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P28976

- L_TSWV1

UniProt

P28976 - L_TSWV1

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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Taxonomic identifieri36413 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]
ProteomesiUP000006674: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28752875RNA-directed RNA polymerase LPRO_0000222027Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1347 – 1530184RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the tospovirus RNA polymerase family.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR007099. RNA-dir_pol_NSvirus.
IPR015841. RNA-dir_pol_tospovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
[Graphical view]
PIRSFiPIRSF036872. L_TospoV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28976-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNIQKIQKLI ENGTTLLLSI EDCVGSNHDL ALDLHKRNSD EIPEDVIINN
60 70 80 90 100
NAKNYETMRE LIVKITADGE GLNKGMATVD VKKLSEMVSL FEQKYLETEL
110 120 130 140 150
ARHDIFGELI SRHLRIKPKQ RNEVEIEHAL REYLDELNKK SCINKLSDDE
160 170 180 190 200
FERINKEYVA TNATPDNYVI YKESKNSELC LIIYDWKISV DARTETKQWR
210 220 230 240 250
NTYKNIWKSF KDIKVNGKPF LEEHPVFVSI VILKPIAGMP ITVTSSRVLE
260 270 280 290 300
KFEDSPSALH GERIKHAKNA KLLNISYVGQ IVGTTPTVVR NYYANTQRIK
310 320 330 340 350
SEVRGILGDD FGSKDVFFSH WTSKYKERNP TEIAYSEDIE RIIDSLVTDE
360 370 380 390 400
IPREEIIHFL FGNFCFHIET MNDQHIADKF KGYQNSCINL KIEPKADLAD
410 420 430 440 450
LKDHLIQKQQ IWESLYGKHL EKIMLRIREK KRKEKEIPDI TTAFNQNAAE
460 470 480 490 500
YEERYPNCFN DLSELKLTFH DLVPSLKIEL SSEVDYNNAI INKFRESFKS
510 520 530 540 550
SSRVIYNSPY SSINNQTNKA RDITNLVRLC LAELSCDTTK MEKQELEDEI
560 570 580 590 600
DINTGSIKVE RTKKSKEWNK QGSCLTRNKN EFCMKDTGRE NKTTYFKGLA
610 620 630 640 650
VMNIGMSSKK RILKKEEIKE RISKGLEYDT SERQADPNDD YSSIDMSSLT
660 670 680 690 700
HMKKLIRHDN DDSLSGKRFK GSFFLLHNFN IIEDGKITSV FNNYAKNPEC
710 720 730 740 750
LYIQDSVLKT ELETCKKINK LCNDLAIYHY SEDMMQFSKG LMVADRYMTK
760 770 780 790 800
ESFKILTTAN TSMMLLAFKG DGMNTGGSGV PYIALHIVDE DMSDHFNICY
810 820 830 840 850
TKEIYSYFRS GSNYIYIMRP QRLNQVRLLR LFKTPSKVPV CFPQFSKKAN
860 870 880 890 900
EIGKSLKNKD IEKVNLFSMT MTVKQILINI VFSSVMIGTV TKLSRMGIFD
910 920 930 940 950
FMRYAGFLRL SDYSNIKEYI RDKSDPDITN CGRYLFRNGI KKLLFRMEDL
960 970 980 990 1000
NLSTNAKPVV VDHENDIIGG ITNLNIKCPI TGSTLLTLED LYNNVYLAIY
1010 1020 1030 1040 1050
MMPKSLHNHV HNLTSLLNLP AEWELKFRKE LGFNIFEDIY PKKAMFDDKD
1060 1070 1080 1090 1100
LFSINGALNV KALSDYYLGN IENVGLMRSE IENKEDFLSP CYKISTLKSS
1110 1120 1130 1140 1150
KKCSQSNIIS TDEIIECLQD AKIQDIENWK GNNLAIIKGL IRTYNEEKNR
1160 1170 1180 1190 1200
LVEFFEDNCV NSLYLIEKLK EIISSGSITV GKSVTSKFIR NNHPLTVETY
1210 1220 1230 1240 1250
LKTKLYYRNN VTVLKSKKVS EELYDLVKQF HDMMEIDLDS VMNLGKGTEG
1260 1270 1280 1290 1300
KKLTFLQMLE FVMSKAKNVT GSVDFLVSVF EKMQRTKTDR EIYLMSMKVK
1310 1320 1330 1340 1350
MMLYFIEHTF KHVAQSDPSE AISISGDNKI RALSTLSLDT ITSYNDILNK
1360 1370 1380 1390 1400
NSKKSRLAFL SADQSKWSAS GLTTYKYVLA IILNPILTTG EASLMIECIL
1410 1420 1430 1440 1450
MYVKLKKVCI PTDIFLNLRK AQQTFGENET AIGLLTKGLT TNTYPVSMNW
1460 1470 1480 1490 1500
LQGNLNYLSS VYHSCAMKAY HNTLECYKNC DFQTRWIVHS DDNATSLIAS
1510 1520 1530 1540 1550
GEVDKMLTDF SSSSLPEMLF RSIEAHFKSF CITLNPKKSY ASSSEVEFIS
1560 1570 1580 1590 1600
ERISKWSDYS SLLQAFSKLL HRIFAYKLFD DLMSLSIHVT MLLRKGCPNE
1610 1620 1630 1640 1650
VIPFAYGAVQ VQALSIYSML PGEVNDSIRI FNKLGVSLKS NEIPTNMGGW
1660 1670 1680 1690 1700
LTSPIEPLSI LGPSSNDQII YYNVIRDFLN KKSLEEVKDS VSSSSYLQMR
1710 1720 1730 1740 1750
FRELKEKYER GTLEEKDKKM IFLINLFEKA SVSEDSDVLT IGMKFQTMLT
1760 1770 1780 1790 1800
QIIKLPNFIN ENALNKMSSY KDFSKLYPNL KKNEDLYKST KNLKIDEDAV
1810 1820 1830 1840 1850
LEEDELYKKI ASSLEMESVH DIMIKNPETI LIAPLNDRDF LLSQLFMYTS
1860 1870 1880 1890 1900
PSKRNQLSNQ STEKLALDRV LRSKARTFVN ISSTVKMTYE ENMEKKILEM
1910 1920 1930 1940 1950
LKFDLDSYCS FKTCVNLVIK DVNFSMLIPI LDSAYPCESR KRDNYNFRWF
1960 1970 1980 1990 2000
QTERWIPVVE GSPGLVVMHA VYGSNYIENL GLKNIPLTDD SINVLTSTFG
2010 2020 2030 2040 2050
TGLIMEDVKS LVNGKDSFET EAFSNSNECQ RLVKACNYMI AAQNRLLAIN
2060 2070 2080 2090 2100
TCFTRKSFPF YSKFNLGRGF ISNTLALLST IYSKEESYHF VSTASYKLDK
2110 2120 2130 2140 2150
TIRTVVSAQQ DMNLEKILDT AVYISDKLQS LFPTITREDI VLILQNVCLD
2160 2170 2180 2190 2200
SKPIWQSLED KMKKINNSTA SGFTVSNVIL SHNSELNTIQ KQIVWMWNMG
2210 2220 2230 2240 2250
LCSHRTLDFV IRYIRRRDVR YVKTEEQDES GNYVSGTMYK IGIMTRSCYV
2260 2270 2280 2290 2300
ELIASDQDVA VSLRTPFEIL NEREYLFDTY RESIEKLLAE IMFDKVNIIN
2310 2320 2330 2340 2350
QTTTDCFLRT RRSCIRMTTD NKMIVKVNAT SRQIRLENVK LVVKIKYENV
2360 2370 2380 2390 2400
NSDVWDIIES QKSLVLRLPE VGEFFSDMYK TADSETETIK TIKNRLMTSL
2410 2420 2430 2440 2450
TFIEAFGNLS QQIKEIVDDD IRETMDEFLM NIRDTCLEGL ENCKSVEEYD
2460 2470 2480 2490 2500
SYLDENGFND TVELFENLLR THDNFENEYS PLFSEIVDKA KQYTRDLEGF
2510 2520 2530 2540 2550
KEILLMLKYS LINDASGFKS YRATGMHAVE LMAKKHIEIG EFNLLGMIQL
2560 2570 2580 2590 2600
IKACETCHNN DSILNLASLR NVLSRTYATF GRRIRLDHDL DLQNNLMEKS
2610 2620 2630 2640 2650
YDFKTLVLPE IKLSELSREI LKENGFVISG ENLKMDRSDE EFVGLASFNV
2660 2670 2680 2690 2700
LRLDEEEMYE GLIKEMKIKR KKKGFLFPAN TLLLSELIKF LIGGIKGTSF
2710 2720 2730 2740 2750
DIETLLRNSF RPDIFSTDRL GRLSSSVPAL KVYATVYMEY KNVNCPLNEI
2760 2770 2780 2790 2800
ADSLEGYLKL TKSRSKEHFL SGRVKKALIQ LRDEQSRTKK LEVYKDIANF
2810 2820 2830 2840 2850
LARHPLCLSE KTLYGRYTYS DINDYIMQTR EIILSKISEL DEVVETDEDN
2860 2870
FLLSYLRGEE DAFDEDELDE EEDTD
Length:2,875
Mass (Da):331,503
Last modified:December 1, 1992 - v1
Checksum:i574B3B55CF07C6FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10066 Genomic RNA. Translation: BAA00955.1.
PIRiJQ1335. RRVUTW.
RefSeqiNP_049362.1. NC_002052.1.

Genome annotation databases

GeneIDi956582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10066 Genomic RNA. Translation: BAA00955.1 .
PIRi JQ1335. RRVUTW.
RefSeqi NP_049362.1. NC_002052.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956582.

Family and domain databases

InterProi IPR007099. RNA-dir_pol_NSvirus.
IPR015841. RNA-dir_pol_tospovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
[Graphical view ]
PIRSFi PIRSF036872. L_TospoV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tomato spotted wilt virus L RNA encodes a putative RNA polymerase."
    de Haan P., Kormelink R., de Oliveira Resende R., van Poelwijk F., Peters D., Goldbach R.
    J. Gen. Virol. 72:2207-2216(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_TSWV1
AccessioniPrimary (citable) accession number: P28976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 1, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3