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P28893 (DUT_ICHVA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:49
OrganismIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) [Reference proteome]
Taxonomic identifier766178 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
Virus hostIctaluridae (bullhead catfishes) [TaxID: 7996]

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182955

Sequences

Sequence LengthMass (Da)Tools
P28893 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: F9E924FA21366EF2

FASTA18820,129
        10         20         30         40         50         60 
MGEMTSGVDG HGSTKRTTSE AQKMDFNTDR GSAIPTGDDR GYQCGVIGDS VRFSVFTGYD 

        70         80         90        100        110        120 
AADVSIPKIS SPGSAGFDLS VLEDREFIRG CHYRLPTGLA IAVPRGYVGI ITPRSSQAKN 

       130        140        150        160        170        180 
FVSTGIIDSD FRGHIHIMVS AIADFSVKKN QRIAQLVVTP CLTQSEVVPY ETLERTRRGT 


GGFGSSGQ 

« Hide

References

[1]"Channel catfish virus: a new type of herpesvirus."
Davison A.J.
Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M75136 Genomic DNA. Translation: AAA88152.1.
PIRWZBEI1. E36791.
RefSeqNP_041140.1. NC_001493.2.

3D structure databases

ProteinModelPortalP28893.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1488441.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_ICHVA
AccessionPrimary (citable) accession number: P28893
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families