SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P28907

- CD38_HUMAN

UniProt

P28907 - CD38_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene
CD38
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Catalytic activityi

NAD+ + H2O = ADP-D-ribose + nicotinamide.1 Publication
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.1 Publication

Enzyme regulationi

ATP inhibits the hydrolyzing activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei119 – 11911 Publication
Active sitei201 – 20111 Publication

GO - Molecular functioni

  1. NAD(P)+ nucleosidase activity Source: UniProtKB-EC
  2. NAD+ nucleosidase activity Source: Ensembl
  3. phosphorus-oxygen lyase activity Source: Ensembl
  4. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic signaling pathway Source: ProtInc
  2. B cell receptor signaling pathway Source: UniProtKB
  3. female pregnancy Source: Ensembl
  4. long term synaptic depression Source: Ensembl
  5. negative regulation of apoptotic process Source: UniProtKB
  6. negative regulation of bone resorption Source: Ensembl
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of B cell proliferation Source: UniProtKB
  9. positive regulation of cell growth Source: Ensembl
  10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  11. positive regulation of insulin secretion Source: Ensembl
  12. positive regulation of transcription, DNA-templated Source: UniProtKB
  13. positive regulation of vasoconstriction Source: Ensembl
  14. response to drug Source: UniProtKB
  15. response to estradiol Source: Ensembl
  16. response to hydroperoxide Source: Ensembl
  17. response to hypoxia Source: Ensembl
  18. response to interleukin-1 Source: Ensembl
  19. response to progesterone Source: Ensembl
  20. response to retinoic acid Source: Ensembl
  21. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor, Transferase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS00103-MONOMER.
SABIO-RKP28907.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
T10
CD_antigen: CD38
Gene namesi
Name:CD38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:1667. CD38.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei22 – 4221Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini43 – 300258Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: ProtInc
  4. nucleus Source: Ensembl
  5. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi119 – 1191C → K: Loss of cADPr hydrolase activity. 1 Publication
Mutagenesisi119 – 1191C → R, E or A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
Mutagenesisi160 – 1601C → A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
Mutagenesisi173 – 1731C → A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
Mutagenesisi201 – 2011C → D, K or A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication
Mutagenesisi201 – 2011C → E: Loss of cADPr hydrolase activity. 1 Publication

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

PharmGKBiPA26214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1PRO_0000144066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 821 Publication
Disulfide bondi99 ↔ 1801 Publication
Glycosylationi100 – 1001N-linked (GlcNAc...)1 Publication
Disulfide bondi160 ↔ 1731 Publication
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi209 – 2091N-linked (GlcNAc...)1 Publication
Glycosylationi219 – 2191N-linked (GlcNAc...)2 Publications
Disulfide bondi254 ↔ 2751 Publication
Disulfide bondi287 ↔ 2961 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP28907.
PaxDbiP28907.
PeptideAtlasiP28907.
PRIDEiP28907.

PTM databases

PhosphoSiteiP28907.

Expressioni

Tissue specificityi

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.1 Publication

Developmental stagei

Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

Gene expression databases

ArrayExpressiP28907.
BgeeiP28907.
CleanExiHS_CD38.
GenevestigatoriP28907.

Organism-specific databases

HPAiCAB002493.
CAB025255.
HPA022132.
HPA052381.

Interactioni

Protein-protein interaction databases

BioGridi107390. 6 interactions.
MINTiMINT-4536880.
STRINGi9606.ENSP00000226279.

Structurei

Secondary structure

1
300
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 533
Helixi59 – 7315
Helixi75 – 773
Helixi82 – 9312
Beta strandi94 – 963
Helixi98 – 1003
Helixi103 – 1064
Helixi107 – 1126
Helixi119 – 1213
Beta strandi122 – 1276
Beta strandi132 – 1343
Helixi136 – 1416
Beta strandi142 – 1443
Helixi145 – 1473
Helixi149 – 1546
Beta strandi165 – 1673
Beta strandi171 – 1733
Turni176 – 1794
Beta strandi181 – 1833
Helixi184 – 19916
Beta strandi202 – 2098
Beta strandi212 – 2165
Beta strandi218 – 2203
Helixi221 – 2244
Helixi227 – 2293
Turni232 – 2343
Beta strandi235 – 2439
Beta strandi246 – 2494
Helixi253 – 2553
Helixi257 – 26812
Beta strandi272 – 2787
Helixi281 – 2899
Turni291 – 2933

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YH3X-ray1.91A/B45-300[»]
1ZVMX-ray2.20A/B/C/D45-300[»]
2EF1X-ray2.40A/B45-300[»]
2HCTX-ray1.95A/B45-300[»]
2I65X-ray1.90A/B45-300[»]
2I66X-ray1.70A/B45-300[»]
2I67X-ray1.71A/B45-300[»]
2O3QX-ray1.98A/B45-300[»]
2O3RX-ray1.75A/B45-300[»]
2O3SX-ray1.50A/B45-300[»]
2O3TX-ray1.68A/B45-300[»]
2O3UX-ray2.11A/B45-300[»]
2PGJX-ray1.71A/B45-300[»]
2PGLX-ray1.76A/B45-300[»]
3DZFX-ray2.01A/B/C/D/E/F45-300[»]
3DZGX-ray1.65A/B45-300[»]
3DZHX-ray1.60A/B45-300[»]
3DZIX-ray1.73A/B45-300[»]
3DZJX-ray1.90A/B45-300[»]
3DZKX-ray1.81A/B45-300[»]
3F6YX-ray1.45A45-300[»]
3I9MX-ray1.75A/B45-300[»]
3I9NX-ray2.01A/B45-300[»]
3OFSX-ray2.20A/B/C/D/E/F46-300[»]
3RAJX-ray3.04A46-300[»]
3ROKX-ray1.65A/B45-296[»]
3ROMX-ray2.04A/B45-296[»]
3ROPX-ray1.94A/B45-296[»]
3ROQX-ray2.10A/B45-296[»]
3U4HX-ray1.88A/B45-300[»]
3U4IX-ray2.12A/B45-300[»]
4F45X-ray2.10A/B46-300[»]
4F46X-ray1.69A/B46-300[»]
ProteinModelPortaliP28907.
SMRiP28907. Positions 45-291.

Miscellaneous databases

EvolutionaryTraceiP28907.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42596.
HOGENOMiHOG000293141.
HOVERGENiHBG005277.
InParanoidiP28907.
KOiK01242.
OMAiKNPCNIT.
OrthoDBiEOG7RBZ9B.
PhylomeDBiP28907.
TreeFamiTF332530.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10912. PTHR10912. 1 hit.
PfamiPF02267. Rib_hydrolayse. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P28907-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MANCEFSPVS GDKPCCRLSR RAQLCLGVSI LVLILVVVLA VVVPRWRQQW    50
SGPGTTKRFP ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN 100
ITEEDYQPLM KLGTQTVPCN KILLWSRIKD LAHQFTQVQR DMFTLEDTLL 150
GYLADDLTWC GEFNTSKINY QSCPDWRKDC SNNPVSVFWK TVSRRFAEAA 200
CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA WVIHGGREDS 250
RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI 300
Length:300
Mass (Da):34,328
Last modified:November 23, 2004 - v2
Checksum:i47BBE38C3DE3E6AA
GO
Isoform 2 (identifier: P28907-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: I → K
     123-300: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:122
Mass (Da):13,788
Checksum:i06312C3A52C6ED5C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401R → W Seems to contribute to the development of type II diabetes; 50% reduction in activity. 1 Publication
Corresponds to variant rs1800561 [ dbSNP | Ensembl ].
VAR_001323

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei122 – 1221I → K in isoform 2. VSP_000707
Alternative sequencei123 – 300178Missing in isoform 2. VSP_000708Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491Q → T in AAA68482. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34461 mRNA. Translation: AAA68482.1.
D84276 mRNA. Translation: BAA18964.1.
D84277 mRNA. Translation: BAA18965.1.
D84284 Genomic DNA. Translation: BAA18966.1.
BC007964 mRNA. Translation: AAH07964.1.
CCDSiCCDS3417.1. [P28907-1]
PIRiA43521.
RefSeqiNP_001766.2. NM_001775.2. [P28907-1]
UniGeneiHs.479214.

Genome annotation databases

EnsembliENST00000226279; ENSP00000226279; ENSG00000004468. [P28907-1]
ENST00000502843; ENSP00000427277; ENSG00000004468. [P28907-2]
GeneIDi952.
KEGGihsa:952.
UCSCiuc003gol.1. human. [P28907-1]

Polymorphism databases

DMDMi55977782.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD38 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34461 mRNA. Translation: AAA68482.1 .
D84276 mRNA. Translation: BAA18964.1 .
D84277 mRNA. Translation: BAA18965.1 .
D84284 Genomic DNA. Translation: BAA18966.1 .
BC007964 mRNA. Translation: AAH07964.1 .
CCDSi CCDS3417.1. [P28907-1 ]
PIRi A43521.
RefSeqi NP_001766.2. NM_001775.2. [P28907-1 ]
UniGenei Hs.479214.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YH3 X-ray 1.91 A/B 45-300 [» ]
1ZVM X-ray 2.20 A/B/C/D 45-300 [» ]
2EF1 X-ray 2.40 A/B 45-300 [» ]
2HCT X-ray 1.95 A/B 45-300 [» ]
2I65 X-ray 1.90 A/B 45-300 [» ]
2I66 X-ray 1.70 A/B 45-300 [» ]
2I67 X-ray 1.71 A/B 45-300 [» ]
2O3Q X-ray 1.98 A/B 45-300 [» ]
2O3R X-ray 1.75 A/B 45-300 [» ]
2O3S X-ray 1.50 A/B 45-300 [» ]
2O3T X-ray 1.68 A/B 45-300 [» ]
2O3U X-ray 2.11 A/B 45-300 [» ]
2PGJ X-ray 1.71 A/B 45-300 [» ]
2PGL X-ray 1.76 A/B 45-300 [» ]
3DZF X-ray 2.01 A/B/C/D/E/F 45-300 [» ]
3DZG X-ray 1.65 A/B 45-300 [» ]
3DZH X-ray 1.60 A/B 45-300 [» ]
3DZI X-ray 1.73 A/B 45-300 [» ]
3DZJ X-ray 1.90 A/B 45-300 [» ]
3DZK X-ray 1.81 A/B 45-300 [» ]
3F6Y X-ray 1.45 A 45-300 [» ]
3I9M X-ray 1.75 A/B 45-300 [» ]
3I9N X-ray 2.01 A/B 45-300 [» ]
3OFS X-ray 2.20 A/B/C/D/E/F 46-300 [» ]
3RAJ X-ray 3.04 A 46-300 [» ]
3ROK X-ray 1.65 A/B 45-296 [» ]
3ROM X-ray 2.04 A/B 45-296 [» ]
3ROP X-ray 1.94 A/B 45-296 [» ]
3ROQ X-ray 2.10 A/B 45-296 [» ]
3U4H X-ray 1.88 A/B 45-300 [» ]
3U4I X-ray 2.12 A/B 45-300 [» ]
4F45 X-ray 2.10 A/B 46-300 [» ]
4F46 X-ray 1.69 A/B 46-300 [» ]
ProteinModelPortali P28907.
SMRi P28907. Positions 45-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107390. 6 interactions.
MINTi MINT-4536880.
STRINGi 9606.ENSP00000226279.

Chemistry

BindingDBi P28907.
ChEMBLi CHEMBL4660.
GuidetoPHARMACOLOGYi 2766.

PTM databases

PhosphoSitei P28907.

Polymorphism databases

DMDMi 55977782.

Proteomic databases

MaxQBi P28907.
PaxDbi P28907.
PeptideAtlasi P28907.
PRIDEi P28907.

Protocols and materials databases

DNASUi 952.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000226279 ; ENSP00000226279 ; ENSG00000004468 . [P28907-1 ]
ENST00000502843 ; ENSP00000427277 ; ENSG00000004468 . [P28907-2 ]
GeneIDi 952.
KEGGi hsa:952.
UCSCi uc003gol.1. human. [P28907-1 ]

Organism-specific databases

CTDi 952.
GeneCardsi GC04P015779.
HGNCi HGNC:1667. CD38.
HPAi CAB002493.
CAB025255.
HPA022132.
HPA052381.
MIMi 107270. gene.
neXtProti NX_P28907.
PharmGKBi PA26214.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42596.
HOGENOMi HOG000293141.
HOVERGENi HBG005277.
InParanoidi P28907.
KOi K01242.
OMAi KNPCNIT.
OrthoDBi EOG7RBZ9B.
PhylomeDBi P28907.
TreeFami TF332530.

Enzyme and pathway databases

BioCyci MetaCyc:HS00103-MONOMER.
SABIO-RK P28907.

Miscellaneous databases

EvolutionaryTracei P28907.
GeneWikii CD38.
GenomeRNAii 952.
NextBioi 3962.
PROi P28907.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28907.
Bgeei P28907.
CleanExi HS_CD38.
Genevestigatori P28907.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR003193. ADP-ribosyl_cyclase.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR10912. PTHR10912. 1 hit.
Pfami PF02267. Rib_hydrolayse. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation."
    Jackson D.G., Bell J.I.
    J. Immunol. 144:2811-2815(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing."
    Nata K., Takamura T., Karasawa T., Kumagai T., Hashioka W., Tohgo A., Yonekura H., Takasawa S., Nakamura S., Okamoto H.
    Gene 186:285-292(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Esophageal carcinoma and Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.
  4. "Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38."
    States D.J., Walseth T.F., Lee H.C.
    Trends Biochem. Sci. 17:495-495(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SIMILARITY TO NADASE.
  5. "Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP."
    Takasawa S., Tohgo A., Noguchi N., Koguma T., Nata K., Sugimoto T., Yonekura H., Okamoto H.
    J. Biol. Chem. 268:26052-26054(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38."
    Tohgo A., Takasawa S., Noguchi N., Koguma T., Nata K., Sugimoto T., Furuya Y., Yonekura H., Okamoto H.
    J. Biol. Chem. 269:28555-28557(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVE SITE, MUTAGENESIS OF CYS-119; CYS-160; CYS-173 AND CYS-201.
  7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  8. "NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases."
    Moreschi I., Bruzzone S., Melone L., De Flora A., Zocchi E.
    Biochem. Biophys. Res. Commun. 345:573-580(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-100; ASN-209 AND ASN-219.
    Tissue: Liver.
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-219.
    Tissue: Leukemic T-cell.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Crystal structure of human CD38 extracellular domain."
    Liu Q., Kriksunov I.A., Graeff R., Munshi C., Lee H.C., Hao Q.
    Structure 13:1331-1339(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 45-300, DISULFIDE BONDS.
  13. "A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro."
    Yagui K., Shimada F., Mimura M., Hashimoto N., Suzuki Y., Tokuyama Y., Nata K., Tohgo A., Ikehata F., Takasawa S., Okamoto H., Makino H., Saito Y., Kanatsuka A.
    Diabetologia 41:1024-1028(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TRP-140.

Entry informationi

Entry nameiCD38_HUMAN
AccessioniPrimary (citable) accession number: P28907
Secondary accession number(s): O00121, O00122, Q96HY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi