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P28908

- TNR8_HUMAN

UniProt

P28908 - TNR8_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 8

Gene

TNFRSF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular response to mechanical stimulus Source: UniProtKB
    2. negative regulation of cell proliferation Source: ProtInc
    3. positive regulation of apoptotic process Source: UniProtKB
    4. positive regulation of TRAIL biosynthetic process Source: UniProtKB
    5. positive regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
    6. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiP28908.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 8
    Alternative name(s):
    CD30L receptor
    Ki-1 antigen
    Lymphocyte activation antigen CD30
    CD_antigen: CD30
    Gene namesi
    Name:TNFRSF8
    Synonyms:CD30, D1S166E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11923. TNFRSF8.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36616.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 595577Tumor necrosis factor receptor superfamily member 8PRO_0000034573Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
    Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 65PROSITE-ProRule annotation
    Disulfide bondi69 ↔ 81PROSITE-ProRule annotation
    Disulfide bondi84 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi87 ↔ 106PROSITE-ProRule annotation
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 122PROSITE-ProRule annotation
    Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
    Disulfide bondi233 ↔ 240PROSITE-ProRule annotation
    Disulfide bondi244 ↔ 256PROSITE-ProRule annotation
    Disulfide bondi259 ↔ 273PROSITE-ProRule annotation
    Disulfide bondi262 ↔ 281PROSITE-ProRule annotation
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi283 ↔ 297PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 300PROSITE-ProRule annotation
    Modified residuei452 – 4521Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated on serine and tyrosine residues.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP28908.
    PaxDbiP28908.
    PRIDEiP28908.

    PTM databases

    PhosphoSiteiP28908.

    Expressioni

    Gene expression databases

    ArrayExpressiP28908.
    BgeeiP28908.
    CleanExiHS_TNFRSF8.
    GenevestigatoriP28908.

    Organism-specific databases

    HPAiCAB000016.

    Interactioni

    Subunit structurei

    Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.5 Publications

    Protein-protein interaction databases

    BioGridi107381. 11 interactions.
    DIPiDIP-2930N.
    IntActiP28908. 3 interactions.
    STRINGi9606.ENSP00000263932.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D01X-ray2.00G/H/I576-583[»]
    ProteinModelPortaliP28908.
    SMRiP28908. Positions 42-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP28908.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 379361ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini408 – 595188CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei380 – 40728HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati28 – 6639TNFR-Cys 1Add
    BLAST
    Repeati68 – 10639TNFR-Cys 2Add
    BLAST
    Repeati107 – 15044TNFR-Cys 3Add
    BLAST
    Repeati205 – 24137TNFR-Cys 4Add
    BLAST
    Repeati243 – 28139TNFR-Cys 5Add
    BLAST
    Repeati282 – 32544TNFR-Cys 6Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi347 – 37731Pro/Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Contains 6 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45191.
    HOGENOMiHOG000220871.
    HOVERGENiHBG005054.
    InParanoidiP28908.
    KOiK05145.
    OrthoDBiEOG786H2Q.
    PhylomeDBiP28908.
    TreeFamiTF331157.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020416. TNFR_8.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01923. TNFACTORR8.
    SMARTiSM00208. TNFR. 4 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

    Isoform 1 (identifier: P28908-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM    50
    GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW 100
    NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPAGMIVKFP GTAQKNTVCE 150
    PASPGVSPAC ASPENCKEPS SGTIPQAKPT PVSPATSSAS TMPVRGGTRL 200
    AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC RKQCEPDYYL 250
    DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC 300
    VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP 350
    TQSLLVDSQA SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG 400
    SSAFLLCHRR ACRKRIRQKL HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG 450
    ASVTEPVAEE RGLMSQPLME TCHSVGAAYL ESLPLQDASP AGGPSSPRDL 500
    PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL AGPAEPELEE 550
    ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK 595
    Length:595
    Mass (Da):63,747
    Last modified:December 1, 1992 - v1
    Checksum:i7A407CC78A6E0BC8
    GO
    Isoform 2 (identifier: P28908-2) [UniParc]FASTAAdd to Basket

    Also known as: Cytoplasmic, Short, C30V

    The sequence of this isoform differs from the canonical sequence as follows:
         1-463: Missing.

    Show »
    Length:132
    Mass (Da):14,088
    Checksum:i211648B504B6313F
    GO
    Isoform 3 (identifier: P28908-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-111: Missing.
         446-446: Missing.

    Show »
    Length:483
    Mass (Da):50,935
    Checksum:i8EA95A0BEA6BD315
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti273 – 2731C → F.
    Corresponds to variant rs2230624 [ dbSNP | Ensembl ].
    VAR_054213
    Natural varianti273 – 2731C → Y.1 Publication
    VAR_018753
    Natural varianti297 – 2971C → R.1 Publication
    Corresponds to variant rs1763642 [ dbSNP | Ensembl ].
    VAR_055257
    Natural varianti314 – 3141P → S.
    Corresponds to variant rs2275170 [ dbSNP | Ensembl ].
    VAR_055258
    Natural varianti402 – 4021S → G.1 Publication
    Corresponds to variant rs2230625 [ dbSNP | Ensembl ].
    VAR_018754
    Natural varianti466 – 4661Q → R.
    Corresponds to variant rs35511003 [ dbSNP | Ensembl ].
    VAR_055259

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 463463Missing in isoform 2. 2 PublicationsVSP_018900Add
    BLAST
    Alternative sequencei1 – 111111Missing in isoform 3. 1 PublicationVSP_055032Add
    BLAST
    Alternative sequencei446 – 4461Missing in isoform 3. 1 PublicationVSP_055033

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83554 mRNA. Translation: AAA51947.1.
    S75768 mRNA. Translation: AAD14188.1.
    D86042 mRNA. Translation: BAA12973.1.
    AJ289159 Genomic DNA. Translation: CAC16652.1.
    AY498860 Genomic DNA. Translation: AAR32099.1.
    AL357835 Genomic DNA. No translation available.
    BC063482 mRNA. Translation: AAH63482.2.
    BC136400 mRNA. Translation: AAI36401.1.
    CCDSiCCDS144.1. [P28908-1]
    CCDS59989.1. [P28908-3]
    PIRiA42086.
    RefSeqiNP_001234.3. NM_001243.4. [P28908-1]
    NP_001268359.2. NM_001281430.2.
    UniGeneiHs.1314.

    Genome annotation databases

    EnsembliENST00000413146; ENSP00000398337; ENSG00000120949. [P28908-2]
    GeneIDi943.
    KEGGihsa:943.
    UCSCiuc001atq.3. human. [P28908-1]
    uc001atr.3. human. [P28908-2]

    Polymorphism databases

    DMDMi115978.

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83554 mRNA. Translation: AAA51947.1 .
    S75768 mRNA. Translation: AAD14188.1 .
    D86042 mRNA. Translation: BAA12973.1 .
    AJ289159 Genomic DNA. Translation: CAC16652.1 .
    AY498860 Genomic DNA. Translation: AAR32099.1 .
    AL357835 Genomic DNA. No translation available.
    BC063482 mRNA. Translation: AAH63482.2 .
    BC136400 mRNA. Translation: AAI36401.1 .
    CCDSi CCDS144.1. [P28908-1 ]
    CCDS59989.1. [P28908-3 ]
    PIRi A42086.
    RefSeqi NP_001234.3. NM_001243.4. [P28908-1 ]
    NP_001268359.2. NM_001281430.2.
    UniGenei Hs.1314.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D01 X-ray 2.00 G/H/I 576-583 [» ]
    ProteinModelPortali P28908.
    SMRi P28908. Positions 42-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107381. 11 interactions.
    DIPi DIP-2930N.
    IntActi P28908. 3 interactions.
    STRINGi 9606.ENSP00000263932.

    Chemistry

    ChEMBLi CHEMBL2364161.
    GuidetoPHARMACOLOGYi 1877.

    PTM databases

    PhosphoSitei P28908.

    Polymorphism databases

    DMDMi 115978.

    Proteomic databases

    MaxQBi P28908.
    PaxDbi P28908.
    PRIDEi P28908.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000413146 ; ENSP00000398337 ; ENSG00000120949 . [P28908-2 ]
    GeneIDi 943.
    KEGGi hsa:943.
    UCSCi uc001atq.3. human. [P28908-1 ]
    uc001atr.3. human. [P28908-2 ]

    Organism-specific databases

    CTDi 943.
    GeneCardsi GC01P012123.
    H-InvDB HIX0200047.
    HGNCi HGNC:11923. TNFRSF8.
    HPAi CAB000016.
    MIMi 153243. gene.
    neXtProti NX_P28908.
    PharmGKBi PA36616.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45191.
    HOGENOMi HOG000220871.
    HOVERGENi HBG005054.
    InParanoidi P28908.
    KOi K05145.
    OrthoDBi EOG786H2Q.
    PhylomeDBi P28908.
    TreeFami TF331157.

    Enzyme and pathway databases

    SignaLinki P28908.

    Miscellaneous databases

    EvolutionaryTracei P28908.
    GeneWikii CD30.
    GenomeRNAii 943.
    NextBioi 35481995.
    PROi P28908.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28908.
    Bgeei P28908.
    CleanExi HS_TNFRSF8.
    Genevestigatori P28908.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020416. TNFR_8.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01923. TNFACTORR8.
    SMARTi SM00208. TNFR. 4 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease."
      Duerkop H., Latza U., Hummel M., Eitelbach F., Seed B., Stein H.
      Cell 68:421-427(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lymphoid tissue.
    2. "Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources."
      Jung W., Krueger S., Renner C., Gause A., Sahin U., Trumper L., Pfreundschuh M.
      Mol. Immunol. 31:1329-1334(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages."
      Horie R., Ito K., Tatewaki M., Nagai M., Aizawa S., Higashihara M., Ishida T., Inoue J., Takizawa H., Watanabe T.
      Blood 88:2422-2432(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Structure of the Hodgkin's disease associated human CD30 gene and the influence of a microsatellite region on its expression in CD30+ cell lines."
      Durkop H., Oberbarnscheidt M., Latza U., Bulfone-Paus S.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1).
      Tissue: Placenta.
    5. NIEHS SNPs program
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS TYR-273 AND GLY-402.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-297.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Blood and Testis.
    8. "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors."
      Lee S.Y., Park C.G., Choi Y.
      J. Exp. Med. 183:669-674(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF1 AND TRAF2.
    9. "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily."
      Boucher L.-M., Marengere L.E., Lu Y., Thukral S., Mak T.W.
      Biochem. Biophys. Res. Commun. 233:592-600(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF3.
    10. "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)."
      Mizushima S., Fujita M., Ishida T., Azuma S., Kato K., Hirai M., Otsuka M., Yamamoto T., Inoue J.
      Gene 207:135-140(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF5.
    11. "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation."
      Aizawa S., Nakano H., Ishida T., Horie R., Nagai M., Ito K., Yagita H., Okumura K., Inoue J., Watanabe T.
      J. Biol. Chem. 272:2042-2045(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF5.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "The structural basis for the recognition of diverse receptor sequences by TRAF2."
      Ye H., Park Y.C., Kreishman M., Kieff E., Wu H.
      Mol. Cell 4:321-330(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 576-583 IN COMPLEX WITH TRAF2, INTERACTION WITH TRAF2.

    Entry informationi

    Entry nameiTNR8_HUMAN
    AccessioniPrimary (citable) accession number: P28908
    Secondary accession number(s): B1AN79
    , B9EGD9, D3YTD8, Q6P4D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 156 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Most specific Hodgkin disease associated antigen.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3