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P28976

- L_TSWV1

UniProt

P28976 - L_TSWV1

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Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
  2. viral RNA genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Gene namesi
Name:L
OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Taxonomic identifieri36413 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
Scirtothrips dorsalis [TaxID: 163899]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Thrips tabaci [TaxID: 161014]
ProteomesiUP000006674: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 28752875RNA-directed RNA polymerase L
PRO_0000222027Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1347 – 1530184RdRp catalytic
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR007099. RNA-dir_pol_NSvirus.
IPR015841. RNA-dir_pol_tospovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view]
PfamiPF04196. Bunya_RdRp. 1 hit.
[Graphical view]
PIRSFiPIRSF036872. L_TospoV. 1 hit.
PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28976-1 [UniParc]FASTAAdd to Basket

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MNIQKIQKLI ENGTTLLLSI EDCVGSNHDL ALDLHKRNSD EIPEDVIINN     50
NAKNYETMRE LIVKITADGE GLNKGMATVD VKKLSEMVSL FEQKYLETEL 100
ARHDIFGELI SRHLRIKPKQ RNEVEIEHAL REYLDELNKK SCINKLSDDE 150
FERINKEYVA TNATPDNYVI YKESKNSELC LIIYDWKISV DARTETKQWR 200
NTYKNIWKSF KDIKVNGKPF LEEHPVFVSI VILKPIAGMP ITVTSSRVLE 250
KFEDSPSALH GERIKHAKNA KLLNISYVGQ IVGTTPTVVR NYYANTQRIK 300
SEVRGILGDD FGSKDVFFSH WTSKYKERNP TEIAYSEDIE RIIDSLVTDE 350
IPREEIIHFL FGNFCFHIET MNDQHIADKF KGYQNSCINL KIEPKADLAD 400
LKDHLIQKQQ IWESLYGKHL EKIMLRIREK KRKEKEIPDI TTAFNQNAAE 450
YEERYPNCFN DLSELKLTFH DLVPSLKIEL SSEVDYNNAI INKFRESFKS 500
SSRVIYNSPY SSINNQTNKA RDITNLVRLC LAELSCDTTK MEKQELEDEI 550
DINTGSIKVE RTKKSKEWNK QGSCLTRNKN EFCMKDTGRE NKTTYFKGLA 600
VMNIGMSSKK RILKKEEIKE RISKGLEYDT SERQADPNDD YSSIDMSSLT 650
HMKKLIRHDN DDSLSGKRFK GSFFLLHNFN IIEDGKITSV FNNYAKNPEC 700
LYIQDSVLKT ELETCKKINK LCNDLAIYHY SEDMMQFSKG LMVADRYMTK 750
ESFKILTTAN TSMMLLAFKG DGMNTGGSGV PYIALHIVDE DMSDHFNICY 800
TKEIYSYFRS GSNYIYIMRP QRLNQVRLLR LFKTPSKVPV CFPQFSKKAN 850
EIGKSLKNKD IEKVNLFSMT MTVKQILINI VFSSVMIGTV TKLSRMGIFD 900
FMRYAGFLRL SDYSNIKEYI RDKSDPDITN CGRYLFRNGI KKLLFRMEDL 950
NLSTNAKPVV VDHENDIIGG ITNLNIKCPI TGSTLLTLED LYNNVYLAIY 1000
MMPKSLHNHV HNLTSLLNLP AEWELKFRKE LGFNIFEDIY PKKAMFDDKD 1050
LFSINGALNV KALSDYYLGN IENVGLMRSE IENKEDFLSP CYKISTLKSS 1100
KKCSQSNIIS TDEIIECLQD AKIQDIENWK GNNLAIIKGL IRTYNEEKNR 1150
LVEFFEDNCV NSLYLIEKLK EIISSGSITV GKSVTSKFIR NNHPLTVETY 1200
LKTKLYYRNN VTVLKSKKVS EELYDLVKQF HDMMEIDLDS VMNLGKGTEG 1250
KKLTFLQMLE FVMSKAKNVT GSVDFLVSVF EKMQRTKTDR EIYLMSMKVK 1300
MMLYFIEHTF KHVAQSDPSE AISISGDNKI RALSTLSLDT ITSYNDILNK 1350
NSKKSRLAFL SADQSKWSAS GLTTYKYVLA IILNPILTTG EASLMIECIL 1400
MYVKLKKVCI PTDIFLNLRK AQQTFGENET AIGLLTKGLT TNTYPVSMNW 1450
LQGNLNYLSS VYHSCAMKAY HNTLECYKNC DFQTRWIVHS DDNATSLIAS 1500
GEVDKMLTDF SSSSLPEMLF RSIEAHFKSF CITLNPKKSY ASSSEVEFIS 1550
ERISKWSDYS SLLQAFSKLL HRIFAYKLFD DLMSLSIHVT MLLRKGCPNE 1600
VIPFAYGAVQ VQALSIYSML PGEVNDSIRI FNKLGVSLKS NEIPTNMGGW 1650
LTSPIEPLSI LGPSSNDQII YYNVIRDFLN KKSLEEVKDS VSSSSYLQMR 1700
FRELKEKYER GTLEEKDKKM IFLINLFEKA SVSEDSDVLT IGMKFQTMLT 1750
QIIKLPNFIN ENALNKMSSY KDFSKLYPNL KKNEDLYKST KNLKIDEDAV 1800
LEEDELYKKI ASSLEMESVH DIMIKNPETI LIAPLNDRDF LLSQLFMYTS 1850
PSKRNQLSNQ STEKLALDRV LRSKARTFVN ISSTVKMTYE ENMEKKILEM 1900
LKFDLDSYCS FKTCVNLVIK DVNFSMLIPI LDSAYPCESR KRDNYNFRWF 1950
QTERWIPVVE GSPGLVVMHA VYGSNYIENL GLKNIPLTDD SINVLTSTFG 2000
TGLIMEDVKS LVNGKDSFET EAFSNSNECQ RLVKACNYMI AAQNRLLAIN 2050
TCFTRKSFPF YSKFNLGRGF ISNTLALLST IYSKEESYHF VSTASYKLDK 2100
TIRTVVSAQQ DMNLEKILDT AVYISDKLQS LFPTITREDI VLILQNVCLD 2150
SKPIWQSLED KMKKINNSTA SGFTVSNVIL SHNSELNTIQ KQIVWMWNMG 2200
LCSHRTLDFV IRYIRRRDVR YVKTEEQDES GNYVSGTMYK IGIMTRSCYV 2250
ELIASDQDVA VSLRTPFEIL NEREYLFDTY RESIEKLLAE IMFDKVNIIN 2300
QTTTDCFLRT RRSCIRMTTD NKMIVKVNAT SRQIRLENVK LVVKIKYENV 2350
NSDVWDIIES QKSLVLRLPE VGEFFSDMYK TADSETETIK TIKNRLMTSL 2400
TFIEAFGNLS QQIKEIVDDD IRETMDEFLM NIRDTCLEGL ENCKSVEEYD 2450
SYLDENGFND TVELFENLLR THDNFENEYS PLFSEIVDKA KQYTRDLEGF 2500
KEILLMLKYS LINDASGFKS YRATGMHAVE LMAKKHIEIG EFNLLGMIQL 2550
IKACETCHNN DSILNLASLR NVLSRTYATF GRRIRLDHDL DLQNNLMEKS 2600
YDFKTLVLPE IKLSELSREI LKENGFVISG ENLKMDRSDE EFVGLASFNV 2650
LRLDEEEMYE GLIKEMKIKR KKKGFLFPAN TLLLSELIKF LIGGIKGTSF 2700
DIETLLRNSF RPDIFSTDRL GRLSSSVPAL KVYATVYMEY KNVNCPLNEI 2750
ADSLEGYLKL TKSRSKEHFL SGRVKKALIQ LRDEQSRTKK LEVYKDIANF 2800
LARHPLCLSE KTLYGRYTYS DINDYIMQTR EIILSKISEL DEVVETDEDN 2850
FLLSYLRGEE DAFDEDELDE EEDTD 2875
Length:2,875
Mass (Da):331,503
Last modified:December 1, 1992 - v1
Checksum:i574B3B55CF07C6FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10066 Genomic RNA. Translation: BAA00955.1.
PIRiJQ1335. RRVUTW.
RefSeqiNP_049362.1. NC_002052.1.

Genome annotation databases

GeneIDi956582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D10066 Genomic RNA. Translation: BAA00955.1 .
PIRi JQ1335. RRVUTW.
RefSeqi NP_049362.1. NC_002052.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956582.

Family and domain databases

InterProi IPR007099. RNA-dir_pol_NSvirus.
IPR015841. RNA-dir_pol_tospovirus.
IPR007322. RNA_pol_bunyavir.
[Graphical view ]
Pfami PF04196. Bunya_RdRp. 1 hit.
[Graphical view ]
PIRSFi PIRSF036872. L_TospoV. 1 hit.
PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tomato spotted wilt virus L RNA encodes a putative RNA polymerase."
    de Haan P., Kormelink R., de Oliveira Resende R., van Poelwijk F., Peters D., Goldbach R.
    J. Gen. Virol. 72:2207-2216(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiL_TSWV1
AccessioniPrimary (citable) accession number: P28976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi