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P28893

- DUT_ICHVA

UniProt

P28893 - DUT_ICHVA

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
49
Organism
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:49
OrganismiIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Taxonomic identifieri766178 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
Virus hostiIctaluridae (bullhead catfishes) [TaxID: 7996]
ProteomesiUP000007643: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182955Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28893.

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

P28893-1 [UniParc]FASTAAdd to Basket

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MGEMTSGVDG HGSTKRTTSE AQKMDFNTDR GSAIPTGDDR GYQCGVIGDS    50
VRFSVFTGYD AADVSIPKIS SPGSAGFDLS VLEDREFIRG CHYRLPTGLA 100
IAVPRGYVGI ITPRSSQAKN FVSTGIIDSD FRGHIHIMVS AIADFSVKKN 150
QRIAQLVVTP CLTQSEVVPY ETLERTRRGT GGFGSSGQ 188
Length:188
Mass (Da):20,129
Last modified:December 1, 1992 - v1
Checksum:iF9E924FA21366EF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75136 Genomic DNA. Translation: AAA88152.1.
PIRiE36791. WZBEI1.
RefSeqiNP_041140.1. NC_001493.2.

Genome annotation databases

GeneIDi1488441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75136 Genomic DNA. Translation: AAA88152.1 .
PIRi E36791. WZBEI1.
RefSeqi NP_041140.1. NC_001493.2.

3D structure databases

ProteinModelPortali P28893.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1488441.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Channel catfish virus: a new type of herpesvirus."
    Davison A.J.
    Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_ICHVA
AccessioniPrimary (citable) accession number: P28893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3