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Protein

Guanylin

Gene

Guca2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

  • guanylate cyclase activator activity Source: RGD
  • guanylate cyclase regulator activity Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-8935690. Digestion.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Gene namesi
Name:Guca2a
Synonyms:Guca2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2766. Guca2a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000001314124 – 1001 PublicationAdd BLAST77
PeptideiPRO_0000013142101 – 115GuanylinAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 82By similarity
Disulfide bondi104 ↔ 112By similarity
Disulfide bondi107 ↔ 115By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP28902.
PRIDEiP28902.

Expressioni

Tissue specificityi

Intestine and in low abundance in adrenal gland, kidney, and uterus/oviduct.

Gene expression databases

BgeeiENSRNOG00000008849.
GenevisibleiP28902. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011867.

Structurei

3D structure databases

ProteinModelPortaliP28902.
SMRiP28902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiP28902.
OMAiQEPRVGK.
OrthoDBiEOG091G0WKF.
PhylomeDBiP28902.
TreeFamiTF330731.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000879. Guanylin.
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiView protein in Pfam
PF02058. Guanylin. 1 hit.
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005588. Guanylin. 1 hit.
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAWLLSVLC LLGALAVLVE GVTVQDGDLS FPLESVKQLK HLREVQEPTL
60 70 80 90 100
MSHKKFALRL PKPVAPELCS QSAFPEALRP LCEKPNAEEI LQRLEAIAQD
110
PNTCEICAYA ACTGC
Length:115
Mass (Da):12,574
Last modified:December 1, 1992 - v1
Checksum:i35AC63C7AC130EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95493 mRNA. Translation: AAA41302.1.
M93005 mRNA. Translation: AAA41300.1.
X67669 mRNA. Translation: CAA47901.1.
PIRiJN0318.
RefSeqiNP_037250.1. NM_013118.1.
UniGeneiRn.11388.

Genome annotation databases

EnsembliENSRNOT00000011867; ENSRNOP00000011867; ENSRNOG00000008849.
GeneIDi25656.
KEGGirno:25656.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGUC2A_RAT
AccessioniPrimary (citable) accession number: P28902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 7, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families