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P28885 (HN_SV5LN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565Hemagglutinin-neuraminidase
PRO_0000142644

Regions

Topological domain1 – 1919Intravirion Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 565525Virion surface Potential

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...); by host Potential
Glycosylation1391N-linked (GlcNAc...); by host Potential
Glycosylation2671N-linked (GlcNAc...); by host Potential
Glycosylation5041N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P28885 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 8F531BB8704F281D

FASTA56562,138
        10         20         30         40         50         60 
MVAEDAPVRG TCRVLFRTTT LLFLCTLLSL SISILYESLI TQNQIMSQAG STGSNSGLGS 

        70         80         90        100        110        120 
ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAFKS LQTSDKLEQN CSWGAALIND 

       130        140        150        160        170        180 
NRYINGINQF YFSIAEGRNL TLGPLLNILS FIPTATTPEG CTRIPSFSLT KTHWCYTHNV 

       190        200        210        220        230        240 
ILNGCQDHVS SNQFVSMGII EPTSAGFPSF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC 

       250        260        270        280        290        300 
FVSTQPERDD YFSAAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW 

       310        320        330        340        350        360 
VLFPIYGGVI KDTSLWNSQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS SWFGNRMIQS 

       370        380        390        400        410        420 
GILACPLQQD LTNECLVLPF SNDQVLMGAE GRLYMYGDSV YYYQRSNSWW PMTMLYKVTI 

       430        440        450        460        470        480 
TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA TNRCPGFCLT GVYADAWLLT NPSSTSTFGS 

       490        500        510        520        530        540 
EATFTGSYLN TATQRINPTM YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI 

       550        560 
YIIELSSSLL GQFQIVPFIR QVTLS 

« Hide

References

[1]"Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5."
Baty D.U., Southern J.A., Randall R.E.
J. Gen. Virol. 72:3103-3107(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

PIRHNNZC3. JQ1307.

3D structure databases

ProteinModelPortalP28885.
SMRP28885. Positions 118-565.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_SV5LN
AccessionPrimary (citable) accession number: P28885
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries