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P28892

- DUT_EHV1B

UniProt

P28892 - DUT_EHV1B

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

9

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    Name:9
    OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
    Taxonomic identifieri31520 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000001189: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182954Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP28892.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P28892-1 [UniParc]FASTAAdd to Basket

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    MASVTNLVDS IVVVECGERW RARAEAAGRL LVLINNHTVE LSGEHGSAGE    50
    FYSVLTDVGV RVACSSGYAI VLTQISGLLP VEPEPGNFSN VTFPENSAKY 100
    YTAYGIVDSG YRGVVKAVQF APGINTSVPP GQMSLGLVLV KLARKSIHVT 150
    SIGSTRDGRT SEANLFYDYF APKRVEDAGY DISAPEDATI DPDESHFVDL 200
    PIVFANSNPA VTPCIFGRSS MNRRGLIVLP TRWVAGRTCC FFILNVNKYP 250
    VSITKGQRVA QLLLTEDIDD ALIPPTVNYD NPFPTYSPSE STKAPQSPVL 300
    WKFTTDFDRE APSSLRADGG FGSTGL 326
    Length:326
    Mass (Da):35,209
    Last modified:December 1, 1992 - v1
    Checksum:i0FE874E975EF51EB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665713 Genomic DNA. Translation: AAT67266.1.
    PIRiA36796. WZBEA8.
    RefSeqiYP_053054.1. NC_001491.2.

    Genome annotation databases

    GeneIDi1487564.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665713 Genomic DNA. Translation: AAT67266.1 .
    PIRi A36796. WZBEA8.
    RefSeqi YP_053054.1. NC_001491.2.

    3D structure databases

    ProteinModelPortali P28892.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1487564.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDUT_EHV1B
    AccessioniPrimary (citable) accession number: P28892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3