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P28893

- DUT_ICHVA

UniProt

P28893 - DUT_ICHVA

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

49

Organism
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:49
OrganismiIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Taxonomic identifieri766178 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
Virus hostiIctaluridae (bullhead catfishes) [TaxID: 7996]
ProteomesiUP000007643: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182955Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28893.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

P28893-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEMTSGVDG HGSTKRTTSE AQKMDFNTDR GSAIPTGDDR GYQCGVIGDS
60 70 80 90 100
VRFSVFTGYD AADVSIPKIS SPGSAGFDLS VLEDREFIRG CHYRLPTGLA
110 120 130 140 150
IAVPRGYVGI ITPRSSQAKN FVSTGIIDSD FRGHIHIMVS AIADFSVKKN
160 170 180
QRIAQLVVTP CLTQSEVVPY ETLERTRRGT GGFGSSGQ
Length:188
Mass (Da):20,129
Last modified:December 1, 1992 - v1
Checksum:iF9E924FA21366EF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75136 Genomic DNA. Translation: AAA88152.1.
PIRiE36791. WZBEI1.
RefSeqiNP_041140.1. NC_001493.2.

Genome annotation databases

GeneIDi1488441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75136 Genomic DNA. Translation: AAA88152.1 .
PIRi E36791. WZBEI1.
RefSeqi NP_041140.1. NC_001493.2.

3D structure databases

ProteinModelPortali P28893.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1488441.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Channel catfish virus: a new type of herpesvirus."
    Davison A.J.
    Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_ICHVA
AccessioniPrimary (citable) accession number: P28893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3