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P29074 (PTN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 4

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase MEG1
Short name=MEG
Short name=PTPase-MEG1
Gene names
Name:PTPN4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act at junctions between the membrane and the cytoskeleton.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 PDZ (DHR) domain.

Contains 1 tyrosine-protein phosphatase domain.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 926926Tyrosine-protein phosphatase non-receptor type 4
PRO_0000219434

Regions

Domain29 – 312284FERM
Domain517 – 58973PDZ
Domain655 – 911257Tyrosine-protein phosphatase
Region852 – 8587Substrate binding By similarity

Sites

Active site8521Phosphocysteine intermediate By similarity
Binding site8201Substrate By similarity
Binding site8961Substrate By similarity

Natural variations

Natural variant9241T → S.
Corresponds to variant rs3189128 [ dbSNP | Ensembl ].
VAR_061033

Experimental info

Sequence conflict1311K → E in BAG37355. Ref.2
Sequence conflict7721G → K no nucleotide entry Ref.4
Sequence conflict8631I → V in BAG37355. Ref.2

Secondary structure

...................... 926
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P29074 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 4DAC6A87A675CFB0

FASTA926105,911
        10         20         30         40         50         60 
MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ GQVLLDVVFK 

        70         80         90        100        110        120 
HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE 

       130        140        150        160        170        180 
YTRYQYFLQI KQDILTGRLP CPSNTAALLA SFAVQSELGD YDQSENLSGY LSDYSFIPNQ 

       190        200        210        220        230        240 
PQDFEKEIAK LHQQHIGLSP AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG 

       250        260        270        280        290        300 
ILIYKNRVRM NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA 

       310        320        330        340        350        360 
CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS 

       370        380        390        400        410        420 
KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR NSTFTQEGTR LRPSSVGHLV 

       430        440        450        460        470        480 
DHMVHTSPSE VFVNQRSPSS TQANSIVLES SPSQETPGDG KPPALPPKQS KKNSWNQIHY 

       490        500        510        520        530        540 
SHSQQDLESH INETFDIPSS PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM 

       550        560        570        580        590        600 
PVIVSRVAPG TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL 

       610        620        630        640        650        660 
VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL ITGTVLTQFD 

       670        680        690        700        710        720 
QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG NEDYINANYI NMEIPSSSII 

       730        740        750        760        770        780 
NQYIACQGPL PHTCTDFWQM TWEQGSSMVV MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ 

       790        800        810        820        830        840 
VTCHSEEGNT AYIFRKMTLF NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK 

       850        860        870        880        890        900 
RAGKEEPVVV HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ 

       910        920 
YRFVCEAILK VYEEGFVKPL TTSTNK 

« Hide

References

« Hide 'large scale' references
[1]"Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1."
Gu M., York J.D., Warshawsky I., Majerus P.W.
Proc. Natl. Acad. Sci. U.S.A. 88:5867-5871(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P."
Honda H., Shibuya M., Chiba S., Yazaki Y., Hirai H.
Leukemia 7:742-746(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 745-858.
Tissue: Leukemia.
[5]"Solution structure of PDZ domain of protein tyrosine phosphatase, non-receptor type 4."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 507-612.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M68941 mRNA. Translation: AAA36530.1.
AK314836 mRNA. Translation: BAG37355.1.
BC010674 mRNA. Translation: AAH10674.1.
PIRA41105.
RefSeqNP_002821.1. NM_002830.3.
UniGeneHs.469809.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CS5NMR-A507-612[»]
2I75X-ray2.45A611-926[»]
2VPHX-ray1.90A/B513-606[»]
3NFKX-ray1.43A/B499-604[»]
3NFLX-ray1.91A/B/C/D499-604[»]
ProteinModelPortalP29074.
SMRP29074. Positions 27-335, 513-913.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111741. 12 interactions.
DIPDIP-34634N.
IntActP29074. 13 interactions.
MINTMINT-1367896.
STRING9606.ENSP00000263708.

Chemistry

BindingDBP29074.
ChEMBLCHEMBL3165.
DrugBankDB00630. Alendronate.

PTM databases

PhosphoSiteP29074.

Polymorphism databases

DMDM131531.

Proteomic databases

PaxDbP29074.
PeptideAtlasP29074.
PRIDEP29074.

Protocols and materials databases

DNASU5775.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263708; ENSP00000263708; ENSG00000088179.
GeneID5775.
KEGGhsa:5775.
UCSCuc002tmf.2. human.

Organism-specific databases

CTD5775.
GeneCardsGC02P120612.
HGNCHGNC:9656. PTPN4.
HPAHPA019351.
MIM176878. gene.
neXtProtNX_P29074.
PharmGKBPA34000.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000007048.
HOVERGENHBG008322.
InParanoidP29074.
KOK01104.
OMAHTCTDFW.
OrthoDBEOG76HQ1B.
PhylomeDBP29074.
TreeFamTF315900.

Gene expression databases

ArrayExpressP29074.
BgeeP29074.
CleanExHS_PTPN4.
GenevestigatorP29074.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000927. Tyr-Ptase_nr3. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00228. PDZ. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS50106. PDZ. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP29074.
GeneWikiPTPN4.
GenomeRNAi5775.
NextBio22462.
PMAP-CutDBP29074.
PROP29074.
SOURCESearch...

Entry information

Entry namePTN4_HUMAN
AccessionPrimary (citable) accession number: P29074
Secondary accession number(s): B2RBV8, Q9UDA7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 19, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM