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P29107

- ILVC_SYNY3

UniProt

P29107 - ILVC_SYNY3

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Protein

Ketol-acid reductoisomerase

Gene

ilvC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Sequence Analysis

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomerase (EC:1.1.1.86)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvC
Ordered Locus Names:sll1363
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 331330Ketol-acid reductoisomerasePRO_0000151372Add
BLAST

Proteomic databases

PaxDbiP29107.

Interactioni

Subunit structurei

Homooctamer.

Protein-protein interaction databases

DIPiDIP-48805N.
IntActiP29107. 1 interaction.
STRINGi1148.sll1363.

Structurei

3D structure databases

ProteinModelPortaliP29107.
SMRiP29107. Positions 3-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketol-acid reductoisomerase family.Curated

Phylogenomic databases

eggNOGiCOG0059.
HOGENOMiHOG000016230.
InParanoidiP29107.
KOiK00053.
OMAiQSDVIMA.
OrthoDBiEOG625K07.
PhylomeDBiP29107.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29107-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARMYYDQDA NLDLLAGKTV AIIGYGSQGH AHALNLKDSG VNVVVGLYSG
60 70 80 90 100
SKSVAKAEGA GLKVLSVAEA AKAADLIMIL LPDEVQKTVY EAEIAPNLVA
110 120 130 140 150
GNVLLFAHGF NINFAQIVPP ADVDVVMAAP KGPGHLVRRT YEQGQGVPAL
160 170 180 190 200
FAVYQDASGQ ARDYAMAYAK GIGGTRAGIL ETTFREETET DLFGEQVVLC
210 220 230 240 250
GGLTALIKAG FDTLVEAGYQ PELAYFECLH EVKLIVDLIV EGGLAKMRDS
260 270 280 290 300
ISNTAEYGDL TRGPRIVTEE TKAEMRQILD EIQSGQFARE FVLENQAGKP
310 320 330
GFTAMRRRES EELIEEVGKD LRAMFSWLKD R
Length:331
Mass (Da):35,822
Last modified:January 23, 2007 - v3
Checksum:i070C9D494F39CD44
GO

Sequence cautioni

The sequence BAA18666.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18666.1. Different initiation.
PIRiS76754. A47037.
RefSeqiNP_442854.1. NC_000911.1.
YP_007452730.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18666; BAA18666; BAA18666.
GeneIDi952138.
KEGGisyn:sll1363.
PATRICi23843490. VBISynSp132158_3280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18666.1 . Different initiation.
PIRi S76754. A47037.
RefSeqi NP_442854.1. NC_000911.1.
YP_007452730.1. NC_020286.1.

3D structure databases

ProteinModelPortali P29107.
SMRi P29107. Positions 3-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48805N.
IntActi P29107. 1 interaction.
STRINGi 1148.sll1363.

Proteomic databases

PaxDbi P29107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18666 ; BAA18666 ; BAA18666 .
GeneIDi 952138.
KEGGi syn:sll1363.
PATRICi 23843490. VBISynSp132158_3280.

Phylogenomic databases

eggNOGi COG0059.
HOGENOMi HOG000016230.
InParanoidi P29107.
KOi K00053.
OMAi QSDVIMA.
OrthoDBi EOG625K07.
PhylomeDBi P29107.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "Purification of glutamyl-tRNA reductase from Synechocystis sp. PCC 6803."
    Rieble S., Beale S.I.
    J. Biol. Chem. 266:9740-9745(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-43.

Entry informationi

Entry nameiILVC_SYNY3
AccessioniPrimary (citable) accession number: P29107
Secondary accession number(s): P74559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally isolated as a glutamyl-tRNA reductase.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3