P29236 (LUXC2_PHOLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA reductase
EC=1.2.1.50

Gene names

Name:

luxC

Organism

Photobacterium leiognathi

Taxonomic identifier

553611 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Catalytic activity	A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.
Pathway	Lipid metabolism; fatty acid reduction for biolumincescence.
Sequence similarities	Belongs to the luxC family.

Ontologies

Keywords
Biological process	Luminescence
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro long-chain-fatty-acyl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Acyl-CoA reductase		PRO_0000220197

Sequences

	Sequence		Length	Mass (Da)
	P29236 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 4716EF699BF7FE4A	FASTA	478	53,713
	10 20 30 40 50 60 MIKKIPMIIG GVVQNTSGYG MRELTLNNNK VNIPIITQSD VEAIQSLNIE NKLTINQIVN 70 80 90 100 110 120 FLYTVGQKWK SETYSRRLTY IRDLIKFLGY SQEMAKLEAN WISMILCSKS ALYDIVENDL 130 140 150 160 170 180 SSRHIIDEWI PQGECYVKAL PKGKSVHLLA GNVPLSGVTS ILRAILTKNE CIIKTSSADP 190 200 210 220 230 240 FTATALVNSF IDVDAEHPIT RSISVMYWSH SEDLAIPKQI MSCADVVIAW GGDDAIKWAT 250 260 270 280 290 300 EHAPSHADIL KFGPKKSISI VDNPTDIKAA AIGVAHDICF YDQQACFSTQ DIYYIGDSID 310 320 330 340 350 360 IFFDELAQQL NKYKDILPKG ERNFDEKAAF SLTERECLFA KYKVQKGESQ SWLLTQSPAG 370 380 390 400 410 420 SFGNQPLSRS AYIHQVNDIS EVIPFVHKAV TQTVAIAPWE SSFKYRDILA EHGAERIIEA 430 440 450 460 470 GMNNIFRVGG AHDGMRPLQR LVNYISHERP STYTTKDVSV KIEQTRYLEE DKFLVFVP

References

[1]

"The lux genes of the luminous bacterial symbiont, Photobacterium leiognathi, of the ponyfish. Nucleotide sequence, difference in gene organization, and high expression in mutant Escherichia coli." Lee C.Y., Szittner R.B., Meighen E.A. Eur. J. Biochem. 201:161-167(1991) [PubMed: 1915359] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25521 / L1 / CIP 665.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M63594 Genomic DNA. Translation: AAA25616.1.
PIR	S17836.
3D structure databases
ProteinModelPortal	P29236.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008670. Acyl-CoA_reduct_LuxC. IPR016161. Ald_DH/histidinol_DH. IPR016162. Ald_DH_N. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF05893. LuxC. 1 hit. [Graphical view]
PIRSF	PIRSF009414. LuxC. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LUXC2_PHOLE

Accession

Primary (citable) accession number: P29236

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	July 27, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program