P28977 (ENV_THOGV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Envelope glycoprotein

Alternative name(s):
Surface glycoprotein 75

Gene names

Name:

P4

Organism

Thogoto virus (isolate SiAr 126) (Tho) [Reference proteome]

Taxonomic identifier

126796 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Thogotovirus › Thogoto virus

Virus host

Amblyomma variegatum (Tropical bont tick) [TaxID: 34610]
Boophilus microplus (Cattle tick) [TaxID: 6941]
Cavia cutleri (Guinea pig) [TaxID: 10144]
Mungos mungo (Banded mongoose) [TaxID: 210652]
Rhipicephalus appendiculatus (Brown ear tick) [TaxID: 34631]

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Possible role in endocytotic fusion events during infection.
Subunit structure	Monomer Probable.
Subcellular location	Virion membrane Potential.
Sequence similarities	Belongs to the baculoviruses gp64 family.

Ontologies

Keywords
Cellular component	Membrane Virion
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	virus-host interaction Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW viral envelope Inferred from electronic annotation. Source: InterPro virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 512	497	Envelope glycoprotein		PRO_0000039175
Regions
	Transmembrane	479 – 502	24	Helical; Potential
Amino acid modifications
	Glycosylation	185	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	263	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	289	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	378	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	416	1	N-linked (GlcNAc...); by host Potential

Sequences

	Sequence		Length	Mass (Da)
	P28977 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 0398FC36284A0DF1	FASTA	512	57,550
	10 20 30 40 50 60 MFLQTALLLL SLGVAEPDCN TKTATGPYIL DRYKPKPVTV SKKLYSATRY TTSAQNELLT 70 80 90 100 110 120 AGYRTAWVAY CYNGGLVDSN TGCNARLLHY PPSRDELLLW GSSHQCSYGD ICHDCWGSDS 130 140 150 160 170 180 YACLGQLDPA KHWAPRKELV RRDANWKFAY HMCNIDWRCG VTTSPVFFNL QWVKNEVKVS 190 200 210 220 230 240 TLLPNGSTVE HSAGEPLFWT EKDFSYLVKD NFEIQREEVK ISCFVDPDYW VGERKTKKAF 250 260 270 280 290 300 CQDGTNFFEV TSHQFCHQYA CYNFSKDELL EAVYKERAHE KSKDLPFGNK SWTVVTASID 310 320 330 340 350 360 DLHALSAAQA FELEGLRASF AELDSRFRQL SEILDTVISS IAKIDERLIG RLIKAPVSSR 370 380 390 400 410 420 FISEDKFLLH QCVDSVANNT NCVGDSAYVD GRWTHVGDNH PCTTVVDEPI GIDIYNFSAL 430 440 450 460 470 480 WYPSAAEVDF RGTVQSEDGW SFVVKSKDAL IQTMMYTKNG GKGTSLTDLL DYPSGWLKGQ 490 500 510 LGGLLYGNIG VYLLIAFAFV LLIRLIKSAG LC

References

[1]	"The glycoprotein of Thogoto virus (a tick-borne orthomyxo-like virus) is related to the baculovirus glycoprotein GP64." Morse M.A., Marriott A.C., Nuttall P.A. Virology 186:640-646(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M77280 Genomic RNA. Translation: AAA47918.1.
PIR	VGIVTH. A40821.
RefSeq	YP_145808.1. NC_006506.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5075737.
Family and domain databases
InterPro	IPR004955. Baculovirus_Gp64. [Graphical view]
Pfam	PF03273. Baculo_gp64. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ENV_THOGV

Accession

Primary (citable) accession number: P28977

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program