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P28885

- HN_SV5LN

UniProt

P28885 - HN_SV5LN

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Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Simian virus 5 (isolate Human/LN) (SV5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiSimian virus 5 (isolate Human/LN) (SV5)
Taxonomic identifieri31610 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Homo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Intravirion Reviewed prediction
Add
BLAST
Transmembranei20 – 4021Helical; Reviewed prediction
Add
BLAST
Topological domaini41 – 565525Virion surface Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Hemagglutinin-neuraminidase
PRO_0000142644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi139 – 1391N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi267 – 2671N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi504 – 5041N-linked (GlcNAc...); by host Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP28885.
SMRiP28885. Positions 118-565.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P28885-1 [UniParc]FASTAAdd to Basket

« Hide

MVAEDAPVRG TCRVLFRTTT LLFLCTLLSL SISILYESLI TQNQIMSQAG    50
STGSNSGLGS ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAFKS 100
LQTSDKLEQN CSWGAALIND NRYINGINQF YFSIAEGRNL TLGPLLNILS 150
FIPTATTPEG CTRIPSFSLT KTHWCYTHNV ILNGCQDHVS SNQFVSMGII 200
EPTSAGFPSF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC FVSTQPERDD 250
YFSAAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW 300
VLFPIYGGVI KDTSLWNSQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS 350
SWFGNRMIQS GILACPLQQD LTNECLVLPF SNDQVLMGAE GRLYMYGDSV 400
YYYQRSNSWW PMTMLYKVTI TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA 450
TNRCPGFCLT GVYADAWLLT NPSSTSTFGS EATFTGSYLN TATQRINPTM 500
YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI YIIELSSSLL 550
GQFQIVPFIR QVTLS 565
Length:565
Mass (Da):62,138
Last modified:December 1, 1992 - v1
Checksum:i8F531BB8704F281D
GO

Sequence databases

PIRiJQ1307. HNNZC3.

Cross-referencesi

Sequence databases

PIRi JQ1307. HNNZC3.

3D structure databases

ProteinModelPortali P28885.
SMRi P28885. Positions 118-565.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5."
    Baty D.U., Southern J.A., Randall R.E.
    J. Gen. Virol. 72:3103-3107(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiHN_SV5LN
AccessioniPrimary (citable) accession number: P28885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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