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P28976 (L_TSWV1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase L

Short name=Protein L
EC=2.7.7.48
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene names
Name:L
OrganismTomato spotted wilt virus (strain Brazilian Br-01) (TSWV) [Reference proteome]
Taxonomic identifier36413 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]

Protein attributes

Sequence length2875 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sequence similarities

Belongs to the tospovirus RNA polymerase family.

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 28752875RNA-directed RNA polymerase L
PRO_0000222027

Regions

Domain1347 – 1530184RdRp catalytic

Sequences

Sequence LengthMass (Da)Tools
P28976 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 574B3B55CF07C6FB

FASTA2,875331,503
        10         20         30         40         50         60 
MNIQKIQKLI ENGTTLLLSI EDCVGSNHDL ALDLHKRNSD EIPEDVIINN NAKNYETMRE 

        70         80         90        100        110        120 
LIVKITADGE GLNKGMATVD VKKLSEMVSL FEQKYLETEL ARHDIFGELI SRHLRIKPKQ 

       130        140        150        160        170        180 
RNEVEIEHAL REYLDELNKK SCINKLSDDE FERINKEYVA TNATPDNYVI YKESKNSELC 

       190        200        210        220        230        240 
LIIYDWKISV DARTETKQWR NTYKNIWKSF KDIKVNGKPF LEEHPVFVSI VILKPIAGMP 

       250        260        270        280        290        300 
ITVTSSRVLE KFEDSPSALH GERIKHAKNA KLLNISYVGQ IVGTTPTVVR NYYANTQRIK 

       310        320        330        340        350        360 
SEVRGILGDD FGSKDVFFSH WTSKYKERNP TEIAYSEDIE RIIDSLVTDE IPREEIIHFL 

       370        380        390        400        410        420 
FGNFCFHIET MNDQHIADKF KGYQNSCINL KIEPKADLAD LKDHLIQKQQ IWESLYGKHL 

       430        440        450        460        470        480 
EKIMLRIREK KRKEKEIPDI TTAFNQNAAE YEERYPNCFN DLSELKLTFH DLVPSLKIEL 

       490        500        510        520        530        540 
SSEVDYNNAI INKFRESFKS SSRVIYNSPY SSINNQTNKA RDITNLVRLC LAELSCDTTK 

       550        560        570        580        590        600 
MEKQELEDEI DINTGSIKVE RTKKSKEWNK QGSCLTRNKN EFCMKDTGRE NKTTYFKGLA 

       610        620        630        640        650        660 
VMNIGMSSKK RILKKEEIKE RISKGLEYDT SERQADPNDD YSSIDMSSLT HMKKLIRHDN 

       670        680        690        700        710        720 
DDSLSGKRFK GSFFLLHNFN IIEDGKITSV FNNYAKNPEC LYIQDSVLKT ELETCKKINK 

       730        740        750        760        770        780 
LCNDLAIYHY SEDMMQFSKG LMVADRYMTK ESFKILTTAN TSMMLLAFKG DGMNTGGSGV 

       790        800        810        820        830        840 
PYIALHIVDE DMSDHFNICY TKEIYSYFRS GSNYIYIMRP QRLNQVRLLR LFKTPSKVPV 

       850        860        870        880        890        900 
CFPQFSKKAN EIGKSLKNKD IEKVNLFSMT MTVKQILINI VFSSVMIGTV TKLSRMGIFD 

       910        920        930        940        950        960 
FMRYAGFLRL SDYSNIKEYI RDKSDPDITN CGRYLFRNGI KKLLFRMEDL NLSTNAKPVV 

       970        980        990       1000       1010       1020 
VDHENDIIGG ITNLNIKCPI TGSTLLTLED LYNNVYLAIY MMPKSLHNHV HNLTSLLNLP 

      1030       1040       1050       1060       1070       1080 
AEWELKFRKE LGFNIFEDIY PKKAMFDDKD LFSINGALNV KALSDYYLGN IENVGLMRSE 

      1090       1100       1110       1120       1130       1140 
IENKEDFLSP CYKISTLKSS KKCSQSNIIS TDEIIECLQD AKIQDIENWK GNNLAIIKGL 

      1150       1160       1170       1180       1190       1200 
IRTYNEEKNR LVEFFEDNCV NSLYLIEKLK EIISSGSITV GKSVTSKFIR NNHPLTVETY 

      1210       1220       1230       1240       1250       1260 
LKTKLYYRNN VTVLKSKKVS EELYDLVKQF HDMMEIDLDS VMNLGKGTEG KKLTFLQMLE 

      1270       1280       1290       1300       1310       1320 
FVMSKAKNVT GSVDFLVSVF EKMQRTKTDR EIYLMSMKVK MMLYFIEHTF KHVAQSDPSE 

      1330       1340       1350       1360       1370       1380 
AISISGDNKI RALSTLSLDT ITSYNDILNK NSKKSRLAFL SADQSKWSAS GLTTYKYVLA 

      1390       1400       1410       1420       1430       1440 
IILNPILTTG EASLMIECIL MYVKLKKVCI PTDIFLNLRK AQQTFGENET AIGLLTKGLT 

      1450       1460       1470       1480       1490       1500 
TNTYPVSMNW LQGNLNYLSS VYHSCAMKAY HNTLECYKNC DFQTRWIVHS DDNATSLIAS 

      1510       1520       1530       1540       1550       1560 
GEVDKMLTDF SSSSLPEMLF RSIEAHFKSF CITLNPKKSY ASSSEVEFIS ERISKWSDYS 

      1570       1580       1590       1600       1610       1620 
SLLQAFSKLL HRIFAYKLFD DLMSLSIHVT MLLRKGCPNE VIPFAYGAVQ VQALSIYSML 

      1630       1640       1650       1660       1670       1680 
PGEVNDSIRI FNKLGVSLKS NEIPTNMGGW LTSPIEPLSI LGPSSNDQII YYNVIRDFLN 

      1690       1700       1710       1720       1730       1740 
KKSLEEVKDS VSSSSYLQMR FRELKEKYER GTLEEKDKKM IFLINLFEKA SVSEDSDVLT 

      1750       1760       1770       1780       1790       1800 
IGMKFQTMLT QIIKLPNFIN ENALNKMSSY KDFSKLYPNL KKNEDLYKST KNLKIDEDAV 

      1810       1820       1830       1840       1850       1860 
LEEDELYKKI ASSLEMESVH DIMIKNPETI LIAPLNDRDF LLSQLFMYTS PSKRNQLSNQ 

      1870       1880       1890       1900       1910       1920 
STEKLALDRV LRSKARTFVN ISSTVKMTYE ENMEKKILEM LKFDLDSYCS FKTCVNLVIK 

      1930       1940       1950       1960       1970       1980 
DVNFSMLIPI LDSAYPCESR KRDNYNFRWF QTERWIPVVE GSPGLVVMHA VYGSNYIENL 

      1990       2000       2010       2020       2030       2040 
GLKNIPLTDD SINVLTSTFG TGLIMEDVKS LVNGKDSFET EAFSNSNECQ RLVKACNYMI 

      2050       2060       2070       2080       2090       2100 
AAQNRLLAIN TCFTRKSFPF YSKFNLGRGF ISNTLALLST IYSKEESYHF VSTASYKLDK 

      2110       2120       2130       2140       2150       2160 
TIRTVVSAQQ DMNLEKILDT AVYISDKLQS LFPTITREDI VLILQNVCLD SKPIWQSLED 

      2170       2180       2190       2200       2210       2220 
KMKKINNSTA SGFTVSNVIL SHNSELNTIQ KQIVWMWNMG LCSHRTLDFV IRYIRRRDVR 

      2230       2240       2250       2260       2270       2280 
YVKTEEQDES GNYVSGTMYK IGIMTRSCYV ELIASDQDVA VSLRTPFEIL NEREYLFDTY 

      2290       2300       2310       2320       2330       2340 
RESIEKLLAE IMFDKVNIIN QTTTDCFLRT RRSCIRMTTD NKMIVKVNAT SRQIRLENVK 

      2350       2360       2370       2380       2390       2400 
LVVKIKYENV NSDVWDIIES QKSLVLRLPE VGEFFSDMYK TADSETETIK TIKNRLMTSL 

      2410       2420       2430       2440       2450       2460 
TFIEAFGNLS QQIKEIVDDD IRETMDEFLM NIRDTCLEGL ENCKSVEEYD SYLDENGFND 

      2470       2480       2490       2500       2510       2520 
TVELFENLLR THDNFENEYS PLFSEIVDKA KQYTRDLEGF KEILLMLKYS LINDASGFKS 

      2530       2540       2550       2560       2570       2580 
YRATGMHAVE LMAKKHIEIG EFNLLGMIQL IKACETCHNN DSILNLASLR NVLSRTYATF 

      2590       2600       2610       2620       2630       2640 
GRRIRLDHDL DLQNNLMEKS YDFKTLVLPE IKLSELSREI LKENGFVISG ENLKMDRSDE 

      2650       2660       2670       2680       2690       2700 
EFVGLASFNV LRLDEEEMYE GLIKEMKIKR KKKGFLFPAN TLLLSELIKF LIGGIKGTSF 

      2710       2720       2730       2740       2750       2760 
DIETLLRNSF RPDIFSTDRL GRLSSSVPAL KVYATVYMEY KNVNCPLNEI ADSLEGYLKL 

      2770       2780       2790       2800       2810       2820 
TKSRSKEHFL SGRVKKALIQ LRDEQSRTKK LEVYKDIANF LARHPLCLSE KTLYGRYTYS 

      2830       2840       2850       2860       2870 
DINDYIMQTR EIILSKISEL DEVVETDEDN FLLSYLRGEE DAFDEDELDE EEDTD 

« Hide

References

[1]"Tomato spotted wilt virus L RNA encodes a putative RNA polymerase."
de Haan P., Kormelink R., de Oliveira Resende R., van Poelwijk F., Peters D., Goldbach R.
J. Gen. Virol. 72:2207-2216(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10066 Genomic RNA. Translation: BAA00955.1.
PIRRRVUTW. JQ1335.
RefSeqNP_049362.1. NC_002052.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956582.

Family and domain databases

InterProIPR007099. RNA-dir_pol_NSvirus.
IPR015841. RNA-dir_pol_tospovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamPF04196. Bunya_RdRp. 1 hit.
[Graphical view]
PIRSFPIRSF036872. L_TospoV. 1 hit.
PROSITEPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameL_TSWV1
AccessionPrimary (citable) accession number: P28976
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families