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P29037

- TBP_MOUSE

UniProt

P29037 - TBP_MOUSE

Protein

TATA-box-binding protein

Gene

Tbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: UniProtKB
    3. RNA polymerase II repressing transcription factor binding Source: MGI
    4. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: InterPro
    2. positive regulation of transcription, DNA-templated Source: Ensembl
    3. spermatogenesis Source: Ensembl
    4. transcription from RNA polymerase III promoter Source: MGI
    5. transcription from RNA polymerase II promoter Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_224328. SIRT1 negatively regulates rRNA Expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA-box-binding protein
    Alternative name(s):
    TATA sequence-binding protein
    TATA-binding factor
    TATA-box factor
    Transcription initiation factor TFIID TBP subunit
    Gene namesi
    Name:Tbp
    Synonyms:Tfiid
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:101838. Tbp.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. female pronucleus Source: MGI
    3. male pronucleus Source: MGI
    4. nuclear euchromatin Source: Ensembl
    5. nucleus Source: MGI
    6. pronucleus Source: MGI
    7. RNA polymerase I transcription factor complex Source: MGI
    8. transcription factor TFIIA complex Source: Ensembl
    9. transcription factor TFIID complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316TATA-box-binding proteinPRO_0000153958Add
    BLAST

    Proteomic databases

    PaxDbiP29037.
    PRIDEiP29037.

    PTM databases

    PhosphoSiteiP29037.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiP29037.
    BgeeiP29037.
    CleanExiMM_TBP.
    GenevestigatoriP29037.

    Interactioni

    Subunit structurei

    Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with BRF2. Interacts with UBTF By similarity. Interacts with UTF1. Interacts with GPBP1. Interacts with SP1 By similarity. Interacts with CITED2.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi203978. 30 interactions.
    DIPiDIP-24197N.
    IntActiP29037. 7 interactions.
    MINTiMINT-4590211.

    Structurei

    3D structure databases

    ProteinModelPortaliP29037.
    SMRiP29037. Positions 136-314.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati142 – 218771Add
    BLAST
    Repeati232 – 309782Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi55 – 7016Poly-GlnAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TBP family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2101.
    HOGENOMiHOG000105164.
    HOVERGENiHBG044997.
    InParanoidiP29037.
    KOiK03120.
    OMAiGQAPQLF.
    PhylomeDBiP29037.
    TreeFamiTF300102.

    Family and domain databases

    Gene3Di3.30.310.10. 2 hits.
    HAMAPiMF_00408. TATA_bind_prot_arch.
    InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view]
    PANTHERiPTHR10126. PTHR10126. 1 hit.
    PfamiPF00352. TBP. 2 hits.
    [Graphical view]
    PRINTSiPR00686. TIFACTORIID.
    PROSITEiPS00351. TFIID. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29037-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS    50
    ILEEQQRQQQ QQQQQQQQQQ AVATAAASVQ QSTSQQPTQG ASGQTPQLFH 100
    SQTLTTAPLP GTTPLYPSPM TPMTPITPAT PASESSGIVP QLQNIVSTVN 150
    LGCKLDLKTI ALRARNAEYN PKRFAAVIMR IREPRTTALI FSSGKMVCTG 200
    AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD VKFPIRLEGL 250
    VLTHQQFSSY EPELFPGLIY RMIKPRIVLL IFVSGKVVLT GAKVRAEIYE 300
    AFENIYPILK GFRKTT 316
    Length:316
    Mass (Da):34,709
    Last modified:December 1, 1992 - v1
    Checksum:iA33D776160B4A393
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411Q → R in AAH50136. (PubMed:15489334)Curated
    Sequence conflicti164 – 1641A → P in BAC39346. (PubMed:16141072)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti70 – 701Q → QQQ in strain: TW18/TW5.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01034 mRNA. Translation: BAA00840.1.
    U63933 mRNA. Translation: AAB53097.1.
    AK085037 mRNA. Translation: BAC39346.1.
    BC050136 mRNA. Translation: AAH50136.1.
    BC012685 mRNA. Translation: AAH12685.1.
    CCDSiCCDS37454.2.
    PIRiS34437.
    RefSeqiNP_038712.3. NM_013684.3.
    UniGeneiMm.244820.

    Genome annotation databases

    EnsembliENSMUST00000014911; ENSMUSP00000014911; ENSMUSG00000014767.
    ENSMUST00000117593; ENSMUSP00000112794; ENSMUSG00000014767.
    ENSMUST00000162505; ENSMUSP00000124317; ENSMUSG00000014767.
    GeneIDi21374.
    KEGGimmu:21374.
    UCSCiuc008aon.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D01034 mRNA. Translation: BAA00840.1 .
    U63933 mRNA. Translation: AAB53097.1 .
    AK085037 mRNA. Translation: BAC39346.1 .
    BC050136 mRNA. Translation: AAH50136.1 .
    BC012685 mRNA. Translation: AAH12685.1 .
    CCDSi CCDS37454.2.
    PIRi S34437.
    RefSeqi NP_038712.3. NM_013684.3.
    UniGenei Mm.244820.

    3D structure databases

    ProteinModelPortali P29037.
    SMRi P29037. Positions 136-314.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203978. 30 interactions.
    DIPi DIP-24197N.
    IntActi P29037. 7 interactions.
    MINTi MINT-4590211.

    PTM databases

    PhosphoSitei P29037.

    Proteomic databases

    PaxDbi P29037.
    PRIDEi P29037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014911 ; ENSMUSP00000014911 ; ENSMUSG00000014767 .
    ENSMUST00000117593 ; ENSMUSP00000112794 ; ENSMUSG00000014767 .
    ENSMUST00000162505 ; ENSMUSP00000124317 ; ENSMUSG00000014767 .
    GeneIDi 21374.
    KEGGi mmu:21374.
    UCSCi uc008aon.2. mouse.

    Organism-specific databases

    CTDi 6908.
    MGIi MGI:101838. Tbp.

    Phylogenomic databases

    eggNOGi COG2101.
    HOGENOMi HOG000105164.
    HOVERGENi HBG044997.
    InParanoidi P29037.
    KOi K03120.
    OMAi GQAPQLF.
    PhylomeDBi P29037.
    TreeFami TF300102.

    Enzyme and pathway databases

    Reactomei REACT_224328. SIRT1 negatively regulates rRNA Expression.

    Miscellaneous databases

    NextBioi 300592.
    PROi P29037.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29037.
    Bgeei P29037.
    CleanExi MM_TBP.
    Genevestigatori P29037.

    Family and domain databases

    Gene3Di 3.30.310.10. 2 hits.
    HAMAPi MF_00408. TATA_bind_prot_arch.
    InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view ]
    PANTHERi PTHR10126. PTHR10126. 1 hit.
    Pfami PF00352. TBP. 2 hits.
    [Graphical view ]
    PRINTSi PR00686. TIFACTORIID.
    PROSITEi PS00351. TFIID. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID)."
      Tamura T.-A., Sumita K., Fujino I., Aoyama A., Horikoshi M., Hoffmann A., Roeder R.G., Muramatsu M., Mikoshiba K.
      Nucleic Acids Res. 19:3861-3865(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome."
      Sumita K., Makino Y., Katoh K., Kashimoto T., Muramatsu M., Mikoshiba K., Tamura T.-A.
      Nucleic Acids Res. 21:2769-2769(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates."
      Trachtulec Z., Hamvas R.M., Forejt J., Lehrach H.R., Vincek V., Klein J.
      Genomics 44:1-7(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: TW18/TW5.
      Tissue: Testis.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    5. "Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice."
      Xiao L., Kim M., DeJong J.
      Gene Expr. Patterns 6:409-419(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: B5/EGFP transgenic ICR mice and FVB/N.
      Tissue: Mammary tumor and Trophoblast.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
    8. "Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1."
      Heix J., Zomerdijk J.C.B.M., Ravanpay A., Tjian R., Grummt I.
      Proc. Natl. Acad. Sci. U.S.A. 94:1733-1738(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TAF1A; TAF1B AND TAF1C.
    9. "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells."
      Okuda A., Fukushima A., Nishimoto M., Orimo A., Yamagishi T., Nabeshima Y., Kuro-o M., Nabeshima Y., Boon K., Keaveney M., Stunnenberg H.G., Muramatsu M.
      EMBO J. 17:2019-2032(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH UTF1.
    10. "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression."
      Glenn D.J., Maurer R.A.
      J. Biol. Chem. 274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CITED2.
    11. "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription."
      Hsu L.-C., Liu S., Abedinpour F., Beech R.D., Lahti J.M., Kidd V.J., Greenspan J.A., Yeung C.-Y.
      Mol. Cell. Biol. 23:8773-8785(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GPBP1.

    Entry informationi

    Entry nameiTBP_MOUSE
    AccessioniPrimary (citable) accession number: P29037
    Secondary accession number(s): O09169, Q80UL8, Q8C3S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3