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Protein

D-beta-hydroxybutyrate dehydrogenase, mitochondrial

Gene

Bdh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.1 Publication

Enzyme regulationi

Requires phosphatidylcholine as an allosteric activator for enzymatic activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei195SubstrateBy similarity1
Active sitei208Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 83NADBy similarityAdd BLAST25

GO - Molecular functioni

  • 3-hydroxybutyrate dehydrogenase activity Source: RGD
  • phospholipid binding Source: RGD

GO - Biological processi

  • adipose tissue development Source: RGD
  • brain development Source: RGD
  • liver development Source: RGD
  • response to cadmium ion Source: RGD
  • response to corticosterone Source: RGD
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to ethanol Source: RGD
  • response to growth hormone Source: RGD
  • response to hormone Source: RGD
  • response to insulin Source: RGD
  • response to nutrient Source: RGD
  • response to starvation Source: RGD
  • response to toxic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP29147.

Names & Taxonomyi

Protein namesi
Recommended name:
D-beta-hydroxybutyrate dehydrogenase, mitochondrialCurated (EC:1.1.1.301 Publication)
Alternative name(s):
3-hydroxybutyrate dehydrogenase1 Publication
Short name:
BDH1 Publication
Gene namesi
Name:Bdh1Imported
Synonyms:Bdh1 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620131. Bdh1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionAdd BLAST46
ChainiPRO_000003196247 – 343D-beta-hydroxybutyrate dehydrogenase, mitochondrialAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73N6-acetyllysineBy similarity1
Modified residuei103N6-acetyllysine; alternateBy similarity1
Modified residuei103N6-succinyllysine; alternateBy similarity1
Modified residuei132N6-acetyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1
Modified residuei212N6-acetyllysineBy similarity1
Glycosylationi219O-linked (GlcNAc)1 Publication1
Modified residuei246PhosphoserineCombined sources1
Modified residuei258N6-acetyllysineBy similarity1
Modified residuei259N6-acetyllysine; alternateBy similarity1
Modified residuei259N6-succinyllysine; alternateBy similarity1
Modified residuei280N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP29147.
PRIDEiP29147.

PTM databases

iPTMnetiP29147.
PhosphoSitePlusiP29147.

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Gene expression databases

BgeeiENSRNOG00000001736.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002366.

Structurei

3D structure databases

ProteinModelPortaliP29147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
InParanoidiP29147.
KOiK00019.
OMAiKGHDGVK.
PhylomeDBiP29147.
TreeFamiTF325617.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAARLSRPL SQLPGKALSV CDRENGTRHT LLFYPASFSP DTRRTYTSQA
60 70 80 90 100
DAASGKAVLV TGCDSGFGFS LAKHLHSKGF LVFAGCLLKD KGDAGVRELD
110 120 130 140 150
SLKSDRLRTI QLNVCNSEEV EKAVETVRSG LKDPEKGMWG LVNNAGISTF
160 170 180 190 200
GEVEFTSMET YKEVAEVNLW GTVRTTKSFL PLLRRAKGRV VNISSMLGRM
210 220 230 240 250
ANPARSPYCI TKFGVEAFSD CLRYEMHPLG VKVSVVEPGN FIAATSLYSP
260 270 280 290 300
ERIQAIAKKM WDELPEVVRK DYGKKYFDEK IAKMETYCNS GSTDTSSVIN
310 320 330 340
AVTHALTAAT PYTRYHPMDY YWWLRMQVMT HFPGAISDKI YIH
Length:343
Mass (Da):38,202
Last modified:July 5, 2005 - v2
Checksum:i6903D2ED27F2B055
GO

Sequence cautioni

The sequence AAB59684 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH85916 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90 – 91DK → EQ in AAB59684 (PubMed:1567834).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89902 mRNA. Translation: AAB59684.1. Different initiation.
BC085916 mRNA. Translation: AAH85916.1. Different initiation.
PIRiA42345.
RefSeqiNP_446447.2. NM_053995.3.
XP_006248540.1. XM_006248478.3.
XP_008766913.1. XM_008768691.2.
UniGeneiRn.36635.

Genome annotation databases

GeneIDi117099.
KEGGirno:117099.
UCSCiRGD:620131. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89902 mRNA. Translation: AAB59684.1. Different initiation.
BC085916 mRNA. Translation: AAH85916.1. Different initiation.
PIRiA42345.
RefSeqiNP_446447.2. NM_053995.3.
XP_006248540.1. XM_006248478.3.
XP_008766913.1. XM_008768691.2.
UniGeneiRn.36635.

3D structure databases

ProteinModelPortaliP29147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002366.

PTM databases

iPTMnetiP29147.
PhosphoSitePlusiP29147.

Proteomic databases

PaxDbiP29147.
PRIDEiP29147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117099.
KEGGirno:117099.
UCSCiRGD:620131. rat.

Organism-specific databases

CTDi622.
RGDi620131. Bdh1.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
HOVERGENiHBG005482.
InParanoidiP29147.
KOiK00019.
OMAiKGHDGVK.
PhylomeDBiP29147.
TreeFamiTF325617.

Enzyme and pathway databases

SABIO-RKP29147.

Miscellaneous databases

PROiP29147.

Gene expression databases

BgeeiENSRNOG00000001736.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBDH_RAT
AccessioniPrimary (citable) accession number: P29147
Secondary accession number(s): Q5U2Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.