ID CD34_HUMAN STANDARD; PRT; 385 AA. AC P28906; Q15970; Q15971; DT 01-DEC-1992 (REL. 24, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE) DE HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34 PRECURSOR. GN CD34. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC PRIMATES; CATARRHINI; HOMINIDAE; HOMO. RN [1] RP SEQUENCE FROM N.A., AND SEQUENCE OF 32-43. RX MEDLINE; 92091783. RA SIMMONS D.L., SATTERTHWAITE A.B., TENEN D.G., SEED B.; RT "Molecular cloning of a cDNA encoding CD34, a sialomucin of human RT hematopoietic stem cells."; RL J. IMMUNOL. 148:267-271(1992). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 92241880. RA SATTERTHWAITE A.B., BURN T.C., LE BEAU M.M., TENEN D.G.; RT "Structure of the gene encoding CD34, a human hematopoietic stem cell RT antigen."; RL GENOMICS 12:788-794(1992). RN [3] RP SEQUENCE FROM N.A. (CD34-F AND CD34-T). RC TISSUE=MEGAKARYOBLAST; RX MEDLINE; 93146100. RA NAKAMURA Y., KOMANO H., NAKAUCHI H.; RT "Two alternative forms of cDNA encoding CD34."; RL EXP. HEMATOL. 21:236-242(1993). RN [4] RP SEQUENCE OF 32-47, AND 175-191, AND CHARACTERIZATION. RX MEDLINE; 89069662. RA SUTHERLAND D.R., WATT S.M., DOWDEN G., KARHI K., BAKER M.A., RA GREAVES M.F., SMART J.E.; RT "Structural and partial amino acid sequence analysis of the human RT hemopoietic progenitor cell antigen CD34."; RL LEUKEMIA 2:793-803(1988). RN [5] RP PHOSPHORYLATION BY PKC. RX MEDLINE; 90293044. RA FACKLER M.J., CIVIN C.I., SUTHERLAND D.R., BACKER M.A., MAY W.S.; RT "Activated protein kinase C directly phosphorylates the CD34 antigen RT on hematopoietic cells."; RL J. BIOL. CHEM. 265:11056-11061(1990). CC -!- FUNCTION: POSSIBLE ADHESION MOLECULE WITH A ROLE IN EARLY CC HEMATOPOIESIS BY MEDIATING THE ATTACHMENT OF STEM CELLS TO THE CC BONE MARROW EXTRACELLULAR MATRIX OR DIRECTLY TO STROMAL CELLS. CC COULD ACT AS A SCAFFOLD FOR THE ATTACHMENT OF LINEAGE SPECIFIC CC GLYCANS, ALLOWING STEM CELLS TO BIND TO LECTINS EXPRESSED BY CC STROMAL CELLS OR OTHER MARROW COMPONENTS. PRESENTS CARBOHYDRATE CC LIGANDS TO SELECTINS. CC -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN. CC -!- TISSUE SPECIFICITY: SELECTIVELY EXPRESSED ON HEMATOPOIETIC CC PROGENITOR CELLS AND THE SMALL VESSEL ENDOTHELIUM OF A VARIETY OF CC TISSUES. CC -!- DEVELOPMENTAL STAGE: ON EARLY HEMATOPOIETIC PROGENITOR CELLS. CC -!- PTM: EXTENSIVELY O-GLYCOSYLATED AND N-GLYCOSYLATED. PHOSPHORYLATED CC ON SERINE RESIDUES BY PKC. CC -!- ALTERNATIVE PRODUCTS: A LONG ISOFORM CD34-F (SHOWN HERE) AND A CC SHORT ISOFORM CD34-T ARE PRODUCED BY ALTERNATIVE SPLICING. BOTH CC ISOFORMS ARE EXPRESSED ON THE CELL SURFACE. CD34-T/CD34-F RATIO CC INCREASES WITH CELL DIFFERENTIATION. CC -!- DISEASE: ABNORMAL CD34 EXPRESSION IN LEUKEMOGENESIS. CC -!- DATABASE: NAME=PROW; NOTE=CD guide CD34 entry; CC WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd34.htm". CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M81104; G180109; ALT_INIT. DR EMBL; M81945; G409019; -. DR EMBL; M81938; G409019; JOINED. DR EMBL; M81939; G409019; JOINED. DR EMBL; M81940; G409019; JOINED. DR EMBL; M81941; G409019; JOINED. DR EMBL; M81942; G409019; JOINED. DR EMBL; M81943; G409019; JOINED. DR EMBL; M81944; G409019; JOINED. DR EMBL; S53910; G264767; -. DR EMBL; S53911; G264769; -. DR PIR; S28534; S28534. DR PIR; A46487; A46487. DR MIM; 142230; -. KW GLYCOPROTEIN; TRANSMEMBRANE; SIGNAL; ANTIGEN; ALTERNATIVE SPLICING; KW PHOSPHORYLATION. FT SIGNAL 1 31 FT CHAIN 32 385 HEMATOPOIETIC PROGENITOR CELL ANTIGEN FT CD34. FT DOMAIN 32 290 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 291 311 POTENTIAL. FT DOMAIN 312 385 CYTOPLASMIC (POTENTIAL). FT VARSPLIC 325 328 GEDP -> ELEP (IN SHORT FORM/CD34-T). FT VARSPLIC 329 385 MISSING (IN SHORT FORM/CD34-T). FT CARBOHYD 36 36 POTENTIAL. FT CARBOHYD 51 51 POTENTIAL. FT CARBOHYD 55 55 POTENTIAL. FT CARBOHYD 85 85 POTENTIAL. FT CARBOHYD 107 107 POTENTIAL. FT CARBOHYD 126 126 POTENTIAL. FT CARBOHYD 142 142 POTENTIAL. FT CARBOHYD 194 194 POTENTIAL. FT CARBOHYD 249 249 POTENTIAL. FT CONFLICT 187 187 Q -> E (IN REF. 4). FT CONFLICT 361 361 E -> K (IN REF. 1 AND 2). SQ SEQUENCE 385 AA; 40716 MW; 6D09B6B1 CRC32; MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL //