ID   CD1B_HUMAN     STANDARD;      PRT;   333 AA.
AC   P29016;
DT   01-DEC-1992 (Rel. 24, Created)
DT   01-DEC-1992 (Rel. 24, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   T-cell surface glycoprotein CD1b precursor (CD1b antigen).
GN   Name=CD1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=88097453; PubMed=2447586;
RA   Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A., Milstein C.;
RT   "Structure and expression of the human thymocyte antigens CD1a, CD1b,
RT   and CD1c.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=89341413; PubMed=2701945;
RA   Aruffo A., Seed B.;
RT   "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c
RT   demonstrates a hierarchy of exclusion in fibroblasts.";
RL   J. Immunol. 143:1723-1730(1989).
CC   -!- FUNCTION: Not known.
CC   -!- SUBUNIT: Associates non-covalently with beta-2-microglobulin.
CC   -!- SUBCELLULAR LOCATION: Type I membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain
CC       T-cell leukemias, and in various other tissues.
CC   -!- SIMILARITY: Contains 1 immunoglobulin-like domain.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CD1 entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd1.htm".
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DR   EMBL; M22173; AAA51940.1; -.
DR   EMBL; M22168; AAA51940.1; JOINED.
DR   EMBL; M22169; AAA51940.1; JOINED.
DR   EMBL; M22170; AAA51940.1; JOINED.
DR   EMBL; M22171; AAA51940.1; JOINED.
DR   EMBL; M22172; AAA51940.1; JOINED.
DR   EMBL; M28826; AAA51939.1; -.
DR   PIR; B39957; HLHUCB.
DR   PDB; 1GZP; 31-JUL-02.
DR   PDB; 1GZQ; 31-JUL-02.
DR   Genew; HGNC:1635; CD1B.
DR   MIM; 188360; -.
DR   GO; GO:0016021; C:integral to membrane; TAS.
DR   GO; GO:0005886; C:plasma membrane; TAS.
DR   GO; GO:0019735; P:antimicrobial humoral response (sensu Verte...; TAS.
DR   InterPro; IPR007110; Ig-like.
DR   Pfam; PF00047; ig; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
KW   Glycoprotein; Signal; Transmembrane; Immunoglobulin domain;
KW   Multigene family; 3D-structure.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    333       T-cell surface glycoprotein CD1b.
FT   DOMAIN       18    303       Extracellular (Potential).
FT   TRANSMEM    304    324       Potential.
FT   DOMAIN      325    333       Cytoplasmic (Potential).
FT   DOMAIN      185    295       Ig-like.
FT   DISULFID    120    184       By similarity.
FT   DISULFID    224    279       By similarity.
FT   CARBOHYD     38     38       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     75     75       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    146    146       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    258    258       N-linked (GlcNAc...) (Potential).
FT   STRAND       27     38
FT   TURN         39     40
FT   STRAND       41     50
FT   TURN         51     52
FT   STRAND       53     59
FT   TURN         60     63
FT   STRAND       64     67
FT   TURN         70     75
FT   HELIX        78    102
FT   TURN        103    107
FT   STRAND      112    122
FT   TURN        124    125
FT   STRAND      128    136
FT   TURN        137    138
FT   STRAND      139    145
FT   TURN        146    147
FT   STRAND      148    151
FT   HELIX       153    155
FT   HELIX       156    166
FT   TURN        167    168
FT   HELIX       170    181
FT   TURN        182    182
FT   HELIX       183    194
FT   TURN        195    195
FT   HELIX       196    199
FT   TURN        200    200
FT   STRAND      203    203
FT   STRAND      206    211
FT   TURN        217    218
FT   STRAND      219    230
FT   STRAND      235    240
FT   TURN        241    242
FT   STRAND      243    244
FT   TURN        246    247
FT   STRAND      249    250
FT   STRAND      254    256
FT   TURN        257    259
FT   STRAND      260    270
FT   HELIX       271    273
FT   TURN        275    276
FT   STRAND      277    282
FT   HELIX       284    286
FT   TURN        287    288
FT   STRAND      291    294
SQ   SEQUENCE   333 AA;  36939 MW;  7D02B670D4DE8CC7 CRC64;
     MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS
     DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC
     ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL
     YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR
     GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS
     IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP
//