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P29163 (COX2_PNECA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Encoded onMitochondrion
OrganismPneumocystis carinii
Taxonomic identifier4754 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaPneumocystidomycetesPneumocystidaceaePneumocystis

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Cytochrome c oxidase subunit 2
PRO_0000183664

Regions

Topological domain1 – 3434Mitochondrial intermembrane Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 7419Mitochondrial matrix Potential
Transmembrane75 – 9723Helical; Potential
Topological domain98 – 243146Mitochondrial intermembrane Potential

Sites

Metal binding1781Copper A Probable
Metal binding2131Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P29163 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 27EB1EB0504AF239

FASTA24327,636
        10         20         30         40         50         60 
MNNIIHNDAP TPWGIYFQDG ASPVYDGIVE LHDQVLFYLL IVLVGVSWIL FSTILRFRGS 

        70         80         90        100        110        120 
GIVHKYHNHS TTIEFVWTVS PALLLIAIAF PSFKLLYLMD EVIDPSITIK AIGHQWYWSY 

       130        140        150        160        170        180 
EYSDYTDKEG QSIEFDSYML PTEDLEEGQL RQLEVDNRVL VPVNTPLRFI ITATDVLHDF 

       190        200        210        220        230        240 
AVPSLGIKVD ASPGRLNQVS TYVQREGVYY GQCSELCGVL HSSMPIVIEA VSLEKFLSWL 


DNQ 

« Hide

References

[1]"Mitochondrial gene sequences show fungal homology for Pneumocystis carinii."
Pixley F.J., Wakefield A.E., Banerji S., Hopkin J.M.
Mol. Microbiol. 5:1347-1351(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

PIROBUNMP. S16283.
RefSeqYP_003354986.1. NC_013660.1.

3D structure databases

ProteinModelPortalP29163.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8677266.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_PNECA
AccessionPrimary (citable) accession number: P29163
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families