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P28892 (DUT_EHV1B) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:9
OrganismEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) [Complete proteome]
Taxonomic identifier31520 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182954

Sequences

Sequence LengthMass (Da)Tools
P28892 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 0FE874E975EF51EB

FASTA32635,209
        10         20         30         40         50         60 
MASVTNLVDS IVVVECGERW RARAEAAGRL LVLINNHTVE LSGEHGSAGE FYSVLTDVGV 

        70         80         90        100        110        120 
RVACSSGYAI VLTQISGLLP VEPEPGNFSN VTFPENSAKY YTAYGIVDSG YRGVVKAVQF 

       130        140        150        160        170        180 
APGINTSVPP GQMSLGLVLV KLARKSIHVT SIGSTRDGRT SEANLFYDYF APKRVEDAGY 

       190        200        210        220        230        240 
DISAPEDATI DPDESHFVDL PIVFANSNPA VTPCIFGRSS MNRRGLIVLP TRWVAGRTCC 

       250        260        270        280        290        300 
FFILNVNKYP VSITKGQRVA QLLLTEDIDD ALIPPTVNYD NPFPTYSPSE STKAPQSPVL 

       310        320 
WKFTTDFDRE APSSLRADGG FGSTGL 

« Hide

References

[1]"The DNA sequence of equine herpesvirus-1."
Telford E.A.R., Watson M.S., McBride K., Davison A.J.
Virology 189:304-316(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY665713 Genomic DNA. Translation: AAT67266.1.
PIRWZBEA8. A36796.
RefSeqYP_053054.1. NC_001491.2.

3D structure databases

ProteinModelPortalP28892.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487564.

Phylogenomic databases

ProtClustDBPHA3126.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_EHV1B
AccessionPrimary (citable) accession number: P28892
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families