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P29064

- AGLU_CANTS

UniProt

P29064 - AGLU_CANTS

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Protein
Alpha-glucosidase
Gene
N/A
Organism
Candida tsukubaensis (Yeast) (Pseudozyma tsukubaensis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes a broad range of alpha-D-linked glucopyranosides, including maltose (alpha-1,4), sucrose (alpha-1,2), isomaltose (alpha-1,6) and turanose (alpha-1,3).

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei526 – 5261Nucleophile By similarity
Active sitei529 – 5291 By similarity
Active sitei730 – 7301Proton donor By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH31. Glycoside Hydrolase Family 31.
mycoCLAPiAGL31A_CANTS.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Cleaved into the following 2 chains:
OrganismiCandida tsukubaensis (Yeast) (Pseudozyma tsukubaensis)
Taxonomic identifieri5483 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaemitosporic UstilaginaceaePseudozyma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 Publication
Add
BLAST
Chaini36 – 612577Alpha-glucosidase subunit 1
PRO_0000018578Add
BLAST
Chaini613 – 1070458Alpha-glucosidase subunit 2
PRO_0000018579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi208 – 2081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi384 – 3841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi458 – 4581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi513 – 5131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi566 – 5661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi578 – 5781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi635 – 6351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi818 – 8181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi885 – 8851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi916 – 9161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi983 – 9831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi992 – 9921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi996 – 9961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1008 – 10081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1029 – 10291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1043 – 10431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1052 – 10521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP29064.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi332 – 3387Poly-Ser

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29064-1 [UniParc]FASTAAdd to Basket

« Hide

MRSIKAASLT PLLAALFTTL SSTLALPSSV WEHQLETNVL ALRDTNNNGS     50
SSTISPSFDV TKCPGYKLVG QPQQSQHGFT AQLSLAGDAC NAYGVDIANL 100
TLSVVYEKQH QLHVHIYDTA KQQYQLPNGL IFDRPGDNPA DIQNGSTADQ 150
SDLVFHHTAE NGTQSGNGGW AFWIARKSSG DVIFDTRASN IPTYNDGLSS 200
VSSNTKRNTT AMPAHEMVFE NQYLQISSAL PTGANIYGLG EYVTGSFRRN 250
PDETLQPFFT LDAGTPVDSN MYGYHPIYTE ARRGSDGKLR THSVHLQNTA 300
GMDVLLRRGV IQYRAIGGTL DFRFFSGDQP ASSSSSSSGN DKAVATVKNS 350
PNTAIQQYVN FIGNPVIHPY WSYGFHLCRW GYNNVSETQA VIDAMRQNNI 400
PLEVQWNDID YLQEFRDFTT DPQRFPQKEF AAMIAKLKDN HQHYIPIIDM 450
AIPKAPTNDT DVYYPGTRGD ELDVFIKNRN GSQYIGEVWP GYTNFVDQQA 500
ENAGKWWTEA IRNFSEIVDF SGIWLDMNEP SSFVIGNAAG PETNLSNTPA 550
YTAATSVAGW PQGYNNLTWG TSGNITVNGS YTYQQGPVQN NDGSKQRRSL 600
LLSRDEDVLV QRDINVNGGN GDKFGPEDPN YQYANSSQRY LSNPPYAIHN 650
GIHISETPLN VNLDKKTVAM EAVGVDGQRA FYDVHNLDGT LEEQHFYNAL 700
RDIRPQERPF LISRSTYPGA GKFTGHWLGD NYALWTILPG EEAYKAGAGM 750
AQSIDGVLQF QIFGIHLIGA DICGFNRNSD EELCNRWMML GAFLPFMRNH 800
NTIGAIAQEP FRWDSVANAS RIAINKRYEI LPSLYSHMAQ SAESGEPAVR 850
ALWYEFDEVF EQTKDYAHQF LFGDDLLVSP VLEPNVTQIK ALFPNAGGKW 900
RNVFSYEALD VEYNKNVTVD AALSTINVHL RPGKVLLTHS KPAYTVYETA 950
QSPYGLIVNL NDQGEAKQTF YLDDGMTPAP TPNSTLTVSA GNNSVNGSIE 1000
GEYKAQQNLT YVVVLDVKQK PTQVMMGGNK TEFSWDQQKT LLNVTGLNAD 1050
LNGSGRFRGL RLELSLLCED 1070
Length:1,070
Mass (Da):118,631
Last modified:December 1, 1992 - v1
Checksum:iEE990FAA0770FA4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56024 Genomic DNA. Translation: CAA39501.1.
PIRiS19686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56024 Genomic DNA. Translation: CAA39501.1 .
PIRi S19686.

3D structure databases

ProteinModelPortali P29064.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH31. Glycoside Hydrolase Family 31.
mycoCLAPi AGL31A_CANTS.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
PS00707. GLYCOSYL_HYDROL_F31_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure and processing of the Candida tsukubaensis alpha-glucosidase. Homology with the rabbit intestinal sucrase-isomaltase complex and human lysosomal alpha-glucosidase."
    Kinsella B.T., Hogan S., Larkin A., Cantwell B.A.
    Eur. J. Biochem. 202:657-664(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 36-49 AND 613-634.
    Strain: CBS 6389.

Entry informationi

Entry nameiAGLU_CANTS
AccessioniPrimary (citable) accession number: P29064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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