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P28906

- CD34_HUMAN

UniProt

P28906 - CD34_HUMAN

Protein

Hematopoietic progenitor cell antigen CD34

Gene

CD34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

    GO - Molecular functioni

    1. carbohydrate binding Source: HGNC
    2. sulfate binding Source: Ensembl
    3. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. cell motility Source: UniProtKB
    2. cell proliferation Source: UniProtKB
    3. endothelial cell proliferation Source: UniProtKB
    4. endothelium development Source: UniProtKB
    5. extracellular vesicular exosome assembly Source: UniProtKB
    6. glomerular endothelium development Source: UniProtKB
    7. glomerular filtration Source: UniProtKB
    8. glutamate metabolic process Source: UniProtKB
    9. hematopoietic stem cell proliferation Source: UniProtKB
    10. hemopoiesis Source: UniProtKB
    11. leukocyte migration Source: HGNC
    12. mesangial cell-matrix adhesion Source: UniProtKB
    13. metanephric glomerular mesangial cell differentiation Source: UniProtKB
    14. negative regulation of blood coagulation Source: UniProtKB
    15. negative regulation of cellular response to heat Source: UniProtKB
    16. negative regulation of cellular response to hypoxia Source: UniProtKB
    17. negative regulation of gene expression Source: UniProtKB
    18. negative regulation of interleukin-2 secretion Source: UniProtKB
    19. negative regulation of neuron death Source: UniProtKB
    20. negative regulation of nitric oxide biosynthetic process Source: UniProtKB
    21. negative regulation of tumor necrosis factor production Source: UniProtKB
    22. paracrine signaling Source: UniProtKB
    23. positive regulation of angiogenesis Source: UniProtKB
    24. positive regulation of gene expression Source: UniProtKB
    25. positive regulation of glial cell line-derived neurotrophic factor secretion Source: UniProtKB
    26. positive regulation of granulocyte colony-stimulating factor production Source: UniProtKB
    27. positive regulation of interleukin-10 production Source: UniProtKB
    28. positive regulation of odontogenesis Source: UniProtKB
    29. positive regulation of transforming growth factor beta production Source: UniProtKB
    30. positive regulation of vasculogenesis Source: UniProtKB
    31. regulation of blood pressure Source: UniProtKB
    32. regulation of immune response Source: Reactome
    33. signal transduction Source: UniProtKB
    34. single organismal cell-cell adhesion Source: HGNC
    35. stem cell proliferation Source: UniProtKB
    36. tissue homeostasis Source: UniProtKB
    37. transdifferentiation Source: UniProtKB
    38. vascular wound healing Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hematopoietic progenitor cell antigen CD34
    Alternative name(s):
    CD_antigen: CD34
    Gene namesi
    Name:CD34
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1662. CD34.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. basal plasma membrane Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. external side of plasma membrane Source: UniProtKB
    5. glomerular endothelium fenestra Source: UniProtKB
    6. integral component of plasma membrane Source: UniProtKB
    7. intercellular bridge Source: UniProtKB
    8. lysosome Source: UniProtKB
    9. perinuclear region of cytoplasm Source: UniProtKB
    10. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26211.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 31312 PublicationsAdd
    BLAST
    Chaini32 – 385354Hematopoietic progenitor cell antigen CD34PRO_0000020900Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Modified residuei329 – 3291PhosphotyrosineBy similarity
    Modified residuei339 – 3391PhosphotyrosineBy similarity

    Post-translational modificationi

    Highly glycosylated.
    Phosphorylated on serine residues by PKC.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP28906.
    PaxDbiP28906.
    PRIDEiP28906.

    PTM databases

    PhosphoSiteiP28906.

    Expressioni

    Tissue specificityi

    Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

    Developmental stagei

    On early hematopoietic progenitor cells.

    Gene expression databases

    ArrayExpressiP28906.
    BgeeiP28906.
    CleanExiHS_CD34.
    GenevestigatoriP28906.

    Organism-specific databases

    HPAiCAB000018.

    Interactioni

    Protein-protein interaction databases

    BioGridi107385. 3 interactions.
    IntActiP28906. 1 interaction.
    STRINGi9606.ENSP00000310036.

    Structurei

    3D structure databases

    ProteinModelPortaliP28906.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 290259ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini312 – 38574CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CD34 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42285.
    HOVERGENiHBG003461.
    InParanoidiP28906.
    KOiK06474.
    OMAiKGEIKCS.
    PhylomeDBiP28906.
    TreeFamiTF335795.

    Family and domain databases

    InterProiIPR008083. CD34.
    IPR013836. CD34/Podocalyxin.
    [Graphical view]
    PANTHERiPTHR16677. PTHR16677. 1 hit.
    PfamiPF06365. CD34_antigen. 1 hit.
    [Graphical view]
    PRINTSiPR01700. CD34ANTIGEN.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation.

    Isoform CD34-F (identifier: P28906-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS    50
    NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT 100
    SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS 150
    TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA 200
    EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR 250
    TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL 300
    LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ 350
    GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL 385
    Length:385
    Mass (Da):40,716
    Last modified:July 15, 1998 - v2
    Checksum:iBC581A8FCFFE2BB3
    GO
    Isoform CD34-T (identifier: P28906-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         325-328: GEDP → ELEP
         329-385: Missing.

    Show »
    Length:328
    Mass (Da):35,011
    Checksum:i7FFBEBC98D4CC61D
    GO

    Sequence cautioni

    The sequence AAA03181.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti187 – 1871Q → E AA sequence (PubMed:2462139)Curated
    Sequence conflicti325 – 3273GED → ELE(PubMed:7678811)Curated
    Sequence conflicti361 – 3611E → K(PubMed:1370171)Curated
    Sequence conflicti361 – 3611E → K(PubMed:1374051)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti367 – 3671A → S.
    Corresponds to variant rs28362497 [ dbSNP | Ensembl ].
    VAR_050774

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei325 – 3284GEDP → ELEP in isoform CD34-T. 1 PublicationVSP_004159
    Alternative sequencei329 – 38557Missing in isoform CD34-T. 1 PublicationVSP_004160Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81104 mRNA. Translation: AAA03181.1. Different initiation.
    M81945
    , M81938, M81939, M81940, M81941, M81942, M81943, M81944 Genomic DNA. Translation: AAA03659.1.
    S53910 mRNA. Translation: AAB25222.1.
    S53911 mRNA. Translation: AAB25223.1.
    AF523361 mRNA. Translation: AAM82157.1.
    AK291529 mRNA. Translation: BAF84218.1.
    AL356275 Genomic DNA. Translation: CAI40195.1.
    AL356275 Genomic DNA. Translation: CAI40196.1.
    CH471100 Genomic DNA. Translation: EAW93459.1.
    BC039146 mRNA. Translation: AAH39146.2.
    CCDSiCCDS31011.1. [P28906-1]
    CCDS31012.1. [P28906-2]
    PIRiA38078.
    I67604.
    RefSeqiNP_001020280.1. NM_001025109.1. [P28906-1]
    NP_001764.1. NM_001773.2. [P28906-2]
    UniGeneiHs.374990.

    Genome annotation databases

    EnsembliENST00000310833; ENSP00000310036; ENSG00000174059. [P28906-1]
    ENST00000356522; ENSP00000348916; ENSG00000174059. [P28906-2]
    GeneIDi947.
    KEGGihsa:947.
    UCSCiuc001hgw.1. human. [P28906-1]
    uc001hgx.1. human. [P28906-2]

    Polymorphism databases

    DMDMi3183511.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CD34 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81104 mRNA. Translation: AAA03181.1 . Different initiation.
    M81945
    , M81938 , M81939 , M81940 , M81941 , M81942 , M81943 , M81944 Genomic DNA. Translation: AAA03659.1 .
    S53910 mRNA. Translation: AAB25222.1 .
    S53911 mRNA. Translation: AAB25223.1 .
    AF523361 mRNA. Translation: AAM82157.1 .
    AK291529 mRNA. Translation: BAF84218.1 .
    AL356275 Genomic DNA. Translation: CAI40195.1 .
    AL356275 Genomic DNA. Translation: CAI40196.1 .
    CH471100 Genomic DNA. Translation: EAW93459.1 .
    BC039146 mRNA. Translation: AAH39146.2 .
    CCDSi CCDS31011.1. [P28906-1 ]
    CCDS31012.1. [P28906-2 ]
    PIRi A38078.
    I67604.
    RefSeqi NP_001020280.1. NM_001025109.1. [P28906-1 ]
    NP_001764.1. NM_001773.2. [P28906-2 ]
    UniGenei Hs.374990.

    3D structure databases

    ProteinModelPortali P28906.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107385. 3 interactions.
    IntActi P28906. 1 interaction.
    STRINGi 9606.ENSP00000310036.

    PTM databases

    PhosphoSitei P28906.

    Polymorphism databases

    DMDMi 3183511.

    Proteomic databases

    MaxQBi P28906.
    PaxDbi P28906.
    PRIDEi P28906.

    Protocols and materials databases

    DNASUi 947.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310833 ; ENSP00000310036 ; ENSG00000174059 . [P28906-1 ]
    ENST00000356522 ; ENSP00000348916 ; ENSG00000174059 . [P28906-2 ]
    GeneIDi 947.
    KEGGi hsa:947.
    UCSCi uc001hgw.1. human. [P28906-1 ]
    uc001hgx.1. human. [P28906-2 ]

    Organism-specific databases

    CTDi 947.
    GeneCardsi GC01M208057.
    HGNCi HGNC:1662. CD34.
    HPAi CAB000018.
    MIMi 142230. gene.
    neXtProti NX_P28906.
    PharmGKBi PA26211.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42285.
    HOVERGENi HBG003461.
    InParanoidi P28906.
    KOi K06474.
    OMAi KGEIKCS.
    PhylomeDBi P28906.
    TreeFami TF335795.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    ChiTaRSi CD34. human.
    GeneWikii CD34.
    GenomeRNAii 947.
    NextBioi 3932.
    PROi P28906.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28906.
    Bgeei P28906.
    CleanExi HS_CD34.
    Genevestigatori P28906.

    Family and domain databases

    InterProi IPR008083. CD34.
    IPR013836. CD34/Podocalyxin.
    [Graphical view ]
    PANTHERi PTHR16677. PTHR16677. 1 hit.
    Pfami PF06365. CD34_antigen. 1 hit.
    [Graphical view ]
    PRINTSi PR01700. CD34ANTIGEN.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells."
      Simmons D.L., Satterthwaite A.B., Tenen D.G., Seed B.
      J. Immunol. 148:267-271(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD34-F), PROTEIN SEQUENCE OF 32-43.
      Tissue: Bone marrow.
    2. "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen."
      Satterthwaite A.B., Burn T.C., le Beau M.M., Tenen D.G.
      Genomics 12:788-794(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM CD34-F).
    3. "Two alternative forms of cDNA encoding CD34."
      Nakamura Y., Komano H., Nakauchi H.
      Exp. Hematol. 21:236-242(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CD34-F AND CD34-T).
      Tissue: Megakaryoblast.
    4. "Sequence analysis of the human CD34 antigen."
      Freund D., Wiebe G.J., Ehninger G., Corbeil D.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD34-F).
      Tissue: Heart.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CD34-F).
      Tissue: Placenta.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CD34-F).
      Tissue: Skin.
    9. "Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34."
      Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.
      Leukemia 2:793-803(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 32-47 AND 175-191, CHARACTERIZATION.
    10. "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells."
      Fackler M.J., Civin C.I., Sutherland D.R., Baker M.A., May W.S.
      J. Biol. Chem. 265:11056-11061(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION BY PKC.

    Entry informationi

    Entry nameiCD34_HUMAN
    AccessioniPrimary (citable) accession number: P28906
    Secondary accession number(s): A8K664
    , Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3