P28892 (DUT_EHV1B) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:

9

Organism

Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) [Complete proteome]

Taxonomic identifier

31520 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Equid herpesvirus 1

Virus host

Equus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182954

Sequences

	Sequence		Length	Mass (Da)
	P28892 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 0FE874E975EF51EB	FASTA	326	35,209
	10 20 30 40 50 60 MASVTNLVDS IVVVECGERW RARAEAAGRL LVLINNHTVE LSGEHGSAGE FYSVLTDVGV 70 80 90 100 110 120 RVACSSGYAI VLTQISGLLP VEPEPGNFSN VTFPENSAKY YTAYGIVDSG YRGVVKAVQF 130 140 150 160 170 180 APGINTSVPP GQMSLGLVLV KLARKSIHVT SIGSTRDGRT SEANLFYDYF APKRVEDAGY 190 200 210 220 230 240 DISAPEDATI DPDESHFVDL PIVFANSNPA VTPCIFGRSS MNRRGLIVLP TRWVAGRTCC 250 260 270 280 290 300 FFILNVNKYP VSITKGQRVA QLLLTEDIDD ALIPPTVNYD NPFPTYSPSE STKAPQSPVL 310 320 WKFTTDFDRE APSSLRADGG FGSTGL

References

[1]	"The DNA sequence of equine herpesvirus-1." Telford E.A.R., Watson M.S., McBride K., Davison A.J. Virology 189:304-316(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY665713 Genomic DNA. Translation: AAT67266.1.
PIR	WZBEA8. A36796.
RefSeq	YP_053054.1. NC_001491.2.
3D structure databases
ProteinModelPortal	P28892.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1487564.
Phylogenomic databases
ProtClustDB	PHA3126.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_EHV1B

Accession

Primary (citable) accession number: P28892

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program