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Protein

Type-1B angiotensin II receptor

Gene

Agtr1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • angiotensin type II receptor activity Source: InterPro
  • angiotensin type I receptor activity Source: RGD
  • peptide hormone binding Source: RGD
  • protein self-association Source: RGD

GO - Biological processi

  • angiotensin-activated signaling pathway Source: RGD
  • blood vessel development Source: Ensembl
  • cellular response to dexamethasone stimulus Source: UniProtKB
  • drinking behavior Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: RGD
  • inflammatory response Source: Ensembl
  • kidney development Source: Ensembl
  • phospholipase C-activating angiotensin-activated signaling pathway Source: GOC
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • regulation of renal output by angiotensin Source: RGD
  • regulation of vasoconstriction Source: InterPro
  • renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: RGD
  • response to angiotensin Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to hypoxia Source: RGD
  • response to immobilization stress Source: RGD
  • response to nicotine Source: RGD
  • response to nutrient Source: RGD
  • response to salt stress Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1B angiotensin II receptor
Alternative name(s):
AT3
Angiotensin II type-1B receptor
Short name:
AT1B
Gene namesi
Name:Agtr1b
Synonyms:Agtr1, At1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2071. Agtr1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 5225Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 6412CytoplasmicSequence analysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini88 – 10215ExtracellularSequence analysisAdd
BLAST
Transmembranei103 – 12422Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14218CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16220Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19230ExtracellularSequence analysisAdd
BLAST
Transmembranei193 – 21422Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini215 – 24026CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26222Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini263 – 27513ExtracellularSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 35963CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • vesicle lumen Source: RGD
  • vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2094250.
GuidetoPHARMACOLOGYi34.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Type-1B angiotensin II receptorPRO_0000069161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP29089.
PRIDEiP29089.

PTM databases

PhosphoSiteiP29089.

Expressioni

Tissue specificityi

Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, and vascular smooth muscle cell. Expressed most abundantly in the adrenal gland.1 Publication

Gene expression databases

GenevisibleiP29089. RN.

Interactioni

Subunit structurei

Interacts with MAS1 (By similarity). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity

GO - Molecular functioni

  • protein self-association Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014175.

Chemistry

BindingDBiP29089.

Structurei

3D structure databases

ProteinModelPortaliP29089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29089.
KOiK04166.
OMAiQKNTPRN.
OrthoDBiEOG7J4473.
PhylomeDBiP29089.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIYRNVY FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFVFPFLI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGI IRDCEIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPTAKSHAGL STKMSTLSYR PSDNMSSSAK

KSASFFEVE
Length:359
Mass (Da):40,912
Last modified:December 1, 1992 - v1
Checksum:iA2CC21E0B3365C5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → I (PubMed:1567388).Curated
Sequence conflicti2 – 21T → I (PubMed:1575725).Curated
Sequence conflicti40 – 401V → M (PubMed:1567388).Curated
Sequence conflicti40 – 401V → M (PubMed:1575725).Curated
Sequence conflicti75 – 751L → Y (PubMed:1575725).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87003 mRNA. Translation: AAA40739.1.
X64052 mRNA. Translation: CAA45410.1.
M90065 mRNA. Translation: AAA40704.1.
S37461 mRNA. Translation: AAB22267.1.
PIRiA42656.
JQ1516.
RefSeqiNP_112271.2. NM_031009.2.
XP_006232248.1. XM_006232186.2.
XP_006232249.1. XM_006232187.2.
XP_008759100.1. XM_008760878.1.
XP_008759101.1. XM_008760879.1.
UniGeneiRn.9815.

Genome annotation databases

EnsembliENSRNOT00000014178; ENSRNOP00000014175; ENSRNOG00000010640.
GeneIDi81638.
KEGGirno:81638.
UCSCiRGD:2071. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87003 mRNA. Translation: AAA40739.1.
X64052 mRNA. Translation: CAA45410.1.
M90065 mRNA. Translation: AAA40704.1.
S37461 mRNA. Translation: AAB22267.1.
PIRiA42656.
JQ1516.
RefSeqiNP_112271.2. NM_031009.2.
XP_006232248.1. XM_006232186.2.
XP_006232249.1. XM_006232187.2.
XP_008759100.1. XM_008760878.1.
XP_008759101.1. XM_008760879.1.
UniGeneiRn.9815.

3D structure databases

ProteinModelPortaliP29089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014175.

Chemistry

BindingDBiP29089.
ChEMBLiCHEMBL2094250.
GuidetoPHARMACOLOGYi34.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP29089.

Proteomic databases

PaxDbiP29089.
PRIDEiP29089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014178; ENSRNOP00000014175; ENSRNOG00000010640.
GeneIDi81638.
KEGGirno:81638.
UCSCiRGD:2071. rat.

Organism-specific databases

CTDi11608.
RGDi2071. Agtr1b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000234122.
HOVERGENiHBG104998.
InParanoidiP29089.
KOiK04166.
OMAiQKNTPRN.
OrthoDBiEOG7J4473.
PhylomeDBiP29089.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

NextBioi615132.
PROiP29089.

Gene expression databases

GenevisibleiP29089. RN.

Family and domain databases

InterProiIPR000190. ATII_AT1_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00635. ANGIOTENSN1R.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Angiotensin II type-1 receptor subtype cDNAs: differential tissue expression and hormonal regulation."
    Kakar S.S., Sellers J.C., Devor D.C., Musgrove L.C., Neill J.D.
    Biochem. Biophys. Res. Commun. 183:1090-1096(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary anterior lobe.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of two subtypes in the rat type I angiotensin II receptor."
    Iwai N., Inagami T.
    FEBS Lett. 298:257-260(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Adrenal gland.
  4. "Cloning and expression of a novel angiotensin II receptor subtype."
    Sandberg K., Ji H., Clark A.J., Shapira H., Catt K.J.
    J. Biol. Chem. 267:9455-9458(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal cortex.
  5. "Characterization of an angiotensin type-1 receptor partial cDNA from rat kidney: evidence for a novel AT1B receptor subtype."
    Ye M.Q., Healy D.P.
    Biochem. Biophys. Res. Commun. 185:204-210(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 84-259.
    Tissue: Kidney.

Entry informationi

Entry nameiAGTRB_RAT
AccessioniPrimary (citable) accession number: P29089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.