P29003 (BMNL2_BOMOR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Bombinin-like peptide 2 Short name=BLP-2
Organism	Bombina orientalis (Oriental fire-bellied toad)
Taxonomic identifier	8346 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Archeobatrachia › Bombinatoridae › Bombina

Protein attributes

Sequence length	27 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has antimicrobial activity, but no hemolytic activity. Preference on killing Gram-negative non-enteric bacteria.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the bombinin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 27	27	Bombinin-like peptide 2		PRO_0000043501
Amino acid modifications
	Modified residue	27	1	Asparagine amide

Sequences

	Sequence		Length	Mass (Da)
	P29003 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: FC69D979166710F5	FASTA	27	2,582
	10 20 GIGSAILSAG KSALKGLAKG LAEHFAN

References

[1]	"Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis." Gibson B.W., Tang D., Mandrell R., Kelly M., Spindel E.R. J. Biol. Chem. 266:23103-23111(1991) [PubMed: 1744108] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.

Cross-references

Sequence databases
PIR	B41575.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR007962. Bombinin. [Graphical view]
Pfam	PF05298. Bombinin. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BMNL2_BOMOR

Accession

Primary (citable) accession number: P29003

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	March 2, 2010
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program