P29005 (BMNL4_BOMOR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Bombinin-like peptide 4 Short name=BLP-4
Organism	Bombina orientalis (Oriental fire-bellied toad)
Taxonomic identifier	8346 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Archeobatrachia › Bombinatoridae › Bombina

Protein attributes

Sequence length	25 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the bombinin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 25	25	Bombinin-like peptide 4		PRO_0000043502
Amino acid modifications
	Modified residue	25	1	Phenylalanine amide

Sequences

	Sequence		Length	Mass (Da)
	P29005 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: E97916634BC3F768	FASTA	25	2,409
	10 20 GIGAAILSAG KSIIKGLANG LAEHF

References

[1]	"Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." Gibson B.W., Tang D., Mandrell R., Kelly M., Spindel E.R. J. Biol. Chem. 266:23103-23111(1991) [PubMed: 1744108] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.

Cross-references

Sequence databases
PIR	D41575.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

BMNL4_BOMOR

Accession

Primary (citable) accession number: P29005

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	March 2, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program