P29172 (TAU_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Microtubule-associated protein tau

Alternative name(s):
Neurofibrillary tangle protein
Paired helical filament-tau
Short name=PHF-tau

Gene names

Name:	MAPT
Synonyms:	TAU

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Subunit structure	Interacts with SQSTM1 when polyubiquitinated. Interacts with PSMC2 through SQSTM1 By similarity. Interacts with FKBP4. Binds to CSNK1D By similarity.
Subcellular location	Cytoplasm › cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton. Cell projection › axon. Note: Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue specificity	Expressed in neurons.
Induction	During neurite outgrowth.
Domain	The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
Post-translational modification	Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome By similarity. Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1: CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Phosphorylation at Ser-269 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated by PHK By similarity. O-glycosylated; contains at least 4 GlcNAc. Site-specific or stoichiometric changes in glycosylation may modulate tau function and also play a role in PHF's formation. Ref.4
Sequence similarities	Contains 4 Tau/MAP repeats.

Ontologies

Keywords
Cellular component	Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Microtubule
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Acetylation Disulfide bond Glycoprotein Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from electronic annotation. Source: Compara axon cargo transport Inferred from electronic annotation. Source: Compara axonogenesis Inferred from electronic annotation. Source: Compara microtubule cytoskeleton organization Inferred from electronic annotation. Source: Compara mitochondrion transport along microtubule Inferred from electronic annotation. Source: Compara negative regulation of intracellular transport Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara positive regulation of axon extension Inferred from electronic annotation. Source: Compara positive regulation of microtubule polymerization Inferred from electronic annotation. Source: Compara regulation of autophagy Inferred from electronic annotation. Source: Compara regulation of microtubule-based movement Inferred from electronic annotation. Source: Compara
Cellular_component	axon Inferred from electronic annotation. Source: UniProtKB-SubCell cilium axoneme Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone Inferred from electronic annotation. Source: Compara microtubule Inferred from electronic annotation. Source: UniProtKB-KW nuclear periphery Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell tubulin complex Inferred from electronic annotation. Source: Compara
Molecular_function	lipoprotein particle binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 20 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 6 of the 14 exons. One of these optional exons contains the additional tau/MAP repeat. Tau-A cDNA has been constructed from two overlapping cDNAs by PubMed:2498649: Tau-G and Tau-H sequences begin with exon 6 or a part of it (exon 6 is missing in isoforms that begin with exon 1). 3 different C-termini are obtained either by the retention or the splicing of intron 13/14 (2 different 5' splice donors).

Isoform Tau-A (identifier: P29172-1)

Also known as: PBT43I12;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Tau-B (identifier: P29172-2)

Also known as: PBT43-12;

The sequence of this isoform differs from the canonical sequence as follows:
     175-192: Missing.

Isoform Tau-C (identifier: P29172-3)

The sequence of this isoform differs from the canonical sequence as follows:
     175-192: Missing.
     282-312: Missing.

Isoform Tau-D (identifier: P29172-4)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.

Isoform Tau-E (identifier: P29172-5)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     175-192: Missing.

Isoform Tau-F (identifier: P29172-6)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     175-192: Missing.
     282-312: Missing.

Isoform Tau-G (identifier: P29172-7)

Also known as: PBT4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: MAEPRQEFDV...DGTGPDDKKT → MPLNHYLPYL...NSGAKEMKVK
     175-192: Missing.

Isoform Tau-H (identifier: P29172-8)

Also known as: PBT7;

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: MAEPRQEFDV...DGTGPDDKKT → MKVK
     175-192: Missing.

Isoform Tau-I (identifier: P29172-9)

The sequence of this isoform differs from the canonical sequence as follows:
     439-448: VSASLAKQGL → PCVCPHHACVSAVRSLVTACPLTTSCCPEFPASPPTPSR

Isoform Tau-J (identifier: P29172-10)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     175-192: Missing.
     439-448: VSASLAKQGL → PCVCPHHACVSAVRSLVTACPLTTSCCPEFPASPPTPSR

Isoform Tau-K (identifier: P29172-11)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     175-192: Missing.
     282-312: Missing.
     439-448: VSASLAKQGL → PCVCPHHACVSAVRSLVTACPLTTSCCPEFPASPPTPSR

Isoform Tau-L (identifier: P29172-12)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     92-113: Missing.
     439-448: VSASLAKQGL → PCVCPHHACVSAVRSLVTACPLTTSCCPEFPASPPTPSR

Isoform Tau-M (identifier: P29172-13)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     92-113: Missing.
     175-192: Missing.
     439-448: VSASLAKQGL → PCVCPHHACVSAVRSLVTACPLTTSCCPEFPASPPTPSR

Isoform Tau-N (identifier: P29172-14)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     92-113: Missing.
     175-192: Missing.
     282-312: Missing.
     439-448: VSASLAKQGL → PCVCPHHACVSAVRSLVTACPLTTSCCPEFPASPPTPSR

Isoform Tau-O (identifier: P29172-15)

The sequence of this isoform differs from the canonical sequence as follows:
     447-448: GL → ALRLPPPRLCVCRAEPGHCLSPHYVMLSRVPRLATHPFSVMDIVPMGRHLLYTKGEVKEGEVQTPGPPSL

Isoform Tau-P (identifier: P29172-16)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     175-192: Missing.
     447-448: GL → ALRLPPPRLCVCRAEPGHCLSPHYVMLSRVPRLATHPFSVMDIVPMGRHLLYTKGEVKEGEVQTPGPPSL

Isoform Tau-Q (identifier: P29172-17)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     175-192: Missing.
     282-312: Missing.
     447-448: GL → ALRLPPPRLCVCRAEPGHCLSPHYVMLSRVPRLATHPFSVMDIVPMGRHLLYTKGEVKEGEVQTPGPPSL

Isoform Tau-R (identifier: P29172-18)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     92-113: Missing.
     447-448: GL → ALRLPPPRLCVCRAEPGHCLSPHYVMLSRVPRLATHPFSVMDIVPMGRHLLYTKGEVKEGEVQTPGPPSL

Isoform Tau-S (identifier: P29172-19)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     92-113: Missing.
     175-192: Missing.
     447-448: GL → ALRLPPPRLCVCRAEPGHCLSPHYVMLSRVPRLATHPFSVMDIVPMGRHLLYTKGEVKEGEVQTPGPPSL

Isoform Tau-T (identifier: P29172-20)

The sequence of this isoform differs from the canonical sequence as follows:
     63-91: Missing.
     92-113: Missing.
     175-192: Missing.
     282-312: Missing.
     447-448: GL → ALRLPPPRLCVCRAEPGHCLSPHYVMLSRVPRLATHPFSVMDIVPMGRHLLYTKGEVKEGEVQTPGPPSL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 448	447	Microtubule-associated protein tau		PRO_0000072736
Regions
	Repeat	251 – 281	31	Tau/MAP 1
	Repeat	282 – 312	31	Tau/MAP 2
	Repeat	313 – 343	31	Tau/MAP 3
	Repeat	344 – 375	32	Tau/MAP 4
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	19	1	Phosphotyrosine; by FYN By similarity
	Modified residue	35	1	Phosphoserine By similarity
	Modified residue	39	1	Phosphothreonine By similarity
	Modified residue	100	1	Phosphothreonine By similarity
	Modified residue	144	1	Phosphothreonine By similarity
	Modified residue	166	1	Phosphothreonine By similarity
	Modified residue	172	1	Phosphothreonine By similarity
	Modified residue	204	1	Phosphotyrosine By similarity
	Modified residue	205	1	Phosphoserine By similarity
	Modified residue	206	1	Phosphoserine By similarity
	Modified residue	209	1	Phosphoserine; by CK1, PDPK1 and TTBK1 By similarity
	Modified residue	212	1	Phosphothreonine; by CK1 and PDPK1 By similarity
	Modified residue	219	1	Phosphothreonine; by BRSK1, BRSK2, DYRK2 and PDPK1 By similarity
	Modified residue	221	1	Phosphoserine By similarity
	Modified residue	224	1	Phosphothreonine By similarity
	Modified residue	238	1	Phosphothreonine; by GSK3-beta and PDPK1 By similarity
	Modified residue	242	1	Phosphoserine By similarity
	Modified residue	244	1	Phosphoserine; by PHK By similarity
	Modified residue	269	1	Phosphoserine; by MARK1, BRSK1, BRSK2 and PHK By similarity
	Modified residue	292	1	Phosphoserine; by PHK By similarity
	Modified residue	296	1	Phosphoserine; by PHK By similarity
	Modified residue	300	1	Phosphoserine By similarity
	Modified residue	312	1	Phosphoserine By similarity
	Modified residue	331	1	Phosphoserine By similarity
	Modified residue	359	1	Phosphoserine; by PHK By similarity
	Modified residue	363	1	Phosphoserine By similarity
	Modified residue	403	1	Phosphoserine; by CK1 and PDPK1 By similarity
	Modified residue	407	1	Phosphoserine By similarity
	Modified residue	410	1	Phosphothreonine By similarity
	Modified residue	411	1	Phosphoserine; by CK1 and PDPK1 By similarity
	Modified residue	416	1	Phosphoserine By similarity
	Modified residue	419	1	Phosphoserine By similarity
	Modified residue	421	1	Phosphothreonine By similarity
	Modified residue	423	1	Phosphoserine By similarity
	Modified residue	429	1	Phosphoserine By similarity
	Modified residue	434	1	Phosphothreonine By similarity
	Disulfide bond	298 ↔ 329		By similarity
Natural variations
	Alternative sequence	1 – 131	131	MAEPR…DDKKT → MPLNHYLPYLFLVSVLFQFV PFSHVLTFILILFMFMFKPS TPSSAKTLKNRPCLSPKRPT PGSSDPLIKPSSPAVCPEPS SSPKHVSSVTPRTGNSGAKE MKVK in isoform Tau-G.		VSP_003165
	Alternative sequence	1 – 131	131	MAEPR…DDKKT → MKVK in isoform Tau-H.		VSP_003166
	Alternative sequence	63 – 91	29	Missing in isoform Tau-D, isoform Tau-E, isoform Tau-F, isoform Tau-J, isoform Tau-K, isoform Tau-L, isoform Tau-M, isoform Tau-N, isoform Tau-P, isoform Tau-Q, isoform Tau-R, isoform Tau-S and isoform Tau-T.		VSP_003167
	Alternative sequence	92 – 113	22	Missing in isoform Tau-L, isoform Tau-M, isoform Tau-N, isoform Tau-R, isoform Tau-S and isoform Tau-T.		VSP_003168
	Alternative sequence	175 – 192	18	Missing in isoform Tau-B, isoform Tau-C, isoform Tau-E, isoform Tau-F, isoform Tau-G, isoform Tau-H, isoform Tau-J, isoform Tau-K, isoform Tau-M, isoform Tau-N, isoform Tau-P, isoform Tau-Q, isoform Tau-S and isoform Tau-T.		VSP_003169
	Alternative sequence	282 – 312	31	Missing in isoform Tau-C, isoform Tau-F, isoform Tau-K, isoform Tau-N, isoform Tau-Q and isoform Tau-T.		VSP_003170
	Alternative sequence	439 – 448	10	VSASLAKQGL → PCVCPHHACVSAVRSLVTAC PLTTSCCPEFPASPPTPSR in isoform Tau-I, isoform Tau-J, isoform Tau-K, isoform Tau-L, isoform Tau-M and isoform Tau-N.		VSP_003171
	Alternative sequence	447 – 448	2	GL → ALRLPPPRLCVCRAEPGHCL SPHYVMLSRVPRLATHPFSV MDIVPMGRHLLYTKGEVKEG EVQTPGPPSL in isoform Tau-O, isoform Tau-P, isoform Tau-Q, isoform Tau-R, isoform Tau-S and isoform Tau-T.		VSP_003172

Sequences

	Sequence		Length	Mass (Da)
	Isoform Tau-A (PBT43I12) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 821638A9C4809602	FASTA	448	46,333
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDATAPLVD EGAPGEQAAA QAPAEIPEGT AAEEAGIGDT SNLEDQAAGH VTQARMVSKG 130 140 150 160 170 180 KDGTGPDDKK TKGADGKPGT KIATPRGAAP PGQKGQANAT RIPAKTTPTP KTSPATMQVQ 190 200 210 220 230 240 KKPPPAGAKS ERGESGKSGD RSGYSSPGSP GTPGSRSRTP SLPTPPTREP KKVAVVRTPP 250 260 270 280 290 300 KSPSAAKSRL QAAPGPMPDL KNVKSKIGST ENLKHQPGGG KVQIINKKLD LSNVQSKCGS 310 320 330 340 350 360 KDNIKHVPGG GSVQIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK LDFKDRVQSK 370 380 390 400 410 420 IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT SPRHLSNVSS 430 440 TGSIDMVDSP QLATLADEVS ASLAKQGL
	Isoform Tau-B (PBT43-12) [UniParc]. Checksum: 9A7A06EFB6895ACD	FASTA	430	44,426
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDATAPLVD EGAPGEQAAA QAPAEIPEGT AAEEAGIGDT SNLEDQAAGH VTQARMVSKG 130 140 150 160 170 180 KDGTGPDDKK TKGADGKPGT KIATPRGAAP PGQKGQANAT RIPAKTTPTP KTSPGESGKS 190 200 210 220 230 240 GDRSGYSSPG SPGTPGSRSR TPSLPTPPTR EPKKVAVVRT PPKSPSAAKS RLQAAPGPMP 250 260 270 280 290 300 DLKNVKSKIG STENLKHQPG GGKVQIINKK LDLSNVQSKC GSKDNIKHVP GGGSVQIVYK 310 320 330 340 350 360 PVDLSKVTSK CGSLGNIHHK PGGGQVEVKS EKLDFKDRVQ SKIGSLDNIT HVPGGGNKKI 370 380 390 400 410 420 ETHKLTFREN AKAKTDHGAE IVYKSPVVSG DTSPRHLSNV SSTGSIDMVD SPQLATLADE 430 VSASLAKQGL
	Isoform Tau-C [UniParc]. Checksum: 6D446DCDC0AA66F2	FASTA	399	41,180
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDATAPLVD EGAPGEQAAA QAPAEIPEGT AAEEAGIGDT SNLEDQAAGH VTQARMVSKG 130 140 150 160 170 180 KDGTGPDDKK TKGADGKPGT KIATPRGAAP PGQKGQANAT RIPAKTTPTP KTSPGESGKS 190 200 210 220 230 240 GDRSGYSSPG SPGTPGSRSR TPSLPTPPTR EPKKVAVVRT PPKSPSAAKS RLQAAPGPMP 250 260 270 280 290 300 DLKNVKSKIG STENLKHQPG GGKVQIVYKP VDLSKVTSKC GSLGNIHHKP GGGQVEVKSE 310 320 330 340 350 360 KLDFKDRVQS KIGSLDNITH VPGGGNKKIE THKLTFRENA KAKTDHGAEI VYKSPVVSGD 370 380 390 TSPRHLSNVS STGSIDMVDS PQLATLADEV SASLAKQGL
	Isoform Tau-D [UniParc]. Checksum: A45E9316169C57BC	FASTA	419	43,603
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPATMQV QKKPPPAGAK SERGESGKSG DRSGYSSPGS 190 200 210 220 230 240 PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP PKSPSAAKSR LQAAPGPMPD LKNVKSKIGS 250 260 270 280 290 300 TENLKHQPGG GKVQIINKKL DLSNVQSKCG SKDNIKHVPG GGSVQIVYKP VDLSKVTSKC 310 320 330 340 350 360 GSLGNIHHKP GGGQVEVKSE KLDFKDRVQS KIGSLDNITH VPGGGNKKIE THKLTFRENA 370 380 390 400 410 KAKTDHGAEI VYKSPVVSGD TSPRHLSNVS STGSIDMVDS PQLATLADEV SASLAKQGL
	Isoform Tau-E [UniParc]. Checksum: EF098A6D436C5450	FASTA	401	41,696
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPGESGK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT 190 200 210 220 230 240 REPKKVAVVR TPPKSPSAAK SRLQAAPGPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK 250 260 270 280 290 300 KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK 310 320 330 340 350 360 SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS 370 380 390 400 GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
	Isoform Tau-F [UniParc]. Checksum: 225B352519AAC090	FASTA	370	38,450
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPGESGK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT 190 200 210 220 230 240 REPKKVAVVR TPPKSPSAAK SRLQAAPGPM PDLKNVKSKI GSTENLKHQP GGGKVQIVYK 250 260 270 280 290 300 PVDLSKVTSK CGSLGNIHHK PGGGQVEVKS EKLDFKDRVQ SKIGSLDNIT HVPGGGNKKI 310 320 330 340 350 360 ETHKLTFREN AKAKTDHGAE IVYKSPVVSG DTSPRHLSNV SSTGSIDMVD SPQLATLADE 370 VSASLAKQGL
	Isoform Tau-G (PBT4) [UniParc]. Checksum: F36BAF6A1BFCF36D	FASTA	403	42,361
	10 20 30 40 50 60 MPLNHYLPYL FLVSVLFQFV PFSHVLTFIL ILFMFMFKPS TPSSAKTLKN RPCLSPKRPT 70 80 90 100 110 120 PGSSDPLIKP SSPAVCPEPS SSPKHVSSVT PRTGNSGAKE MKVKKGADGK PGTKIATPRG 130 140 150 160 170 180 AAPPGQKGQA NATRIPAKTT PTPKTSPGES GKSGDRSGYS SPGSPGTPGS RSRTPSLPTP 190 200 210 220 230 240 PTREPKKVAV VRTPPKSPSA AKSRLQAAPG PMPDLKNVKS KIGSTENLKH QPGGGKVQII 250 260 270 280 290 300 NKKLDLSNVQ SKCGSKDNIK HVPGGGSVQI VYKPVDLSKV TSKCGSLGNI HHKPGGGQVE 310 320 330 340 350 360 VKSEKLDFKD RVQSKIGSLD NITHVPGGGN KKIETHKLTF RENAKAKTDH GAEIVYKSPV 370 380 390 400 VSGDTSPRHL SNVSSTGSID MVDSPQLATL ADEVSASLAK QGL
	Isoform Tau-H (PBT7) [UniParc]. Checksum: 7DF858C2EAD31A03	FASTA	303	31,420
	10 20 30 40 50 60 MKVKKGADGK PGTKIATPRG AAPPGQKGQA NATRIPAKTT PTPKTSPGES GKSGDRSGYS 70 80 90 100 110 120 SPGSPGTPGS RSRTPSLPTP PTREPKKVAV VRTPPKSPSA AKSRLQAAPG PMPDLKNVKS 130 140 150 160 170 180 KIGSTENLKH QPGGGKVQII NKKLDLSNVQ SKCGSKDNIK HVPGGGSVQI VYKPVDLSKV 190 200 210 220 230 240 TSKCGSLGNI HHKPGGGQVE VKSEKLDFKD RVQSKIGSLD NITHVPGGGN KKIETHKLTF 250 260 270 280 290 300 RENAKAKTDH GAEIVYKSPV VSGDTSPRHL SNVSSTGSID MVDSPQLATL ADEVSASLAK QGL
	Isoform Tau-I [UniParc]. Checksum: 1B0AC87B27070C23	FASTA	477	49,383
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDATAPLVD EGAPGEQAAA QAPAEIPEGT AAEEAGIGDT SNLEDQAAGH VTQARMVSKG 130 140 150 160 170 180 KDGTGPDDKK TKGADGKPGT KIATPRGAAP PGQKGQANAT RIPAKTTPTP KTSPATMQVQ 190 200 210 220 230 240 KKPPPAGAKS ERGESGKSGD RSGYSSPGSP GTPGSRSRTP SLPTPPTREP KKVAVVRTPP 250 260 270 280 290 300 KSPSAAKSRL QAAPGPMPDL KNVKSKIGST ENLKHQPGGG KVQIINKKLD LSNVQSKCGS 310 320 330 340 350 360 KDNIKHVPGG GSVQIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK LDFKDRVQSK 370 380 390 400 410 420 IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT SPRHLSNVSS 430 440 450 460 470 TGSIDMVDSP QLATLADEPC VCPHHACVSA VRSLVTACPL TTSCCPEFPA SPPTPSR
	Isoform Tau-J [UniParc]. Checksum: D75BD68C7085B7B7	FASTA	430	44,747
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPGESGK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT 190 200 210 220 230 240 REPKKVAVVR TPPKSPSAAK SRLQAAPGPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK 250 260 270 280 290 300 KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK 310 320 330 340 350 360 SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS 370 380 390 400 410 420 GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EPCVCPHHAC VSAVRSLVTA CPLTTSCCPE 430 FPASPPTPSR
	Isoform Tau-K [UniParc]. Checksum: E2CF718753CE169A	FASTA	399	41,500
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPGESGK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT 190 200 210 220 230 240 REPKKVAVVR TPPKSPSAAK SRLQAAPGPM PDLKNVKSKI GSTENLKHQP GGGKVQIVYK 250 260 270 280 290 300 PVDLSKVTSK CGSLGNIHHK PGGGQVEVKS EKLDFKDRVQ SKIGSLDNIT HVPGGGNKKI 310 320 330 340 350 360 ETHKLTFREN AKAKTDHGAE IVYKSPVVSG DTSPRHLSNV SSTGSIDMVD SPQLATLADE 370 380 390 PCVCPHHACV SAVRSLVTAC PLTTSCCPEF PASPPTPSR
	Isoform Tau-L [UniParc]. Checksum: B2ABCB5CD3DC4B82	FASTA	426	44,458
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEARMVSKGK DGTGPDDKKT KGADGKPGTK IATPRGAAPP GQKGQANATR IPAKTTPTPK 130 140 150 160 170 180 TSPATMQVQK KPPPAGAKSE RGESGKSGDR SGYSSPGSPG TPGSRSRTPS LPTPPTREPK 190 200 210 220 230 240 KVAVVRTPPK SPSAAKSRLQ AAPGPMPDLK NVKSKIGSTE NLKHQPGGGK VQIINKKLDL 250 260 270 280 290 300 SNVQSKCGSK DNIKHVPGGG SVQIVYKPVD LSKVTSKCGS LGNIHHKPGG GQVEVKSEKL 310 320 330 340 350 360 DFKDRVQSKI GSLDNITHVP GGGNKKIETH KLTFRENAKA KTDHGAEIVY KSPVVSGDTS 370 380 390 400 410 420 PRHLSNVSST GSIDMVDSPQ LATLADEPCV CPHHACVSAV RSLVTACPLT TSCCPEFPAS PPTPSR
	Isoform Tau-M [UniParc]. Checksum: 27B9A11F85B4E29A	FASTA	408	42,552
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEARMVSKGK DGTGPDDKKT KGADGKPGTK IATPRGAAPP GQKGQANATR IPAKTTPTPK 130 140 150 160 170 180 TSPGESGKSG DRSGYSSPGS PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP PKSPSAAKSR 190 200 210 220 230 240 LQAAPGPMPD LKNVKSKIGS TENLKHQPGG GKVQIINKKL DLSNVQSKCG SKDNIKHVPG 250 260 270 280 290 300 GGSVQIVYKP VDLSKVTSKC GSLGNIHHKP GGGQVEVKSE KLDFKDRVQS KIGSLDNITH 310 320 330 340 350 360 VPGGGNKKIE THKLTFRENA KAKTDHGAEI VYKSPVVSGD TSPRHLSNVS STGSIDMVDS 370 380 390 400 PQLATLADEP CVCPHHACVS AVRSLVTACP LTTSCCPEFP ASPPTPSR
	Isoform Tau-N [UniParc]. Checksum: FF2F16682EF06E96	FASTA	377	39,305
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEARMVSKGK DGTGPDDKKT KGADGKPGTK IATPRGAAPP GQKGQANATR IPAKTTPTPK 130 140 150 160 170 180 TSPGESGKSG DRSGYSSPGS PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP PKSPSAAKSR 190 200 210 220 230 240 LQAAPGPMPD LKNVKSKIGS TENLKHQPGG GKVQIVYKPV DLSKVTSKCG SLGNIHHKPG 250 260 270 280 290 300 GGQVEVKSEK LDFKDRVQSK IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV 310 320 330 340 350 360 YKSPVVSGDT SPRHLSNVSS TGSIDMVDSP QLATLADEPC VCPHHACVSA VRSLVTACPL 370 TTSCCPEFPA SPPTPSR
	Isoform Tau-O [UniParc]. Checksum: E73FCB53C3678CCA	FASTA	516	53,884
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEDATAPLVD EGAPGEQAAA QAPAEIPEGT AAEEAGIGDT SNLEDQAAGH VTQARMVSKG 130 140 150 160 170 180 KDGTGPDDKK TKGADGKPGT KIATPRGAAP PGQKGQANAT RIPAKTTPTP KTSPATMQVQ 190 200 210 220 230 240 KKPPPAGAKS ERGESGKSGD RSGYSSPGSP GTPGSRSRTP SLPTPPTREP KKVAVVRTPP 250 260 270 280 290 300 KSPSAAKSRL QAAPGPMPDL KNVKSKIGST ENLKHQPGGG KVQIINKKLD LSNVQSKCGS 310 320 330 340 350 360 KDNIKHVPGG GSVQIVYKPV DLSKVTSKCG SLGNIHHKPG GGQVEVKSEK LDFKDRVQSK 370 380 390 400 410 420 IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV YKSPVVSGDT SPRHLSNVSS 430 440 450 460 470 480 TGSIDMVDSP QLATLADEVS ASLAKQALRL PPPRLCVCRA EPGHCLSPHY VMLSRVPRLA 490 500 510 THPFSVMDIV PMGRHLLYTK GEVKEGEVQT PGPPSL
	Isoform Tau-P [UniParc]. Checksum: 913E117E5F1BC2A5	FASTA	469	49,248
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPGESGK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT 190 200 210 220 230 240 REPKKVAVVR TPPKSPSAAK SRLQAAPGPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK 250 260 270 280 290 300 KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK 310 320 330 340 350 360 SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS 370 380 390 400 410 420 GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQA LRLPPPRLCV CRAEPGHCLS 430 440 450 460 PHYVMLSRVP RLATHPFSVM DIVPMGRHLL YTKGEVKEGE VQTPGPPSL
	Isoform Tau-Q [UniParc]. Checksum: 438E48674EB03EEB	FASTA	438	46,002
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEAEEAGIGD TSNLEDQAAG HVTQARMVSK GKDGTGPDDK KTKGADGKPG TKIATPRGAA 130 140 150 160 170 180 PPGQKGQANA TRIPAKTTPT PKTSPGESGK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT 190 200 210 220 230 240 REPKKVAVVR TPPKSPSAAK SRLQAAPGPM PDLKNVKSKI GSTENLKHQP GGGKVQIVYK 250 260 270 280 290 300 PVDLSKVTSK CGSLGNIHHK PGGGQVEVKS EKLDFKDRVQ SKIGSLDNIT HVPGGGNKKI 310 320 330 340 350 360 ETHKLTFREN AKAKTDHGAE IVYKSPVVSG DTSPRHLSNV SSTGSIDMVD SPQLATLADE 370 380 390 400 410 420 VSASLAKQAL RLPPPRLCVC RAEPGHCLSP HYVMLSRVPR LATHPFSVMD IVPMGRHLLY 430 TKGEVKEGEV QTPGPPSL
	Isoform Tau-R [UniParc]. Checksum: CD8C23689F259F95	FASTA	465	48,959
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEARMVSKGK DGTGPDDKKT KGADGKPGTK IATPRGAAPP GQKGQANATR IPAKTTPTPK 130 140 150 160 170 180 TSPATMQVQK KPPPAGAKSE RGESGKSGDR SGYSSPGSPG TPGSRSRTPS LPTPPTREPK 190 200 210 220 230 240 KVAVVRTPPK SPSAAKSRLQ AAPGPMPDLK NVKSKIGSTE NLKHQPGGGK VQIINKKLDL 250 260 270 280 290 300 SNVQSKCGSK DNIKHVPGGG SVQIVYKPVD LSKVTSKCGS LGNIHHKPGG GQVEVKSEKL 310 320 330 340 350 360 DFKDRVQSKI GSLDNITHVP GGGNKKIETH KLTFRENAKA KTDHGAEIVY KSPVVSGDTS 370 380 390 400 410 420 PRHLSNVSST GSIDMVDSPQ LATLADEVSA SLAKQALRLP PPRLCVCRAE PGHCLSPHYV 430 440 450 460 MLSRVPRLAT HPFSVMDIVP MGRHLLYTKG EVKEGEVQTP GPPSL
	Isoform Tau-S [UniParc]. Checksum: CB410E5C23BC1AA1	FASTA	447	47,053
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEARMVSKGK DGTGPDDKKT KGADGKPGTK IATPRGAAPP GQKGQANATR IPAKTTPTPK 130 140 150 160 170 180 TSPGESGKSG DRSGYSSPGS PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP PKSPSAAKSR 190 200 210 220 230 240 LQAAPGPMPD LKNVKSKIGS TENLKHQPGG GKVQIINKKL DLSNVQSKCG SKDNIKHVPG 250 260 270 280 290 300 GGSVQIVYKP VDLSKVTSKC GSLGNIHHKP GGGQVEVKSE KLDFKDRVQS KIGSLDNITH 310 320 330 340 350 360 VPGGGNKKIE THKLTFRENA KAKTDHGAEI VYKSPVVSGD TSPRHLSNVS STGSIDMVDS 370 380 390 400 410 420 PQLATLADEV SASLAKQALR LPPPRLCVCR AEPGHCLSPH YVMLSRVPRL ATHPFSVMDI 430 440 VPMGRHLLYT KGEVKEGEVQ TPGPPSL
	Isoform Tau-T [UniParc]. Checksum: 430F6DB600ECFEA7	FASTA	416	43,806
	10 20 30 40 50 60 MAEPRQEFDV MEDHAQGDYT LQDQEGDMDP GLKESPLQTP ADDGSEEPGS ETSDAKSTPT 70 80 90 100 110 120 AEARMVSKGK DGTGPDDKKT KGADGKPGTK IATPRGAAPP GQKGQANATR IPAKTTPTPK 130 140 150 160 170 180 TSPGESGKSG DRSGYSSPGS PGTPGSRSRT PSLPTPPTRE PKKVAVVRTP PKSPSAAKSR 190 200 210 220 230 240 LQAAPGPMPD LKNVKSKIGS TENLKHQPGG GKVQIVYKPV DLSKVTSKCG SLGNIHHKPG 250 260 270 280 290 300 GGQVEVKSEK LDFKDRVQSK IGSLDNITHV PGGGNKKIET HKLTFRENAK AKTDHGAEIV 310 320 330 340 350 360 YKSPVVSGDT SPRHLSNVSS TGSIDMVDSP QLATLADEVS ASLAKQALRL PPPRLCVCRA 370 380 390 400 410 EPGHCLSPHY VMLSRVPRLA THPFSVMDIV PMGRHLLYTK GEVKEGEVQT PGPPSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains." Himmler A., Drechsel D., Kirschner M.W., Martin D.W. Jr. Mol. Cell. Biol. 9:1381-1388(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS TAU-A; TAU-B; TAU-G AND TAU-H). Tissue: Brain.
[2]	"Structure of the bovine tau gene: alternatively spliced transcripts generate a protein family." Himmler A. Mol. Cell. Biol. 9:1389-1396(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS TAU-A; TAU-B; TAU-C; TAU-D; TAU-E; TAU-F; TAU-I; TAU-J; TAU-K; TAU-L; TAU-M; TAU-N; TAU-O; TAU-P; TAU-Q; TAU-R; TAU-S AND TAU-T). Tissue: Brain.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM TAU-F). Strain: Crossbred X Angus. Tissue: Liver.
[4]	"The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine." Arnold C.S., Johnson G.V.W., Cole R.N., Dong D.L.-Y., Lee M., Hart G.W. J. Biol. Chem. 271:28741-28744(1996) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L34953 , L34940, L34941, L34942, L34943, L34944, L34946, L34947, L34948, L34949, L34950, L34951, L34952 Genomic DNA. Translation: AAA51609.1. M26157 mRNA. Translation: AAA30770.1. M26158 mRNA. Translation: AAA30771.1. M26178 , L34940, L34941, L34942, L34943, L34944, L34946, L34947, L34948, L34949, L34950, L34951 Genomic DNA. Translation: AAA51601.1. Sequence problems. M26178 , L34940, L34941, L34943, L34944, L34946, L34948, L34949, L34950, L34951 Genomic DNA. Translation: AAA51602.1. Sequence problems. M26178 , L34940, L34941, L34943, L34944, L34946, L34948, L34950, L34951 Genomic DNA. Translation: AAA51603.1. Sequence problems. M26178 , L34940, L34941, L34944, L34946, L34947, L34948, L34949, L34950, L34951 Genomic DNA. Translation: AAA51604.1. Sequence problems. M26178 , L34940, L34941, L34944, L34946, L34948, L34949, L34950, L34951 Genomic DNA. Translation: AAA51605.1. Sequence problems. M26178 , L34940, L34941, L34944, L34946, L34948, L34950, L34951 Genomic DNA. Translation: AAA51606.1. Sequence problems. BC109941 mRNA. Translation: AAI09942.1.
IPI	IPI00688243. IPI00689184. IPI00689650. IPI00691424. IPI00691678. IPI00693156. IPI00695008. IPI00695963. IPI00702850. IPI00703952. IPI00705840. IPI00706820. IPI00707389. IPI00710658. IPI00710788. IPI00713146. IPI00713909. IPI00716398. IPI00717925. IPI00718776.
PIR	QRBOT1. A31939. QRBOT2. B31939.
RefSeq	NP_776531.1. NM_174106.2.
UniGene	Bt.34217.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P29172.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000023284; ENSBTAP00000023284; ENSBTAG00000017512. ENSBTAT00000042687; ENSBTAP00000040320; ENSBTAG00000017512. ENSBTAT00000064492; ENSBTAP00000054412; ENSBTAG00000017512. ENSBTAT00000064966; ENSBTAP00000054994; ENSBTAG00000017512. ENSBTAT00000065509; ENSBTAP00000056351; ENSBTAG00000017512. ENSBTAT00000065660; ENSBTAP00000056547; ENSBTAG00000017512.
GeneID	281296.
KEGG	bta:281296.
Organism-specific databases
CTD	4137.
Phylogenomic databases
eggNOG	NOG148882.
GeneTree	ENSGT00530000063491.
HOVERGEN	HBG000991.
InParanoid	P29172.
KO	K04380.
OMA	AGHVTQX.
OrthoDB	EOG4B8JDC.
Gene expression databases
ArrayExpress	P29172.
Family and domain databases
InterPro	IPR027324. MAP2/MAP4/Tau. IPR001084. Tau/MAP_tubulin-bd_rpt. IPR002955. Tau_protein. [Graphical view]
PANTHER	PTHR11501. PTHR11501. 1 hit.
Pfam	PF00418. Tubulin-binding. 4 hits. [Graphical view]
PRINTS	PR01261. TAUPROTEIN.
PROSITE	PS00229. TAU_MAP_1. 4 hits. PS51491. TAU_MAP_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805325.

Entry information

Entry name

TAU_BOVIN

Accession

Primary (citable) accession number: P29172
Secondary accession number(s): P29173 , Q28185, Q28186, Q28187, Q28188, Q28189, Q28190, Q32KT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program