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P29037

- TBP_MOUSE

UniProt

P29037 - TBP_MOUSE

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Protein

TATA-box-binding protein

Gene

Tbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II repressing transcription factor binding Source: MGI
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. DNA-templated transcription, initiation Source: InterPro
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. spermatogenesis Source: Ensembl
  4. transcription from RNA polymerase III promoter Source: MGI
  5. transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_224328. SIRT1 negatively regulates rRNA Expression.
REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232235. RNA Polymerase I Promoter Escape.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_235780. RNA Polymerase I Transcription Initiation.
REACT_240508. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.
REACT_257165. RNA Polymerase I Transcription Termination.
REACT_259097. RNA Polymerase I Chain Elongation.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:Tbp
Synonyms:Tfiid
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:101838. Tbp.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. female pronucleus Source: MGI
  3. male pronucleus Source: MGI
  4. nuclear euchromatin Source: Ensembl
  5. nucleus Source: MGI
  6. pronucleus Source: MGI
  7. RNA polymerase I transcription factor complex Source: MGI
  8. transcription factor TFIIA complex Source: Ensembl
  9. transcription factor TFIID complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316TATA-box-binding proteinPRO_0000153958Add
BLAST

Proteomic databases

MaxQBiP29037.
PaxDbiP29037.
PRIDEiP29037.

PTM databases

PhosphoSiteiP29037.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiP29037.
CleanExiMM_TBP.
ExpressionAtlasiP29037. baseline and differential.
GenevestigatoriP29037.

Interactioni

Subunit structurei

Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with BRF2. Interacts with UBTF (By similarity). Interacts with UTF1. Interacts with GPBP1. Interacts with SP1 (By similarity). Interacts with CITED2.By similarity4 Publications

Protein-protein interaction databases

BioGridi203978. 30 interactions.
DIPiDIP-24197N.
IntActiP29037. 7 interactions.
MINTiMINT-4590211.

Structurei

3D structure databases

ProteinModelPortaliP29037.
SMRiP29037. Positions 136-314.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati142 – 218771Add
BLAST
Repeati232 – 309782Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 7016Poly-GlnAdd
BLAST

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG2101.
HOGENOMiHOG000105164.
HOVERGENiHBG044997.
InParanoidiP29037.
KOiK03120.
OMAiGQAPQLF.
PhylomeDBiP29037.
TreeFamiTF300102.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29037-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS
60 70 80 90 100
ILEEQQRQQQ QQQQQQQQQQ AVATAAASVQ QSTSQQPTQG ASGQTPQLFH
110 120 130 140 150
SQTLTTAPLP GTTPLYPSPM TPMTPITPAT PASESSGIVP QLQNIVSTVN
160 170 180 190 200
LGCKLDLKTI ALRARNAEYN PKRFAAVIMR IREPRTTALI FSSGKMVCTG
210 220 230 240 250
AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD VKFPIRLEGL
260 270 280 290 300
VLTHQQFSSY EPELFPGLIY RMIKPRIVLL IFVSGKVVLT GAKVRAEIYE
310
AFENIYPILK GFRKTT
Length:316
Mass (Da):34,709
Last modified:December 1, 1992 - v1
Checksum:iA33D776160B4A393
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411Q → R in AAH50136. (PubMed:15489334)Curated
Sequence conflicti164 – 1641A → P in BAC39346. (PubMed:16141072)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701Q → QQQ in strain: TW18/TW5.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01034 mRNA. Translation: BAA00840.1.
U63933 mRNA. Translation: AAB53097.1.
AK085037 mRNA. Translation: BAC39346.1.
BC050136 mRNA. Translation: AAH50136.1.
BC012685 mRNA. Translation: AAH12685.1.
CCDSiCCDS37454.2.
PIRiS34437.
RefSeqiNP_038712.3. NM_013684.3.
UniGeneiMm.244820.

Genome annotation databases

EnsembliENSMUST00000014911; ENSMUSP00000014911; ENSMUSG00000014767.
ENSMUST00000117593; ENSMUSP00000112794; ENSMUSG00000014767.
ENSMUST00000162505; ENSMUSP00000124317; ENSMUSG00000014767.
GeneIDi21374.
KEGGimmu:21374.
UCSCiuc008aon.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01034 mRNA. Translation: BAA00840.1 .
U63933 mRNA. Translation: AAB53097.1 .
AK085037 mRNA. Translation: BAC39346.1 .
BC050136 mRNA. Translation: AAH50136.1 .
BC012685 mRNA. Translation: AAH12685.1 .
CCDSi CCDS37454.2.
PIRi S34437.
RefSeqi NP_038712.3. NM_013684.3.
UniGenei Mm.244820.

3D structure databases

ProteinModelPortali P29037.
SMRi P29037. Positions 136-314.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203978. 30 interactions.
DIPi DIP-24197N.
IntActi P29037. 7 interactions.
MINTi MINT-4590211.

PTM databases

PhosphoSitei P29037.

Proteomic databases

MaxQBi P29037.
PaxDbi P29037.
PRIDEi P29037.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014911 ; ENSMUSP00000014911 ; ENSMUSG00000014767 .
ENSMUST00000117593 ; ENSMUSP00000112794 ; ENSMUSG00000014767 .
ENSMUST00000162505 ; ENSMUSP00000124317 ; ENSMUSG00000014767 .
GeneIDi 21374.
KEGGi mmu:21374.
UCSCi uc008aon.2. mouse.

Organism-specific databases

CTDi 6908.
MGIi MGI:101838. Tbp.

Phylogenomic databases

eggNOGi COG2101.
HOGENOMi HOG000105164.
HOVERGENi HBG044997.
InParanoidi P29037.
KOi K03120.
OMAi GQAPQLF.
PhylomeDBi P29037.
TreeFami TF300102.

Enzyme and pathway databases

Reactomei REACT_224328. SIRT1 negatively regulates rRNA Expression.
REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232235. RNA Polymerase I Promoter Escape.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_235780. RNA Polymerase I Transcription Initiation.
REACT_240508. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_250309. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
REACT_251592. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.
REACT_257165. RNA Polymerase I Transcription Termination.
REACT_259097. RNA Polymerase I Chain Elongation.
REACT_261233. RNA Polymerase III Abortive And Retractive Initiation.

Miscellaneous databases

NextBioi 300592.
PROi P29037.
SOURCEi Search...

Gene expression databases

Bgeei P29037.
CleanExi MM_TBP.
ExpressionAtlasi P29037. baseline and differential.
Genevestigatori P29037.

Family and domain databases

Gene3Di 3.30.310.10. 2 hits.
HAMAPi MF_00408. TATA_bind_prot_arch.
InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view ]
PANTHERi PTHR10126. PTHR10126. 1 hit.
Pfami PF00352. TBP. 2 hits.
[Graphical view ]
PRINTSi PR00686. TIFACTORIID.
PROSITEi PS00351. TFIID. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID)."
    Tamura T.-A., Sumita K., Fujino I., Aoyama A., Horikoshi M., Hoffmann A., Roeder R.G., Muramatsu M., Mikoshiba K.
    Nucleic Acids Res. 19:3861-3865(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome."
    Sumita K., Makino Y., Katoh K., Kashimoto T., Muramatsu M., Mikoshiba K., Tamura T.-A.
    Nucleic Acids Res. 21:2769-2769(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates."
    Trachtulec Z., Hamvas R.M., Forejt J., Lehrach H.R., Vincek V., Klein J.
    Genomics 44:1-7(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: TW18/TW5.
    Tissue: Testis.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  5. "Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice."
    Xiao L., Kim M., DeJong J.
    Gene Expr. Patterns 6:409-419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: B5/EGFP transgenic ICR mice and FVB/N.
    Tissue: Mammary tumor and Trophoblast.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-36.
  8. "Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1."
    Heix J., Zomerdijk J.C.B.M., Ravanpay A., Tjian R., Grummt I.
    Proc. Natl. Acad. Sci. U.S.A. 94:1733-1738(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TAF1A; TAF1B AND TAF1C.
  9. "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells."
    Okuda A., Fukushima A., Nishimoto M., Orimo A., Yamagishi T., Nabeshima Y., Kuro-o M., Nabeshima Y., Boon K., Keaveney M., Stunnenberg H.G., Muramatsu M.
    EMBO J. 17:2019-2032(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UTF1.
  10. "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression."
    Glenn D.J., Maurer R.A.
    J. Biol. Chem. 274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CITED2.
  11. "The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription."
    Hsu L.-C., Liu S., Abedinpour F., Beech R.D., Lahti J.M., Kidd V.J., Greenspan J.A., Yeung C.-Y.
    Mol. Cell. Biol. 23:8773-8785(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GPBP1.

Entry informationi

Entry nameiTBP_MOUSE
AccessioniPrimary (citable) accession number: P29037
Secondary accession number(s): O09169, Q80UL8, Q8C3S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3