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Protein

T-cell surface glycoprotein CD1c

Gene

CD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.4 Publications

GO - Molecular functioni

  • beta-2-microglobulin binding Source: GO_Central
  • endogenous lipid antigen binding Source: UniProtKB
  • exogenous lipid antigen binding Source: UniProtKB
  • glycolipid binding Source: UniProtKB
  • lipopeptide binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158481-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1c
Alternative name(s):
CD_antigen: CD1c
Gene namesi
Name:CD1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1636. CD1C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 302ExtracellularSequence analysisAdd BLAST285
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 333CytoplasmicSequence analysis10

GO - Cellular componenti

  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • lysosome Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi911.
OpenTargetsiENSG00000158481.
PharmGKBiPA26195.

Polymorphism and mutation databases

BioMutaiCD1C.
DMDMi143811371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001458018 – 333T-cell surface glycoprotein CD1cAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)2 Publications1
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)1 Publication1
Glycosylationi78N-linked (GlcNAc...); atypical1 Publication1
Disulfide bondi120 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi225 ↔ 280PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29017.
PaxDbiP29017.
PeptideAtlasiP29017.
PRIDEiP29017.

PTM databases

iPTMnetiP29017.
PhosphoSitePlusiP29017.
SwissPalmiP29017.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

BgeeiENSG00000158481.
CleanExiHS_CD1C.
ExpressionAtlasiP29017. baseline and differential.
GenevisibleiP29017. HS.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP29017. 2 interactors.
MINTiMINT-4656025.
STRINGi9606.ENSP00000357152.

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 38Combined sources14
Beta strandi41 – 50Combined sources10
Beta strandi53 – 59Combined sources7
Turni60 – 63Combined sources4
Beta strandi64 – 67Combined sources4
Turni70 – 75Combined sources6
Helixi78 – 103Combined sources26
Helixi107 – 109Combined sources3
Beta strandi111 – 123Combined sources13
Beta strandi129 – 136Combined sources8
Beta strandi139 – 144Combined sources6
Beta strandi146 – 151Combined sources6
Helixi157 – 168Combined sources12
Helixi171 – 182Combined sources12
Helixi184 – 200Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
4ONOX-ray2.70A24-201[»]
5C9JX-ray2.40A24-203[»]
ProteinModelPortaliP29017.
SMRiP29017.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29017.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 296Ig-likeAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Internalization signal4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP29017.
KOiK06448.
OMAiSFVNQSW.
OrthoDBiEOG091G0H36.
PhylomeDBiP29017.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL
60 70 80 90 100
DELQTHGWDS ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ
110 120 130 140 150
DHASQDYSKY PFEVQVKAGC ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV
160 170 180 190 200
PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL IRSTCPRFLL GLLDAGKMYV
210 220 230 240 250
HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM RNEQEQLGTK
260 270 280 290 300
HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF
310 320 330
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL
Length:333
Mass (Da):37,654
Last modified:April 3, 2007 - v2
Checksum:i8E4E057097E3E440
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290Q → R in CAG33361 (Ref. 3) Curated1
Sequence conflicti327 – 333CSYQDIL → W in AAA51942 (PubMed:2447586).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03156470N → T.Corresponds to variant rs3138100dbSNPEnsembl.1
Natural variantiVAR_031565300F → S.1 PublicationCorresponds to variant rs3138105dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
CCDSiCCDS1175.1.
PIRiC45801. HLHUCC.
RefSeqiNP_001756.2. NM_001765.2.
UniGeneiHs.132448.

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481.
GeneIDi911.
KEGGihsa:911.
UCSCiuc001fru.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
CCDSiCCDS1175.1.
PIRiC45801. HLHUCC.
RefSeqiNP_001756.2. NM_001765.2.
UniGeneiHs.132448.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
4ONOX-ray2.70A24-201[»]
5C9JX-ray2.40A24-203[»]
ProteinModelPortaliP29017.
SMRiP29017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29017. 2 interactors.
MINTiMINT-4656025.
STRINGi9606.ENSP00000357152.

PTM databases

iPTMnetiP29017.
PhosphoSitePlusiP29017.
SwissPalmiP29017.

Polymorphism and mutation databases

BioMutaiCD1C.
DMDMi143811371.

Proteomic databases

MaxQBiP29017.
PaxDbiP29017.
PeptideAtlasiP29017.
PRIDEiP29017.

Protocols and materials databases

DNASUi911.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481.
GeneIDi911.
KEGGihsa:911.
UCSCiuc001fru.4. human.

Organism-specific databases

CTDi911.
DisGeNETi911.
GeneCardsiCD1C.
HGNCiHGNC:1636. CD1C.
MIMi188340. gene.
neXtProtiNX_P29017.
OpenTargetsiENSG00000158481.
PharmGKBiPA26195.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP29017.
KOiK06448.
OMAiSFVNQSW.
OrthoDBiEOG091G0H36.
PhylomeDBiP29017.
TreeFamiTF336723.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158481-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSiCD1C. human.
EvolutionaryTraceiP29017.
GenomeRNAii911.
PROiP29017.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158481.
CleanExiHS_CD1C.
ExpressionAtlasiP29017. baseline and differential.
GenevisibleiP29017. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD1C_HUMAN
AccessioniPrimary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7
, Q6IAS4, Q9UMM0, Q9UN96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: November 2, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.