P28893 (DUT_ICHVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:

49

Organism

Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) [Reference proteome]

Taxonomic identifier

766178 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Alloherpesviridae › Ictalurivirus › Ictalurid herpesvirus 1

Virus host

Ictaluridae (bullhead catfishes) [TaxID: 7996]

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182955

Sequences

	Sequence		Length	Mass (Da)
	P28893 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: F9E924FA21366EF2	FASTA	188	20,129
	10 20 30 40 50 60 MGEMTSGVDG HGSTKRTTSE AQKMDFNTDR GSAIPTGDDR GYQCGVIGDS VRFSVFTGYD 70 80 90 100 110 120 AADVSIPKIS SPGSAGFDLS VLEDREFIRG CHYRLPTGLA IAVPRGYVGI ITPRSSQAKN 130 140 150 160 170 180 FVSTGIIDSD FRGHIHIMVS AIADFSVKKN QRIAQLVVTP CLTQSEVVPY ETLERTRRGT GGFGSSGQ

References

[1]	"Channel catfish virus: a new type of herpesvirus." Davison A.J. Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M75136 Genomic DNA. Translation: AAA88152.1.
PIR	WZBEI1. E36791.
RefSeq	NP_041140.1. NC_001493.1.
3D structure databases
ProteinModelPortal	P28893.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1488441.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DUT_ICHVA

Accession

Primary (citable) accession number: P28893

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program