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P29036 (FRI1_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-1, chloroplastic

EC=1.16.3.1
Alternative name(s):
ZmFer1
Gene names
Name:FER1
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Subcellular location

Plastidchloroplast. Plastid.

Tissue specificity

Ferritins accumulate in seed during maturation. Then, they are degraded during the first days of germination. Present in roots and leaves after iron treatment.

Induction

By iron.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Sequence caution

The sequence CAA43663.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

flower development

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

iron ion transport

Inferred from electronic annotation. Source: InterPro

leaf development

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

photosynthesis

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to abscisic acid

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to iron ion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to reactive oxygen species

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentchloroplast envelope

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

chloroplast stroma

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

membrane

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

mitochondrion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4646Chloroplast Ref.1
Chain47 – 254208Ferritin-1, chloroplastic
PRO_0000008859

Regions

Domain84 – 237154Ferritin-like diiron
Region47 – 8337Extension peptide (EP)

Sites

Metal binding1011Iron 1 By similarity
Metal binding1361Iron 1 By similarity
Metal binding1361Iron 2 By similarity
Metal binding1391Iron 1 By similarity
Metal binding1851Iron 2 By similarity
Metal binding2191Iron 2 By similarity

Experimental info

Sequence conflict321Missing in CAA58146. Ref.2
Sequence conflict2141E → D in CAA58146. Ref.2
Sequence conflict2201G → V in CAA58146. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P29036 [UniParc].

Last modified April 11, 2003. Version 2.
Checksum: 7B74EBB843DBA28D

FASTA25428,025
        10         20         30         40         50         60 
MMLRVSPSPA AAVPTQLSGA PATPAPVVRV AAPRGVASPS AGAACRAAGK GKEVLSGVVF 

        70         80         90        100        110        120 
QPFEEIKGEL ALVPQSPDKS LARHKFVDDC EAALNEQINV EYNASYAYHS LFAYFDRDNV 

       130        140        150        160        170        180 
ALKGFAKFFK ESSDEEREHA EKLMEYQNKR GGRVRLQSIV TPLTEFDHPE KGDALYAMEL 

       190        200        210        220        230        240 
ALALEKLVNE KLHNLHGVAT RCNDPQLTDF IESEFLEEQG EAINKISKYV AQLRRVGKGH 

       250 
GVWHFDQMLL EEEA 

« Hide

References

[1]"Iron induces ferritin synthesis in maize plantlets."
Lobreaux S., Massenet O., Briat J.-F.
Plant Mol. Biol. 19:563-575(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-75.
Strain: cv. Missouri 17.
Tissue: Root and Seed.
[2]"Structure and differential expression of two maize ferritin genes in response to iron and abscisic acid."
Fobis-Loisy I., Loridon K., Lobreaux S., Lebrun M., Briat J.-F.
Eur. J. Biochem. 231:609-619(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Wisconsin 22.
Tissue: Seedling.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61391 mRNA. Translation: CAA43663.1. Different initiation.
X83076 Genomic DNA. Translation: CAA58146.1.
PIRS22498.
RefSeqNP_001105563.1. NM_001112093.1.
UniGeneZm.99.

3D structure databases

ProteinModelPortalP29036.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP29036.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID542553.
KEGGzma:542553.

Organism-specific databases

GrameneP29036.
MaizeGDB25278.

Phylogenomic databases

HOGENOMHOG000223383.
KOK00522.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI1_MAIZE
AccessionPrimary (citable) accession number: P29036
Secondary accession number(s): Q43258
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 11, 2003
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families