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Protein

ATP-binding/permease protein CydD

Gene

cydD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system.

Miscellaneous

Required for growth at high temperatures.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi383 – 390ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATPase activity, coupled to transmembrane movement of substances Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
  • lipid-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cell redox homeostasis Source: EcoCyc
  • cysteine export across plasma membrane Source: EcoCyc
  • glutathione transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CYDD-MONOMER
MetaCyc:CYDD-MONOMER

Protein family/group databases

TCDBi3.A.1.129.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding/permease protein CydD
Gene namesi
Name:cydD
Synonyms:htrD
Ordered Locus Names:b0887, JW0870
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11405 cydD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei62 – 82HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei140 – 160HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei163 – 183HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei250 – 270HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei284 – 304HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000922441 – 588ATP-binding/permease protein CydDAdd BLAST588

Proteomic databases

PaxDbiP29018
PRIDEiP29018

Interactioni

Protein-protein interaction databases

BioGridi4261714, 25 interactors
DIPiDIP-9363N
IntActiP29018, 1 interactor
STRINGi316385.ECDH10B_0957

Structurei

3D structure databases

ProteinModelPortaliP29018
SMRiP29018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 316ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST293
Domaini350 – 583ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJ9 Bacteria
COG4988 LUCA
InParanoidiP29018
KOiK16013
OMAiFPLNWAA
PhylomeDBiP29018

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR014216 ABC_transptr_CydD
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02857 CydD, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P29018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSRQKELT RWLKQQSVIS QRWLNISRLL GFVSGILIIA QAWFMARILQ
60 70 80 90 100
HMIMENIPRE ALLLPFTLLV LTFVLRAWVV WLRERVGYHA GQHIRFAIRR
110 120 130 140 150
QVLDRLQQAG PAWIQGKPAG SWATLVLEQI DDMHDYYARY LPQMALAVSV
160 170 180 190 200
PLLIVVAIFP SNWAAALILL GTAPLIPLFM ALVGMGAADA NRRNFLALAR
210 220 230 240 250
LSGHFLDRLR GMETLRIFGR GEAEIESIRS ASEDFRQRTM EVLRLAFLSS
260 270 280 290 300
GILEFFTSLS IALVAVYFGF SYLGELDFGH YDTGVTLAAG FLALILAPEF
310 320 330 340 350
FQPLRDLGTF YHAKAQAVGA ADSLKTFMET PLAHPQRGEA ELASTDPVTI
360 370 380 390 400
EAEELFITSP EGKTLAGPLN FTLPAGQRAV LVGRSGSGKS SLLNALSGFL
410 420 430 440 450
SYQGSLRING IELRDLSPES WRKHLSWVGQ NPQLPAATLR DNVLLARPDA
460 470 480 490 500
SEQELQAALD NAWVSEFLPL LPQGVDTPVG DQAARLSVGQ AQRVAVARAL
510 520 530 540 550
LNPCSLLLLD EPAASLDAHS EQRVMEALNA ASLRQTTLMV THQLEDLADW
560 570 580
DVIWVMQDGR IIEQGRYAEL SVAGGPFATL LAHRQEEI
Length:588
Mass (Da):65,056
Last modified:November 1, 1997 - v3
Checksum:i8EB3212039E382D0
GO

Sequence cautioni

The sequence AAA23995 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64Missing in AAA23995 (PubMed:8380150).Curated1
Sequence conflicti313A → R in AAC36863 (PubMed:8276245).Curated1
Sequence conflicti427W → S in AAA66171 (PubMed:7934832).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21749 Genomic DNA Translation: AAA66171.1
U00096 Genomic DNA Translation: AAC73973.1
AP009048 Genomic DNA Translation: BAA35612.1
L25859 Unassigned DNA Translation: AAC36863.1
M95935 Genomic DNA Translation: AAA23995.1 Frameshift.
PIRiF64827
RefSeqiNP_415407.1, NC_000913.3
WP_001043598.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73973; AAC73973; b0887
BAA35612; BAA35612; BAA35612
GeneIDi949052
KEGGiecj:JW0870
eco:b0887
PATRICifig|1411691.4.peg.1391

Similar proteinsi

Entry informationi

Entry nameiCYDD_ECOLI
AccessioniPrimary (citable) accession number: P29018
Secondary accession number(s): P77275, Q47656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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