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Protein

ATP-binding/permease protein CydD

Gene

cydD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi383 – 390ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATPase activity, coupled to transmembrane movement of substances Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
  • lipid-transporting ATPase activity Source: GO_Central

GO - Biological processi

  • cell redox homeostasis Source: EcoCyc
  • cysteine export Source: EcoCyc
  • glutathione transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CYDD-MONOMER.
ECOL316407:JW0870-MONOMER.
MetaCyc:CYDD-MONOMER.

Protein family/group databases

TCDBi3.A.1.129.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding/permease protein CydD
Gene namesi
Name:cydD
Synonyms:htrD
Ordered Locus Names:b0887, JW0870
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11405. cydD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei62 – 82HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei140 – 160HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei163 – 183HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei250 – 270HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei284 – 304HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000922441 – 588ATP-binding/permease protein CydDAdd BLAST588

Proteomic databases

PaxDbiP29018.
PRIDEiP29018.

Interactioni

Protein-protein interaction databases

DIPiDIP-9363N.
IntActiP29018. 1 interactor.
STRINGi511145.b0887.

Structurei

3D structure databases

ProteinModelPortaliP29018.
SMRiP29018.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 316ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST293
Domaini350 – 583ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJ9. Bacteria.
COG4988. LUCA.
InParanoidiP29018.
KOiK16013.
OMAiLGFLPYQ.
PhylomeDBiP29018.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR014216. ABC_transptr_CydD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02857. CydD. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSRQKELT RWLKQQSVIS QRWLNISRLL GFVSGILIIA QAWFMARILQ
60 70 80 90 100
HMIMENIPRE ALLLPFTLLV LTFVLRAWVV WLRERVGYHA GQHIRFAIRR
110 120 130 140 150
QVLDRLQQAG PAWIQGKPAG SWATLVLEQI DDMHDYYARY LPQMALAVSV
160 170 180 190 200
PLLIVVAIFP SNWAAALILL GTAPLIPLFM ALVGMGAADA NRRNFLALAR
210 220 230 240 250
LSGHFLDRLR GMETLRIFGR GEAEIESIRS ASEDFRQRTM EVLRLAFLSS
260 270 280 290 300
GILEFFTSLS IALVAVYFGF SYLGELDFGH YDTGVTLAAG FLALILAPEF
310 320 330 340 350
FQPLRDLGTF YHAKAQAVGA ADSLKTFMET PLAHPQRGEA ELASTDPVTI
360 370 380 390 400
EAEELFITSP EGKTLAGPLN FTLPAGQRAV LVGRSGSGKS SLLNALSGFL
410 420 430 440 450
SYQGSLRING IELRDLSPES WRKHLSWVGQ NPQLPAATLR DNVLLARPDA
460 470 480 490 500
SEQELQAALD NAWVSEFLPL LPQGVDTPVG DQAARLSVGQ AQRVAVARAL
510 520 530 540 550
LNPCSLLLLD EPAASLDAHS EQRVMEALNA ASLRQTTLMV THQLEDLADW
560 570 580
DVIWVMQDGR IIEQGRYAEL SVAGGPFATL LAHRQEEI
Length:588
Mass (Da):65,056
Last modified:November 1, 1997 - v3
Checksum:i8EB3212039E382D0
GO

Sequence cautioni

The sequence AAA23995 differs from that shown. Reason: Frameshift at position 102.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64Missing in AAA23995 (PubMed:8380150).Curated1
Sequence conflicti313A → R in AAC36863 (PubMed:8276245).Curated1
Sequence conflicti427W → S in AAA66171 (PubMed:7934832).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21749 Genomic DNA. Translation: AAA66171.1.
U00096 Genomic DNA. Translation: AAC73973.1.
AP009048 Genomic DNA. Translation: BAA35612.1.
L25859 Unassigned DNA. Translation: AAC36863.1.
M95935 Genomic DNA. Translation: AAA23995.1. Frameshift.
PIRiF64827.
RefSeqiNP_415407.1. NC_000913.3.
WP_001043598.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73973; AAC73973; b0887.
BAA35612; BAA35612; BAA35612.
GeneIDi949052.
KEGGiecj:JW0870.
eco:b0887.
PATRICi32116983. VBIEscCol129921_0916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21749 Genomic DNA. Translation: AAA66171.1.
U00096 Genomic DNA. Translation: AAC73973.1.
AP009048 Genomic DNA. Translation: BAA35612.1.
L25859 Unassigned DNA. Translation: AAC36863.1.
M95935 Genomic DNA. Translation: AAA23995.1. Frameshift.
PIRiF64827.
RefSeqiNP_415407.1. NC_000913.3.
WP_001043598.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP29018.
SMRiP29018.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-9363N.
IntActiP29018. 1 interactor.
STRINGi511145.b0887.

Protein family/group databases

TCDBi3.A.1.129.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP29018.
PRIDEiP29018.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73973; AAC73973; b0887.
BAA35612; BAA35612; BAA35612.
GeneIDi949052.
KEGGiecj:JW0870.
eco:b0887.
PATRICi32116983. VBIEscCol129921_0916.

Organism-specific databases

EchoBASEiEB1377.
EcoGeneiEG11405. cydD.

Phylogenomic databases

eggNOGiENOG4108JJ9. Bacteria.
COG4988. LUCA.
InParanoidiP29018.
KOiK16013.
OMAiLGFLPYQ.
PhylomeDBiP29018.

Enzyme and pathway databases

BioCyciEcoCyc:CYDD-MONOMER.
ECOL316407:JW0870-MONOMER.
MetaCyc:CYDD-MONOMER.

Miscellaneous databases

PROiP29018.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR014216. ABC_transptr_CydD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02857. CydD. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYDD_ECOLI
AccessioniPrimary (citable) accession number: P29018
Secondary accession number(s): P77275, Q47656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Required for growth at high temperatures.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.