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Protein

Chitinase 2

Gene

CHI2

Organism
Rhizopus oligosporus
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the apical growth and branching of fungal hyphae.

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

CAZyiCBM19. Carbohydrate-Binding Module Family 19.
GH18. Glycoside Hydrolase Family 18.
mycoCLAPiCHI18B_RHIOL.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase 2 (EC:3.2.1.14)
Gene namesi
Name:CHI2
OrganismiRhizopus oligosporus
Taxonomic identifieri4847 [NCBI]
Taxonomic lineageiEukaryotaFungiMucoromycotaMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001193223 – 446Chitinase 2Add BLAST424
PropeptideiPRO_0000011933447 – 542Sequence analysisAdd BLAST96

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Glycoprotein, Zymogen

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP29027.
SMRiP29027.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 312CatalyticAdd BLAST290
Regioni355 – 406Chitin-binding, high affinityAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi313 – 354Ser/Thr-richAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR005089. CBM_fam19.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF03427. CBM_19. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29027-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRTFLGMA ISAFLASTGV QAAWSSHGPN VMYYWGQNSA GGSNTQASLG
60 70 80 90 100
TYCESGQVDA VLLSFLHVFN VGGIPEINLS SACAGTYFPN TQLLSCPAVG
110 120 130 140 150
ADIKKCQDKG VKVILSLGGA AGVYGFTSDA QGQQFAQTIW NLFGGGNSDT
160 170 180 190 200
RPFGDAVIDG VDLDIEGGSS TGYVAFVNAL RQKFSSNFLI GAAPQCPFPD
210 220 230 240 250
AILGSVLNSA SFDYVNVQFY NNYCSATGSS FNFDTWDNWA KTTSPNKNVK
260 270 280 290 300
IMFTVPGSST AAGSGYVPMS TLQTIVPSLA SKYSSYGGVS VWDASQAWNN
310 320 330 340 350
GGFNSQLYSL VHSGGSTPPP PSSSSATKTT TKTTATSTKT TTTTAPTATS
360 370 380 390 400
TPGSCPVANQ PCSTQNQYAC TADGKYAVCD HGKWVASSCP SNTVCIPTTD
410 420 430 440 450
GASIYCGYAT GSGSTCPSVS ALEITAASLG SKNGPVPRPY KASKVAAQLA
460 470 480 490 500
VTSTDKNSFE AVINARRTTL TPFEKSVTIE FTTPSNIKFT ESDMGPVRQV
510 520 530 540
GNKVRIQAKN DYNESMTLVV KVKGSINSGV FVAPSTSAWN FK
Length:542
Mass (Da):56,528
Last modified:December 1, 1992 - v1
Checksum:i3E8F17DA551FD0A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10158 Genomic DNA. Translation: BAA01022.1.
PIRiB47022.

Similar proteinsi

Entry informationi

Entry nameiCHI2_RHIOL
AccessioniPrimary (citable) accession number: P29027
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 10, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families