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Protein

TATA-box-binding protein

Gene

Tbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: Ensembl
  • RNA polymerase II transcriptional preinitiation complex assembly Source: MGI
  • spermatogenesis Source: Ensembl
  • transcription by RNA polymerase II Source: MGI
  • transcription by RNA polymerase III Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-6807505 RNA polymerase II transcribes snRNA genes
R-MMU-73762 RNA Polymerase I Transcription Initiation
R-MMU-73772 RNA Polymerase I Promoter Escape
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-73863 RNA Polymerase I Transcription Termination
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:Tbp
Synonyms:Tfiid
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:101838 Tbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539581 – 316TATA-box-binding proteinAdd BLAST316

Proteomic databases

EPDiP29037
PaxDbiP29037
PeptideAtlasiP29037
PRIDEiP29037

PTM databases

iPTMnetiP29037
PhosphoSitePlusiP29037

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000014767
CleanExiMM_TBP
ExpressionAtlasiP29037 baseline and differential
GenevisibleiP29037 MM

Interactioni

Subunit structurei

Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C (PubMed:9050847). Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4 (By similarity). Interacts with UTF1 (PubMed:9524124). Interacts with BRF2; this interaction promotes recruitment of BRF2 to TATA box-containing promoters. Interacts with UBTF (By similarity). Interacts with GPBP1 (PubMed:14612417). Interacts with CITED2 (PubMed:10593900). Interacts with ATF7IP (Probable). Interacts with LLPH (PubMed:26961175). Interacts with HSF1 (via transactivation domain) (By similarity).By similarityCurated5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203978, 31 interactors
CORUMiP29037
DIPiDIP-24197N
IntActiP29037, 7 interactors
MINTiP29037
STRINGi10090.ENSMUSP00000014911

Structurei

3D structure databases

ProteinModelPortaliP29037
SMRiP29037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati142 – 2181Add BLAST77
Repeati232 – 3092Add BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 70Poly-GlnAdd BLAST16

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105164
HOVERGENiHBG044997
InParanoidiP29037
KOiK03120
OMAiMMPYGSG
OrthoDBiEOG091G0ENY
PhylomeDBiP29037
TreeFamiTF300102

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

P29037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNNSLPPY AQGLASPQGA MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS
60 70 80 90 100
ILEEQQRQQQ QQQQQQQQQQ AVATAAASVQ QSTSQQPTQG ASGQTPQLFH
110 120 130 140 150
SQTLTTAPLP GTTPLYPSPM TPMTPITPAT PASESSGIVP QLQNIVSTVN
160 170 180 190 200
LGCKLDLKTI ALRARNAEYN PKRFAAVIMR IREPRTTALI FSSGKMVCTG
210 220 230 240 250
AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD VKFPIRLEGL
260 270 280 290 300
VLTHQQFSSY EPELFPGLIY RMIKPRIVLL IFVSGKVVLT GAKVRAEIYE
310
AFENIYPILK GFRKTT
Length:316
Mass (Da):34,709
Last modified:December 1, 1992 - v1
Checksum:iA33D776160B4A393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141Q → R in AAH50136 (PubMed:15489334).Curated1
Sequence conflicti164A → P in BAC39346 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti70Q → QQQ in strain: TW18/TW5. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D01034 mRNA Translation: BAA00840.1
U63933 mRNA Translation: AAB53097.1
AK085037 mRNA Translation: BAC39346.1
BC050136 mRNA Translation: AAH50136.1
BC012685 mRNA Translation: AAH12685.1
CCDSiCCDS37454.2
PIRiS34437
RefSeqiNP_038712.3, NM_013684.3
UniGeneiMm.244820

Genome annotation databases

EnsembliENSMUST00000014911; ENSMUSP00000014911; ENSMUSG00000014767
ENSMUST00000117593; ENSMUSP00000112794; ENSMUSG00000014767
ENSMUST00000162505; ENSMUSP00000124317; ENSMUSG00000014767
GeneIDi21374
KEGGimmu:21374
UCSCiuc008aon.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTBP_MOUSE
AccessioniPrimary (citable) accession number: P29037
Secondary accession number(s): O09169, Q80UL8, Q8C3S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 25, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health