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P28906

- CD34_HUMAN

UniProt

P28906 - CD34_HUMAN

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Protein

Hematopoietic progenitor cell antigen CD34

Gene
CD34
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

GO - Molecular functioni

  1. carbohydrate binding Source: HGNC
  2. sulfate binding Source: Ensembl
  3. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. cell motility Source: UniProtKB
  2. cell proliferation Source: UniProtKB
  3. endothelial cell proliferation Source: UniProtKB
  4. endothelium development Source: UniProtKB
  5. extracellular vesicular exosome assembly Source: UniProtKB
  6. glomerular endothelium development Source: UniProtKB
  7. glomerular filtration Source: UniProtKB
  8. glutamate metabolic process Source: UniProtKB
  9. hematopoietic stem cell proliferation Source: UniProtKB
  10. hemopoiesis Source: UniProtKB
  11. leukocyte migration Source: HGNC
  12. mesangial cell-matrix adhesion Source: UniProtKB
  13. metanephric glomerular mesangial cell differentiation Source: UniProtKB
  14. negative regulation of blood coagulation Source: UniProtKB
  15. negative regulation of cellular response to heat Source: UniProtKB
  16. negative regulation of cellular response to hypoxia Source: UniProtKB
  17. negative regulation of gene expression Source: UniProtKB
  18. negative regulation of interleukin-2 secretion Source: UniProtKB
  19. negative regulation of neuron death Source: UniProtKB
  20. negative regulation of nitric oxide biosynthetic process Source: UniProtKB
  21. negative regulation of tumor necrosis factor production Source: UniProtKB
  22. paracrine signaling Source: UniProtKB
  23. positive regulation of angiogenesis Source: UniProtKB
  24. positive regulation of gene expression Source: UniProtKB
  25. positive regulation of glial cell line-derived neurotrophic factor secretion Source: UniProtKB
  26. positive regulation of granulocyte colony-stimulating factor production Source: UniProtKB
  27. positive regulation of interleukin-10 production Source: UniProtKB
  28. positive regulation of odontogenesis Source: UniProtKB
  29. positive regulation of transforming growth factor beta production Source: UniProtKB
  30. positive regulation of vasculogenesis Source: UniProtKB
  31. regulation of blood pressure Source: UniProtKB
  32. regulation of immune response Source: Reactome
  33. signal transduction Source: UniProtKB
  34. single organismal cell-cell adhesion Source: HGNC
  35. stem cell proliferation Source: UniProtKB
  36. tissue homeostasis Source: UniProtKB
  37. transdifferentiation Source: UniProtKB
  38. vascular wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietic progenitor cell antigen CD34
Alternative name(s):
CD_antigen: CD34
Gene namesi
Name:CD34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1662. CD34.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 290259Extracellular Reviewed predictionAdd
BLAST
Transmembranei291 – 31121Helical; Reviewed predictionAdd
BLAST
Topological domaini312 – 38574Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. basal plasma membrane Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. external side of plasma membrane Source: UniProtKB
  5. glomerular endothelium fenestra Source: UniProtKB
  6. integral component of plasma membrane Source: UniProtKB
  7. intercellular bridge Source: UniProtKB
  8. lysosome Source: UniProtKB
  9. perinuclear region of cytoplasm Source: UniProtKB
  10. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31312 PublicationsAdd
BLAST
Chaini32 – 385354Hematopoietic progenitor cell antigen CD34PRO_0000020900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi85 – 851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Modified residuei329 – 3291Phosphotyrosine By similarity
Modified residuei339 – 3391Phosphotyrosine By similarity

Post-translational modificationi

Highly glycosylated.
Phosphorylated on serine residues by PKC.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP28906.
PaxDbiP28906.
PRIDEiP28906.

PTM databases

PhosphoSiteiP28906.

Expressioni

Tissue specificityi

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Developmental stagei

On early hematopoietic progenitor cells.

Gene expression databases

ArrayExpressiP28906.
BgeeiP28906.
CleanExiHS_CD34.
GenevestigatoriP28906.

Organism-specific databases

HPAiCAB000018.

Interactioni

Protein-protein interaction databases

BioGridi107385. 3 interactions.
IntActiP28906. 1 interaction.
STRINGi9606.ENSP00000310036.

Structurei

3D structure databases

ProteinModelPortaliP28906.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD34 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42285.
HOVERGENiHBG003461.
InParanoidiP28906.
KOiK06474.
OMAiKGEIKCS.
PhylomeDBiP28906.
TreeFamiTF335795.

Family and domain databases

InterProiIPR008083. CD34.
IPR013836. CD34/Podocalyxin.
[Graphical view]
PANTHERiPTHR16677. PTHR16677. 1 hit.
PfamiPF06365. CD34_antigen. 1 hit.
[Graphical view]
PRINTSiPR01700. CD34ANTIGEN.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation.

Isoform CD34-F (identifier: P28906-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS    50
NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT 100
SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS 150
TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA 200
EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR 250
TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL 300
LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ 350
GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL 385
Length:385
Mass (Da):40,716
Last modified:July 15, 1998 - v2
Checksum:iBC581A8FCFFE2BB3
GO
Isoform CD34-T (identifier: P28906-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-328: GEDP → ELEP
     329-385: Missing.

Show »
Length:328
Mass (Da):35,011
Checksum:i7FFBEBC98D4CC61D
GO

Sequence cautioni

The sequence AAA03181.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671A → S.
Corresponds to variant rs28362497 [ dbSNP | Ensembl ].
VAR_050774

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 3284GEDP → ELEP in isoform CD34-T. VSP_004159
Alternative sequencei329 – 38557Missing in isoform CD34-T. VSP_004160Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871Q → E AA sequence 1 Publication
Sequence conflicti325 – 3273GED → ELE1 Publication
Sequence conflicti361 – 3611E → K1 Publication
Sequence conflicti361 – 3611E → K1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81104 mRNA. Translation: AAA03181.1. Different initiation.
M81945
, M81938, M81939, M81940, M81941, M81942, M81943, M81944 Genomic DNA. Translation: AAA03659.1.
S53910 mRNA. Translation: AAB25222.1.
S53911 mRNA. Translation: AAB25223.1.
AF523361 mRNA. Translation: AAM82157.1.
AK291529 mRNA. Translation: BAF84218.1.
AL356275 Genomic DNA. Translation: CAI40195.1.
AL356275 Genomic DNA. Translation: CAI40196.1.
CH471100 Genomic DNA. Translation: EAW93459.1.
BC039146 mRNA. Translation: AAH39146.2.
CCDSiCCDS31011.1. [P28906-1]
CCDS31012.1. [P28906-2]
PIRiA38078.
I67604.
RefSeqiNP_001020280.1. NM_001025109.1. [P28906-1]
NP_001764.1. NM_001773.2. [P28906-2]
UniGeneiHs.374990.

Genome annotation databases

EnsembliENST00000310833; ENSP00000310036; ENSG00000174059. [P28906-1]
ENST00000356522; ENSP00000348916; ENSG00000174059. [P28906-2]
GeneIDi947.
KEGGihsa:947.
UCSCiuc001hgw.1. human. [P28906-1]
uc001hgx.1. human. [P28906-2]

Polymorphism databases

DMDMi3183511.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CD34 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81104 mRNA. Translation: AAA03181.1 . Different initiation.
M81945
, M81938 , M81939 , M81940 , M81941 , M81942 , M81943 , M81944 Genomic DNA. Translation: AAA03659.1 .
S53910 mRNA. Translation: AAB25222.1 .
S53911 mRNA. Translation: AAB25223.1 .
AF523361 mRNA. Translation: AAM82157.1 .
AK291529 mRNA. Translation: BAF84218.1 .
AL356275 Genomic DNA. Translation: CAI40195.1 .
AL356275 Genomic DNA. Translation: CAI40196.1 .
CH471100 Genomic DNA. Translation: EAW93459.1 .
BC039146 mRNA. Translation: AAH39146.2 .
CCDSi CCDS31011.1. [P28906-1 ]
CCDS31012.1. [P28906-2 ]
PIRi A38078.
I67604.
RefSeqi NP_001020280.1. NM_001025109.1. [P28906-1 ]
NP_001764.1. NM_001773.2. [P28906-2 ]
UniGenei Hs.374990.

3D structure databases

ProteinModelPortali P28906.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107385. 3 interactions.
IntActi P28906. 1 interaction.
STRINGi 9606.ENSP00000310036.

PTM databases

PhosphoSitei P28906.

Polymorphism databases

DMDMi 3183511.

Proteomic databases

MaxQBi P28906.
PaxDbi P28906.
PRIDEi P28906.

Protocols and materials databases

DNASUi 947.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310833 ; ENSP00000310036 ; ENSG00000174059 . [P28906-1 ]
ENST00000356522 ; ENSP00000348916 ; ENSG00000174059 . [P28906-2 ]
GeneIDi 947.
KEGGi hsa:947.
UCSCi uc001hgw.1. human. [P28906-1 ]
uc001hgx.1. human. [P28906-2 ]

Organism-specific databases

CTDi 947.
GeneCardsi GC01M208057.
HGNCi HGNC:1662. CD34.
HPAi CAB000018.
MIMi 142230. gene.
neXtProti NX_P28906.
PharmGKBi PA26211.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42285.
HOVERGENi HBG003461.
InParanoidi P28906.
KOi K06474.
OMAi KGEIKCS.
PhylomeDBi P28906.
TreeFami TF335795.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

ChiTaRSi CD34. human.
GeneWikii CD34.
GenomeRNAii 947.
NextBioi 3932.
PROi P28906.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28906.
Bgeei P28906.
CleanExi HS_CD34.
Genevestigatori P28906.

Family and domain databases

InterProi IPR008083. CD34.
IPR013836. CD34/Podocalyxin.
[Graphical view ]
PANTHERi PTHR16677. PTHR16677. 1 hit.
Pfami PF06365. CD34_antigen. 1 hit.
[Graphical view ]
PRINTSi PR01700. CD34ANTIGEN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells."
    Simmons D.L., Satterthwaite A.B., Tenen D.G., Seed B.
    J. Immunol. 148:267-271(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD34-F), PROTEIN SEQUENCE OF 32-43.
    Tissue: Bone marrow.
  2. "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen."
    Satterthwaite A.B., Burn T.C., le Beau M.M., Tenen D.G.
    Genomics 12:788-794(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM CD34-F).
  3. "Two alternative forms of cDNA encoding CD34."
    Nakamura Y., Komano H., Nakauchi H.
    Exp. Hematol. 21:236-242(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CD34-F AND CD34-T).
    Tissue: Megakaryoblast.
  4. "Sequence analysis of the human CD34 antigen."
    Freund D., Wiebe G.J., Ehninger G., Corbeil D.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD34-F).
    Tissue: Heart.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CD34-F).
    Tissue: Placenta.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CD34-F).
    Tissue: Skin.
  9. "Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34."
    Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.
    Leukemia 2:793-803(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 32-47 AND 175-191, CHARACTERIZATION.
  10. "Activated protein kinase C directly phosphorylates the CD34 antigen on hematopoietic cells."
    Fackler M.J., Civin C.I., Sutherland D.R., Baker M.A., May W.S.
    J. Biol. Chem. 265:11056-11061(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY PKC.

Entry informationi

Entry nameiCD34_HUMAN
AccessioniPrimary (citable) accession number: P28906
Secondary accession number(s): A8K664
, Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi