisibleiP29275. HS.

Organism-specific databases

HPAiHPA073747.

Interactioni

Protein-protein interaction databases

BioGridi106648. 4 interactors.
IntActiP29275. 2 interactors.
STRINGi9606.ENSP00000304501.

Chemistry databases

BindingDBiP29275.

Structurei

3D structure databases

ProteinModelPortaliP29275.
SMRiP29275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 182Agonist bindingBy similarity10
Regioni247 – 254Agonist bindingBy similarity8
Regioni266 – 276Agonist bindingBy similarityAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP29275.
KOiK04267.
OMAiFENVVPM.
OrthoDBiEOG091G0I3U.
PhylomeDBiP29275.
TreeFamiTF325296.

Family and domain databases

InterProiView protein in InterPro
IPR001435. Adeno_A2B_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00554. ADENOSINA2BR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P29275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA
60 70 80 90 100
AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA
160 170 180 190 200
TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV
210 220 230 240 250
IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT
310 320 330
FHKIISRYLL CQADVKSGNG QAGVQPALGV GL
Length:332
Mass (Da):36,333
Last modified:December 1, 1992 - v1
Checksum:i38AD088E2439C7FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97759 mRNA. Translation: AAA51598.1.
X68487 mRNA. Translation: CAA48505.1.
AY136748 mRNA. Translation: AAN01274.1.
BC025722 mRNA. Translation: AAH25722.1.
CCDSiCCDS11173.1.
PIRiJC1229.
RefSeqiNP_000667.1. NM_000676.2.
UniGeneiHs.167046.

Genome annotation databases

EnsembliENST00000304222; ENSP00000304501; ENSG00000170425.
GeneIDi136.
KEGGihsa:136.
UCSCiuc002gpd.2. human.

Similar proteinsi

Entry informationi

Entry nameiAA2BR_HUMAN
AccessioniPrimary (citable) accession number: P29275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 27, 2017
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families