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P29126

- XYNA_RUMFL

UniProt

P29126 - XYNA_RUMFL

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Protein
Bifunctional endo-1,4-beta-xylanase XylA
Gene
xynA
Organism
Ruminococcus flavefaciens
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Xylanase domain 1 releases more xylo-oligosaccharides and domain 2 more xylose.

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221Nucleophile By similarity
Active sitei223 – 2231Proton donor By similarity
Active sitei774 – 7741Proton donor By similarity
Active sitei884 – 8841Nucleophile By similarity

GO - Molecular functioni

  1. endo-1,4-beta-xylanase activity Source: UniProtKB-EC

GO - Biological processi

  1. xylan catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH10. Glycoside Hydrolase Family 10.
GH11. Glycoside Hydrolase Family 11.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional endo-1,4-beta-xylanase XylA (EC:3.2.1.8)
Gene namesi
Name:xynA
OrganismiRuminococcus flavefaciens
Taxonomic identifieri1265 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeRuminococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Or 28, or 29 Reviewed prediction
Add
BLAST
Chaini28 – 954927Bifunctional endo-1,4-beta-xylanase XylA
PRO_0000008015Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP29126.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 244217Xylanase domain 1
Add
BLAST
Regioni623 – 954332Xylanase domain 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 622378Asn/Gln/Trp-rich (linker)
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyl hydrolase 11 (cellulase G) family.
In the C-terminal section; belongs to the glycosyl hydrolase 10 (cellulase F) family.

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR001000. Glyco_hydro_10.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00331. Glyco_hydro_10. 1 hit.
PF00457. Glyco_hydro_11. 1 hit.
[Graphical view]
PRINTSiPR00911. GLHYDRLASE11.
SMARTiSM00633. Glyco_10. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00591. GLYCOSYL_HYDROL_F10. 1 hit.
PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29126-1 [UniParc]FASTAAdd to Basket

« Hide

MKLSKIKKVL SGTVSALMIA SAAPVVASAA DQQTRGNVGG YDYEMWNQNG    50
QGQASMNPGA GSFTCSWSNI ENFLARMGKN YDSQKKNYKA FGNIVLTYDV 100
EYTPRGNSYM CVYGWTRNPL MEYYIVEGWG DWRPPGNDGE VKGTVSANGN 150
TYDIRKTMRY NQPSLDGTAT FPQYWSVRQT SGSANNQTNY MKGTIDVTKH 200
FDAWSAAGLD MSGTLYEVSL NIEGYRSNGS ANVKSVSVTQ GGSSDNGGQQ 250
QNNDWNQQNN NQQQNNDWNN WGQQNNDWNQ WNNQGQQNND WNNWGQQNND 300
WNQWNNQGQQ QNNDWNNWGQ QNNDWNQWNN QGQQQNNDWN NWGQQNNDWN 350
QWNNQGQQQN NDWNNWGQQN NDWNQWNNQN NNQQNAWNGW DNNNNWNQNN 400
QQQNNWDWNN QNNWNNNQQQ NNDWNQWNNQ NNWNNNQQQN NDWNQWNNQG 450
QQNNDWNQWN NQNNWNQNNN QQNAWNGWDN NNNWNQWDQN NQWNNQQQNN 500
TWDWNNQNNW NNNQQNNDWN QWNNQGQQQN NDWNQWNNQN NNQNNGWDWN 550
NQNNWNQNNN QQNAWNGWDN NNNWNQWGGQ NNDWNNQQQN NDWNQWNNQG 600
QQQNNDWNNQ NNWNQGQQNN NNSAGSSDSL KGAFSKYFKI GTSVSPHELN 650
SGADFLKKHY NSITPENELK PESILDQGAC QQKGNNVNTQ ISLSRAAQTL 700
KFCEQNGIAL RGHTFVWYSQ TPDWFFRENF SQNGAYVSKD IMNQRLESMI 750
KNTFAALKSQ YPNLDVYSYD VCNELFLNNG GGMRGADNSN WVKIYGDDSF 800
VINAFKYARQ YAPAGCKLYL NDYNEYIPAK TNDIYNMAMK LKQLGYIDGI 850
GMQSHLATNY PDANTYETAL KKFLSTGLEV QITELDITCT NSAEQADLYE 900
KIFKLAMQNS AQIPAVTIWG TQDTVSWRSS QNPLLFSAGY QPKPAYDRVM 950
ALAK 954
Length:954
Mass (Da):111,362
Last modified:December 1, 1992 - v1
Checksum:i1033567D4B526EBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11127 Genomic DNA. Translation: CAA77476.1.
PIRiS20907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11127 Genomic DNA. Translation: CAA77476.1 .
PIRi S20907.

3D structure databases

ProteinModelPortali P29126.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH10. Glycoside Hydrolase Family 10.
GH11. Glycoside Hydrolase Family 11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00114 .

Family and domain databases

Gene3Di 2.60.120.180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR001000. Glyco_hydro_10.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00331. Glyco_hydro_10. 1 hit.
PF00457. Glyco_hydro_11. 1 hit.
[Graphical view ]
PRINTSi PR00911. GLHYDRLASE11.
SMARTi SM00633. Glyco_10. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEi PS00591. GLYCOSYL_HYDROL_F10. 1 hit.
PS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
PS00777. GLYCOSYL_HYDROL_F11_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A bifunctional xylanase encoded by the xynA gene of the rumen cellulolytic bacterium Ruminococcus flavefaciens 17 comprises two dissimilar domains linked by an asparagine/glutamine-rich sequence."
    Zhang J.-X., Flint H.J.
    Mol. Microbiol. 6:1013-1023(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 17.

Entry informationi

Entry nameiXYNA_RUMFL
AccessioniPrimary (citable) accession number: P29126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 13, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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