ID CD1B_HUMAN STANDARD; PRT; 333 AA. AC P29016; Q9UMM2; DT 01-DEC-1992 (Rel. 24, Created) DT 01-DEC-1992 (Rel. 24, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE T-cell surface glycoprotein CD1b precursor (CD1b antigen). GN Name=CD1B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=88097453; PubMed=2447586; RA Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A.G., Milstein C.; RT "Structure and expression of the human thymocyte antigens CD1a, CD1b, RT and CD1c."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=89341413; PubMed=2701945; RA Aruffo A., Seed B.; RT "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c RT demonstrates a hierarchy of exclusion in fibroblasts."; RL J. Immunol. 143:1723-1730(1989). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [4] RP NUCLEOTIDE SEQUENCE OF 203-295. RX PubMed=3097645; RA Martin L.H., Calabi F., Milstein C.; RT "Isolation of CD1 genes: a family of major histocompatibility complex- RT related differentiation antigens."; RL Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986). CC -!- FUNCTION: Not known. CC -!- SUBUNIT: Associates non-covalently with beta-2-microglobulin. CC -!- SUBCELLULAR LOCATION: Type I membrane protein. CC -!- TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain CC T-cell leukemias, and in various other tissues. CC -!- SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M22173; AAA51940.1; -; Genomic_DNA. DR EMBL; M22168; AAA51940.1; JOINED; Genomic_DNA. DR EMBL; M22169; AAA51940.1; JOINED; Genomic_DNA. DR EMBL; M22170; AAA51940.1; JOINED; Genomic_DNA. DR EMBL; M22171; AAA51940.1; JOINED; Genomic_DNA. DR EMBL; M22172; AAA51940.1; JOINED; Genomic_DNA. DR EMBL; M28826; AAA51939.1; -; mRNA. DR EMBL; BC069481; AAH69481.1; -; mRNA. DR EMBL; BC074747; AAH74747.1; -; mRNA. DR EMBL; M14665; AAA51936.1; -; Genomic_DNA. DR PIR; B39957; HLHUCB. DR PDB; 1GZP; X-ray; A=18-295. DR PDB; 1GZQ; X-ray; A=18-295. DR PDB; 1UQS; X-ray; A=18-295. DR Ensembl; ENSG00000158485; Homo sapiens. DR HGNC; HGNC:1635; CD1B. DR MIM; 188360; -. DR LinkHub; P29016; -. DR GO; GO:0016021; C:integral to membrane; TAS. DR GO; GO:0005886; C:plasma membrane; TAS. DR GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_c1. DR Pfam; PF07654; C1-set; 1. DR SMART; SM00407; IGc1; 1. DR PROSITE; PS50835; IG_LIKE; 1. KW 3D-structure; Glycoprotein; Immunoglobulin domain; Membrane; KW Multigene family; Signal; Transmembrane. FT SIGNAL 1 17 Potential. FT CHAIN 18 333 T-cell surface glycoprotein CD1b. FT /FTId=PRO_0000014579. FT TOPO_DOM 18 303 Extracellular (Potential). FT TRANSMEM 304 324 Potential. FT TOPO_DOM 325 333 Cytoplasmic (Potential). FT DOMAIN 185 295 Ig-like. FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential). FT CARBOHYD 75 75 N-linked (GlcNAc...) (Potential). FT CARBOHYD 146 146 N-linked (GlcNAc...) (Potential). FT CARBOHYD 258 258 N-linked (GlcNAc...) (Potential). FT DISULFID 120 184 By similarity. FT DISULFID 224 279 By similarity. FT STRAND 24 24 FT STRAND 27 38 FT TURN 39 40 FT STRAND 41 50 FT TURN 51 52 FT STRAND 53 59 FT TURN 60 63 FT STRAND 64 67 FT STRAND 69 69 FT TURN 70 75 FT HELIX 78 102 FT TURN 103 107 FT STRAND 110 122 FT TURN 124 125 FT STRAND 126 126 FT STRAND 128 136 FT TURN 137 138 FT STRAND 139 145 FT TURN 146 147 FT STRAND 148 151 FT HELIX 153 166 FT TURN 167 168 FT HELIX 170 181 FT TURN 182 182 FT HELIX 183 194 FT TURN 195 195 FT HELIX 196 199 FT TURN 200 200 FT STRAND 203 203 FT STRAND 206 211 FT STRAND 215 216 FT TURN 217 218 FT STRAND 219 232 FT STRAND 235 240 FT TURN 241 242 FT STRAND 243 244 FT TURN 246 247 FT STRAND 249 250 FT STRAND 254 256 FT TURN 257 259 FT STRAND 260 270 FT HELIX 271 273 FT STRAND 274 274 FT TURN 275 276 FT STRAND 277 282 FT HELIX 284 286 FT TURN 287 288 FT STRAND 291 294 SQ SEQUENCE 333 AA; 36939 MW; 7D02B670D4DE8CC7 CRC64; MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP //