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P28892

- DUT_EHV1B

UniProt

P28892 - DUT_EHV1B

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

9

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:9
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000001189: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182954Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P28892-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVTNLVDS IVVVECGERW RARAEAAGRL LVLINNHTVE LSGEHGSAGE
60 70 80 90 100
FYSVLTDVGV RVACSSGYAI VLTQISGLLP VEPEPGNFSN VTFPENSAKY
110 120 130 140 150
YTAYGIVDSG YRGVVKAVQF APGINTSVPP GQMSLGLVLV KLARKSIHVT
160 170 180 190 200
SIGSTRDGRT SEANLFYDYF APKRVEDAGY DISAPEDATI DPDESHFVDL
210 220 230 240 250
PIVFANSNPA VTPCIFGRSS MNRRGLIVLP TRWVAGRTCC FFILNVNKYP
260 270 280 290 300
VSITKGQRVA QLLLTEDIDD ALIPPTVNYD NPFPTYSPSE STKAPQSPVL
310 320
WKFTTDFDRE APSSLRADGG FGSTGL
Length:326
Mass (Da):35,209
Last modified:December 1, 1992 - v1
Checksum:i0FE874E975EF51EB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665713 Genomic DNA. Translation: AAT67266.1.
PIRiA36796. WZBEA8.
RefSeqiYP_053054.1. NC_001491.2.

Genome annotation databases

GeneIDi1487564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665713 Genomic DNA. Translation: AAT67266.1 .
PIRi A36796. WZBEA8.
RefSeqi YP_053054.1. NC_001491.2.

3D structure databases

ProteinModelPortali P28892.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487564.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_EHV1B
AccessioniPrimary (citable) accession number: P28892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3