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P29107

- ILVC_SYNY3

UniProt

P29107 - ILVC_SYNY3

Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
    (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Sequence Analysis

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
    2. valine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00047; UER00056.
    UPA00049; UER00060.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ketol-acid reductoisomerase (EC:1.1.1.86)
    Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacyl reductoisomerase
    Gene namesi
    Name:ilvC
    Ordered Locus Names:sll1363
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 331330Ketol-acid reductoisomerasePRO_0000151372Add
    BLAST

    Proteomic databases

    PaxDbiP29107.

    Interactioni

    Subunit structurei

    Homooctamer.

    Protein-protein interaction databases

    DIPiDIP-48805N.
    IntActiP29107. 1 interaction.
    STRINGi1148.sll1363.

    Structurei

    3D structure databases

    ProteinModelPortaliP29107.
    SMRiP29107. Positions 3-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketol-acid reductoisomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG0059.
    HOGENOMiHOG000016230.
    KOiK00053.
    OMAiQSDVIMA.
    OrthoDBiEOG625K07.
    PhylomeDBiP29107.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    HAMAPiMF_00435. IlvC.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view]
    PANTHERiPTHR21371. PTHR21371. 1 hit.
    PfamiPF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00465. ilvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29107-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARMYYDQDA NLDLLAGKTV AIIGYGSQGH AHALNLKDSG VNVVVGLYSG    50
    SKSVAKAEGA GLKVLSVAEA AKAADLIMIL LPDEVQKTVY EAEIAPNLVA 100
    GNVLLFAHGF NINFAQIVPP ADVDVVMAAP KGPGHLVRRT YEQGQGVPAL 150
    FAVYQDASGQ ARDYAMAYAK GIGGTRAGIL ETTFREETET DLFGEQVVLC 200
    GGLTALIKAG FDTLVEAGYQ PELAYFECLH EVKLIVDLIV EGGLAKMRDS 250
    ISNTAEYGDL TRGPRIVTEE TKAEMRQILD EIQSGQFARE FVLENQAGKP 300
    GFTAMRRRES EELIEEVGKD LRAMFSWLKD R 331
    Length:331
    Mass (Da):35,822
    Last modified:January 23, 2007 - v3
    Checksum:i070C9D494F39CD44
    GO

    Sequence cautioni

    The sequence BAA18666.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18666.1. Different initiation.
    PIRiS76754. A47037.
    RefSeqiNP_442854.1. NC_000911.1.
    YP_007452730.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18666; BAA18666; BAA18666.
    GeneIDi952138.
    KEGGisyn:sll1363.
    syz:MYO_129910.
    PATRICi23843490. VBISynSp132158_3280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18666.1 . Different initiation.
    PIRi S76754. A47037.
    RefSeqi NP_442854.1. NC_000911.1.
    YP_007452730.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P29107.
    SMRi P29107. Positions 3-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48805N.
    IntActi P29107. 1 interaction.
    STRINGi 1148.sll1363.

    Proteomic databases

    PaxDbi P29107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18666 ; BAA18666 ; BAA18666 .
    GeneIDi 952138.
    KEGGi syn:sll1363.
    syz:MYO_129910.
    PATRICi 23843490. VBISynSp132158_3280.

    Phylogenomic databases

    eggNOGi COG0059.
    HOGENOMi HOG000016230.
    KOi K00053.
    OMAi QSDVIMA.
    OrthoDBi EOG625K07.
    PhylomeDBi P29107.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00056 .
    UPA00049 ; UER00060 .

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    HAMAPi MF_00435. IlvC.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013023. AcH_isomrdctse.
    IPR000506. AcH_isomrdctse_C.
    IPR013328. DH_multihelical.
    IPR013116. IlvN.
    [Graphical view ]
    PANTHERi PTHR21371. PTHR21371. 1 hit.
    Pfami PF01450. IlvC. 1 hit.
    PF07991. IlvN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00465. ilvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    2. "Purification of glutamyl-tRNA reductase from Synechocystis sp. PCC 6803."
      Rieble S., Beale S.I.
      J. Biol. Chem. 266:9740-9745(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-43.

    Entry informationi

    Entry nameiILVC_SYNY3
    AccessioniPrimary (citable) accession number: P29107
    Secondary accession number(s): P74559
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally isolated as a glutamyl-tRNA reductase.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3