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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:9
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000001189 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829541 – 326Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST326

Structurei

3D structure databases

ProteinModelPortaliP28892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 220Substrate bindingUniRule annotation3
Regioni321 – 322Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900009U

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 2 hits

Sequencei

Sequence statusi: Complete.

P28892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTNLVDS IVVVECGERW RARAEAAGRL LVLINNHTVE LSGEHGSAGE
60 70 80 90 100
FYSVLTDVGV RVACSSGYAI VLTQISGLLP VEPEPGNFSN VTFPENSAKY
110 120 130 140 150
YTAYGIVDSG YRGVVKAVQF APGINTSVPP GQMSLGLVLV KLARKSIHVT
160 170 180 190 200
SIGSTRDGRT SEANLFYDYF APKRVEDAGY DISAPEDATI DPDESHFVDL
210 220 230 240 250
PIVFANSNPA VTPCIFGRSS MNRRGLIVLP TRWVAGRTCC FFILNVNKYP
260 270 280 290 300
VSITKGQRVA QLLLTEDIDD ALIPPTVNYD NPFPTYSPSE STKAPQSPVL
310 320
WKFTTDFDRE APSSLRADGG FGSTGL
Length:326
Mass (Da):35,209
Last modified:December 1, 1992 - v1
Checksum:i0FE874E975EF51EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665713 Genomic DNA Translation: AAT67266.1
PIRiA36796 WZBEA8
RefSeqiYP_053054.1, NC_001491.2

Genome annotation databases

GeneIDi1487564
KEGGivg:1487564

Similar proteinsi

Entry informationi

Entry nameiDUT_EHV1B
AccessioniPrimary (citable) accession number: P28892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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