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Protein

39kDa core protein

Gene

VACWR123

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the virion core.

Names & Taxonomyi

Protein namesi
Recommended name:
39kDa core protein
Short name:
p39
Alternative name(s):
Protein A4
Gene namesi
Ordered Locus Names:VACWR123
ORF Names:A4L
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000992191 – 28139kDa core proteinAdd BLAST281

Post-translational modificationi

Its phosphorylation state is regulated by the F10 kinase and the H1 phosphatase.Curated

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.1 Publication

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with P4A/A10 and its cleaved form 4A.1 Publication

Protein-protein interaction databases

DIPiDIP-2173N.
IntActiP29191. 1 interactor.
MINTiMINT-131232.

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae A4 family.Curated

Phylogenomic databases

OrthoDBiVOG090000R9.

Family and domain databases

InterProiView protein in InterPro
IPR010396. Orthopox_A5.
PfamiView protein in Pfam
PF06193. Orthopox_A5L. 1 hit.

Sequencei

Sequence statusi: Complete.

P29191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFFNKFSQG LAESSTPKSS IYYSEEKDPD TKKDEAIEIG LKSQESYYQR
60 70 80 90 100
QLREQLARDN MTVASRQPIQ PLQPTIHITP QPVPTATPAP ILLPSSTVPT
110 120 130 140 150
PKPRQQTNTS SDMSNLFDWL SEDTDAPASS LLPALTPSNA VQDIISKFNK
160 170 180 190 200
DQKTTTPPST QPSQTLPTTT CTQQSDGNIS CTTPTVTPPQ PPIVATVCTP
210 220 230 240 250
TPTGGTVCTT AQQNPNPGAA SQQNLDDMAL KDLMSNVERD MHQLQAETND
260 270 280
LVTNVYDARE YTRRAIDQIL QLVKGFERFQ K
Length:281
Mass (Da):30,927
Last modified:December 1, 1992 - v1
Checksum:i124AE6E52CB70BAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76473 Genomic DNA. No translation available.
AY243312 Genomic DNA. Translation: AAO89402.1.
PIRiA41806. QQVZA5.
RefSeqiYP_233005.1. NC_006998.1.

Genome annotation databases

GeneIDi3707521.
KEGGivg:3707521.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA4_VACCW
AccessioniPrimary (citable) accession number: P29191
Secondary accession number(s): Q76ZQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 15, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families