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P28907

- CD38_HUMAN

UniProt

P28907 - CD38_HUMAN

Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

CD38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

    Catalytic activityi

    NAD+ + H2O = ADP-D-ribose + nicotinamide.1 Publication
    NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.1 Publication

    Enzyme regulationi

    ATP inhibits the hydrolyzing activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei119 – 11911 Publication
    Active sitei201 – 20111 Publication

    GO - Molecular functioni

    1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
    2. NAD+ nucleosidase activity Source: Ensembl
    3. phosphorus-oxygen lyase activity Source: Ensembl
    4. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic signaling pathway Source: ProtInc
    2. B cell receptor signaling pathway Source: UniProtKB
    3. female pregnancy Source: Ensembl
    4. long term synaptic depression Source: Ensembl
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of bone resorption Source: Ensembl
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of B cell proliferation Source: UniProtKB
    9. positive regulation of cell growth Source: Ensembl
    10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    11. positive regulation of insulin secretion Source: Ensembl
    12. positive regulation of transcription, DNA-templated Source: UniProtKB
    13. positive regulation of vasoconstriction Source: Ensembl
    14. response to drug Source: UniProtKB
    15. response to estradiol Source: Ensembl
    16. response to hydroperoxide Source: Ensembl
    17. response to hypoxia Source: Ensembl
    18. response to interleukin-1 Source: Ensembl
    19. response to progesterone Source: Ensembl
    20. response to retinoic acid Source: Ensembl
    21. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Receptor, Transferase

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS00103-MONOMER.
    SABIO-RKP28907.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
    Alternative name(s):
    2'-phospho-ADP-ribosyl cyclase
    2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
    2'-phospho-cyclic-ADP-ribose transferase
    ADP-ribosyl cyclase 1
    Short name:
    ADPRC 1
    Cyclic ADP-ribose hydrolase 1
    Short name:
    cADPr hydrolase 1
    T10
    CD_antigen: CD38
    Gene namesi
    Name:CD38
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:1667. CD38.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: ProtInc
    4. nucleus Source: Ensembl
    5. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi119 – 1191C → K: Loss of cADPr hydrolase activity. 1 Publication
    Mutagenesisi119 – 1191C → R, E or A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
    Mutagenesisi160 – 1601C → A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
    Mutagenesisi173 – 1731C → A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
    Mutagenesisi201 – 2011C → D, K or A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
    Mutagenesisi201 – 2011C → E: Loss of cADPr hydrolase activity. 1 Publication

    Keywords - Diseasei

    Diabetes mellitus

    Organism-specific databases

    PharmGKBiPA26214.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1PRO_0000144066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 821 Publication
    Disulfide bondi99 ↔ 1801 Publication
    Glycosylationi100 – 1001N-linked (GlcNAc...)1 Publication
    Disulfide bondi160 ↔ 1731 Publication
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)1 Publication
    Glycosylationi219 – 2191N-linked (GlcNAc...)2 Publications
    Disulfide bondi254 ↔ 2751 Publication
    Disulfide bondi287 ↔ 2961 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP28907.
    PaxDbiP28907.
    PeptideAtlasiP28907.
    PRIDEiP28907.

    PTM databases

    PhosphoSiteiP28907.

    Expressioni

    Tissue specificityi

    Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.1 Publication

    Developmental stagei

    Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

    Gene expression databases

    ArrayExpressiP28907.
    BgeeiP28907.
    CleanExiHS_CD38.
    GenevestigatoriP28907.

    Organism-specific databases

    HPAiCAB002493.
    CAB025255.
    HPA022132.
    HPA052381.

    Interactioni

    Protein-protein interaction databases

    BioGridi107390. 6 interactions.
    MINTiMINT-4536880.
    STRINGi9606.ENSP00000226279.

    Structurei

    Secondary structure

    1
    300
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi51 – 533
    Helixi59 – 7315
    Helixi75 – 773
    Helixi82 – 9312
    Beta strandi94 – 963
    Helixi98 – 1003
    Helixi103 – 1064
    Helixi107 – 1126
    Helixi119 – 1213
    Beta strandi122 – 1276
    Beta strandi132 – 1343
    Helixi136 – 1416
    Beta strandi142 – 1443
    Helixi145 – 1473
    Helixi149 – 1546
    Beta strandi165 – 1673
    Beta strandi171 – 1733
    Turni176 – 1794
    Beta strandi181 – 1833
    Helixi184 – 19916
    Beta strandi202 – 2098
    Beta strandi212 – 2165
    Beta strandi218 – 2203
    Helixi221 – 2244
    Helixi227 – 2293
    Turni232 – 2343
    Beta strandi235 – 2439
    Beta strandi246 – 2494
    Helixi253 – 2553
    Helixi257 – 26812
    Beta strandi272 – 2787
    Helixi281 – 2899
    Turni291 – 2933

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YH3X-ray1.91A/B45-300[»]
    1ZVMX-ray2.20A/B/C/D45-300[»]
    2EF1X-ray2.40A/B45-300[»]
    2HCTX-ray1.95A/B45-300[»]
    2I65X-ray1.90A/B45-300[»]
    2I66X-ray1.70A/B45-300[»]
    2I67X-ray1.71A/B45-300[»]
    2O3QX-ray1.98A/B45-300[»]
    2O3RX-ray1.75A/B45-300[»]
    2O3SX-ray1.50A/B45-300[»]
    2O3TX-ray1.68A/B45-300[»]
    2O3UX-ray2.11A/B45-300[»]
    2PGJX-ray1.71A/B45-300[»]
    2PGLX-ray1.76A/B45-300[»]
    3DZFX-ray2.01A/B/C/D/E/F45-300[»]
    3DZGX-ray1.65A/B45-300[»]
    3DZHX-ray1.60A/B45-300[»]
    3DZIX-ray1.73A/B45-300[»]
    3DZJX-ray1.90A/B45-300[»]
    3DZKX-ray1.81A/B45-300[»]
    3F6YX-ray1.45A45-300[»]
    3I9MX-ray1.75A/B45-300[»]
    3I9NX-ray2.01A/B45-300[»]
    3OFSX-ray2.20A/B/C/D/E/F46-300[»]
    3RAJX-ray3.04A46-300[»]
    3ROKX-ray1.65A/B45-296[»]
    3ROMX-ray2.04A/B45-296[»]
    3ROPX-ray1.94A/B45-296[»]
    3ROQX-ray2.10A/B45-296[»]
    3U4HX-ray1.88A/B45-300[»]
    3U4IX-ray2.12A/B45-300[»]
    4F45X-ray2.10A/B46-300[»]
    4F46X-ray1.69A/B46-300[»]
    ProteinModelPortaliP28907.
    SMRiP28907. Positions 45-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP28907.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini43 – 300258ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADP-ribosyl cyclase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42596.
    HOGENOMiHOG000293141.
    HOVERGENiHBG005277.
    InParanoidiP28907.
    KOiK01242.
    OMAiKNPCNIT.
    OrthoDBiEOG7RBZ9B.
    PhylomeDBiP28907.
    TreeFamiTF332530.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10912. PTHR10912. 1 hit.
    PfamiPF02267. Rib_hydrolayse. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P28907-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MANCEFSPVS GDKPCCRLSR RAQLCLGVSI LVLILVVVLA VVVPRWRQQW    50
    SGPGTTKRFP ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN 100
    ITEEDYQPLM KLGTQTVPCN KILLWSRIKD LAHQFTQVQR DMFTLEDTLL 150
    GYLADDLTWC GEFNTSKINY QSCPDWRKDC SNNPVSVFWK TVSRRFAEAA 200
    CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA WVIHGGREDS 250
    RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI 300
    Length:300
    Mass (Da):34,328
    Last modified:November 23, 2004 - v2
    Checksum:i47BBE38C3DE3E6AA
    GO
    Isoform 2 (identifier: P28907-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         122-122: I → K
         123-300: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:122
    Mass (Da):13,788
    Checksum:i06312C3A52C6ED5C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491Q → T in AAA68482. (PubMed:2319135)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401R → W Seems to contribute to the development of type II diabetes; 50% reduction in activity. 1 Publication
    Corresponds to variant rs1800561 [ dbSNP | Ensembl ].
    VAR_001323

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei122 – 1221I → K in isoform 2. 1 PublicationVSP_000707
    Alternative sequencei123 – 300178Missing in isoform 2. 1 PublicationVSP_000708Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34461 mRNA. Translation: AAA68482.1.
    D84276 mRNA. Translation: BAA18964.1.
    D84277 mRNA. Translation: BAA18965.1.
    D84284 Genomic DNA. Translation: BAA18966.1.
    BC007964 mRNA. Translation: AAH07964.1.
    CCDSiCCDS3417.1. [P28907-1]
    PIRiA43521.
    RefSeqiNP_001766.2. NM_001775.2. [P28907-1]
    UniGeneiHs.479214.

    Genome annotation databases

    EnsembliENST00000226279; ENSP00000226279; ENSG00000004468. [P28907-1]
    ENST00000502843; ENSP00000427277; ENSG00000004468. [P28907-2]
    GeneIDi952.
    KEGGihsa:952.
    UCSCiuc003gol.1. human. [P28907-1]

    Polymorphism databases

    DMDMi55977782.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CD38 entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34461 mRNA. Translation: AAA68482.1 .
    D84276 mRNA. Translation: BAA18964.1 .
    D84277 mRNA. Translation: BAA18965.1 .
    D84284 Genomic DNA. Translation: BAA18966.1 .
    BC007964 mRNA. Translation: AAH07964.1 .
    CCDSi CCDS3417.1. [P28907-1 ]
    PIRi A43521.
    RefSeqi NP_001766.2. NM_001775.2. [P28907-1 ]
    UniGenei Hs.479214.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YH3 X-ray 1.91 A/B 45-300 [» ]
    1ZVM X-ray 2.20 A/B/C/D 45-300 [» ]
    2EF1 X-ray 2.40 A/B 45-300 [» ]
    2HCT X-ray 1.95 A/B 45-300 [» ]
    2I65 X-ray 1.90 A/B 45-300 [» ]
    2I66 X-ray 1.70 A/B 45-300 [» ]
    2I67 X-ray 1.71 A/B 45-300 [» ]
    2O3Q X-ray 1.98 A/B 45-300 [» ]
    2O3R X-ray 1.75 A/B 45-300 [» ]
    2O3S X-ray 1.50 A/B 45-300 [» ]
    2O3T X-ray 1.68 A/B 45-300 [» ]
    2O3U X-ray 2.11 A/B 45-300 [» ]
    2PGJ X-ray 1.71 A/B 45-300 [» ]
    2PGL X-ray 1.76 A/B 45-300 [» ]
    3DZF X-ray 2.01 A/B/C/D/E/F 45-300 [» ]
    3DZG X-ray 1.65 A/B 45-300 [» ]
    3DZH X-ray 1.60 A/B 45-300 [» ]
    3DZI X-ray 1.73 A/B 45-300 [» ]
    3DZJ X-ray 1.90 A/B 45-300 [» ]
    3DZK X-ray 1.81 A/B 45-300 [» ]
    3F6Y X-ray 1.45 A 45-300 [» ]
    3I9M X-ray 1.75 A/B 45-300 [» ]
    3I9N X-ray 2.01 A/B 45-300 [» ]
    3OFS X-ray 2.20 A/B/C/D/E/F 46-300 [» ]
    3RAJ X-ray 3.04 A 46-300 [» ]
    3ROK X-ray 1.65 A/B 45-296 [» ]
    3ROM X-ray 2.04 A/B 45-296 [» ]
    3ROP X-ray 1.94 A/B 45-296 [» ]
    3ROQ X-ray 2.10 A/B 45-296 [» ]
    3U4H X-ray 1.88 A/B 45-300 [» ]
    3U4I X-ray 2.12 A/B 45-300 [» ]
    4F45 X-ray 2.10 A/B 46-300 [» ]
    4F46 X-ray 1.69 A/B 46-300 [» ]
    ProteinModelPortali P28907.
    SMRi P28907. Positions 45-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107390. 6 interactions.
    MINTi MINT-4536880.
    STRINGi 9606.ENSP00000226279.

    Chemistry

    BindingDBi P28907.
    ChEMBLi CHEMBL4660.
    GuidetoPHARMACOLOGYi 2766.

    PTM databases

    PhosphoSitei P28907.

    Polymorphism databases

    DMDMi 55977782.

    Proteomic databases

    MaxQBi P28907.
    PaxDbi P28907.
    PeptideAtlasi P28907.
    PRIDEi P28907.

    Protocols and materials databases

    DNASUi 952.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226279 ; ENSP00000226279 ; ENSG00000004468 . [P28907-1 ]
    ENST00000502843 ; ENSP00000427277 ; ENSG00000004468 . [P28907-2 ]
    GeneIDi 952.
    KEGGi hsa:952.
    UCSCi uc003gol.1. human. [P28907-1 ]

    Organism-specific databases

    CTDi 952.
    GeneCardsi GC04P015779.
    HGNCi HGNC:1667. CD38.
    HPAi CAB002493.
    CAB025255.
    HPA022132.
    HPA052381.
    MIMi 107270. gene.
    neXtProti NX_P28907.
    PharmGKBi PA26214.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42596.
    HOGENOMi HOG000293141.
    HOVERGENi HBG005277.
    InParanoidi P28907.
    KOi K01242.
    OMAi KNPCNIT.
    OrthoDBi EOG7RBZ9B.
    PhylomeDBi P28907.
    TreeFami TF332530.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS00103-MONOMER.
    SABIO-RK P28907.

    Miscellaneous databases

    EvolutionaryTracei P28907.
    GeneWikii CD38.
    GenomeRNAii 952.
    NextBioi 3962.
    PROi P28907.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28907.
    Bgeei P28907.
    CleanExi HS_CD38.
    Genevestigatori P28907.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR003193. ADP-ribosyl_cyclase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10912. PTHR10912. 1 hit.
    Pfami PF02267. Rib_hydrolayse. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation."
      Jackson D.G., Bell J.I.
      J. Immunol. 144:2811-2815(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing."
      Nata K., Takamura T., Karasawa T., Kumagai T., Hashioka W., Tohgo A., Yonekura H., Takasawa S., Nakamura S., Okamoto H.
      Gene 186:285-292(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
      Tissue: Esophageal carcinoma and Pancreas.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell.
    4. "Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38."
      States D.J., Walseth T.F., Lee H.C.
      Trends Biochem. Sci. 17:495-495(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: SIMILARITY TO NADASE.
    5. "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP."
      Takasawa S., Tohgo A., Noguchi N., Koguma T., Nata K., Sugimoto T., Yonekura H., Okamoto H.
      J. Biol. Chem. 268:26052-26054(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38."
      Tohgo A., Takasawa S., Noguchi N., Koguma T., Nata K., Sugimoto T., Furuya Y., Yonekura H., Okamoto H.
      J. Biol. Chem. 269:28555-28557(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACTIVE SITE, MUTAGENESIS OF CYS-119; CYS-160; CYS-173 AND CYS-201.
    7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    8. "NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."
      Moreschi I., Bruzzone S., Melone L., De Flora A., Zocchi E.
      Biochem. Biophys. Res. Commun. 345:573-580(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-209 AND ASN-219.
      Tissue: Liver.
    10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-219.
      Tissue: Leukemic T-cell.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Crystal structure of human CD38 extracellular domain."
      Liu Q., Kriksunov I.A., Graeff R., Munshi C., Lee H.C., Hao Q.
      Structure 13:1331-1339(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 45-300, DISULFIDE BONDS.
    13. "A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."
      Yagui K., Shimada F., Mimura M., Hashimoto N., Suzuki Y., Tokuyama Y., Nata K., Tohgo A., Ikehata F., Takasawa S., Okamoto H., Makino H., Saito Y., Kanatsuka A.
      Diabetologia 41:1024-1028(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TRP-140.

    Entry informationi

    Entry nameiCD38_HUMAN
    AccessioniPrimary (citable) accession number: P28907
    Secondary accession number(s): O00121, O00122, Q96HY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 156 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3