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Protein

Guanylin

Gene

Guca2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

  • guanylate cyclase activator activity Source: RGD
  • guanylate cyclase regulator activity Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-8935690 Digestion

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Gene namesi
Name:Guca2a
Synonyms:Guca2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2766 Guca2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000001314124 – 1001 PublicationAdd BLAST77
PeptideiPRO_0000013142101 – 115GuanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 82By similarity
Disulfide bondi104 ↔ 112By similarity
Disulfide bondi107 ↔ 115By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP28902
PRIDEiP28902

Expressioni

Tissue specificityi

Intestine and in low abundance in adrenal gland, kidney, and uterus/oviduct.

Gene expression databases

BgeeiENSRNOG00000008849
GenevisibleiP28902 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011867

Structurei

3D structure databases

ProteinModelPortaliP28902
SMRiP28902
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S Eukaryota
ENOG410Z6NA LUCA
GeneTreeiENSGT00730000111358
HOGENOMiHOG000231183
HOVERGENiHBG051861
InParanoidiP28902
OMAiSCEICAF
OrthoDBiEOG091G0WKF
PhylomeDBiP28902
TreeFamiTF330731

Family and domain databases

Gene3Di3.90.1450.10, 1 hit
InterProiView protein in InterPro
IPR000879 Guanylin
IPR036382 Guanylin_sf
PANTHERiPTHR11318 PTHR11318, 1 hit
PfamiView protein in Pfam
PF02058 Guanylin, 1 hit
PIRSFiPIRSF001849 Guanylin, 1 hit
PRINTSiPR00774 GUANYLIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588 Guanylin, 1 hit
SUPFAMiSSF89890 SSF89890, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAWLLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKQLK HLREVQEPTL
60 70 80 90 100
MSHKKFALRL PKPVAPELCS QSAFPEALRP LCEKPNAEEI LQRLEAIAQD
110
PNTCEICAYA ACTGC
Length:115
Mass (Da):12,574
Last modified:December 1, 1992 - v1
Checksum:i35AC63C7AC130EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95493 mRNA Translation: AAA41302.1
M93005 mRNA Translation: AAA41300.1
X67669 mRNA Translation: CAA47901.1
PIRiJN0318
RefSeqiNP_037250.1, NM_013118.1
UniGeneiRn.11388

Genome annotation databases

EnsembliENSRNOT00000011867; ENSRNOP00000011867; ENSRNOG00000008849
GeneIDi25656
KEGGirno:25656

Similar proteinsi

Entry informationi

Entry nameiGUC2A_RAT
AccessioniPrimary (citable) accession number: P28902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health