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P29036

- FRI1_MAIZE

UniProt

P29036 - FRI1_MAIZE

Protein

Ferritin-1, chloroplastic

Gene

FER1

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011Iron 1PROSITE-ProRule annotation
    Metal bindingi136 – 1361Iron 1PROSITE-ProRule annotation
    Metal bindingi136 – 1361Iron 2PROSITE-ProRule annotation
    Metal bindingi139 – 1391Iron 1PROSITE-ProRule annotation
    Metal bindingi185 – 1851Iron 2PROSITE-ProRule annotation
    Metal bindingi219 – 2191Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. flower development Source: EnsemblPlants/Gramene
    3. iron ion transport Source: InterPro
    4. leaf development Source: EnsemblPlants/Gramene
    5. photosynthesis Source: EnsemblPlants/Gramene
    6. response to abscisic acid Source: EnsemblPlants/Gramene
    7. response to iron ion Source: EnsemblPlants/Gramene
    8. response to reactive oxygen species Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin-1, chloroplastic (EC:1.16.3.1)
    Alternative name(s):
    ZmFer1
    Gene namesi
    Name:FER1
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiP29036.
    MaizeGDBi25278.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast envelope Source: EnsemblPlants/Gramene
    2. chloroplast stroma Source: EnsemblPlants/Gramene
    3. membrane Source: EnsemblPlants/Gramene
    4. mitochondrion Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4646Chloroplast1 PublicationAdd
    BLAST
    Chaini47 – 254208Ferritin-1, chloroplasticPRO_0000008859Add
    BLAST

    Proteomic databases

    PRIDEiP29036.

    Expressioni

    Tissue specificityi

    Ferritins accumulate in seed during maturation. Then, they are degraded during the first days of germination. Present in roots and leaves after iron treatment.

    Inductioni

    By iron.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Structurei

    3D structure databases

    ProteinModelPortaliP29036.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 237154Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni47 – 8337Extension peptide (EP)Add
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000223383.
    KOiK00522.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29036-1 [UniParc]FASTAAdd to Basket

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    MMLRVSPSPA AAVPTQLSGA PATPAPVVRV AAPRGVASPS AGAACRAAGK    50
    GKEVLSGVVF QPFEEIKGEL ALVPQSPDKS LARHKFVDDC EAALNEQINV 100
    EYNASYAYHS LFAYFDRDNV ALKGFAKFFK ESSDEEREHA EKLMEYQNKR 150
    GGRVRLQSIV TPLTEFDHPE KGDALYAMEL ALALEKLVNE KLHNLHGVAT 200
    RCNDPQLTDF IESEFLEEQG EAINKISKYV AQLRRVGKGH GVWHFDQMLL 250
    EEEA 254
    Length:254
    Mass (Da):28,025
    Last modified:April 11, 2003 - v2
    Checksum:i7B74EBB843DBA28D
    GO

    Sequence cautioni

    The sequence CAA43663.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321Missing in CAA58146. (PubMed:7649160)Curated
    Sequence conflicti214 – 2141E → D in CAA58146. (PubMed:7649160)Curated
    Sequence conflicti220 – 2201G → V in CAA58146. (PubMed:7649160)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61391 mRNA. Translation: CAA43663.1. Different initiation.
    X83076 Genomic DNA. Translation: CAA58146.1.
    PIRiS22498.
    RefSeqiNP_001105563.1. NM_001112093.1.
    UniGeneiZm.99.

    Genome annotation databases

    GeneIDi542553.
    KEGGizma:542553.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61391 mRNA. Translation: CAA43663.1 . Different initiation.
    X83076 Genomic DNA. Translation: CAA58146.1 .
    PIRi S22498.
    RefSeqi NP_001105563.1. NM_001112093.1.
    UniGenei Zm.99.

    3D structure databases

    ProteinModelPortali P29036.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P29036.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 542553.
    KEGGi zma:542553.

    Organism-specific databases

    Gramenei P29036.
    MaizeGDBi 25278.

    Phylogenomic databases

    HOGENOMi HOG000223383.
    KOi K00522.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Iron induces ferritin synthesis in maize plantlets."
      Lobreaux S., Massenet O., Briat J.-F.
      Plant Mol. Biol. 19:563-575(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-75.
      Strain: cv. Missouri 17.
      Tissue: Root and Seed.
    2. "Structure and differential expression of two maize ferritin genes in response to iron and abscisic acid."
      Fobis-Loisy I., Loridon K., Lobreaux S., Lebrun M., Briat J.-F.
      Eur. J. Biochem. 231:609-619(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Wisconsin 22.
      Tissue: Seedling.

    Entry informationi

    Entry nameiFRI1_MAIZE
    AccessioniPrimary (citable) accession number: P29036
    Secondary accession number(s): Q43258
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3