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Protein

Chaperonin CPN60-1, mitochondrial

Gene

CPN60I

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

GO - Molecular functioni

  • ATPase binding Source: AgBase
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • protein folding Source: AgBase
  • protein refolding Source: InterPro

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin CPN60-1, mitochondrial
Alternative name(s):
HSP60-1
Gene namesi
Name:CPN60I
Synonyms:CPNA
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 5

Organism-specific databases

MaizeGDBi65669.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000000501435 – 577Chaperonin CPN60-1, mitochondrialAdd BLAST543

Proteomic databases

PRIDEiP29185.

Expressioni

Inductioni

By heat shock.

Gene expression databases

ExpressionAtlasiP29185. baseline and differential.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliP29185.
SMRiP29185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRAAASLAS KARQAGNSLA TRQVGSRLAW SRNYAAKDIK FGVEARALML
60 70 80 90 100
RGVEELADAV KVTMGPKGRN VVIEQSFGAP KVTKDGVTVA KSIEFKDRVK
110 120 130 140 150
NVGASLVKQV ANATNDTAGD GTTCATVLTK AIFTEGCKSV AAGMNAMDLR
160 170 180 190 200
RGISMAVDAV VTNLKGMARM ISTSEEIAQV GTISANGERE IGELIAKAME
210 220 230 240 250
KVGKEGVITI ADGNTLYNEL EVVEGMKLDR GYISPYFITN SKTQKCELED
260 270 280 290 300
PLILIHDKKV TNMHAVVKVL EMALKKQKPL LIVAEDVESE ALGTLIINKL
310 320 330 340 350
RAGIKVCAVK APGFGENRKA NLQDLAILTG GEVITEELGM NLENFEPHML
360 370 380 390 400
GTCKKVTVSK DDTVILDGAG DKKSIEERAE QIRSAIENST SDYDKEKLQE
410 420 430 440 450
RLAKLSGGVA VLKIGGASEA EVGEKKDRVT DALNATKAAV EEGIVPGGGV
460 470 480 490 500
ALLYASKELD KLQTANFDQK IGVQIIQNAL KTPVHTIASN AGVEGAVVVG
510 520 530 540 550
KLLEQENTDL GYDAAKGEYV DMVKTGIIDP LKVIRTALVD AASVSSLMTT
560 570
TESIIVEIPK EEAPAPAMGG GMGGMDY
Length:577
Mass (Da):61,211
Last modified:November 1, 1997 - v2
Checksum:i31D3BFFD46701C0B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21T → A in CAA78100 (Ref. 3) Curated1
Sequence conflicti108 – 109KQ → NR in CAA77645 (PubMed:1349837).Curated2
Sequence conflicti125A → D in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti148D → N in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti241S → P in CAA78100 (Ref. 3) Curated1
Sequence conflicti328L → F in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti382I → L in CAA77645 (PubMed:1349837).Curated1
Sequence conflicti403A → P in AAA33450 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11546 mRNA. Translation: CAA77645.1.
L21007 Genomic DNA. Translation: AAA33450.1.
Z12114 mRNA. Translation: CAA78100.1.
PIRiS20875.
S26582.
RefSeqiNP_001105716.1. NM_001112246.1.
UniGeneiZm.2489.

Genome annotation databases

EnsemblPlantsiZm00001d014090_T001; Zm00001d014090_P001; Zm00001d014090.
Zm00001d014090_T002; Zm00001d014090_P002; Zm00001d014090.
GeneIDi542736.
GrameneiZm00001d014090_T001; Zm00001d014090_P001; Zm00001d014090.
Zm00001d014090_T002; Zm00001d014090_P002; Zm00001d014090.
KEGGizma:542736.

Similar proteinsi

Entry informationi

Entry nameiCH61_MAIZE
AccessioniPrimary (citable) accession number: P29185
Secondary accession number(s): Q43251, Q43252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: January 31, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families