ID   CD34_HUMAN     STANDARD;      PRT;   385 AA.
AC   P28906; Q15970; Q15971;
DT   01-DEC-1992 (REL. 24, CREATED)
DT   15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE)
DT   15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE)
DE   HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34 PRECURSOR.
GN   CD34.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 32-43.
RX   MEDLINE; 92091783.
RA   SIMMONS D.L., SATTERTHWAITE A.B., TENEN D.G., SEED B.;
RL   J. IMMUNOL. 148:267-271(1992).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 92241880.
RA   SATTERTHWAITE A.B., BURN T.C., LE BEAU M.M., TENEN D.G.;
RL   GENOMICS 12:788-794(1992).
RN   [3]
RP   SEQUENCE FROM N.A. (CD34-F AND CD34-T).
RC   TISSUE=MEGAKARYOBLAST;
RX   MEDLINE; 93146100.
RA   NAKAMURA Y., KOMANO H., NAKAUCHI H.;
RL   EXP. HEMATOL. 21:236-242(1993).
RN   [4]
RP   SEQUENCE OF 32-47, AND 175-191, AND CHARACTERIZATION.
RX   MEDLINE; 89069662.
RA   SUTHERLAND D.R., WATT S.M., DOWDEN G., KARHI K., BAKER M.A.,
RA   GREAVES M.F., SMART J.E.;
RL   LEUKEMIA 2:793-803(1988).
RN   [5]
RP   PHOSPHORYLATION BY PKC.
RX   MEDLINE; 90293044.
RA   FACKLER M.J., CIVIN C.I., SUTHERLAND D.R., BACKER M.A., MAY W.S.;
RL   J. BIOL. CHEM. 265:11056-11061(1990).
CC   -!- FUNCTION: POSSIBLE ADHESION MOLECULE WITH A ROLE IN EARLY
CC       HEMATOPOIESIS BY MEDIATING THE ATTACHMENT OF STEM CELLS TO THE
CC       BONE MARROW EXTRACELLULAR MATRIX OR DIRECTLY TO STROMAL CELLS.
CC       COULD ACT AS A SCAFFOLD FOR THE ATTACHMENT OF LINEAGE SPECIFIC
CC       GLYCANS, ALLOWING STEM CELLS TO BIND TO LECTINS EXPRESSED BY
CC       STROMAL CELLS OR OTHER MARROW COMPONENTS. PRESENTS CARBOHYDRATE
CC       LIGANDS TO SELECTINS.
CC   -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN.
CC   -!- TISSUE SPECIFICITY: SELECTIVELY EXPRESSED ON HEMATOPOIETIC
CC       PROGENITOR CELLS AND THE SMALL VESSEL ENDOTHELIUM OF A VARIETY OF
CC       TISSUES.
CC   -!- DEVELOPMENTAL STAGE: ON EARLY HEMATOPOIETIC PROGENITOR CELLS.
CC   -!- PTM: EXTENSIVELY O-GLYCOSYLATED AND N-GLYCOSYLATED. PHOSPHORYLATED
CC       ON SERINE RESIDUES BY PKC.
CC   -!- ALTERNATIVE PRODUCTS: A LONG ISOFORM CD34-F (SHOWN HERE) AND A
CC       SHORT ISOFORM CD34-T ARE PRODUCED BY ALTERNATIVE SPLICING. BOTH
CC       ISOFORMS ARE EXPRESSED ON THE CELL SURFACE. CD34-T/CD34-F RATIO
CC       INCREASES WITH CELL DIFFERENTIATION.
CC   -!- DISEASE: ABNORMAL CD34 EXPRESSION IN LEUKEMOGENESIS.
CC   -!- DATABASE: NAME=PROW; NOTE=CD guide CD34 entry;
CC       WWW="http://www.ncbi.nlm.nih.gov/prow/cd/cd34.htm".
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DR   EMBL; M81104; G180109; ALT_INIT.
DR   EMBL; M81945; G409019; -.
DR   EMBL; M81938; G409019; JOINED.
DR   EMBL; M81939; G409019; JOINED.
DR   EMBL; M81940; G409019; JOINED.
DR   EMBL; M81941; G409019; JOINED.
DR   EMBL; M81942; G409019; JOINED.
DR   EMBL; M81943; G409019; JOINED.
DR   EMBL; M81944; G409019; JOINED.
DR   EMBL; S53910; G264767; -.
DR   EMBL; S53911; G264769; -.
DR   PIR; S28534; S28534.
DR   PIR; A46487; A46487.
DR   MIM; 142230; -.
KW   GLYCOPROTEIN; TRANSMEMBRANE; SIGNAL; ANTIGEN; ALTERNATIVE SPLICING;
KW   PHOSPHORYLATION.
FT   SIGNAL        1     31
FT   CHAIN        32    385       HEMATOPOIETIC PROGENITOR CELL ANTIGEN
FT                                CD34.
FT   DOMAIN       32    290       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    291    311       POTENTIAL.
FT   DOMAIN      312    385       CYTOPLASMIC (POTENTIAL).
FT   VARSPLIC    325    328       GEDP -> ELEP (IN SHORT FORM/CD34-T).
FT   VARSPLIC    329    385       MISSING (IN SHORT FORM/CD34-T).
FT   CARBOHYD     36     36       POTENTIAL.
FT   CARBOHYD     51     51       POTENTIAL.
FT   CARBOHYD     55     55       POTENTIAL.
FT   CARBOHYD     85     85       POTENTIAL.
FT   CARBOHYD    107    107       POTENTIAL.
FT   CARBOHYD    126    126       POTENTIAL.
FT   CARBOHYD    142    142       POTENTIAL.
FT   CARBOHYD    194    194       POTENTIAL.
FT   CARBOHYD    249    249       POTENTIAL.
FT   CONFLICT    187    187       Q -> E (IN REF. 4).
FT   CONFLICT    361    361       E -> K (IN REF. 1 AND 2).
SQ   SEQUENCE   385 AA;  40715 MW;  2AD949A0 CRC32;
     MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE
     TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV
     FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI
     REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP
     QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL
     LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ
     ENGTGQATSR NGHSARQHVV ADTEL
//