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P29074

- PTN4_HUMAN

UniProt

P29074 - PTN4_HUMAN

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Protein

Tyrosine-protein phosphatase non-receptor type 4

Gene

PTPN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May act at junctions between the membrane and the cytoskeleton.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei820 – 8201SubstrateBy similarity
Active sitei852 – 8521Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei896 – 8961SubstrateBy similarity

GO - Molecular functioni

  1. non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: GOC
  2. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 4 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG1
Short name:
MEG
Short name:
PTPase-MEG1
Gene namesi
Name:PTPN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9656. PTPN4.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic side of plasma membrane Source: UniProtKB
  3. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Tyrosine-protein phosphatase non-receptor type 4PRO_0000219434Add
BLAST

Proteomic databases

MaxQBiP29074.
PaxDbiP29074.
PeptideAtlasiP29074.
PRIDEiP29074.

PTM databases

PhosphoSiteiP29074.

Miscellaneous databases

PMAP-CutDBP29074.

Expressioni

Gene expression databases

BgeeiP29074.
CleanExiHS_PTPN4.
ExpressionAtlasiP29074. baseline and differential.
GenevestigatoriP29074.

Organism-specific databases

HPAiHPA019351.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKP461083EBI-710431,EBI-886
KAT5Q929932EBI-710431,EBI-399080
MAPK12P537782EBI-710431,EBI-602406
NCK1P163333EBI-710431,EBI-389883

Protein-protein interaction databases

BioGridi111741. 13 interactions.
DIPiDIP-34634N.
IntActiP29074. 14 interactions.
MINTiMINT-1367896.
STRINGi9606.ENSP00000263708.

Structurei

Secondary structure

1
926
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi516 – 5205Combined sources
Beta strandi524 – 5263Combined sources
Beta strandi530 – 5356Combined sources
Helixi536 – 5383Combined sources
Beta strandi540 – 5478Combined sources
Beta strandi549 – 5513Combined sources
Helixi552 – 5554Combined sources
Beta strandi556 – 5583Combined sources
Beta strandi565 – 5695Combined sources
Helixi579 – 5879Combined sources
Helixi589 – 5913Combined sources
Beta strandi596 – 6027Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CS5NMR-A507-612[»]
2I75X-ray2.45A611-926[»]
2VPHX-ray1.90A/B513-606[»]
3NFKX-ray1.43A/B499-604[»]
3NFLX-ray1.91A/B/C/D499-604[»]
ProteinModelPortaliP29074.
SMRiP29074. Positions 31-310, 513-913.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29074.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 312284FERMPROSITE-ProRule annotationAdd
BLAST
Domaini517 – 58973PDZPROSITE-ProRule annotationAdd
BLAST
Domaini655 – 911257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni852 – 8587Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00770000120472.
HOGENOMiHOG000007048.
HOVERGENiHBG008322.
InParanoidiP29074.
KOiK18037.
OMAiHTCTDFW.
OrthoDBiEOG76HQ1B.
PhylomeDBiP29074.
TreeFamiTF315900.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29074-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ
60 70 80 90 100
GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP
110 120 130 140 150
YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA
160 170 180 190 200
SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP
210 220 230 240 250
AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM
260 270 280 290 300
NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA
310 320 330 340 350
CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN
360 370 380 390 400
KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR
410 420 430 440 450
NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES
460 470 480 490 500
SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS
510 520 530 540 550
PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG
560 570 580 590 600
TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL
610 620 630 640 650
VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL
660 670 680 690 700
ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG
710 720 730 740 750
NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV
760 770 780 790 800
MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF
810 820 830 840 850
NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV
860 870 880 890 900
HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ
910 920
YRFVCEAILK VYEEGFVKPL TTSTNK
Length:926
Mass (Da):105,911
Last modified:December 1, 1992 - v1
Checksum:i4DAC6A87A675CFB0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311K → E in BAG37355. (PubMed:14702039)Curated
Sequence conflicti772 – 7721G → K no nucleotide entry (PubMed:8483328)Curated
Sequence conflicti863 – 8631I → V in BAG37355. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti924 – 9241T → S.
Corresponds to variant rs3189128 [ dbSNP | Ensembl ].
VAR_061033

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68941 mRNA. Translation: AAA36530.1.
AK314836 mRNA. Translation: BAG37355.1.
BC010674 mRNA. Translation: AAH10674.1.
CCDSiCCDS2129.1.
PIRiA41105.
RefSeqiNP_002821.1. NM_002830.3.
UniGeneiHs.469809.

Genome annotation databases

EnsembliENST00000263708; ENSP00000263708; ENSG00000088179.
GeneIDi5775.
KEGGihsa:5775.
UCSCiuc002tmf.2. human.

Polymorphism databases

DMDMi131531.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68941 mRNA. Translation: AAA36530.1 .
AK314836 mRNA. Translation: BAG37355.1 .
BC010674 mRNA. Translation: AAH10674.1 .
CCDSi CCDS2129.1.
PIRi A41105.
RefSeqi NP_002821.1. NM_002830.3.
UniGenei Hs.469809.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CS5 NMR - A 507-612 [» ]
2I75 X-ray 2.45 A 611-926 [» ]
2VPH X-ray 1.90 A/B 513-606 [» ]
3NFK X-ray 1.43 A/B 499-604 [» ]
3NFL X-ray 1.91 A/B/C/D 499-604 [» ]
ProteinModelPortali P29074.
SMRi P29074. Positions 31-310, 513-913.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111741. 13 interactions.
DIPi DIP-34634N.
IntActi P29074. 14 interactions.
MINTi MINT-1367896.
STRINGi 9606.ENSP00000263708.

Chemistry

BindingDBi P29074.
ChEMBLi CHEMBL3165.
DrugBanki DB00630. Alendronate.

PTM databases

PhosphoSitei P29074.

Polymorphism databases

DMDMi 131531.

Proteomic databases

MaxQBi P29074.
PaxDbi P29074.
PeptideAtlasi P29074.
PRIDEi P29074.

Protocols and materials databases

DNASUi 5775.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263708 ; ENSP00000263708 ; ENSG00000088179 .
GeneIDi 5775.
KEGGi hsa:5775.
UCSCi uc002tmf.2. human.

Organism-specific databases

CTDi 5775.
GeneCardsi GC02P120612.
HGNCi HGNC:9656. PTPN4.
HPAi HPA019351.
MIMi 176878. gene.
neXtProti NX_P29074.
PharmGKBi PA34000.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00770000120472.
HOGENOMi HOG000007048.
HOVERGENi HBG008322.
InParanoidi P29074.
KOi K18037.
OMAi HTCTDFW.
OrthoDBi EOG76HQ1B.
PhylomeDBi P29074.
TreeFami TF315900.

Miscellaneous databases

ChiTaRSi PTPN4. human.
EvolutionaryTracei P29074.
GeneWikii PTPN4.
GenomeRNAii 5775.
NextBioi 22462.
PMAP-CutDB P29074.
PROi P29074.
SOURCEi Search...

Gene expression databases

Bgeei P29074.
CleanExi HS_PTPN4.
ExpressionAtlasi P29074. baseline and differential.
Genevestigatori P29074.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1."
    Gu M., York J.D., Warshawsky I., Majerus P.W.
    Proc. Natl. Acad. Sci. U.S.A. 88:5867-5871(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. "Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P."
    Honda H., Shibuya M., Chiba S., Yazaki Y., Hirai H.
    Leukemia 7:742-746(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 745-858.
    Tissue: Leukemia.
  5. "Solution structure of PDZ domain of protein tyrosine phosphatase, non-receptor type 4."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 507-612.

Entry informationi

Entry nameiPTN4_HUMAN
AccessioniPrimary (citable) accession number: P29074
Secondary accession number(s): B2RBV8, Q9UDA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3