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P29274

- AA2AR_HUMAN

UniProt

P29274 - AA2AR_HUMAN

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Protein

Adenosine receptor A2a

Gene

ADORA2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. G-protein coupled adenosine receptor activity Source: UniProtKB
  3. identical protein binding Source: IntAct

GO - Biological processi

  1. activation of adenylate cyclase activity Source: Reactome
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  3. apoptotic process Source: ProtInc
  4. blood circulation Source: ProtInc
  5. blood coagulation Source: ProtInc
  6. cAMP biosynthetic process Source: ProtInc
  7. cell-cell signaling Source: ProtInc
  8. cellular defense response Source: ProtInc
  9. central nervous system development Source: ProtInc
  10. inflammatory response Source: ProtInc
  11. neurotrophin TRK receptor signaling pathway Source: Reactome
  12. phagocytosis Source: ProtInc
  13. positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway Source: UniProtKB
  14. sensory perception Source: ProtInc
  15. transmembrane receptor protein tyrosine kinase signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_11046. NGF-independant TRKA activation.
REACT_18288. Adenosine P1 receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:ADORA2A
Synonyms:ADORA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:263. ADORA2A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane Source: ProtInc
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti363549. Acute encephalopathy with biphasic seizures and late reduced diffusion.
PharmGKBiPA24584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Adenosine receptor A2aPRO_0000068999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 1591 PublicationPROSITE-ProRule annotation
Disulfide bondi74 ↔ 1461 PublicationPROSITE-ProRule annotation
Disulfide bondi77 ↔ 1661 PublicationPROSITE-ProRule annotation
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi259 ↔ 2621 PublicationPROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP29274.
PRIDEiP29274.

PTM databases

PhosphoSiteiP29274.

Expressioni

Gene expression databases

BgeeiP29274.
CleanExiHS_ADORA2A.
ExpressionAtlasiP29274. baseline.
GenevestigatoriP29274.

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-2902702,EBI-2902702
ADORA1P305424EBI-2902702,EBI-2903663
CALM3P621583EBI-2902702,EBI-397435
CYTH2Q994186EBI-2902702,EBI-448974
DRD2P144162EBI-2902702,EBI-2928178
Grm5P31424-13EBI-2902702,EBI-2902778From a different organism.
NECAB2Q7Z6G35EBI-2902702,EBI-950070
USP4Q131074EBI-2902702,EBI-723290

Protein-protein interaction databases

BioGridi106647. 8 interactions.
IntActiP29274. 9 interactions.
MINTiMINT-4823612.
STRINGi9606.ENSP00000336630.

Structurei

Secondary structure

1
412
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 3332
Helixi35 – 373
Helixi40 – 5718
Helixi59 – 679
Beta strandi71 – 733
Helixi74 – 10734
Helixi109 – 1157
Helixi118 – 13619
Helixi138 – 1414
Helixi145 – 1473
Helixi151 – 1566
Beta strandi163 – 1653
Helixi168 – 1714
Helixi174 – 1796
Helixi180 – 1867
Helixi187 – 20822
Beta strandi213 – 2164
Helixi219 – 25840
Beta strandi260 – 2623
Helixi267 – 29125
Helixi293 – 30513
Turni308 – 3103
Helixi312 – 3176

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MMHmodel-16-36[»]
242-69[»]
378-102[»]
4117-143[»]
5175-203[»]
6233-260[»]
7264-296[»]
1UPEmodel-A1-304[»]
2YDOX-ray3.00A1-317[»]
2YDVX-ray2.60A1-317[»]
3EMLX-ray2.60A2-208[»]
A222-316[»]
3PWHX-ray3.30A1-317[»]
3QAKX-ray2.71A2-208[»]
A222-316[»]
3REYX-ray3.31A1-317[»]
3RFMX-ray3.60A1-317[»]
3UZAX-ray3.27A1-317[»]
3UZCX-ray3.34A1-317[»]
3VG9X-ray2.70A1-316[»]
3VGAX-ray3.10A1-316[»]
4EIYX-ray1.80A2-208[»]
A219-316[»]
ProteinModelPortaliP29274.
SMRiP29274. Positions 2-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29274.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Extracellular1 Publication
Topological domaini33 – 4210Cytoplasmic1 Publication
Topological domaini67 – 7711Extracellular1 PublicationAdd
BLAST
Topological domaini101 – 12020Cytoplasmic1 PublicationAdd
BLAST
Topological domaini144 – 17330Extracellular1 PublicationAdd
BLAST
Topological domaini199 – 23436Cytoplasmic1 PublicationAdd
BLAST
Topological domaini259 – 2668Extracellular1 Publication
Topological domaini291 – 412122Cytoplasmic1 PublicationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 3225Helical; Name=1Add
BLAST
Transmembranei43 – 6624Helical; Name=2Add
BLAST
Transmembranei78 – 10023Helical; Name=3Add
BLAST
Transmembranei121 – 14323Helical; Name=4Add
BLAST
Transmembranei174 – 19825Helical; Name=5Add
BLAST
Transmembranei235 – 25824Helical; Name=6Add
BLAST
Transmembranei267 – 29024Helical; Name=7Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 17710Agonist binding
Regioni246 – 2538Agonist binding
Regioni264 – 27411Agonist bindingAdd
BLAST

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287824.
HOGENOMiHOG000015770.
HOVERGENiHBG106962.
InParanoidiP29274.
KOiK04266.
OMAiPGVWANG.
TreeFamiTF325296.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29274-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA
60 70 80 90 100
ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI
110 120 130 140 150
DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK
160 170 180 190 200
EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI
210 220 230 240 250
FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH
260 270 280 290 300
IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR
310 320 330 340 350
KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS
360 370 380 390 400
APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL
410
DDPLAQDGAG VS
Length:412
Mass (Da):44,707
Last modified:June 1, 1994 - v2
Checksum:i9438E9D64A6BE61B
GO

Sequence cautioni

The sequence AAA58356.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501A → V.1 Publication
Corresponds to variant rs4530 [ dbSNP | Ensembl ].
VAR_011835
Natural varianti300 – 3001R → H.
Corresponds to variant rs4990 [ dbSNP | Ensembl ].
VAR_011836
Natural varianti392 – 3921G → R.
VAR_003451

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97370 mRNA. Translation: AAA58356.1. Different initiation.
X68486 mRNA. Translation: CAA48504.1.
S46950 mRNA. Translation: AAB23956.1.
U40771, U40770 Genomic DNA. Translation: AAA83270.1.
AY136747 mRNA. Translation: AAN01273.1.
CR456367 mRNA. Translation: CAG30253.1.
BT006999 mRNA. Translation: AAP35645.1.
AK312946 mRNA. Translation: BAG35787.1.
CH471095 Genomic DNA. Translation: EAW59658.1.
BC013780 mRNA. Translation: AAH13780.1.
CCDSiCCDS13826.1.
PIRiA48978.
RefSeqiNP_000666.2. NM_000675.5.
NP_001265426.1. NM_001278497.1.
NP_001265427.1. NM_001278498.1.
NP_001265428.1. NM_001278499.1.
NP_001265429.1. NM_001278500.1.
UniGeneiHs.197029.

Genome annotation databases

EnsembliENST00000337539; ENSP00000336630; ENSG00000128271.
ENST00000610595; ENSP00000480012; ENSG00000128271.
ENST00000611543; ENSP00000483102; ENSG00000128271.
ENST00000618076; ENSP00000481552; ENSG00000128271.
GeneIDi135.
KEGGihsa:135.
UCSCiuc002zzx.3. human.

Polymorphism databases

DMDMi543740.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97370 mRNA. Translation: AAA58356.1 . Different initiation.
X68486 mRNA. Translation: CAA48504.1 .
S46950 mRNA. Translation: AAB23956.1 .
U40771 , U40770 Genomic DNA. Translation: AAA83270.1 .
AY136747 mRNA. Translation: AAN01273.1 .
CR456367 mRNA. Translation: CAG30253.1 .
BT006999 mRNA. Translation: AAP35645.1 .
AK312946 mRNA. Translation: BAG35787.1 .
CH471095 Genomic DNA. Translation: EAW59658.1 .
BC013780 mRNA. Translation: AAH13780.1 .
CCDSi CCDS13826.1.
PIRi A48978.
RefSeqi NP_000666.2. NM_000675.5.
NP_001265426.1. NM_001278497.1.
NP_001265427.1. NM_001278498.1.
NP_001265428.1. NM_001278499.1.
NP_001265429.1. NM_001278500.1.
UniGenei Hs.197029.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MMH model - 1 6-36 [» ]
2 42-69 [» ]
3 78-102 [» ]
4 117-143 [» ]
5 175-203 [» ]
6 233-260 [» ]
7 264-296 [» ]
1UPE model - A 1-304 [» ]
2YDO X-ray 3.00 A 1-317 [» ]
2YDV X-ray 2.60 A 1-317 [» ]
3EML X-ray 2.60 A 2-208 [» ]
A 222-316 [» ]
3PWH X-ray 3.30 A 1-317 [» ]
3QAK X-ray 2.71 A 2-208 [» ]
A 222-316 [» ]
3REY X-ray 3.31 A 1-317 [» ]
3RFM X-ray 3.60 A 1-317 [» ]
3UZA X-ray 3.27 A 1-317 [» ]
3UZC X-ray 3.34 A 1-317 [» ]
3VG9 X-ray 2.70 A 1-316 [» ]
3VGA X-ray 3.10 A 1-316 [» ]
4EIY X-ray 1.80 A 2-208 [» ]
A 219-316 [» ]
ProteinModelPortali P29274.
SMRi P29274. Positions 2-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106647. 8 interactions.
IntActi P29274. 9 interactions.
MINTi MINT-4823612.
STRINGi 9606.ENSP00000336630.

Chemistry

BindingDBi P29274.
ChEMBLi CHEMBL2094257.
DrugBanki DB00640. Adenosine.
DB00201. Caffeine.
DB04932. Defibrotide.
DB00651. Dyphylline.
DB00824. Enprofylline.
DB00358. Mefloquine.
DB01303. Oxtriphylline.
DB00806. Pentoxifylline.
DB06213. Regadenoson.
DB01412. Theobromine.
DB00277. Theophylline.
GuidetoPHARMACOLOGYi 19.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P29274.

Polymorphism databases

DMDMi 543740.

Proteomic databases

PaxDbi P29274.
PRIDEi P29274.

Protocols and materials databases

DNASUi 135.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337539 ; ENSP00000336630 ; ENSG00000128271 .
ENST00000610595 ; ENSP00000480012 ; ENSG00000128271 .
ENST00000611543 ; ENSP00000483102 ; ENSG00000128271 .
ENST00000618076 ; ENSP00000481552 ; ENSG00000128271 .
GeneIDi 135.
KEGGi hsa:135.
UCSCi uc002zzx.3. human.

Organism-specific databases

CTDi 135.
GeneCardsi GC22P024813.
HGNCi HGNC:263. ADORA2A.
MIMi 102776. gene.
neXtProti NX_P29274.
Orphaneti 363549. Acute encephalopathy with biphasic seizures and late reduced diffusion.
PharmGKBi PA24584.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287824.
HOGENOMi HOG000015770.
HOVERGENi HBG106962.
InParanoidi P29274.
KOi K04266.
OMAi PGVWANG.
TreeFami TF325296.

Enzyme and pathway databases

Reactomei REACT_11046. NGF-independant TRKA activation.
REACT_18288. Adenosine P1 receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

EvolutionaryTracei P29274.
GeneWikii Adenosine_A2A_receptor.
GenomeRNAii 135.
NextBioi 543.
PROi P29274.
SOURCEi Search...

Gene expression databases

Bgeei P29274.
CleanExi HS_ADORA2A.
ExpressionAtlasi P29274. baseline.
Genevestigatori P29274.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001513. Adeno_A2A_rcpt.
IPR001634. Adenosn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00553. ADENOSINA2AR.
PR00424. ADENOSINER.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tiffany H.L., Murphy P.M.
    Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Salvatore C.A., Luneau C.J., Johnson R.G., Jacobson M.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Molecular characterization of a human brain adenosine A2 receptor."
    Furlong T.J., Pierce K.D., Selbie L.A., Shine J.
    Brain Res. Mol. Brain Res. 15:62-66(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  4. "Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A."
    Le F., Townsend-Nicholson A., Baker E., Sutherland G.R., Schofield P.R.
    Biochem. Biophys. Res. Commun. 223:461-467(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  11. "The dopamine D(4) receptor, the ultimate disordered protein."
    Woods A.S.
    J. Recept. Signal Transduct. 30:331-336(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INTERACTION WITH DRD4.
  12. "Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor."
    Kim J., Wess J., van Rhee A.M., Schoneberg T., Jacobson K.A.
    J. Biol. Chem. 270:13987-13997(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF TRANSMEMBRANE DOMAINS.
  13. "The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor."
    Milojevic T., Reiterer V., Stefan E., Korkhov V.M., Dorostkar M.M., Ducza E., Ogris E., Boehm S., Freissmuth M., Nanoff C.
    Mol. Pharmacol. 69:1083-1094(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH USP4, UBIQUITINATION, DEUBIQUITINATION BY USP4.
  14. "The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist."
    Jaakola V.-P., Griffith M.T., Hanson M.A., Cherezov V., Chien E.Y.T., Lane J.R., Ijzerman A.P., Stevens R.C.
    Science 322:1211-1217(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-316 IN COMPLEX WITH ANTAGONIST, TOPOLOGY, DISULFIDE BONDS.
  15. Cited for: VARIANT VAL-50.

Entry informationi

Entry nameiAA2AR_HUMAN
AccessioniPrimary (citable) accession number: P29274
Secondary accession number(s): B2R7E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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