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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

9

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:9
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000001189 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182954Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28892.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.

Sequencei

Sequence statusi: Complete.

P28892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTNLVDS IVVVECGERW RARAEAAGRL LVLINNHTVE LSGEHGSAGE
60 70 80 90 100
FYSVLTDVGV RVACSSGYAI VLTQISGLLP VEPEPGNFSN VTFPENSAKY
110 120 130 140 150
YTAYGIVDSG YRGVVKAVQF APGINTSVPP GQMSLGLVLV KLARKSIHVT
160 170 180 190 200
SIGSTRDGRT SEANLFYDYF APKRVEDAGY DISAPEDATI DPDESHFVDL
210 220 230 240 250
PIVFANSNPA VTPCIFGRSS MNRRGLIVLP TRWVAGRTCC FFILNVNKYP
260 270 280 290 300
VSITKGQRVA QLLLTEDIDD ALIPPTVNYD NPFPTYSPSE STKAPQSPVL
310 320
WKFTTDFDRE APSSLRADGG FGSTGL
Length:326
Mass (Da):35,209
Last modified:December 1, 1992 - v1
Checksum:i0FE874E975EF51EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665713 Genomic DNA. Translation: AAT67266.1.
PIRiA36796. WZBEA8.
RefSeqiYP_053054.1. NC_001491.2.

Genome annotation databases

GeneIDi1487564.
KEGGivg:1487564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665713 Genomic DNA. Translation: AAT67266.1.
PIRiA36796. WZBEA8.
RefSeqiYP_053054.1. NC_001491.2.

3D structure databases

ProteinModelPortaliP28892.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487564.
KEGGivg:1487564.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDUT_EHV1B
AccessioniPrimary (citable) accession number: P28892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.