Reviewed, UniProtKB/Swiss-Prot P29017 (CD1C_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell surface glycoprotein CD1c
Alternative name(s):
    CD_antigen=CD1c

Gene names

Name:

CD1C

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Ref.8 Ref.9 Ref.10
Subunit structure	Heterodimer with B2M (beta-2-microglobulin).
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note: Subject to intracellular trafficking between the cell membrane and endosomes. Ref.8 Ref.10
Tissue specificity	Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Miscellaneous	During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immune response
Cellular component	Cell membrane Endosome Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: InterPro endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 333	316	T-cell surface glycoprotein CD1c		PRO_0000014580
Regions
	Topological domain	18 – 302	285	Extracellular Potential
	Transmembrane	303 – 323	21	Potential
	Topological domain	324 – 333	10	Cytoplasmic Potential
	Domain	206 – 296	91	Ig-like
	Motif	329 – 332	4	Internalization signal
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	75	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	78	1	N-linked (GlcNAc...) Ref.11
	Glycosylation	146	1	N-linked (GlcNAc...) Potential
	Disulfide bond	120 ↔ 185		By similarity
	Disulfide bond	225 ↔ 280		By similarity
Natural variations
	Natural variant	70	1	N → T: dbSNP rs3138100.		VAR_031564
	Natural variant	300	1	F → S: dbSNP rs3138105. Ref.2		VAR_031565
Experimental info
	Sequence conflict	290	1	Q → R in CAG33361. Ref.3
	Sequence conflict	327 – 333	7	CSYQDIL → W in AAA51942. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P29017-1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 8E4E057097E3E440	FASTA	333	37,654
	10 20 30 40 50 60 MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS 70 80 90 100 110 120 ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC 130 140 150 160 170 180 ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL 190 200 210 220 230 240 IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM 250 260 270 280 290 300 RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF 310 320 330 SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c." Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C. Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed: 2447586] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts." Aruffo A., Seed B. J. Immunol. 143:1723-1730(1989) [PubMed: 2701945] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-300.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Polymorphism of human CD1 genes." Han M., Hannick L.I., DiBrino M., Robinson M.A. Tissue Antigens 54:122-127(1999) [PubMed: 10488738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-109.
[7]	"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens." Martin L.H., Calabi F., Milstein C. Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed: 3097645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-296.
[8]	"Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens." Briken V., Jackman R.M., Watts G.F.M., Rogers R.A., Porcelli S.A. J. Exp. Med. 192:281-288(2000) [PubMed: 10899914] [Abstract] Cited for: FUNCTION, INTERNALIZATION SIGNAL, SUBCELLULAR LOCATION.
[9]	"CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection." Moody D.B., Ulrichs T., Muehlecker W., Young D.C., Gurcha S.S., Grant E., Rosat J.-P., Brenner M.B., Costello C.E., Besra G.S., Porcelli S.A. Nature 404:884-888(2000) [PubMed: 10786796] [Abstract] Cited for: FUNCTION.
[10]	"CD1c molecules broadly survey the endocytic system." Sugita M., van Der Wel N., Rogers R.A., Peters P.J., Brenner M.B. Proc. Natl. Acad. Sci. U.S.A. 97:8445-8450(2000) [PubMed: 10890914] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[11]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38; ASN-75 AND ASN-78, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M22178 , M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1. M28827 mRNA. Translation: AAA51941.1. CR457080 mRNA. Translation: CAG33361.1. AL121986 Genomic DNA. Translation: CAI10850.1. BC126465 mRNA. Translation: AAI26466.1. BC126467 mRNA. Translation: AAI26468.1. AF142667 Genomic DNA. Translation: AAD37580.1. M14667 Genomic DNA. Translation: AAA51938.1.
IPI	IPI00019850.
PIR	HLHUCC. C45801.
RefSeq	NP_001756.2.
UniGene	Hs.132448
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P29017.
Proteomic databases
PRIDE	P29017.
Genome annotation databases
Ensembl	ENST00000368170; ENSP00000357152; ENSG00000158481; Homo sapiens. [Genome view]
GeneID	911.
KEGG	hsa:911.
NMPDR	fig|9606.3.peg.2363.
UCSC	uc001fru.1. human.
Organism-specific databases
CTD	911.
GeneCards	GC01P156526.
H-InvDB	HIX0028804.
HGNC	HGNC:1636. CD1C.
MIM	188340. gene.
PharmGKB	PA26195.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P29017.
Gene expression databases
ArrayExpress	P29017.
Bgee	P29017.
CleanEx	HS_CD1C.
Genevestigator	P29017.
GermOnline	ENSG00000158481. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. [Graphical view]
SMART	SM00407. IGc1. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3758.
SOURCE	Search...

Entry information

Entry name

CD1C_HUMAN

Accession

Primary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7 , Q6IAS4, Q9UMM0, Q9UN96

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	April 3, 2007
Last modified:	November 24, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.