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P29126

- XYNA_RUMFL

UniProt

P29126 - XYNA_RUMFL

Protein

Bifunctional endo-1,4-beta-xylanase XylA

Gene

xynA

Organism
Ruminococcus flavefaciens
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Xylanase domain 1 releases more xylo-oligosaccharides and domain 2 more xylose.

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei122 – 1221NucleophileBy similarity
    Active sitei223 – 2231Proton donorPROSITE-ProRule annotation
    Active sitei774 – 7741Proton donorPROSITE-ProRule annotation
    Active sitei884 – 8841NucleophileBy similarity

    GO - Molecular functioni

    1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

    GO - Biological processi

    1. xylan catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

    Enzyme and pathway databases

    UniPathwayiUPA00114.

    Protein family/group databases

    CAZyiGH10. Glycoside Hydrolase Family 10.
    GH11. Glycoside Hydrolase Family 11.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional endo-1,4-beta-xylanase XylA (EC:3.2.1.8)
    Gene namesi
    Name:xynA
    OrganismiRuminococcus flavefaciens
    Taxonomic identifieri1265 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Or 28, or 29Sequence AnalysisAdd
    BLAST
    Chaini28 – 954927Bifunctional endo-1,4-beta-xylanase XylAPRO_0000008015Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP29126.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 244217Xylanase domain 1Add
    BLAST
    Regioni623 – 954332Xylanase domain 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi245 – 622378Asn/Gln/Trp-rich (linker)Add
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the glycosyl hydrolase 11 (cellulase G) family.Curated
    In the C-terminal section; belongs to the glycosyl hydrolase 10 (cellulase F) family.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.120.180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR001000. Glyco_hydro_10.
    IPR001137. Glyco_hydro_11.
    IPR013319. Glyco_hydro_11/12.
    IPR018208. Glyco_hydro_11_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00331. Glyco_hydro_10. 1 hit.
    PF00457. Glyco_hydro_11. 1 hit.
    [Graphical view]
    PRINTSiPR00911. GLHYDRLASE11.
    SMARTiSM00633. Glyco_10. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
    PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29126-1 [UniParc]FASTAAdd to Basket

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    MKLSKIKKVL SGTVSALMIA SAAPVVASAA DQQTRGNVGG YDYEMWNQNG    50
    QGQASMNPGA GSFTCSWSNI ENFLARMGKN YDSQKKNYKA FGNIVLTYDV 100
    EYTPRGNSYM CVYGWTRNPL MEYYIVEGWG DWRPPGNDGE VKGTVSANGN 150
    TYDIRKTMRY NQPSLDGTAT FPQYWSVRQT SGSANNQTNY MKGTIDVTKH 200
    FDAWSAAGLD MSGTLYEVSL NIEGYRSNGS ANVKSVSVTQ GGSSDNGGQQ 250
    QNNDWNQQNN NQQQNNDWNN WGQQNNDWNQ WNNQGQQNND WNNWGQQNND 300
    WNQWNNQGQQ QNNDWNNWGQ QNNDWNQWNN QGQQQNNDWN NWGQQNNDWN 350
    QWNNQGQQQN NDWNNWGQQN NDWNQWNNQN NNQQNAWNGW DNNNNWNQNN 400
    QQQNNWDWNN QNNWNNNQQQ NNDWNQWNNQ NNWNNNQQQN NDWNQWNNQG 450
    QQNNDWNQWN NQNNWNQNNN QQNAWNGWDN NNNWNQWDQN NQWNNQQQNN 500
    TWDWNNQNNW NNNQQNNDWN QWNNQGQQQN NDWNQWNNQN NNQNNGWDWN 550
    NQNNWNQNNN QQNAWNGWDN NNNWNQWGGQ NNDWNNQQQN NDWNQWNNQG 600
    QQQNNDWNNQ NNWNQGQQNN NNSAGSSDSL KGAFSKYFKI GTSVSPHELN 650
    SGADFLKKHY NSITPENELK PESILDQGAC QQKGNNVNTQ ISLSRAAQTL 700
    KFCEQNGIAL RGHTFVWYSQ TPDWFFRENF SQNGAYVSKD IMNQRLESMI 750
    KNTFAALKSQ YPNLDVYSYD VCNELFLNNG GGMRGADNSN WVKIYGDDSF 800
    VINAFKYARQ YAPAGCKLYL NDYNEYIPAK TNDIYNMAMK LKQLGYIDGI 850
    GMQSHLATNY PDANTYETAL KKFLSTGLEV QITELDITCT NSAEQADLYE 900
    KIFKLAMQNS AQIPAVTIWG TQDTVSWRSS QNPLLFSAGY QPKPAYDRVM 950
    ALAK 954
    Length:954
    Mass (Da):111,362
    Last modified:December 1, 1992 - v1
    Checksum:i1033567D4B526EBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11127 Genomic DNA. Translation: CAA77476.1.
    PIRiS20907.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11127 Genomic DNA. Translation: CAA77476.1 .
    PIRi S20907.

    3D structure databases

    ProteinModelPortali P29126.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH10. Glycoside Hydrolase Family 10.
    GH11. Glycoside Hydrolase Family 11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00114 .

    Family and domain databases

    Gene3Di 2.60.120.180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR001000. Glyco_hydro_10.
    IPR001137. Glyco_hydro_11.
    IPR013319. Glyco_hydro_11/12.
    IPR018208. Glyco_hydro_11_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00331. Glyco_hydro_10. 1 hit.
    PF00457. Glyco_hydro_11. 1 hit.
    [Graphical view ]
    PRINTSi PR00911. GLHYDRLASE11.
    SMARTi SM00633. Glyco_10. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
    PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
    PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A bifunctional xylanase encoded by the xynA gene of the rumen cellulolytic bacterium Ruminococcus flavefaciens 17 comprises two dissimilar domains linked by an asparagine/glutamine-rich sequence."
      Zhang J.-X., Flint H.J.
      Mol. Microbiol. 6:1013-1023(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 17.

    Entry informationi

    Entry nameiXYNA_RUMFL
    AccessioniPrimary (citable) accession number: P29126
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3