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Protein

Bombinin-like peptides 1

Gene
N/A
Organism
Bombina variegata (Yellow-bellied toad)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has antimicrobial activity, but no hemolytic activity. Preliminary evidence indicates that this peptide does not lyse and thus kill the bacteria by its antimicrobial activity.
Bombinin H has antibacterial and hemolytic activity.

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Bombinin-like peptides 1
Cleaved into the following 5 chains:
OrganismiBombina variegata (Yellow-bellied toad)
Taxonomic identifieri8348 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PeptideiPRO_000000306719 – 43Acidic peptide 1-1Sequence analysisAdd BLAST25
PeptideiPRO_000000306844 – 70Bombinin-like peptide 1Add BLAST27
PeptideiPRO_000000306974 – 81Octapeptide 1Sequence analysis8
PeptideiPRO_000000307084 – 114Acidic peptide 1-2Sequence analysisAdd BLAST31
PeptideiPRO_0000003071117 – 136Bombinin-HAdd BLAST20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70Asparagine amide1 Publication1
Modified residuei118D-allo-isoleucine1 Publication1
Modified residuei136Isoleucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, D-amino acid

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Belongs to the bombinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG031694.

Family and domain databases

InterProiView protein in InterPro
IPR007962. Bombinin.
PfamiView protein in Pfam
PF05298. Bombinin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFKYIVAVS ILIASAYARS EENDIQSLSQ RDVLEEESLR EIRGIGGALL
60 70 80 90 100
SAAKVGLKGL AKGLAEHFAN GKRTAEEREV MKRLEAAMRD LDSFEHPEEA
110 120 130
SEKETRGFNQ EEKEKRIIGP VLGLVGSALG GLLKKIG
Length:137
Mass (Da):14,982
Last modified:December 1, 1992 - v1
Checksum:i3EC3EF6E47CA1F92
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti117I → L. 1
Natural varianti124L → M. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59695 mRNA. Translation: CAA42216.1.
PIRiS16222.

Similar proteinsi

Entry informationi

Entry nameiBMNL1_BOMVA
AccessioniPrimary (citable) accession number: P29006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 15, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families