P29176 (FOSX_MSVFR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transforming protein v-Fos/v-Fox

Gene names

Name:

FOS-FOX

Organism

FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

Taxonomic identifier

11806 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › unclassified Gammaretrovirus › Murine osteosarcoma virus

Virus host

Mus musculus (Mouse) [TaxID: 10090]

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Host nucleus Potential.
Miscellaneous	This protein is synthesized as a Gag-Fos-Fox polyprotein.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP (basic-leucine zipper) domain.
Sequence caution	The sequence AAA46573.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Host nucleus
Disease	Oncogene
Ligand	DNA-binding
Gene Ontology (GO)
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	Transforming protein v-Fos/v-Fox		PRO_0000076461
Regions
	Domain	113 – 176	64	bZIP
	Region	1 – 236	236	Transforming protein v-Fos
	Region	115 – 135	21	Basic motif By similarity
	Region	141 – 169	29	Leucine-zipper By similarity
	Region	237 – 244	8	Transforming protein v-Fox

Sequences

	Sequence		Length	Mass (Da)
	P29176 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 95C904B66B0EB270	FASTA	244	26,622
	10 20 30 40 50 60 DSLSYYHSPA DSFSSMGSPV NTQDFCADLS VSSANFIPTE TAISTSPDLQ WLVQPTLVSS 70 80 90 100 110 120 VAPSQTRAPH PYGLPTQSAG AYARAGMVKT VSGGRAQSIG RRGKVEQLSP EEEVKRRIRR 130 140 150 160 170 180 ERNKMAAAKC RNRRRELTDT LQAETDQLED EKSALQTEIA NLLKEKEKLE FILAAHRPAC 190 200 210 220 230 240 KIPDDLGFPE EMSVASLDLT GGLLPLLNDP EPKPSLEPVK SSFDDFLFPA SSGHSGFISM AGWQ

References

[1]

"FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes." van Beveren C., Enami S., Curran T., Verma I.M. Virology 135:229-243(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	K02712 Genomic DNA. Translation: AAA46573.1. Different initiation.
PIR	TVMVFB. B23244.
3D structure databases
ProteinModelPortal	P29176.
SMR	P29176. Positions 116-168.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR004827. bZIP. IPR000837. Leuzip_Fos. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FOSX_MSVFR

Accession

Primary (citable) accession number: P29176

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program