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Protein

T-cell surface glycoprotein CD1c

Gene

CD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.4 Publications

GO - Molecular functioni

  • beta-2-microglobulin binding Source: GO_Central
  • endogenous lipid antigen binding Source: UniProtKB
  • exogenous lipid antigen binding Source: UniProtKB
  • glycolipid binding Source: UniProtKB
  • lipopeptide binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1c
Alternative name(s):
CD_antigen: CD1c
Gene namesi
Name:CD1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1636. CD1C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 302285ExtracellularSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Topological domaini324 – 33310CytoplasmicSequence analysis

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • lysosome Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26195.

Polymorphism and mutation databases

BioMutaiCD1C.
DMDMi143811371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 333316T-cell surface glycoprotein CD1cPRO_0000014580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)2 Publications
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence analysis
Glycosylationi75 – 751N-linked (GlcNAc...)1 Publication
Glycosylationi78 – 781N-linked (GlcNAc...); atypical1 Publication
Disulfide bondi120 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi225 ↔ 280PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29017.
PaxDbiP29017.
PeptideAtlasiP29017.
PRIDEiP29017.

PTM databases

iPTMnetiP29017.
PhosphoSiteiP29017.
SwissPalmiP29017.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

BgeeiENSG00000158481.
CleanExiHS_CD1C.
ExpressionAtlasiP29017. baseline and differential.
GenevisibleiP29017. HS.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP29017. 2 interactions.
MINTiMINT-4656025.
STRINGi9606.ENSP00000357152.

Structurei

Secondary structure

1
333
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 3814Combined sources
Beta strandi41 – 5010Combined sources
Beta strandi53 – 597Combined sources
Turni60 – 634Combined sources
Beta strandi64 – 674Combined sources
Turni70 – 756Combined sources
Helixi78 – 10326Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 12313Combined sources
Beta strandi129 – 1368Combined sources
Beta strandi139 – 1446Combined sources
Beta strandi146 – 1516Combined sources
Helixi157 – 16812Combined sources
Helixi171 – 18212Combined sources
Helixi184 – 20017Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
4ONOX-ray2.70A24-201[»]
5C9JX-ray2.40A24-203[»]
ProteinModelPortaliP29017.
SMRiP29017. Positions 24-298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29017.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 29691Ig-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi329 – 3324Internalization signal

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP29017.
KOiK06448.
OMAiSFVNQSW.
OrthoDBiEOG091G0H36.
PhylomeDBiP29017.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL
60 70 80 90 100
DELQTHGWDS ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ
110 120 130 140 150
DHASQDYSKY PFEVQVKAGC ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV
160 170 180 190 200
PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL IRSTCPRFLL GLLDAGKMYV
210 220 230 240 250
HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM RNEQEQLGTK
260 270 280 290 300
HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF
310 320 330
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL
Length:333
Mass (Da):37,654
Last modified:April 3, 2007 - v2
Checksum:i8E4E057097E3E440
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901Q → R in CAG33361 (Ref. 3) Curated
Sequence conflicti327 – 3337CSYQDIL → W in AAA51942 (PubMed:2447586).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701N → T.
Corresponds to variant rs3138100 [ dbSNP | Ensembl ].
VAR_031564
Natural varianti300 – 3001F → S.1 Publication
Corresponds to variant rs3138105 [ dbSNP | Ensembl ].
VAR_031565

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
CCDSiCCDS1175.1.
PIRiC45801. HLHUCC.
RefSeqiNP_001756.2. NM_001765.2.
UniGeneiHs.132448.

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481.
GeneIDi911.
KEGGihsa:911.
UCSCiuc001fru.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
CCDSiCCDS1175.1.
PIRiC45801. HLHUCC.
RefSeqiNP_001756.2. NM_001765.2.
UniGeneiHs.132448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
4ONOX-ray2.70A24-201[»]
5C9JX-ray2.40A24-203[»]
ProteinModelPortaliP29017.
SMRiP29017. Positions 24-298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29017. 2 interactions.
MINTiMINT-4656025.
STRINGi9606.ENSP00000357152.

PTM databases

iPTMnetiP29017.
PhosphoSiteiP29017.
SwissPalmiP29017.

Polymorphism and mutation databases

BioMutaiCD1C.
DMDMi143811371.

Proteomic databases

MaxQBiP29017.
PaxDbiP29017.
PeptideAtlasiP29017.
PRIDEiP29017.

Protocols and materials databases

DNASUi911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481.
GeneIDi911.
KEGGihsa:911.
UCSCiuc001fru.4. human.

Organism-specific databases

CTDi911.
GeneCardsiCD1C.
HGNCiHGNC:1636. CD1C.
MIMi188340. gene.
neXtProtiNX_P29017.
PharmGKBiPA26195.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP29017.
KOiK06448.
OMAiSFVNQSW.
OrthoDBiEOG091G0H36.
PhylomeDBiP29017.
TreeFamiTF336723.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCD1C. human.
EvolutionaryTraceiP29017.
GenomeRNAii911.
PROiP29017.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158481.
CleanExiHS_CD1C.
ExpressionAtlasiP29017. baseline and differential.
GenevisibleiP29017. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD1C_HUMAN
AccessioniPrimary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7
, Q6IAS4, Q9UMM0, Q9UN96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: September 7, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.