ID   CD34_HUMAN     STANDARD;      PRT;   373 AA.
AC   P28906;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   01-DEC-1992 (REL. 24, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   HEMOPOIETIC PROGENITOR CELL ANTIGEN CD34 PRECURSOR.
GN   CD34.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 20-31.
RX   MEDLINE; 92091783.
RA   SIMMONS D.L., SATTERTHWAITE A.B., TENEN D.G., SEED B.;
RL   J. IMMUNOL. 148:267-271(1992).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 92241880.
RA   SATTERTHWAITE A.B., BURN T.C., LE BEAU M.M., TENEN D.G.;
RL   GENOMICS 12:788-794(1992).
CC   -!- FUNCTION: HYPOTHETICAL ADHESION MOLECULE WITH A ROLE IN
CC       HEMATOPOIESIS BY MEDIATING THE ATTACHMENT OF STEM CELLS TO THE
CC       BONE MARROW EXTRACELLULAR MATRIX OR DIRECTLY TO STROMAL CELLS.
CC       COULD ACT AS A SCAFFOLD FOR THE ATTACHMENT OF LINEAGE SPECIFIC
CC       GLYCANS, ALLOWING STEM CELLS TO BIND TO LECTINS EXPRESSED BY
CC       STROMAL CELLS OR OTHER MARROW COMPONENTS. PRESENTS CARBOHYDRATE
CC       LIGANDS TO SELECTINS.
CC   -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN.
CC   -!- DEVELOPMENTAL STAGE: ON EARLY HEMATOPOIETIC PROGENITOR CELLS.
CC   -!- DISEASE: ABNORMAL CD34 EXPRESSION IN LEUKEMOGENESIS.
CC   -!- PTM: EXTENSIVELY O-GLYCOSYLATED.
CC   -!- TISSUE SPECIFICITY: SELECTIVELY EXPRESSED ON HEMATOPOIETIC
CC       PROGENITOR CELLS AND THE SMALL VESSEL ENDOTHELIUM OF A VARIETY OF
CC       TISSUES.
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DR   EMBL; M81104; G180109; -.
DR   EMBL; M81945; G409019; ALT_INIT.
DR   EMBL; M81938; G409019; JOINED.
DR   EMBL; M81939; G409019; JOINED.
DR   EMBL; M81940; G409019; JOINED.
DR   EMBL; M81941; G409019; JOINED.
DR   EMBL; M81942; G409019; JOINED.
DR   EMBL; M81943; G409019; JOINED.
DR   EMBL; M81944; G409019; JOINED.
DR   PIR; S28534; S28534.
DR   PIR; A46487; A46487.
DR   MIM; 142230; 11TH EDITION.
KW   GLYCOPROTEIN; TRANSMEMBRANE; SIGNAL; ANTIGEN.
FT   SIGNAL        1     16       OR 17 (POTENTIAL).
FT   PROPEP       17     19       POTENTIAL.
FT   CHAIN        20    373       HEMOPOIETIC PROGENITOR CELL ANTIGEN CD34.
FT   DOMAIN       20    277       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    279    300       POTENTIAL.
FT   DOMAIN      301    373       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD     24     24       POTENTIAL.
FT   CARBOHYD     39     39       POTENTIAL.
FT   CARBOHYD     43     43       POTENTIAL.
FT   CARBOHYD     73     73       POTENTIAL.
FT   CARBOHYD     95     95       POTENTIAL.
FT   CARBOHYD    114    114       POTENTIAL.
FT   CARBOHYD    130    130       POTENTIAL.
FT   CARBOHYD    182    182       POTENTIAL.
FT   CARBOHYD    237    237       POTENTIAL.
FT   CARBOHYD    350    350       POTENTIAL.
SQ   SEQUENCE   373 AA;  39394 MW;  0D432A84 CRC32;
     MPRGWTALCL LSLLPSGFMS LDNNGTATPE LPTQGTFSNV STNVSYQETT TPSTLGSTSL
     HPVSQHGNEA TTNITETTVK FTSTSVITSV YGNTNSSVQS QTSVISTVFT TPANVSTPET
     TLKPSLSPGN VSDLSTTSTS LATSPTKPYT SSSPILSDIK AEIKCSGIRE VKLTQGICLE
     QNKTSSCAEF KKDRGEGLAR VLCGEEQADA DAGAQVCSLL LAQSEVRPQC LLLVLANRTE
     ISSKLQLMKK HQSDLKKLGI LDFTEQDVAS HQSYSQKTLI ALVTSGALLA VLGITGYFLM
     NRRSWSPTGE RLGEDPYYTE NGGGQGYSSG PGTSPEAQGK ASVNRGAQKN GTGQATSRNG
     HSARQHVVAD TEL
//