ID CD34_HUMAN Reviewed; 385 AA. AC P28906; A8K664; Q15970; Q15971; Q5JTA3; Q5JTA4; Q9UJB1; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 28-NOV-2012, entry version 119. DE RecName: Full=Hematopoietic progenitor cell antigen CD34; DE AltName: CD_antigen=CD34; DE Flags: Precursor; GN Name=CD34; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD34-F), AND PROTEIN SEQUENCE OF RP 32-43. RC TISSUE=Bone marrow; RX MEDLINE=92091783; PubMed=1370171; RA Simmons D.L., Satterthwaite A.B., Tenen D.G., Seed B.; RT "Molecular cloning of a cDNA encoding CD34, a sialomucin of human RT hematopoietic stem cells."; RL J. Immunol. 148:267-271(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM CD34-F). RX MEDLINE=92241880; PubMed=1374051; DOI=10.1016/0888-7543(92)90310-O; RA Satterthwaite A.B., Burn T.C., le Beau M.M., Tenen D.G.; RT "Structure of the gene encoding CD34, a human hematopoietic stem cell RT antigen."; RL Genomics 12:788-794(1992). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CD34-F AND CD34-T). RC TISSUE=Megakaryoblast; RX MEDLINE=93146100; PubMed=7678811; RA Nakamura Y., Komano H., Nakauchi H.; RT "Two alternative forms of cDNA encoding CD34."; RL Exp. Hematol. 21:236-242(1993). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD34-F). RC TISSUE=Heart; RA Freund D., Wiebe G.J., Ehninger G., Corbeil D.; RT "Sequence analysis of the human CD34 antigen."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CD34-F). RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CD34-F). RC TISSUE=Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP PROTEIN SEQUENCE OF 32-47 AND 175-191, AND CHARACTERIZATION. RX MEDLINE=89069662; PubMed=2462139; RA Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., RA Greaves M.F., Smart J.E.; RT "Structural and partial amino acid sequence analysis of the human RT hemopoietic progenitor cell antigen CD34."; RL Leukemia 2:793-803(1988). RN [10] RP PHOSPHORYLATION BY PKC. RX MEDLINE=90293044; PubMed=1694174; RA Fackler M.J., Civin C.I., Sutherland D.R., Baker M.A., May W.S.; RT "Activated protein kinase C directly phosphorylates the CD34 antigen RT on hematopoietic cells."; RL J. Biol. Chem. 265:11056-11061(1990). CC -!- FUNCTION: Possible adhesion molecule with a role in early CC hematopoiesis by mediating the attachment of stem cells to the CC bone marrow extracellular matrix or directly to stromal cells. CC Could act as a scaffold for the attachment of lineage specific CC glycans, allowing stem cells to bind to lectins expressed by CC stromal cells or other marrow components. Presents carbohydrate CC ligands to selectins. CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Comment=Both isoforms are expressed on the cell surface. CC CD34-T/CD34-F ratio increases with cell differentiation; CC Name=CD34-F; CC IsoId=P28906-1; Sequence=Displayed; CC Name=CD34-T; CC IsoId=P28906-2; Sequence=VSP_004159, VSP_004160; CC -!- TISSUE SPECIFICITY: Selectively expressed on hematopoietic CC progenitor cells and the small vessel endothelium of a variety of CC tissues. CC -!- DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells. CC -!- PTM: Highly glycosylated. CC -!- PTM: Phosphorylated on serine residues by PKC. CC -!- SIMILARITY: Belongs to the CD34 family. CC -!- SEQUENCE CAUTION: CC Sequence=AAA03181.1; Type=Erroneous initiation; CC -!- WEB RESOURCE: Name=Wikipedia; Note=CD34 entry; CC URL="http://en.wikipedia.org/wiki/CD34"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M81104; AAA03181.1; ALT_INIT; mRNA. DR EMBL; M81945; AAA03659.1; -; Genomic_DNA. DR EMBL; M81938; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; M81939; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; M81940; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; M81941; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; M81942; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; M81943; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; M81944; AAA03659.1; JOINED; Genomic_DNA. DR EMBL; S53910; AAB25222.1; -; mRNA. DR EMBL; S53911; AAB25223.1; -; mRNA. DR EMBL; AF523361; AAM82157.1; -; mRNA. DR EMBL; AK291529; BAF84218.1; -; mRNA. DR EMBL; AL356275; CAI40195.1; -; Genomic_DNA. DR EMBL; AL356275; CAI40196.1; -; Genomic_DNA. DR EMBL; CH471100; EAW93459.1; -; Genomic_DNA. DR EMBL; BC039146; AAH39146.2; -; mRNA. DR IPI; IPI00006070; -. DR IPI; IPI00299994; -. DR PIR; A38078; A38078. DR PIR; I67604; I67604. DR RefSeq; NP_001020280.1; NM_001025109.1. DR RefSeq; NP_001764.1; NM_001773.2. DR UniGene; Hs.374990; -. DR ProteinModelPortal; P28906; -. DR IntAct; P28906; 1. DR STRING; P28906; -. DR PhosphoSite; P28906; -. DR DMDM; 3183511; -. DR PaxDb; P28906; -. DR PRIDE; P28906; -. DR DNASU; 947; -. DR Ensembl; ENST00000310833; ENSP00000310036; ENSG00000174059. DR Ensembl; ENST00000356522; ENSP00000348916; ENSG00000174059. DR GeneID; 947; -. DR KEGG; hsa:947; -. DR UCSC; uc001hgw.1; human. DR UCSC; uc001hgx.1; human. DR CTD; 947; -. DR GeneCards; GC01M208057; -. DR HGNC; HGNC:1662; CD34. DR HPA; CAB000018; -. DR MIM; 142230; gene. DR neXtProt; NX_P28906; -. DR PharmGKB; PA26211; -. DR eggNOG; NOG42285; -. DR HOVERGEN; HBG003461; -. DR InParanoid; P28906; -. DR KO; K06474; -. DR OMA; QGICLEQ; -. DR OrthoDB; EOG4GF3G0; -. DR PhylomeDB; P28906; -. DR Reactome; REACT_6900; Immune System. DR GenomeRNAi; 947; -. DR NextBio; 3932; -. DR ArrayExpress; P28906; -. DR Bgee; P28906; -. DR CleanEx; HS_CD34; -. DR Genevestigator; P28906; -. DR GermOnline; ENSG00000174059; Homo sapiens. DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB. DR GO; GO:0009925; C:basal plasma membrane; ISS:UniProtKB. DR GO; GO:0009897; C:external side of plasma membrane; IDA:UniProtKB. DR GO; GO:0036053; C:glomerular endothelium fenestra; ISS:UniProtKB. DR GO; GO:0005887; C:integral to plasma membrane; TAS:UniProtKB. DR GO; GO:0045171; C:intercellular bridge; IDA:UniProtKB. DR GO; GO:0005764; C:lysosome; ISS:UniProtKB. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. DR GO; GO:0030246; F:carbohydrate binding; IDA:HGNC. DR GO; GO:0043199; F:sulfate binding; IEA:Compara. DR GO; GO:0016337; P:cell-cell adhesion; IDA:HGNC. DR GO; GO:0001935; P:endothelial cell proliferation; IDA:UniProtKB. DR GO; GO:0003158; P:endothelium development; IEP:UniProtKB. DR GO; GO:0071971; P:extracellular vesicular exosome assembly; IDA:UniProtKB. DR GO; GO:0072011; P:glomerular endothelium development; IEP:UniProtKB. DR GO; GO:0003094; P:glomerular filtration; IEP:UniProtKB. DR GO; GO:0006536; P:glutamate metabolic process; IDA:UniProtKB. DR GO; GO:0071425; P:hemopoietic stem cell proliferation; IMP:UniProtKB. DR GO; GO:0050900; P:leukocyte migration; ISS:HGNC. DR GO; GO:0035759; P:mesangial cell-matrix adhesion; ISS:UniProtKB. DR GO; GO:0072254; P:metanephric glomerular mesangial cell differentiation; IEP:UniProtKB. DR GO; GO:0030195; P:negative regulation of blood coagulation; IDA:UniProtKB. DR GO; GO:1900035; P:negative regulation of cellular response to heat; IDA:UniProtKB. DR GO; GO:1900038; P:negative regulation of cellular response to hypoxia; IDA:UniProtKB. DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB. DR GO; GO:1900041; P:negative regulation of interleukin-2 secretion; IMP:UniProtKB. DR GO; GO:0060547; P:negative regulation of necrotic cell death; IDA:UniProtKB. DR GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:UniProtKB. DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IDA:UniProtKB. DR GO; GO:0038001; P:paracrine signaling; IDA:UniProtKB. DR GO; GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB. DR GO; GO:0010628; P:positive regulation of gene expression; IEP:UniProtKB. DR GO; GO:1900168; P:positive regulation of glial cell line-derived neurotrophic factor secretion; IDA:UniProtKB. DR GO; GO:0071657; P:positive regulation of granulocyte colony-stimulating factor production; IDA:UniProtKB. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IDA:UniProtKB. DR GO; GO:0042482; P:positive regulation of odontogenesis; IDA:UniProtKB. DR GO; GO:0071636; P:positive regulation of transforming growth factor beta production; IDA:UniProtKB. DR GO; GO:2001214; P:positive regulation of vasculogenesis; IDA:UniProtKB. DR GO; GO:0008217; P:regulation of blood pressure; IDA:UniProtKB. DR GO; GO:0050776; P:regulation of immune response; TAS:Reactome. DR GO; GO:0007165; P:signal transduction; IEP:UniProtKB. DR GO; GO:0072089; P:stem cell proliferation; IEP:UniProtKB. DR GO; GO:0001894; P:tissue homeostasis; IDA:UniProtKB. DR GO; GO:0060290; P:transdifferentiation; IEP:UniProtKB. DR GO; GO:0061042; P:vascular wound healing; IEP:UniProtKB. DR InterPro; IPR008083; CD34. DR InterPro; IPR013836; CD34/Podocalyxin. DR PANTHER; PTHR16677; PTHR16677; 1. DR Pfam; PF06365; CD34_antigen; 1. DR PRINTS; PR01700; CD34ANTIGEN. PE 1: Evidence at protein level; KW Alternative splicing; Cell adhesion; Complete proteome; KW Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein; KW Polymorphism; Reference proteome; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 31 FT CHAIN 32 385 Hematopoietic progenitor cell antigen FT CD34. FT /FTId=PRO_0000020900. FT TOPO_DOM 32 290 Extracellular (Potential). FT TRANSMEM 291 311 Helical; (Potential). FT TOPO_DOM 312 385 Cytoplasmic (Potential). FT MOD_RES 329 329 Phosphotyrosine (By similarity). FT MOD_RES 339 339 Phosphotyrosine (By similarity). FT CARBOHYD 36 36 N-linked (GlcNAc...) (Potential). FT CARBOHYD 51 51 N-linked (GlcNAc...) (Potential). FT CARBOHYD 55 55 N-linked (GlcNAc...) (Potential). FT CARBOHYD 85 85 N-linked (GlcNAc...) (Potential). FT CARBOHYD 107 107 N-linked (GlcNAc...) (Potential). FT CARBOHYD 126 126 N-linked (GlcNAc...) (Potential). FT CARBOHYD 142 142 N-linked (GlcNAc...) (Potential). FT CARBOHYD 194 194 N-linked (GlcNAc...) (Potential). FT CARBOHYD 249 249 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 325 328 GEDP -> ELEP (in isoform CD34-T). FT /FTId=VSP_004159. FT VAR_SEQ 329 385 Missing (in isoform CD34-T). FT /FTId=VSP_004160. FT VARIANT 367 367 A -> S (in dbSNP:rs28362497). FT /FTId=VAR_050774. FT CONFLICT 187 187 Q -> E (in Ref. 9; AA sequence). FT CONFLICT 325 327 GED -> ELE (in Ref. 3). FT CONFLICT 361 361 E -> K (in Ref. 1 and 2). SQ SEQUENCE 385 AA; 40716 MW; BC581A8FCFFE2BB3 CRC64; MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL //