ID   CD1B_HUMAN     STANDARD;      PRT;   333 AA.
AC   P29016;
DT   01-DEC-1992 (Rel. 24, Created)
DT   01-DEC-1992 (Rel. 24, Last sequence update)
DT   15-JUL-1999 (Rel. 38, Last annotation update)
DE   T-CELL SURFACE GLYCOPROTEIN CD1B PRECURSOR (CD1B ANTIGEN).
GN   CD1B.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 88097453.
RA   Martin L.H., Calabi F., Lefebvre F.-A., Bilsland C.A., Milstein C.;
RT   "Structure and expression of the human thymocyte antigens CD1a, CD1b,
RT   and CD1c.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 89341413.
RA   Aruffo A., Seed B.;
RT   "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c
RT   demonstrates a hierarchy of exclusion in fibroblasts.";
RL   J. Immunol. 143:1723-1730(1989).
CC   -!- FUNCTION: NOT KNOWN.
CC   -!- SUBUNIT: ASSOCIATES NON-COVALENTLY WITH BETA-2-MICROGLOBULIN.
CC   -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN.
CC   -!- TISSUE SPECIFICITY: EXPRESSED ON CORTICAL THYMOCYTES, ON CERTAIN
CC       T-CELL LEUKEMIAS, AND IN VARIOUS OTHER TISSUES.
CC   -!- SIMILARITY: BELONGS TO THE IMMUNOGLOBULIN SUPERFAMILY.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CD1 entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd1.htm".
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DR   EMBL; M22173; AAA51940.1; -.
DR   EMBL; M22168; AAA51940.1; JOINED.
DR   EMBL; M22169; AAA51940.1; JOINED.
DR   EMBL; M22170; AAA51940.1; JOINED.
DR   EMBL; M22171; AAA51940.1; JOINED.
DR   EMBL; M22172; AAA51940.1; JOINED.
DR   EMBL; M28826; AAA51939.1; -.
DR   PIR; B39957; B39957.
DR   PIR; B45801; B45801.
DR   HSSP; P11609; 1CD1.
DR   MIM; 188360; -.
DR   INTERPRO; IPR003006; -.
DR   PFAM; PF00047; ig; 1.
KW   Glycoprotein; Signal; Transmembrane; Immunoglobulin domain; T-cell;
KW   Multigene family.
FT   SIGNAL        1     17       POTENTIAL.
FT   CHAIN        18    333       T-CELL SURFACE GLYCOPROTEIN CD1B.
FT   DOMAIN       18    109       EXTRACELLULAR ALPHA-1.
FT   DOMAIN      110    202       EXTRACELLULAR ALPHA-2.
FT   DOMAIN      203    295       EXTRACELLULAR ALPHA-3.
FT   TRANSMEM    301    324       POTENTIAL.
FT   DOMAIN      325    333       CYTOPLASMIC (POTENTIAL).
FT   DISULFID    120    184       BY SIMILARITY.
FT   DISULFID    224    279       BY SIMILARITY.
FT   CARBOHYD     38     38       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD     75     75       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    146    146       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    258    258       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   333 AA;  36939 MW;  7D02B670D4DE8CC7 CRC64;
     MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS
     DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC
     ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL
     YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR
     GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS
     IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP
//