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P29017

- CD1C_HUMAN

UniProt

P29017 - CD1C_HUMAN

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Protein

T-cell surface glycoprotein CD1c

Gene
CD1C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.4 Publications

GO - Molecular functioni

  1. beta-2-microglobulin binding Source: RefGenome
  2. endogenous lipid antigen binding Source: UniProtKB
  3. exogenous lipid antigen binding Source: UniProtKB
  4. glycolipid binding Source: UniProtKB
  5. lipopeptide binding Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: RefGenome
  2. T cell activation involved in immune response Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1c
Alternative name(s):
CD_antigen: CD1c
Gene namesi
Name:CD1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1636. CD1C.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Endosome membrane
Note: Subject to intracellular trafficking between the cell membrane and endosomes.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 302285Extracellular Reviewed predictionAdd
BLAST
Transmembranei303 – 32321Helical; Reviewed predictionAdd
BLAST
Topological domaini324 – 33310Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26195.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 333316T-cell surface glycoprotein CD1cPRO_0000014580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)2 Publications
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...)1 Publication
Glycosylationi78 – 781N-linked (GlcNAc...); atypical1 Publication
Disulfide bondi120 ↔ 1851 Publication
Glycosylationi146 – 1461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi225 ↔ 280 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29017.
PaxDbiP29017.
PRIDEiP29017.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

ArrayExpressiP29017.
BgeeiP29017.
CleanExiHS_CD1C.
GenevestigatoriP29017.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin).1 Publication

Protein-protein interaction databases

IntActiP29017. 2 interactions.
MINTiMINT-4656025.
STRINGi9606.ENSP00000357152.

Structurei

Secondary structure

1
333
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 4016
Beta strandi42 – 509
Beta strandi53 – 597
Turni60 – 634
Beta strandi64 – 674
Turni70 – 756
Helixi78 – 10023
Beta strandi112 – 12312
Beta strandi128 – 1369
Beta strandi139 – 1457
Beta strandi148 – 1514
Helixi157 – 16812
Helixi173 – 18210
Helixi184 – 19916

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
ProteinModelPortaliP29017.
SMRiP29017. Positions 24-298.

Miscellaneous databases

EvolutionaryTraceiP29017.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 29691Ig-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi329 – 3324Internalization signal

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319535.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
KOiK06448.
OMAiSFVNQSW.
OrthoDBiEOG7DZ8K9.
PhylomeDBiP29017.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29017-1 [UniParc]FASTAAdd to Basket

« Hide

MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL    50
DELQTHGWDS ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ 100
DHASQDYSKY PFEVQVKAGC ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV 150
PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL IRSTCPRFLL GLLDAGKMYV 200
HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM RNEQEQLGTK 250
HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF 300
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL 333
Length:333
Mass (Da):37,654
Last modified:April 3, 2007 - v2
Checksum:i8E4E057097E3E440
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701N → T.
Corresponds to variant rs3138100 [ dbSNP | Ensembl ].
VAR_031564
Natural varianti300 – 3001F → S.1 Publication
Corresponds to variant rs3138105 [ dbSNP | Ensembl ].
VAR_031565

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901Q → R in CAG33361. 1 Publication
Sequence conflicti327 – 3337CSYQDIL → W in AAA51942. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA. Translation: AAA51942.1.
M28827 mRNA. Translation: AAA51941.1.
CR457080 mRNA. Translation: CAG33361.1.
AL121986 Genomic DNA. Translation: CAI10850.1.
BC126465 mRNA. Translation: AAI26466.1.
BC126467 mRNA. Translation: AAI26468.1.
AF142667 Genomic DNA. Translation: AAD37580.1.
M14667 Genomic DNA. Translation: AAA51938.1.
CCDSiCCDS1175.1.
PIRiC45801. HLHUCC.
RefSeqiNP_001756.2. NM_001765.2.
UniGeneiHs.132448.

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481.
GeneIDi911.
KEGGihsa:911.
UCSCiuc001fru.3. human.

Polymorphism databases

DMDMi143811371.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M22178
, M22174 , M22175 , M22176 , M22177 Genomic DNA. Translation: AAA51942.1 .
M28827 mRNA. Translation: AAA51941.1 .
CR457080 mRNA. Translation: CAG33361.1 .
AL121986 Genomic DNA. Translation: CAI10850.1 .
BC126465 mRNA. Translation: AAI26466.1 .
BC126467 mRNA. Translation: AAI26468.1 .
AF142667 Genomic DNA. Translation: AAD37580.1 .
M14667 Genomic DNA. Translation: AAA51938.1 .
CCDSi CCDS1175.1.
PIRi C45801. HLHUCC.
RefSeqi NP_001756.2. NM_001765.2.
UniGenei Hs.132448.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OV6 X-ray 2.50 A 19-201 [» ]
ProteinModelPortali P29017.
SMRi P29017. Positions 24-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P29017. 2 interactions.
MINTi MINT-4656025.
STRINGi 9606.ENSP00000357152.

Polymorphism databases

DMDMi 143811371.

Proteomic databases

MaxQBi P29017.
PaxDbi P29017.
PRIDEi P29017.

Protocols and materials databases

DNASUi 911.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368170 ; ENSP00000357152 ; ENSG00000158481 .
GeneIDi 911.
KEGGi hsa:911.
UCSCi uc001fru.3. human.

Organism-specific databases

CTDi 911.
GeneCardsi GC01P158259.
HGNCi HGNC:1636. CD1C.
MIMi 188340. gene.
neXtProti NX_P29017.
PharmGKBi PA26195.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319535.
HOGENOMi HOG000111666.
HOVERGENi HBG004453.
KOi K06448.
OMAi SFVNQSW.
OrthoDBi EOG7DZ8K9.
PhylomeDBi P29017.
TreeFami TF336723.

Miscellaneous databases

EvolutionaryTracei P29017.
GenomeRNAii 911.
NextBioi 3758.
PROi P29017.
SOURCEi Search...

Gene expression databases

ArrayExpressi P29017.
Bgeei P29017.
CleanExi HS_CD1C.
Genevestigatori P29017.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."
    Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.
    Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."
    Aruffo A., Seed B.
    J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-300.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-109.
  7. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
    Martin L.H., Calabi F., Milstein C.
    Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-296.
  8. "Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens."
    Briken V., Jackman R.M., Watts G.F.M., Rogers R.A., Porcelli S.A.
    J. Exp. Med. 192:281-288(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERNALIZATION SIGNAL, SUBCELLULAR LOCATION.
  9. "CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection."
    Moody D.B., Ulrichs T., Muehlecker W., Young D.C., Gurcha S.S., Grant E., Rosat J.-P., Brenner M.B., Costello C.E., Besra G.S., Porcelli S.A.
    Nature 404:884-888(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-38; ASN-75 AND ASN-78.
    Tissue: Leukemic T-cell.
  12. "The 2.5 a structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation."
    Scharf L., Li N.S., Hawk A.J., Garzon D., Zhang T., Fox L.M., Kazen A.R., Shah S., Haddadian E.J., Gumperz J.E., Saghatelian A., Faraldo-Gomez J.D., Meredith S.C., Piccirilli J.A., Adams E.J.
    Immunity 33:853-862(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 19-201 IN COMPLEX WITH MANNOSYL-BETA1-PHOSPHOMYCOKETIDE, FUNCTION, SUBUNIT, DISULFIDE BOND, GLYCOSYLATION AT ASN-38.

Entry informationi

Entry nameiCD1C_HUMAN
AccessioniPrimary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7
, Q6IAS4, Q9UMM0, Q9UN96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: July 9, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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