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Protein

Transforming protein v-Fos/v-Fox

Gene

FOS-FOX

Organism
FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming protein v-Fos/v-Fox
Gene namesi
Name:FOS-FOX
OrganismiFBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)
Taxonomic identifieri11806 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirusunclassified Gammaretrovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764611 – 244Transforming protein v-Fos/v-FoxAdd BLAST244

Structurei

3D structure databases

ProteinModelPortaliP29176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 176bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 236Transforming protein v-FosAdd BLAST236
Regioni115 – 135Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni141 – 169Leucine-zipperPROSITE-ProRule annotationAdd BLAST29
Regioni237 – 244Transforming protein v-Fox8

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029816. c-Fos/v-Fos.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF4. PTHR23351:SF4. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DSLSYYHSPA DSFSSMGSPV NTQDFCADLS VSSANFIPTE TAISTSPDLQ
60 70 80 90 100
WLVQPTLVSS VAPSQTRAPH PYGLPTQSAG AYARAGMVKT VSGGRAQSIG
110 120 130 140 150
RRGKVEQLSP EEEVKRRIRR ERNKMAAAKC RNRRRELTDT LQAETDQLED
160 170 180 190 200
EKSALQTEIA NLLKEKEKLE FILAAHRPAC KIPDDLGFPE EMSVASLDLT
210 220 230 240
GGLLPLLNDP EPKPSLEPVK SSFDDFLFPA SSGHSGFISM AGWQ
Length:244
Mass (Da):26,622
Last modified:December 1, 1992 - v1
Checksum:i95C904B66B0EB270
GO

Sequence cautioni

The sequence AAA46573 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02712 Genomic DNA. Translation: AAA46573.1. Different initiation.
PIRiB23244. TVMVFB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02712 Genomic DNA. Translation: AAA46573.1. Different initiation.
PIRiB23244. TVMVFB.

3D structure databases

ProteinModelPortaliP29176.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029816. c-Fos/v-Fos.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF4. PTHR23351:SF4. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOSX_MSVFR
AccessioniPrimary (citable) accession number: P29176
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Fos-Fox polyprotein.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.