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P29163

- COX2_PNECA

UniProt

P29163 - COX2_PNECA

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Protein

Cytochrome c oxidase subunit 2

Gene
N/A
Organism
Pneumocystis carinii
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi178 – 1781Copper ACurated
Metal bindingi213 – 2131Copper ACurated
Metal bindingi217 – 2171Copper ACurated
Metal bindingi221 – 2211Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Encoded oniMitochondrion
OrganismiPneumocystis carinii
Taxonomic identifieri4754 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaPneumocystidomycetesPneumocystidaceaePneumocystis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Topological domaini56 – 7419Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei75 – 9723HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 243146Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Cytochrome c oxidase subunit 2PRO_0000183664Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29163-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNIIHNDAP TPWGIYFQDG ASPVYDGIVE LHDQVLFYLL IVLVGVSWIL
60 70 80 90 100
FSTILRFRGS GIVHKYHNHS TTIEFVWTVS PALLLIAIAF PSFKLLYLMD
110 120 130 140 150
EVIDPSITIK AIGHQWYWSY EYSDYTDKEG QSIEFDSYML PTEDLEEGQL
160 170 180 190 200
RQLEVDNRVL VPVNTPLRFI ITATDVLHDF AVPSLGIKVD ASPGRLNQVS
210 220 230 240
TYVQREGVYY GQCSELCGVL HSSMPIVIEA VSLEKFLSWL DNQ
Length:243
Mass (Da):27,636
Last modified:December 1, 1992 - v1
Checksum:i27EB1EB0504AF239
GO

Sequence databases

PIRiS16283. OBUNMP.
RefSeqiYP_003354986.1. NC_013660.1.

Genome annotation databases

GeneIDi8677266.

Cross-referencesi

Sequence databases

PIRi S16283. OBUNMP.
RefSeqi YP_003354986.1. NC_013660.1.

3D structure databases

ProteinModelPortali P29163.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8677266.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial gene sequences show fungal homology for Pneumocystis carinii."
    Pixley F.J., Wakefield A.E., Banerji S., Hopkin J.M.
    Mol. Microbiol. 5:1347-1351(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiCOX2_PNECA
AccessioniPrimary (citable) accession number: P29163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3