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Protein

Guanylin

Gene

Guca2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

  • guanylate cyclase activator activity Source: RGD
  • guanylate cyclase regulator activity Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Gene namesi
Name:Guca2a
Synonyms:Guca2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2766. Guca2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 100771 PublicationPRO_0000013141Add
BLAST
Peptidei101 – 11515GuanylinPRO_0000013142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 82By similarity
Disulfide bondi104 ↔ 112By similarity
Disulfide bondi107 ↔ 115By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP28902.
PRIDEiP28902.

Expressioni

Tissue specificityi

Intestine and in low abundance in adrenal gland, kidney, and uterus/oviduct.

Gene expression databases

BgeeiENSRNOG00000008849.
GenevisibleiP28902. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011867.

Structurei

3D structure databases

ProteinModelPortaliP28902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP28902.
OMAiSCEICAF.
OrthoDBiEOG091G0WKF.
PhylomeDBiP28902.
TreeFamiTF330731.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAWLLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKQLK HLREVQEPTL
60 70 80 90 100
MSHKKFALRL PKPVAPELCS QSAFPEALRP LCEKPNAEEI LQRLEAIAQD
110
PNTCEICAYA ACTGC
Length:115
Mass (Da):12,574
Last modified:December 1, 1992 - v1
Checksum:i35AC63C7AC130EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95493 mRNA. Translation: AAA41302.1.
M93005 mRNA. Translation: AAA41300.1.
X67669 mRNA. Translation: CAA47901.1.
PIRiJN0318.
RefSeqiNP_037250.1. NM_013118.1.
UniGeneiRn.11388.

Genome annotation databases

EnsembliENSRNOT00000011867; ENSRNOP00000011867; ENSRNOG00000008849.
GeneIDi25656.
KEGGirno:25656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95493 mRNA. Translation: AAA41302.1.
M93005 mRNA. Translation: AAA41300.1.
X67669 mRNA. Translation: CAA47901.1.
PIRiJN0318.
RefSeqiNP_037250.1. NM_013118.1.
UniGeneiRn.11388.

3D structure databases

ProteinModelPortaliP28902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011867.

Proteomic databases

PaxDbiP28902.
PRIDEiP28902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011867; ENSRNOP00000011867; ENSRNOG00000008849.
GeneIDi25656.
KEGGirno:25656.

Organism-specific databases

CTDi2980.
RGDi2766. Guca2a.

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP28902.
OMAiSCEICAF.
OrthoDBiEOG091G0WKF.
PhylomeDBiP28902.
TreeFamiTF330731.

Miscellaneous databases

PROiP28902.

Gene expression databases

BgeeiENSRNOG00000008849.
GenevisibleiP28902. RN.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2A_RAT
AccessioniPrimary (citable) accession number: P28902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.