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P29017 (CD1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell surface glycoprotein CD1c
Alternative name(s):
CD_antigen=CD1c
Gene names
Name:CD1C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Ref.8 Ref.9 Ref.10 Ref.12

Subunit structure

Heterodimer with B2M (beta-2-microglobulin). Ref.12

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note: Subject to intracellular trafficking between the cell membrane and endosomes. Ref.8 Ref.10

Tissue specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 333316T-cell surface glycoprotein CD1c
PRO_0000014580

Regions

Topological domain18 – 302285Extracellular Potential
Transmembrane303 – 32321Helical; Potential
Topological domain324 – 33310Cytoplasmic Potential
Domain206 – 29691Ig-like
Motif329 – 3324Internalization signal

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Ref.11 Ref.12
Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Ref.11
Glycosylation781N-linked (GlcNAc...); atypical Ref.11
Glycosylation1461N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 185 Ref.12
Disulfide bond225 ↔ 280 By similarity

Natural variations

Natural variant701N → T.
Corresponds to variant rs3138100 [ dbSNP | Ensembl ].
VAR_031564
Natural variant3001F → S. Ref.2
Corresponds to variant rs3138105 [ dbSNP | Ensembl ].
VAR_031565

Experimental info

Sequence conflict2901Q → R in CAG33361. Ref.3
Sequence conflict327 – 3337CSYQDIL → W in AAA51942. Ref.1

Secondary structure

............................. 333
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P29017 [UniParc].

Last modified April 3, 2007. Version 2.
Checksum: 8E4E057097E3E440

FASTA33337,654
        10         20         30         40         50         60 
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS 

        70         80         90        100        110        120 
ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC 

       130        140        150        160        170        180 
ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL 

       190        200        210        220        230        240 
IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM 

       250        260        270        280        290        300 
RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF 

       310        320        330 
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."
Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.
Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."
Aruffo A., Seed B.
J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-300.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Polymorphism of human CD1 genes."
Han M., Hannick L.I., DiBrino M., Robinson M.A.
Tissue Antigens 54:122-127(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-109.
[7]"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
Martin L.H., Calabi F., Milstein C.
Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-296.
[8]"Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens."
Briken V., Jackman R.M., Watts G.F.M., Rogers R.A., Porcelli S.A.
J. Exp. Med. 192:281-288(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERNALIZATION SIGNAL, SUBCELLULAR LOCATION.
[9]"CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection."
Moody D.B., Ulrichs T., Muehlecker W., Young D.C., Gurcha S.S., Grant E., Rosat J.-P., Brenner M.B., Costello C.E., Besra G.S., Porcelli S.A.
Nature 404:884-888(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[10]"CD1c molecules broadly survey the endocytic system."
Sugita M., van Der Wel N., Rogers R.A., Peters P.J., Brenner M.B.
Proc. Natl. Acad. Sci. U.S.A. 97:8445-8450(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[11]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38; ASN-75 AND ASN-78.
Tissue: Leukemic T-cell.
[12]"The 2.5 a structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation."
Scharf L., Li N.S., Hawk A.J., Garzon D., Zhang T., Fox L.M., Kazen A.R., Shah S., Haddadian E.J., Gumperz J.E., Saghatelian A., Faraldo-Gomez J.D., Meredith S.C., Piccirilli J.A., Adams E.J.
Immunity 33:853-862(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 19-201 IN COMPLEX WITH MANNOSYL-BETA1-PHOSPHOMYCOKETIDE, FUNCTION, SUBUNIT, DISULFIDE BOND, GLYCOSYLATION AT ASN-38.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22178 expand/collapse EMBL AC list , M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
PIRHLHUCC. C45801.
RefSeqNP_001756.2. NM_001765.2.
UniGeneHs.132448.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
ProteinModelPortalP29017.
SMRP29017. Positions 24-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP29017. 2 interactions.
MINTMINT-4656025.
STRING9606.ENSP00000357152.

Polymorphism databases

DMDM143811371.

Proteomic databases

PaxDbP29017.
PRIDEP29017.

Protocols and materials databases

DNASU911.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000368170; ENSP00000357152; ENSG00000158481.
GeneID911.
KEGGhsa:911.
UCSCuc001fru.3. human.

Organism-specific databases

CTD911.
GeneCardsGC01P158259.
HGNCHGNC:1636. CD1C.
MIM188340. gene.
neXtProtNX_P29017.
PharmGKBPA26195.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319535.
HOGENOMHOG000111666.
HOVERGENHBG004453.
KOK06448.
OMASFVNQSW.
OrthoDBEOG7DZ8K9.
PhylomeDBP29017.
TreeFamTF336723.

Gene expression databases

ArrayExpressP29017.
BgeeP29017.
CleanExHS_CD1C.
GenevestigatorP29017.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP29017.
GenomeRNAi911.
NextBio3758.
PROP29017.
SOURCESearch...

Entry information

Entry nameCD1C_HUMAN
AccessionPrimary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7 expand/collapse secondary AC list , Q6IAS4, Q9UMM0, Q9UN96
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: April 16, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries