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P29183

- LIPP_HORSE

UniProt

P29183 - LIPP_HORSE

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Protein
Pancreatic triacylglycerol lipase
Gene
PNLIP
Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651Nucleophile
Active sitei189 – 1891Charge relay system
Metal bindingi200 – 2001Calcium; via carbonyl oxygen
Metal bindingi203 – 2031Calcium; via carbonyl oxygen
Metal bindingi205 – 2051Calcium
Metal bindingi208 – 2081Calcium
Active sitei276 – 2761Charge relay system

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. triglyceride lipase activity Source: UniProtKB-EC

GO - Biological processi

  1. intestinal cholesterol absorption Source: Ensembl
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic triacylglycerol lipase (EC:3.1.1.3)
Short name:
PL
Short name:
PTL
Short name:
Pancreatic lipase
Gene namesi
Name:PNLIP
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi165 – 1651S → X: 80% loss of P-nitrophenyl acetate hydrolysis activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 12›12
Add
BLAST
Chaini13 – 461449Pancreatic triacylglycerol lipase
PRO_0000017784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi16 ↔ 22
Disulfide bondi103 ↔ 114
Disulfide bondi250 ↔ 274
Disulfide bondi298 ↔ 309
Disulfide bondi312 ↔ 317
Disulfide bondi445 ↔ 461

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By colipase/CLPS in the presence of bile salts.

Interactioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000007877.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi14 – 174
Turni18 – 203
Beta strandi21 – 244
Beta strandi29 – 324
Helixi44 – 474
Beta strandi50 – 556
Beta strandi58 – 658
Helixi69 – 746
Beta strandi81 – 877
Helixi98 – 10912
Beta strandi112 – 1187
Helixi120 – 1234
Helixi127 – 15226
Helixi156 – 1583
Beta strandi159 – 1646
Helixi167 – 17711
Turni178 – 1803
Beta strandi182 – 1898
Turni193 – 1975
Turni200 – 2023
Helixi206 – 2083
Beta strandi209 – 2157
Helixi222 – 2254
Beta strandi235 – 2417
Helixi261 – 2655
Helixi274 – 28815
Helixi301 – 3055
Beta strandi319 – 3213
Helixi324 – 3263
Turni328 – 3314
Beta strandi332 – 3409
Beta strandi344 – 3474
Beta strandi351 – 36111
Beta strandi364 – 37411
Beta strandi382 – 3898
Beta strandi394 – 40310
Beta strandi407 – 41711
Beta strandi427 – 4359
Beta strandi441 – 4455
Beta strandi456 – 4616

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HPLX-ray2.30A/B13-461[»]
ProteinModelPortaliP29183.
SMRiP29183. Positions 13-461.

Miscellaneous databases

EvolutionaryTraceiP29183.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini351 – 461111PLAT
Add
BLAST

Sequence similaritiesi

Contains 1 PLAT domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40923.
HOGENOMiHOG000038552.
HOVERGENiHBG003243.
InParanoidiP29183.
KOiK14073.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSiPR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29183-1 [UniParc]FASTAAdd to Basket

« Hide

WTLSLLLGAV VGNEVCYERL GCFSDDSPWA GIVERPLKIL PWSPEKVNTR    50
FLLYTNENPD NFQEIVADPS TIQSSNFNTG RKTRFIIHGF IDKGEESWLS 100
TMCQNMFKVE SVNCICVDWK SGSRTAYSQA SQNVRIVGAE VAYLVGVLQS 150
SFDYSPSNVH IIGHSLGSHA AGEAGRRTNG AVGRITGLDP AEPCFQGTPE 200
LVRLDPSDAQ FVDVIHTDIA PFIPNLGFGM SQTAGHLDFF PNGGKEMPGC 250
QKNVLSQIVD IDGIWQGTRD FAACNHLRSY KYYTDSILNP DGFAGFSCAS 300
YSDFTANKCF PCSSEGCPQM GHYADRFPGR TKGVGQLFYL NTGDASNFAR 350
WRYRVDVTLS GKKVTGHVLV SLFGNKGNSR QYEIFQGTLK PDNTYSNEFD 400
SDVEVGDLEK VKFIWYNNVI NLTLPKVGAS KITVERNDGS VFNFCSEETV 450
REDVLLTLTA C 461
Length:461
Mass (Da):50,921
Last modified:April 1, 1993 - v2
Checksum:i382F33F3CE446738
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66218 mRNA. Translation: CAA46961.1.
PIRiS21223.
RefSeqiNP_001157421.1. NM_001163949.1.
UniGeneiEca.12462.

Genome annotation databases

GeneIDi100034202.
KEGGiecb:100034202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66218 mRNA. Translation: CAA46961.1 .
PIRi S21223.
RefSeqi NP_001157421.1. NM_001163949.1.
UniGenei Eca.12462.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HPL X-ray 2.30 A/B 13-461 [» ]
ProteinModelPortali P29183.
SMRi P29183. Positions 13-461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000007877.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100034202.
KEGGi ecb:100034202.

Organism-specific databases

CTDi 5406.

Phylogenomic databases

eggNOGi NOG40923.
HOGENOMi HOG000038552.
HOVERGENi HBG003243.
InParanoidi P29183.
KOi K14073.

Miscellaneous databases

EvolutionaryTracei P29183.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000734. Lipase.
IPR008976. Lipase_LipOase.
IPR013818. Lipase_N.
IPR002331. Lipase_panc.
IPR016272. Lipoprotein_lipase_LIPH.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11610. PTHR11610. 1 hit.
Pfami PF00151. Lipase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
PRINTSi PR00823. PANCLIPASE.
PR00821. TAGLIPASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF49723. SSF49723. 1 hit.
SSF53474. SSF53474. 1 hit.
PROSITEi PS00120. LIPASE_SER. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of horse pancreatic lipase as determined by protein and cDNA sequencing. Implications for p-nitrophenyl acetate hydrolysis by pancreatic lipases."
    Kerfelec B., Foglizzo E., Bonicel J., Bougis P.E., Chapus C.
    Eur. J. Biochem. 206:279-287(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Horse pancreatic lipase. The crystal structure refined at 2.3-A resolution."
    Bourne Y., Martinez C., Kerfelec B., Lombardo D., Chapus C., Cambillau C.
    J. Mol. Biol. 238:709-732(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiLIPP_HORSE
AccessioniPrimary (citable) accession number: P29183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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