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P28976

- L_TSWV1

UniProt

P28976 - L_TSWV1

Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro
    2. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase L (EC:2.7.7.48)
    Short name:
    Protein L
    Alternative name(s):
    Large structural protein
    Replicase
    Transcriptase
    Gene namesi
    Name:L
    OrganismiTomato spotted wilt virus (strain Brazilian Br-01) (TSWV)
    Taxonomic identifieri36413 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeTospovirus
    Virus hostiFrankliniella occidentalis (Western flower thrips) [TaxID: 133901]
    Scirtothrips dorsalis [TaxID: 163899]
    Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
    Thrips tabaci [TaxID: 161014]
    ProteomesiUP000006674: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 28752875RNA-directed RNA polymerase LPRO_0000222027Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1347 – 1530184RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the tospovirus RNA polymerase family.Curated
    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007099. RNA-dir_pol_NSvirus.
    IPR015841. RNA-dir_pol_tospovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view]
    PfamiPF04196. Bunya_RdRp. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036872. L_TospoV. 1 hit.
    PROSITEiPS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28976-1 [UniParc]FASTAAdd to Basket

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    MNIQKIQKLI ENGTTLLLSI EDCVGSNHDL ALDLHKRNSD EIPEDVIINN     50
    NAKNYETMRE LIVKITADGE GLNKGMATVD VKKLSEMVSL FEQKYLETEL 100
    ARHDIFGELI SRHLRIKPKQ RNEVEIEHAL REYLDELNKK SCINKLSDDE 150
    FERINKEYVA TNATPDNYVI YKESKNSELC LIIYDWKISV DARTETKQWR 200
    NTYKNIWKSF KDIKVNGKPF LEEHPVFVSI VILKPIAGMP ITVTSSRVLE 250
    KFEDSPSALH GERIKHAKNA KLLNISYVGQ IVGTTPTVVR NYYANTQRIK 300
    SEVRGILGDD FGSKDVFFSH WTSKYKERNP TEIAYSEDIE RIIDSLVTDE 350
    IPREEIIHFL FGNFCFHIET MNDQHIADKF KGYQNSCINL KIEPKADLAD 400
    LKDHLIQKQQ IWESLYGKHL EKIMLRIREK KRKEKEIPDI TTAFNQNAAE 450
    YEERYPNCFN DLSELKLTFH DLVPSLKIEL SSEVDYNNAI INKFRESFKS 500
    SSRVIYNSPY SSINNQTNKA RDITNLVRLC LAELSCDTTK MEKQELEDEI 550
    DINTGSIKVE RTKKSKEWNK QGSCLTRNKN EFCMKDTGRE NKTTYFKGLA 600
    VMNIGMSSKK RILKKEEIKE RISKGLEYDT SERQADPNDD YSSIDMSSLT 650
    HMKKLIRHDN DDSLSGKRFK GSFFLLHNFN IIEDGKITSV FNNYAKNPEC 700
    LYIQDSVLKT ELETCKKINK LCNDLAIYHY SEDMMQFSKG LMVADRYMTK 750
    ESFKILTTAN TSMMLLAFKG DGMNTGGSGV PYIALHIVDE DMSDHFNICY 800
    TKEIYSYFRS GSNYIYIMRP QRLNQVRLLR LFKTPSKVPV CFPQFSKKAN 850
    EIGKSLKNKD IEKVNLFSMT MTVKQILINI VFSSVMIGTV TKLSRMGIFD 900
    FMRYAGFLRL SDYSNIKEYI RDKSDPDITN CGRYLFRNGI KKLLFRMEDL 950
    NLSTNAKPVV VDHENDIIGG ITNLNIKCPI TGSTLLTLED LYNNVYLAIY 1000
    MMPKSLHNHV HNLTSLLNLP AEWELKFRKE LGFNIFEDIY PKKAMFDDKD 1050
    LFSINGALNV KALSDYYLGN IENVGLMRSE IENKEDFLSP CYKISTLKSS 1100
    KKCSQSNIIS TDEIIECLQD AKIQDIENWK GNNLAIIKGL IRTYNEEKNR 1150
    LVEFFEDNCV NSLYLIEKLK EIISSGSITV GKSVTSKFIR NNHPLTVETY 1200
    LKTKLYYRNN VTVLKSKKVS EELYDLVKQF HDMMEIDLDS VMNLGKGTEG 1250
    KKLTFLQMLE FVMSKAKNVT GSVDFLVSVF EKMQRTKTDR EIYLMSMKVK 1300
    MMLYFIEHTF KHVAQSDPSE AISISGDNKI RALSTLSLDT ITSYNDILNK 1350
    NSKKSRLAFL SADQSKWSAS GLTTYKYVLA IILNPILTTG EASLMIECIL 1400
    MYVKLKKVCI PTDIFLNLRK AQQTFGENET AIGLLTKGLT TNTYPVSMNW 1450
    LQGNLNYLSS VYHSCAMKAY HNTLECYKNC DFQTRWIVHS DDNATSLIAS 1500
    GEVDKMLTDF SSSSLPEMLF RSIEAHFKSF CITLNPKKSY ASSSEVEFIS 1550
    ERISKWSDYS SLLQAFSKLL HRIFAYKLFD DLMSLSIHVT MLLRKGCPNE 1600
    VIPFAYGAVQ VQALSIYSML PGEVNDSIRI FNKLGVSLKS NEIPTNMGGW 1650
    LTSPIEPLSI LGPSSNDQII YYNVIRDFLN KKSLEEVKDS VSSSSYLQMR 1700
    FRELKEKYER GTLEEKDKKM IFLINLFEKA SVSEDSDVLT IGMKFQTMLT 1750
    QIIKLPNFIN ENALNKMSSY KDFSKLYPNL KKNEDLYKST KNLKIDEDAV 1800
    LEEDELYKKI ASSLEMESVH DIMIKNPETI LIAPLNDRDF LLSQLFMYTS 1850
    PSKRNQLSNQ STEKLALDRV LRSKARTFVN ISSTVKMTYE ENMEKKILEM 1900
    LKFDLDSYCS FKTCVNLVIK DVNFSMLIPI LDSAYPCESR KRDNYNFRWF 1950
    QTERWIPVVE GSPGLVVMHA VYGSNYIENL GLKNIPLTDD SINVLTSTFG 2000
    TGLIMEDVKS LVNGKDSFET EAFSNSNECQ RLVKACNYMI AAQNRLLAIN 2050
    TCFTRKSFPF YSKFNLGRGF ISNTLALLST IYSKEESYHF VSTASYKLDK 2100
    TIRTVVSAQQ DMNLEKILDT AVYISDKLQS LFPTITREDI VLILQNVCLD 2150
    SKPIWQSLED KMKKINNSTA SGFTVSNVIL SHNSELNTIQ KQIVWMWNMG 2200
    LCSHRTLDFV IRYIRRRDVR YVKTEEQDES GNYVSGTMYK IGIMTRSCYV 2250
    ELIASDQDVA VSLRTPFEIL NEREYLFDTY RESIEKLLAE IMFDKVNIIN 2300
    QTTTDCFLRT RRSCIRMTTD NKMIVKVNAT SRQIRLENVK LVVKIKYENV 2350
    NSDVWDIIES QKSLVLRLPE VGEFFSDMYK TADSETETIK TIKNRLMTSL 2400
    TFIEAFGNLS QQIKEIVDDD IRETMDEFLM NIRDTCLEGL ENCKSVEEYD 2450
    SYLDENGFND TVELFENLLR THDNFENEYS PLFSEIVDKA KQYTRDLEGF 2500
    KEILLMLKYS LINDASGFKS YRATGMHAVE LMAKKHIEIG EFNLLGMIQL 2550
    IKACETCHNN DSILNLASLR NVLSRTYATF GRRIRLDHDL DLQNNLMEKS 2600
    YDFKTLVLPE IKLSELSREI LKENGFVISG ENLKMDRSDE EFVGLASFNV 2650
    LRLDEEEMYE GLIKEMKIKR KKKGFLFPAN TLLLSELIKF LIGGIKGTSF 2700
    DIETLLRNSF RPDIFSTDRL GRLSSSVPAL KVYATVYMEY KNVNCPLNEI 2750
    ADSLEGYLKL TKSRSKEHFL SGRVKKALIQ LRDEQSRTKK LEVYKDIANF 2800
    LARHPLCLSE KTLYGRYTYS DINDYIMQTR EIILSKISEL DEVVETDEDN 2850
    FLLSYLRGEE DAFDEDELDE EEDTD 2875
    Length:2,875
    Mass (Da):331,503
    Last modified:December 1, 1992 - v1
    Checksum:i574B3B55CF07C6FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10066 Genomic RNA. Translation: BAA00955.1.
    PIRiJQ1335. RRVUTW.
    RefSeqiNP_049362.1. NC_002052.1.

    Genome annotation databases

    GeneIDi956582.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10066 Genomic RNA. Translation: BAA00955.1 .
    PIRi JQ1335. RRVUTW.
    RefSeqi NP_049362.1. NC_002052.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956582.

    Family and domain databases

    InterProi IPR007099. RNA-dir_pol_NSvirus.
    IPR015841. RNA-dir_pol_tospovirus.
    IPR007322. RNA_pol_bunyavir.
    [Graphical view ]
    Pfami PF04196. Bunya_RdRp. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036872. L_TospoV. 1 hit.
    PROSITEi PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tomato spotted wilt virus L RNA encodes a putative RNA polymerase."
      de Haan P., Kormelink R., de Oliveira Resende R., van Poelwijk F., Peters D., Goldbach R.
      J. Gen. Virol. 72:2207-2216(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiL_TSWV1
    AccessioniPrimary (citable) accession number: P28976
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3