ID CD34_HUMAN STANDARD; PRT; 385 AA. AC P28906; Q15970; Q15971; DT 01-DEC-1992 (Rel. 24, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Hematopoietic progenitor cell antigen CD34 precursor. GN CD34. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM CD34-F), AND SEQUENCE OF 32-43. RC TISSUE=Bone marrow; RX MEDLINE=92091783; PubMed=1370171; RA Simmons D.L., Satterthwaite A.B., Tenen D.G., Seed B.; RT "Molecular cloning of a cDNA encoding CD34, a sialomucin of human RT hematopoietic stem cells."; RL J. Immunol. 148:267-271(1992). RN [2] RP SEQUENCE FROM N.A. (ISOFORM CD34-F). RX MEDLINE=92241880; PubMed=1374051; RA Satterthwaite A.B., Burn T.C., le Beau M.M., Tenen D.G.; RT "Structure of the gene encoding CD34, a human hematopoietic stem cell RT antigen."; RL Genomics 12:788-794(1992). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS CD34-F AND CD34-T). RC TISSUE=Megakaryoblast; RX MEDLINE=93146100; PubMed=7678811; RA Nakamura Y., Komano H., Nakauchi H.; RT "Two alternative forms of cDNA encoding CD34."; RL Exp. Hematol. 21:236-242(1993). RN [4] RP SEQUENCE FROM N.A. (ISOFORM CD34-F). RC TISSUE=Heart; RA Freund D., Wiebe G.J., Ehninger G., Corbeil D.; RT "Sequence analysis of the human CD34 antigen."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP SEQUENCE OF 32-47 AND 175-191, AND CHARACTERIZATION. RX MEDLINE=89069662; PubMed=2462139; RA Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., RA Greaves M.F., Smart J.E.; RT "Structural and partial amino acid sequence analysis of the human RT hemopoietic progenitor cell antigen CD34."; RL Leukemia 2:793-803(1988). RN [6] RP PHOSPHORYLATION BY PKC. RX MEDLINE=90293044; PubMed=1694174; RA Fackler M.J., Civin C.I., Sutherland D.R., Baker M.A., May W.S.; RT "Activated protein kinase C directly phosphorylates the CD34 antigen RT on hematopoietic cells."; RL J. Biol. Chem. 265:11056-11061(1990). CC -!- FUNCTION: Possible adhesion molecule with a role in early CC hematopoiesis by mediating the attachment of stem cells to the CC bone marrow extracellular matrix or directly to stromal cells. CC Could act as a scaffold for the attachment of lineage specific CC glycans, allowing stem cells to bind to lectins expressed by CC stromal cells or other marrow components. Presents carbohydrate CC ligands to selectins. CC -!- SUBCELLULAR LOCATION: Type I membrane protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Comment=Both isoforms are expressed on the cell surface. CC CD34-T/CD34-F ratio increases with cell differentiation; CC Name=CD34-F; CC IsoId=P28906-1; Sequence=Displayed; CC Name=CD34-T; CC IsoId=P28906-2; Sequence=VSP_004159, VSP_004160; CC -!- TISSUE SPECIFICITY: Selectively expressed on hematopoietic CC progenitor cells and the small vessel endothelium of a variety of CC tissues. CC -!- DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells. CC -!- PTM: Extensively O-glycosylated and N-glycosylated. Phosphorylated CC on serine residues by PKC. CC -!- DISEASE: Abnormal CD34 expression in leukemogenesis. CC -!- SIMILARITY: Belongs to the CD34 family. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD34 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd34.htm". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M81104; AAA03181.1; ALT_INIT. DR EMBL; M81945; AAA03659.1; -. DR EMBL; M81938; AAA03659.1; JOINED. DR EMBL; M81939; AAA03659.1; JOINED. DR EMBL; M81940; AAA03659.1; JOINED. DR EMBL; M81941; AAA03659.1; JOINED. DR EMBL; M81942; AAA03659.1; JOINED. DR EMBL; M81943; AAA03659.1; JOINED. DR EMBL; M81944; AAA03659.1; JOINED. DR EMBL; S53910; AAB25222.1; -. DR EMBL; S53911; AAB25223.1; -. DR EMBL; AF523361; AAM82157.1; -. DR PIR; A38078; A38078. DR PIR; I67604; I67604. DR Genew; HGNC:1662; CD34. DR MIM; 142230; -. DR GO; GO:0005886; C:plasma membrane; TAS. DR InterPro; IPR008083; CD34. DR Pfam; PF06365; CD34_antigen; 1. DR PRINTS; PR01700; CD34ANTIGEN. KW Cell adhesion; Antigen; Signal; Transmembrane; Glycoprotein; KW Phosphorylation; Alternative splicing. FT SIGNAL 1 31 FT CHAIN 32 385 Hematopoietic progenitor cell antigen FT CD34. FT DOMAIN 32 290 Extracellular (Potential). FT TRANSMEM 291 311 Potential. FT DOMAIN 312 385 Cytoplasmic (Potential). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT CARBOHYD 55 55 N-linked (GlcNAc...) (Potential). FT CARBOHYD 85 85 N-linked (GlcNAc...) (Potential). FT CARBOHYD 107 107 N-linked (GlcNAc...) (Potential). FT CARBOHYD 126 126 N-linked (GlcNAc...) (Potential). FT CARBOHYD 142 142 N-linked (GlcNAc...) (Potential). FT CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). FT CARBOHYD 249 249 N-linked (GlcNAc...) (Potential). FT VARSPLIC 325 328 GEDP -> ELEP (in isoform CD34-T). FT /FTId=VSP_004159. FT VARSPLIC 329 385 Missing (in isoform CD34-T). FT /FTId=VSP_004160. FT CONFLICT 187 187 Q -> E (in Ref. 5). FT CONFLICT 361 361 E -> K (in Ref. 1 and 2). SQ SEQUENCE 385 AA; 40716 MW; BC581A8FCFFE2BB3 CRC64; MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL //