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Protein

T-cell surface glycoprotein CD1b

Gene

CD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158485-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1b
Alternative name(s):
CD_antigen: CD1b
Gene namesi
Name:CD1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1635. CD1B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 303ExtracellularSequence analysisAdd BLAST286
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 333CytoplasmicSequence analysis9

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
  • lysosomal membrane Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi329 – 330YQ → AA: Strongly reduced internalization and trafficking to endosomes. 1 Publication2

Organism-specific databases

DisGeNETi910.
OpenTargetsiENSG00000158485.
PharmGKBiPA26194.

Polymorphism and mutation databases

BioMutaiCD1B.
DMDMi115962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001457918 – 333T-cell surface glycoprotein CD1bAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)1 Publication1
Glycosylationi75N-linked (GlcNAc...)2 Publications1
Disulfide bondi120 ↔ 184Combined sources3 Publications
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 163Combined sources3 Publications
Disulfide bondi224 ↔ 279Combined sources3 Publications
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29016.
PaxDbiP29016.
PeptideAtlasiP29016.
PRIDEiP29016.

PTM databases

iPTMnetiP29016.
PhosphoSitePlusiP29016.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

BgeeiENSG00000158485.
CleanExiHS_CD1B.
ExpressionAtlasiP29016. baseline and differential.
GenevisibleiP29016. HS.

Organism-specific databases

HPAiHPA021824.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B2MP617693EBI-1033762,EBI-714718

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107348. 51 interactors.
IntActiP29016. 1 interactor.
MINTiMINT-242013.
STRINGi9606.ENSP00000357150.

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 38Combined sources12
Beta strandi41 – 50Combined sources10
Beta strandi53 – 59Combined sources7
Turni60 – 63Combined sources4
Beta strandi64 – 67Combined sources4
Turni70 – 75Combined sources6
Helixi78 – 102Combined sources25
Turni103 – 107Combined sources5
Beta strandi110 – 122Combined sources13
Beta strandi128 – 136Combined sources9
Beta strandi139 – 145Combined sources7
Beta strandi148 – 151Combined sources4
Helixi153 – 155Combined sources3
Helixi156 – 166Combined sources11
Helixi170 – 181Combined sources12
Helixi183 – 194Combined sources12
Helixi196 – 199Combined sources4
Beta strandi206 – 213Combined sources8
Beta strandi219 – 232Combined sources14
Beta strandi234 – 240Combined sources7
Beta strandi254 – 256Combined sources3
Turni257 – 259Combined sources3
Beta strandi261 – 270Combined sources10
Helixi271 – 273Combined sources3
Beta strandi277 – 283Combined sources7
Helixi284 – 286Combined sources3
Beta strandi291 – 296Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZPX-ray2.80A18-295[»]
1GZQX-ray2.26A18-295[»]
1UQSX-ray3.10A18-295[»]
2H26X-ray1.80A19-298[»]
3OV6X-ray2.50A166-295[»]
3T8XX-ray1.90A/C19-298[»]
4ONOX-ray2.70A201-295[»]
5C9JX-ray2.40A203-295[»]
ProteinModelPortaliP29016.
SMRiP29016.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29016.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 295Ig-likeAdd BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Internalization signal4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP29016.
KOiK06448.
OMAiWAQTQGS.
OrthoDBiEOG091G0H36.
PhylomeDBiP29016.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29016-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL
60 70 80 90 100
DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ
110 120 130 140 150
DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV
160 170 180 190 200
PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ
210 220 230 240 250
RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL
260 270 280 290 300
GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS
310 320 330
IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP
Length:333
Mass (Da):36,939
Last modified:December 1, 1992 - v1
Checksum:i7D02B670D4DE8CC7
GO
Isoform 2 (identifier: P29016-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-296: Missing.

Show »
Length:278
Mass (Da):30,740
Checksum:i087FD5FF65921339
GO

Sequence cautioni

The sequence CAI10852 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016911242 – 296Missing in isoform 2. CuratedAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22173
, M22168, M22169, M22170, M22171, M22172 Genomic DNA. Translation: AAA51940.1.
M28826 mRNA. Translation: AAA51939.1.
AL121986 Genomic DNA. Translation: CAI10852.1. Sequence problems.
AL121986 Genomic DNA. Translation: CAI10853.1.
BC069481 mRNA. Translation: AAH69481.1.
BC074747 mRNA. Translation: AAH74747.1.
BC104216 mRNA. Translation: AAI04217.1.
BC104217 mRNA. Translation: AAI04218.1.
M14665 Genomic DNA. Translation: AAA51936.1.
CCDSiCCDS1176.1. [P29016-1]
PIRiB39957. HLHUCB.
RefSeqiNP_001755.1. NM_001764.2. [P29016-1]
XP_011508421.1. XM_011510119.2. [P29016-2]
UniGeneiHs.1310.

Genome annotation databases

EnsembliENST00000368168; ENSP00000357150; ENSG00000158485. [P29016-1]
GeneIDi910.
KEGGihsa:910.
UCSCiuc001frx.4. human. [P29016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22173
, M22168, M22169, M22170, M22171, M22172 Genomic DNA. Translation: AAA51940.1.
M28826 mRNA. Translation: AAA51939.1.
AL121986 Genomic DNA. Translation: CAI10852.1. Sequence problems.
AL121986 Genomic DNA. Translation: CAI10853.1.
BC069481 mRNA. Translation: AAH69481.1.
BC074747 mRNA. Translation: AAH74747.1.
BC104216 mRNA. Translation: AAI04217.1.
BC104217 mRNA. Translation: AAI04218.1.
M14665 Genomic DNA. Translation: AAA51936.1.
CCDSiCCDS1176.1. [P29016-1]
PIRiB39957. HLHUCB.
RefSeqiNP_001755.1. NM_001764.2. [P29016-1]
XP_011508421.1. XM_011510119.2. [P29016-2]
UniGeneiHs.1310.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZPX-ray2.80A18-295[»]
1GZQX-ray2.26A18-295[»]
1UQSX-ray3.10A18-295[»]
2H26X-ray1.80A19-298[»]
3OV6X-ray2.50A166-295[»]
3T8XX-ray1.90A/C19-298[»]
4ONOX-ray2.70A201-295[»]
5C9JX-ray2.40A203-295[»]
ProteinModelPortaliP29016.
SMRiP29016.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107348. 51 interactors.
IntActiP29016. 1 interactor.
MINTiMINT-242013.
STRINGi9606.ENSP00000357150.

PTM databases

iPTMnetiP29016.
PhosphoSitePlusiP29016.

Polymorphism and mutation databases

BioMutaiCD1B.
DMDMi115962.

Proteomic databases

MaxQBiP29016.
PaxDbiP29016.
PeptideAtlasiP29016.
PRIDEiP29016.

Protocols and materials databases

DNASUi910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368168; ENSP00000357150; ENSG00000158485. [P29016-1]
GeneIDi910.
KEGGihsa:910.
UCSCiuc001frx.4. human. [P29016-1]

Organism-specific databases

CTDi910.
DisGeNETi910.
GeneCardsiCD1B.
HGNCiHGNC:1635. CD1B.
HPAiHPA021824.
MIMi188360. gene.
neXtProtiNX_P29016.
OpenTargetsiENSG00000158485.
PharmGKBiPA26194.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG. Eukaryota.
ENOG41113WA. LUCA.
GeneTreeiENSGT00480000042665.
HOGENOMiHOG000111666.
HOVERGENiHBG004453.
InParanoidiP29016.
KOiK06448.
OMAiWAQTQGS.
OrthoDBiEOG091G0H36.
PhylomeDBiP29016.
TreeFamiTF336723.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158485-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiP29016.
GenomeRNAii910.
PROiP29016.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158485.
CleanExiHS_CD1B.
ExpressionAtlasiP29016. baseline and differential.
GenevisibleiP29016. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD1B_HUMAN
AccessioniPrimary (citable) accession number: P29016
Secondary accession number(s): Q5TDK9, Q5TDL0, Q9UMM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.