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P29074

- PTN4_HUMAN

UniProt

P29074 - PTN4_HUMAN

Protein

Tyrosine-protein phosphatase non-receptor type 4

Gene

PTPN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    May act at junctions between the membrane and the cytoskeleton.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei820 – 8201SubstrateBy similarity
    Active sitei852 – 8521Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei896 – 8961SubstrateBy similarity

    GO - Molecular functioni

    1. non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. peptidyl-tyrosine dephosphorylation Source: GOC
    2. protein dephosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 4 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase MEG1
    Short name:
    MEG
    Short name:
    PTPase-MEG1
    Gene namesi
    Name:PTPN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:9656. PTPN4.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic side of plasma membrane Source: UniProtKB
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34000.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 926926Tyrosine-protein phosphatase non-receptor type 4PRO_0000219434Add
    BLAST

    Proteomic databases

    MaxQBiP29074.
    PaxDbiP29074.
    PeptideAtlasiP29074.
    PRIDEiP29074.

    PTM databases

    PhosphoSiteiP29074.

    Miscellaneous databases

    PMAP-CutDBP29074.

    Expressioni

    Gene expression databases

    ArrayExpressiP29074.
    BgeeiP29074.
    CleanExiHS_PTPN4.
    GenevestigatoriP29074.

    Organism-specific databases

    HPAiHPA019351.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRKP461083EBI-710431,EBI-886
    KAT5Q929932EBI-710431,EBI-399080
    NCK1P163333EBI-710431,EBI-389883

    Protein-protein interaction databases

    BioGridi111741. 12 interactions.
    DIPiDIP-34634N.
    IntActiP29074. 13 interactions.
    MINTiMINT-1367896.
    STRINGi9606.ENSP00000263708.

    Structurei

    Secondary structure

    1
    926
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi516 – 5205
    Beta strandi524 – 5263
    Beta strandi530 – 5356
    Helixi536 – 5383
    Beta strandi540 – 5478
    Beta strandi549 – 5513
    Helixi552 – 5554
    Beta strandi556 – 5583
    Beta strandi565 – 5695
    Helixi579 – 5879
    Helixi589 – 5913
    Beta strandi596 – 6027

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CS5NMR-A507-612[»]
    2I75X-ray2.45A611-926[»]
    2VPHX-ray1.90A/B513-606[»]
    3NFKX-ray1.43A/B499-604[»]
    3NFLX-ray1.91A/B/C/D499-604[»]
    ProteinModelPortaliP29074.
    SMRiP29074. Positions 31-310, 513-913.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP29074.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 312284FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 58973PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 911257Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni852 – 8587Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000007048.
    HOVERGENiHBG008322.
    InParanoidiP29074.
    KOiK18037.
    OMAiHTCTDFW.
    OrthoDBiEOG76HQ1B.
    PhylomeDBiP29074.
    TreeFamiTF315900.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ    50
    GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP 100
    YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA 150
    SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP 200
    AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM 250
    NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA 300
    CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN 350
    KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR 400
    NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES 450
    SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS 500
    PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG 550
    TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL 600
    VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL 650
    ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG 700
    NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV 750
    MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF 800
    NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV 850
    HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ 900
    YRFVCEAILK VYEEGFVKPL TTSTNK 926
    Length:926
    Mass (Da):105,911
    Last modified:December 1, 1992 - v1
    Checksum:i4DAC6A87A675CFB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti131 – 1311K → E in BAG37355. (PubMed:14702039)Curated
    Sequence conflicti772 – 7721G → K no nucleotide entry (PubMed:8483328)Curated
    Sequence conflicti863 – 8631I → V in BAG37355. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti924 – 9241T → S.
    Corresponds to variant rs3189128 [ dbSNP | Ensembl ].
    VAR_061033

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68941 mRNA. Translation: AAA36530.1.
    AK314836 mRNA. Translation: BAG37355.1.
    BC010674 mRNA. Translation: AAH10674.1.
    CCDSiCCDS2129.1.
    PIRiA41105.
    RefSeqiNP_002821.1. NM_002830.3.
    UniGeneiHs.469809.

    Genome annotation databases

    EnsembliENST00000263708; ENSP00000263708; ENSG00000088179.
    GeneIDi5775.
    KEGGihsa:5775.
    UCSCiuc002tmf.2. human.

    Polymorphism databases

    DMDMi131531.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68941 mRNA. Translation: AAA36530.1 .
    AK314836 mRNA. Translation: BAG37355.1 .
    BC010674 mRNA. Translation: AAH10674.1 .
    CCDSi CCDS2129.1.
    PIRi A41105.
    RefSeqi NP_002821.1. NM_002830.3.
    UniGenei Hs.469809.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CS5 NMR - A 507-612 [» ]
    2I75 X-ray 2.45 A 611-926 [» ]
    2VPH X-ray 1.90 A/B 513-606 [» ]
    3NFK X-ray 1.43 A/B 499-604 [» ]
    3NFL X-ray 1.91 A/B/C/D 499-604 [» ]
    ProteinModelPortali P29074.
    SMRi P29074. Positions 31-310, 513-913.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111741. 12 interactions.
    DIPi DIP-34634N.
    IntActi P29074. 13 interactions.
    MINTi MINT-1367896.
    STRINGi 9606.ENSP00000263708.

    Chemistry

    BindingDBi P29074.
    ChEMBLi CHEMBL3165.
    DrugBanki DB00630. Alendronate.

    PTM databases

    PhosphoSitei P29074.

    Polymorphism databases

    DMDMi 131531.

    Proteomic databases

    MaxQBi P29074.
    PaxDbi P29074.
    PeptideAtlasi P29074.
    PRIDEi P29074.

    Protocols and materials databases

    DNASUi 5775.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263708 ; ENSP00000263708 ; ENSG00000088179 .
    GeneIDi 5775.
    KEGGi hsa:5775.
    UCSCi uc002tmf.2. human.

    Organism-specific databases

    CTDi 5775.
    GeneCardsi GC02P120612.
    HGNCi HGNC:9656. PTPN4.
    HPAi HPA019351.
    MIMi 176878. gene.
    neXtProti NX_P29074.
    PharmGKBi PA34000.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000007048.
    HOVERGENi HBG008322.
    InParanoidi P29074.
    KOi K18037.
    OMAi HTCTDFW.
    OrthoDBi EOG76HQ1B.
    PhylomeDBi P29074.
    TreeFami TF315900.

    Miscellaneous databases

    EvolutionaryTracei P29074.
    GeneWikii PTPN4.
    GenomeRNAii 5775.
    NextBioi 22462.
    PMAP-CutDB P29074.
    PROi P29074.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29074.
    Bgeei P29074.
    CleanExi HS_PTPN4.
    Genevestigatori P29074.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    2.30.42.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014847. FERM-adjacent.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR001478. PDZ.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012151. Tyr_Pase_non-rcpt_typ-3/4.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08736. FA. 1 hit.
    PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000927. Tyr-Ptase_nr3. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00228. PDZ. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50106. PDZ. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1."
      Gu M., York J.D., Warshawsky I., Majerus P.W.
      Proc. Natl. Acad. Sci. U.S.A. 88:5867-5871(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    4. "Identification of novel protein-tyrosine phosphatases in a human leukemia cell line, F-36P."
      Honda H., Shibuya M., Chiba S., Yazaki Y., Hirai H.
      Leukemia 7:742-746(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 745-858.
      Tissue: Leukemia.
    5. "Solution structure of PDZ domain of protein tyrosine phosphatase, non-receptor type 4."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 507-612.

    Entry informationi

    Entry nameiPTN4_HUMAN
    AccessioniPrimary (citable) accession number: P29074
    Secondary accession number(s): B2RBV8, Q9UDA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3