Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28893

- DUT_ICHVA

UniProt

P28893 - DUT_ICHVA

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

49

Organism
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:49
    OrganismiIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
    Taxonomic identifieri766178 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
    Virus hostiIctaluridae (bullhead catfishes) [TaxID: 7996]
    ProteomesiUP000007643: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 188188Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182955Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP28893.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P28893-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEMTSGVDG HGSTKRTTSE AQKMDFNTDR GSAIPTGDDR GYQCGVIGDS    50
    VRFSVFTGYD AADVSIPKIS SPGSAGFDLS VLEDREFIRG CHYRLPTGLA 100
    IAVPRGYVGI ITPRSSQAKN FVSTGIIDSD FRGHIHIMVS AIADFSVKKN 150
    QRIAQLVVTP CLTQSEVVPY ETLERTRRGT GGFGSSGQ 188
    Length:188
    Mass (Da):20,129
    Last modified:December 1, 1992 - v1
    Checksum:iF9E924FA21366EF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75136 Genomic DNA. Translation: AAA88152.1.
    PIRiE36791. WZBEI1.
    RefSeqiNP_041140.1. NC_001493.2.

    Genome annotation databases

    GeneIDi1488441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75136 Genomic DNA. Translation: AAA88152.1 .
    PIRi E36791. WZBEI1.
    RefSeqi NP_041140.1. NC_001493.2.

    3D structure databases

    ProteinModelPortali P28893.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1488441.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Channel catfish virus: a new type of herpesvirus."
      Davison A.J.
      Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_ICHVA
    AccessioniPrimary (citable) accession number: P28893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3