##gff-version 3
P29120	UniProtKB	Signal peptide	1	27	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
P29120	UniProtKB	Propeptide	28	110	.	.	.	ID=PRO_0000027057;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P29120	UniProtKB	Chain	111	753	.	.	.	ID=PRO_0000027058;Note=Neuroendocrine convertase 1	
P29120	UniProtKB	Domain	129	450	.	.	.	Note=Peptidase S8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P29120	UniProtKB	Domain	460	597	.	.	.	Note=P/Homo B;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01173	
P29120	UniProtKB	Region	596	662	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P29120	UniProtKB	Compositional bias	596	616	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P29120	UniProtKB	Compositional bias	618	632	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P29120	UniProtKB	Compositional bias	633	652	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P29120	UniProtKB	Active site	167	167	.	.	.	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P29120	UniProtKB	Active site	208	208	.	.	.	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P29120	UniProtKB	Active site	382	382	.	.	.	Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240	
P29120	UniProtKB	Glycosylation	173	173	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P29120	UniProtKB	Glycosylation	401	401	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
P29120	UniProtKB	Glycosylation	632	632	.	.	.	Note=O-linked (GalNAc...) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23234360;Dbxref=PMID:23234360	
P29120	UniProtKB	Disulfide bond	225	374	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P29120	UniProtKB	Disulfide bond	317	347	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P29120	UniProtKB	Disulfide bond	467	494	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
P29120	UniProtKB	Alternative sequence	1	59	.	.	.	ID=VSP_046100;Note=In isoform 2. MERRAWSLQCTAFVLFCAWCALNSAKAKRQFVNEWAAEIPGGPEAASAIAEELGYDLLG->MGKGSISFLFFS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
P29120	UniProtKB	Natural variant	80	80	.	.	.	ID=VAR_013906;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8666140;Dbxref=dbSNP:rs1799904,PMID:8666140	
P29120	UniProtKB	Natural variant	213	213	.	.	.	ID=VAR_022777;Note=In PC1 deficiency. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14617756;Dbxref=dbSNP:rs137852823,PMID:14617756	
P29120	UniProtKB	Natural variant	221	221	.	.	.	ID=VAR_013907;Note=Risk factor for obesity%3B induces a 10.4%25 reduction of activity (P %3D 0.03) when compared to the wild-type enzyme. N->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:18604207;Dbxref=dbSNP:rs6232,PMID:10391209,PMID:18604207	
P29120	UniProtKB	Natural variant	307	307	.	.	.	ID=VAR_055002;Note=In PC1 deficiency%3B in vitro the mutation markedly impairs the catalytic activity of the enzyme%3B however intracellular trafficking of this mutant enzyme appears normal%3B retains some autocatalytic activity even though it is completely inactive on other substrates. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17595246;Dbxref=dbSNP:rs137852824,PMID:17595246	
P29120	UniProtKB	Natural variant	483	483	.	.	.	ID=VAR_022778;Note=In PC1 deficiency%3B prevents processing of pro-PCSK1 and leads to its retention in the endoplasmic reticulum. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9207799;Dbxref=dbSNP:rs137852821,PMID:9207799	
P29120	UniProtKB	Natural variant	665	665	.	.	.	ID=VAR_013908;Note=Q->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:17595246,ECO:0000269|PubMed:8666140;Dbxref=dbSNP:rs6234,PMID:10391209,PMID:17595246,PMID:8666140	
P29120	UniProtKB	Natural variant	690	690	.	.	.	ID=VAR_013909;Note=S->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10391209,ECO:0000269|PubMed:17595246;Dbxref=dbSNP:rs6235,PMID:10391209,PMID:17595246	
P29120	UniProtKB	Sequence conflict	357	357	.	.	.	Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P29120	UniProtKB	Sequence conflict	370	371	.	.	.	Note=LH->VD;Ontology_term=ECO:0000305;evidence=ECO:0000305	
P29120	UniProtKB	Sequence conflict	617	617	.	.	.	Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305