Reviewed, UniProtKB/Swiss-Prot P29067 (ARRB2_RAT)

Names and origin

Protein names

Recommended name:
    Beta-arrestin-2
Alternative name(s):
    Arrestin beta-2

Gene names

Name:

Arrb2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Tissue specificity	Predominantly localized in neuronal tissues and in the spleen.
Sequence similarities	Belongs to the arrestin family.

Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Cytoplasm Nucleus
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from direct assay. Source: RGD desensitization of G-protein coupled receptor protein signaling pathway by arrestin Traceable author statement. Source: RGD endocytosis Inferred from direct assay. Source: RGD regulation of cAMP biosynthetic process Traceable author statement. Source: RGD regulation of cAMP catabolic process Traceable author statement. Source: RGD response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell postsynaptic membrane Ref.1 Inferred from direct assay. Source: RGD
Molecular function	G-protein-coupled receptor binding Traceable author statement. Source: RGD clathrin binding Traceable author statement. Source: RGD protein domain specific binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
AKT1	P31749	2	EBI-1636616,EBI-296087	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Beta-arrestin-2		PRO_0000205201
Regions
	Motif	390 – 400	11	Nuclear export signal By similarity
Amino acid modifications
	Modified residue	48	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P29067-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 0DFA6A897C2B86BA	FASTA	410	46,340
	10 20 30 40 50 60 MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC 70 80 90 100 110 120 AFRYGREDLD VLGLSFRKDL FIATYQAFPP MPNPPRPPTR LQDRLLKKLG QHAHPFFFTI 130 140 150 160 170 180 PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSIEEKSH KRNSVRLIIR KVQFAPETPG 190 200 210 220 230 240 PQPSAETTRH FLMSDRRSLH LEASLDKELY YHGEPLNVNV HVTNNSAKTV KKIRVSVRQY 250 260 270 280 290 300 ADICLFSTAQ YKCPVAQLEQ DDQVSPSSTF CKVYTITPLL SDNREKRGLA LDGQLKHEDT 310 320 330 340 350 360 NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHITLPRPQ 370 380 390 400 410 SAPREIDIPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDCDDQFC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family." Attramadal H., Arriza J.L., Aoki C., Dawson T.M., Codina J., Kwatra M.M., Snyder S.H., Caron M.G., Lefkowitz R.J. J. Biol. Chem. 267:17882-17890(1992) [PubMed: 1517224] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Cone arrestin identified by targeting expression of a functional family." Craft C.M., Whitmore D.H., Wiechmann A.F. J. Biol. Chem. 269:4613-4619(1994) [PubMed: 8308033] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-410. Tissue: Pineal gland.
[4]	"Differential expression of alternative splice variants of beta-arrestin-1 and -2 in rat central nervous system and peripheral tissues." Komori N., Cain S.D., Roch J.-M., Miller K.E., Matsumoto H. Eur. J. Neurosci. 10:2607-2616(1998) [PubMed: 9767391] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 305-386. Strain: Sprague-Dawley. Tissue: Retina.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M91590 mRNA. Translation: AAA74460.1. BC087578 mRNA. Translation: AAH87578.1. U03627 mRNA. Translation: AAA17551.1. AF051457 Genomic DNA. Translation: AAC28617.1.
IPI	IPI00231135.
PIR	A59279.
RefSeq	NP_037043.1.
UniGene	Rn.32973
3D structure databases
HSSP	HSSP built from PDB template 1G4M based on UniProtKB P17870.
ModBase	Search...
Protein-protein interaction databases
IntAct	P29067. 5 interactions.
PTM databases
PhosphoSite	P29067.
Genome annotation databases
Ensembl	ENSRNOG00000019308. Rattus norvegicus. [Contig view]
GeneID	25388.
KEGG	rno:25388.
Organism-specific databases
RGD	2157. Arrb2.
Phylogenomic databases
HOVERGEN	P29067.
Gene expression databases
GermOnline	ENSRNOG00000019308. Rattus norvegicus.
Family and domain databases
InterPro	IPR000698. Arrestin. IPR011022. Arrestin-like_C. IPR011021. Arrestin-like_N. IPR014752. Arrestin_C. IPR017864. Arrestin_CS. IPR014753. Arrestin_N. [Graphical view]
Gene3D	G3DSA:2.60.40.640. Arrestin_C. 1 hit. G3DSA:2.60.40.840. Arrestin_N. 1 hit.
PANTHER	PTHR11792. Arrestin. 1 hit.
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
PRINTS	PR00309. ARRESTIN.
ProDom	PD002099. Arrestin. 2 hits. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00295. ARRESTINS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	606447.

Entry information

Entry name

ARRB2_RAT

Accession

Primary (citable) accession number: P29067

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)